arXiv subjects

Haofu Liao

Publications and source records attributed to Haofu Liao.

36 records · Page 2Linked to original sources

arXiv2020

Structured Landmark Detection via Topology-Adapting Deep Graph Learning

Image landmark detection aims to automatically identify the locations of predefined fiducial points. Despite recent success in this field, higher-ordered structural modeling to capture implicit or explicit relationships among anatomical landmarks has not been adequately exploited. In this work, we present a new topology-adapting deep graph learning approach for accurate anatomical facial and medical (e.g., hand, pelvis) landmark detection. The proposed method constructs graph signals leveraging both local image features and global shape features. The adaptive graph topology naturally explores and lands on task-specific structures which are learned end-to-end with two Graph Convolutional Networks (GCNs). Extensive experiments are conducted on three public facial image datasets (WFLW, 300W, and COFW-68) as well as three real-world X-ray medical datasets (Cephalometric (public), Hand and Pelvis). Quantitative results comparing with the previous state-of-the-art approaches across all studied datasets indicating the superior performance in both robustness and accuracy. Qualitative visualizations of the learned graph topologies demonstrate a physically plausible connectivity laying behind the landmarks.

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arXiv2020

Encoding Metal Mask Projection for Metal Artifact Reduction in Computed Tomography

Metal artifact reduction (MAR) in computed tomography (CT) is a notoriously challenging task because the artifacts are structured and non-local in the image domain. However, they are inherently local in the sinogram domain. Thus, one possible approach to MAR is to exploit the latter characteristic by learning to reduce artifacts in the sinogram. However, if we directly treat the metal-affected regions in sinogram as missing and replace them with the surrogate data generated by a neural network, the artifact-reduced CT images tend to be over-smoothed and distorted since fine-grained details within the metal-affected regions are completely ignored. In this work, we provide analytical investigation to the issue and propose to address the problem by (1) retaining the metal-affected regions in sinogram and (2) replacing the binarized metal trace with the metal mask projection such that the geometry information of metal implants is encoded. Extensive experiments on simulated datasets and expert evaluations on clinical images demonstrate that our novel network yields anatomically more precise artifact-reduced images than the state-of-the-art approaches, especially when metallic objects are large.

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arXiv2020

Unsupervised Learning of Landmarks based on Inter-Intra Subject Consistencies

We present a novel unsupervised learning approach to image landmark discovery by incorporating the inter-subject landmark consistencies on facial images. This is achieved via an inter-subject mapping module that transforms original subject landmarks based on an auxiliary subject-related structure. To recover from the transformed images back to the original subject, the landmark detector is forced to learn spatial locations that contain the consistent semantic meanings both for the paired intra-subject images and between the paired inter-subject images. Our proposed method is extensively evaluated on two public facial image datasets (MAFL, AFLW) with various settings. Experimental results indicate that our method can extract the consistent landmarks for both datasets and achieve better performances compared to the previous state-of-the-art methods quantitatively and qualitatively.

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arXiv2020

Alleviating the Incompatibility between Cross Entropy Loss and Episode Training for Few-shot Skin Disease Classification

Skin disease classification from images is crucial to dermatological diagnosis. However, identifying skin lesions involves a variety of aspects in terms of size, color, shape, and texture. To make matters worse, many categories only contain very few samples, posing great challenges to conventional machine learning algorithms and even human experts. Inspired by the recent success of Few-Shot Learning (FSL) in natural image classification, we propose to apply FSL to skin disease identification to address the extreme scarcity of training sample problem. However, directly applying FSL to this task does not work well in practice, and we find that the problem can be largely attributed to the incompatibility between Cross Entropy (CE) and episode training, which are both commonly used in FSL. Based on a detailed analysis, we propose the Query-Relative (QR) loss, which proves superior to CE under episode training and is closely related to recently proposed mutual information estimation. Moreover, we further strengthen the proposed QR loss with a novel adaptive hard margin strategy. Comprehensive experiments validate the effectiveness of the proposed FSL scheme and the possibility to diagnosis rare skin disease with a few labeled samples.

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arXiv2020

Example-Guided Image Synthesis across Arbitrary Scenes using Masked Spatial-Channel Attention and Self-Supervision

Example-guided image synthesis has recently been attempted to synthesize an image from a semantic label map and an exemplary image. In the task, the additional exemplar image provides the style guidance that controls the appearance of the synthesized output. Despite the controllability advantage, the existing models are designed on datasets with specific and roughly aligned objects. In this paper, we tackle a more challenging and general task, where the exemplar is an arbitrary scene image that is semantically different from the given label map. To this end, we first propose a Masked Spatial-Channel Attention (MSCA) module which models the correspondence between two arbitrary scenes via efficient decoupled attention. Next, we propose an end-to-end network for joint global and local feature alignment and synthesis. Finally, we propose a novel self-supervision task to enable training. Experiments on the large-scale and more diverse COCO-stuff dataset show significant improvements over the existing methods. Moreover, our approach provides interpretability and can be readily extended to other content manipulation tasks including style and spatial interpolation or extrapolation.

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arXiv2020

SAINT: Spatially Aware Interpolation NeTwork for Medical Slice Synthesis

Deep learning-based single image super-resolution (SISR) methods face various challenges when applied to 3D medical volumetric data (i.e., CT and MR images) due to the high memory cost and anisotropic resolution, which adversely affect their performance. Furthermore, mainstream SISR methods are designed to work over specific upsampling factors, which makes them ineffective in clinical practice. In this paper, we introduce a Spatially Aware Interpolation NeTwork (SAINT) for medical slice synthesis to alleviate the memory constraint that volumetric data poses. Compared to other super-resolution methods, SAINT utilizes voxel spacing information to provide desirable levels of details, and allows for the upsampling factor to be determined on the fly. Our evaluations based on 853 CT scans from four datasets that contain liver, colon, hepatic vessels, and kidneys show that SAINT consistently outperforms other SISR methods in terms of medical slice synthesis quality, while using only a single model to deal with different upsampling factors.

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arXiv2019

Artifact Disentanglement Network for Unsupervised Metal Artifact Reduction

Current deep neural network based approaches to computed tomography (CT) metal artifact reduction (MAR) are supervised methods which rely heavily on synthesized data for training. However, as synthesized data may not perfectly simulate the underlying physical mechanisms of CT imaging, the supervised methods often generalize poorly to clinical applications. To address this problem, we propose, to the best of our knowledge, the first unsupervised learning approach to MAR. Specifically, we introduce a novel artifact disentanglement network that enables different forms of generations and regularizations between the artifact-affected and artifact-free image domains to support unsupervised learning. Extensive experiments show that our method significantly outperforms the existing unsupervised models for image-to-image translation problems, and achieves comparable performance to existing supervised models on a synthesized dataset. When applied to clinical datasets, our method achieves considerable improvements over the supervised models. The source code of this paper is publicly available at https://github.com/liaohaofu/adn.

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arXiv2019

ADN: Artifact Disentanglement Network for Unsupervised Metal Artifact Reduction

Current deep neural network based approaches to computed tomography (CT) metal artifact reduction (MAR) are supervised methods that rely on synthesized metal artifacts for training. However, as synthesized data may not accurately simulate the underlying physical mechanisms of CT imaging, the supervised methods often generalize poorly to clinical applications. To address this problem, we propose, to the best of our knowledge, the first unsupervised learning approach to MAR. Specifically, we introduce a novel artifact disentanglement network that disentangles the metal artifacts from CT images in the latent space. It supports different forms of generations (artifact reduction, artifact transfer, and self-reconstruction, etc.) with specialized loss functions to obviate the need for supervision with synthesized data. Extensive experiments show that when applied to a synthesized dataset, our method addresses metal artifacts significantly better than the existing unsupervised models designed for natural image-to-image translation problems, and achieves comparable performance to existing supervised models for MAR. When applied to clinical datasets, our method demonstrates better generalization ability over the supervised models. The source code of this paper is publicly available at https://github.com/liaohaofu/adn.

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arXiv2019

Example-Guided Scene Image Synthesis using Masked Spatial-Channel Attention and Patch-Based Self-Supervision

Example-guided image synthesis has been recently attempted to synthesize an image from a semantic label map and an exemplary image. In the task, the additional exemplary image serves to provide style guidance that controls the appearance of the synthesized output. Despite the controllability advantage, the previous models are designed on datasets with specific and roughly aligned objects. In this paper, we tackle a more challenging and general task, where the exemplar is an arbitrary scene image that is semantically unaligned to the given label map. To this end, we first propose a new Masked Spatial-Channel Attention (MSCA) module which models the correspondence between two unstructured scenes via cross-attention. Next, we propose an end-to-end network for joint global and local feature alignment and synthesis. In addition, we propose a novel patch-based self-supervision scheme to enable training. Experiments on the large-scale CCOO-stuff dataset show significant improvements over existing methods. Moreover, our approach provides interpretability and can be readily extended to other tasks including style and spatial interpolation or extrapolation, as well as other content manipulation.

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arXiv2019

Deep Slice Interpolation via Marginal Super-Resolution, Fusion and Refinement

We propose a marginal super-resolution (MSR) approach based on 2D convolutional neural networks (CNNs) for interpolating an anisotropic brain magnetic resonance scan along the highly under-sampled direction, which is assumed to axial without loss of generality. Previous methods for slice interpolation only consider data from pairs of adjacent 2D slices. The possibility of fusing information from the direction orthogonal to the 2D slices remains unexplored. Our approach performs MSR in both sagittal and coronal directions, which provides an initial estimate for slice interpolation. The interpolated slices are then fused and refined in the axial direction for improved consistency. Since MSR consists of only 2D operations, it is more feasible in terms of GPU memory consumption and requires fewer training samples compared to 3D CNNs. Our experiments demonstrate that the proposed method outperforms traditional linear interpolation and baseline 2D/3D CNN-based approaches. We conclude by showcasing the method's practical utility in estimating brain volumes from under-sampled brain MR scans through semantic segmentation.

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arXiv2019

Automatic Radiology Report Generation based on Multi-view Image Fusion and Medical Concept Enrichment

Generating radiology reports is time-consuming and requires extensive expertise in practice. Therefore, reliable automatic radiology report generation is highly desired to alleviate the workload. Although deep learning techniques have been successfully applied to image classification and image captioning tasks, radiology report generation remains challenging in regards to understanding and linking complicated medical visual contents with accurate natural language descriptions. In addition, the data scales of open-access datasets that contain paired medical images and reports remain very limited. To cope with these practical challenges, we propose a generative encoder-decoder model and focus on chest x-ray images and reports with the following improvements. First, we pretrain the encoder with a large number of chest x-ray images to accurately recognize 14 common radiographic observations, while taking advantage of the multi-view images by enforcing the cross-view consistency. Second, we synthesize multi-view visual features based on a sentence-level attention mechanism in a late fusion fashion. In addition, in order to enrich the decoder with descriptive semantics and enforce the correctness of the deterministic medical-related contents such as mentions of organs or diagnoses, we extract medical concepts based on the radiology reports in the training data and fine-tune the encoder to extract the most frequent medical concepts from the x-ray images. Such concepts are fused with each decoding step by a word-level attention model. The experimental results conducted on the Indiana University Chest X-Ray dataset demonstrate that the proposed model achieves the state-of-the-art performance compared with other baseline approaches.

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arXiv2019

Patch Transformer for Multi-tagging Whole Slide Histopathology Images

Automated whole slide image (WSI) tagging has become a growing demand due to the increasing volume and diversity of WSIs collected nowadays in histopathology. Various methods have been studied to classify WSIs with single tags but none of them focuses on labeling WSIs with multiple tags. To this end, we propose a novel end-to-end trainable deep neural network named Patch Transformer which can effectively predict multiple slide-level tags from WSI patches based on both the correlations and the uniqueness between the tags. Specifically, the proposed method learns patch characteristics considering 1) patch-wise relations through a patch transformation module and 2) tag-wise uniqueness for each tagging task through a multi-tag attention module. Extensive experiments on a large and diverse dataset consisting of 4,920 WSIs prove the effectiveness of the proposed model.

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arXiv2019

DuDoNet: Dual Domain Network for CT Metal Artifact Reduction

Computed tomography (CT) is an imaging modality widely used for medical diagnosis and treatment. CT images are often corrupted by undesirable artifacts when metallic implants are carried by patients, which creates the problem of metal artifact reduction (MAR). Existing methods for reducing the artifacts due to metallic implants are inadequate for two main reasons. First, metal artifacts are structured and non-local so that simple image domain enhancement approaches would not suffice. Second, the MAR approaches which attempt to reduce metal artifacts in the X-ray projection (sinogram) domain inevitably lead to severe secondary artifact due to sinogram inconsistency. To overcome these difficulties, we propose an end-to-end trainable Dual Domain Network (DuDoNet) to simultaneously restore sinogram consistency and enhance CT images. The linkage between the sigogram and image domains is a novel Radon inversion layer that allows the gradients to back-propagate from the image domain to the sinogram domain during training. Extensive experiments show that our method achieves significant improvements over other single domain MAR approaches. To the best of our knowledge, it is the first end-to-end dual-domain network for MAR.

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arXiv2018

Adversarial Sparse-View CBCT Artifact Reduction

We present an effective post-processing method to reduce the artifacts from sparsely reconstructed cone-beam CT (CBCT) images. The proposed method is based on the state-of-the-art, image-to-image generative models with a perceptual loss as regulation. Unlike the traditional CT artifact-reduction approaches, our method is trained in an adversarial fashion that yields more perceptually realistic outputs while preserving the anatomical structures. To address the streak artifacts that are inherently local and appear across various scales, we further propose a novel discriminator architecture based on feature pyramid networks and a differentially modulated focus map to induce the adversarial training. Our experimental results show that the proposed method can greatly correct the cone-beam artifacts from clinical CBCT images reconstructed using 1/3 projections, and outperforms strong baseline methods both quantitatively and qualitatively.

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arXiv2018

Joint Vertebrae Identification and Localization in Spinal CT Images by Combining Short- and Long-Range Contextual Information

Automatic vertebrae identification and localization from arbitrary CT images is challenging. Vertebrae usually share similar morphological appearance. Because of pathology and the arbitrary field-of-view of CT scans, one can hardly rely on the existence of some anchor vertebrae or parametric methods to model the appearance and shape. To solve the problem, we argue that one should make use of the short-range contextual information, such as the presence of some nearby organs (if any), to roughly estimate the target vertebrae; due to the unique anatomic structure of the spine column, vertebrae have fixed sequential order which provides the important long-range contextual information to further calibrate the results. We propose a robust and efficient vertebrae identification and localization system that can inherently learn to incorporate both the short-range and long-range contextual information in a supervised manner. To this end, we develop a multi-task 3D fully convolutional neural network (3D FCN) to effectively extract the short-range contextual information around the target vertebrae. For the long-range contextual information, we propose a multi-task bidirectional recurrent neural network (Bi-RNN) to encode the spatial and contextual information among the vertebrae of the visible spine column. We demonstrate the effectiveness of the proposed approach on a challenging dataset and the experimental results show that our approach outperforms the state-of-the-art methods by a significant margin.

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arXiv2018

CariGAN: Caricature Generation through Weakly Paired Adversarial Learning

Caricature generation is an interesting yet challenging task. The primary goal is to generate plausible caricatures with reasonable exaggerations given face images. Conventional caricature generation approaches mainly use low-level geometric transformations such as image warping to generate exaggerated images, which lack richness and diversity in terms of content and style. The recent progress in generative adversarial networks (GANs) makes it possible to learn an image-to-image transformation from data, so that richer contents and styles can be generated. However, directly applying the GAN-based models to this task leads to unsatisfactory results because there is a large variance in the caricature distribution. Moreover, some models require strictly paired training data which largely limits their usage scenarios. In this paper, we propose CariGAN overcome these problems. Instead of training on paired data, CariGAN learns transformations only from weakly paired images. Specifically, to enforce reasonable exaggeration and facial deformation, facial landmarks are adopted as an additional condition to constrain the generated image. Furthermore, an attention mechanism is introduced to encourage our model to focus on the key facial parts so that more vivid details in these regions can be generated. Finally, a Diversity Loss is proposed to encourage the model to produce diverse results to help alleviate the `mode collapse' problem of the conventional GAN-based models. Extensive experiments on a new large-scale `WebCaricature' dataset show that the proposed CariGAN can generate more plausible caricatures with larger diversity compared with the state-of-the-art models.

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arXiv2017

Sum of previous inpatient serum creatinine measurements predicts acute kidney injury in rehospitalized patients

Acute Kidney Injury (AKI), the abrupt decline in kidney function due to temporary or permanent injury, is associated with increased mortality, morbidity, length of stay, and hospital cost. Sometimes, simple interventions such as medication review or hydration can prevent AKI. There is therefore interest in estimating risk of AKI at hospitalization. To gain insight into this task, we employ multilayer perceptron (MLP) and recurrent neural networks (RNNs) using serum creatinine (sCr) as a lone feature. We explore different feature input structures, including variable-length look-backs and a nested formulation for rehospitalized patients with previous sCr measurements. Experimental results show that the simplest model, MLP processing the sum of sCr, had best performance: AUROC 0.92 and AUPRC 0.70. Such a simple model could be easily integrated into an EHR. Preliminary results also suggest that inpatient data streams with missing outpatient measurements---common in the medical setting---might be best modeled with a tailored architecture.

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arXiv2016

Do They All Look the Same? Deciphering Chinese, Japanese and Koreans by Fine-Grained Deep Learning

We study to what extend Chinese, Japanese and Korean faces can be classified and which facial attributes offer the most important cues. First, we propose a novel way of obtaining large numbers of facial images with nationality labels. Then we train state-of-the-art neural networks with these labeled images. We are able to achieve an accuracy of 75.03% in the classification task, with chances being 33.33% and human accuracy 38.89% . Further, we train multiple facial attribute classifiers to identify the most distinctive features for each group. We find that Chinese, Japanese and Koreans do exhibit substantial differences in certain attributes, such as bangs, smiling, and bushy eyebrows. Along the way, we uncover several gender-related cross-country patterns as well. Our work, which complements existing APIs such as Microsoft Cognitive Services and Face++, could find potential applications in tourism, e-commerce, social media marketing, criminal justice and even counter-terrorism.

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