arXiv subjects

Haotian Wang

Publications and source records attributed to Haotian Wang.

115 records · Page 7Linked to original sources

arXiv2021

Sharp-GAN: Sharpness Loss Regularized GAN for Histopathology Image Synthesis

Existing deep learning-based approaches for histopathology image analysis require large annotated training sets to achieve good performance; but annotating histopathology images is slow and resource-intensive. Conditional generative adversarial networks have been applied to generate synthetic histopathology images to alleviate this issue, but current approaches fail to generate clear contours for overlapped and touching nuclei. In this study, We propose a sharpness loss regularized generative adversarial network to synthesize realistic histopathology images. The proposed network uses normalized nucleus distance map rather than the binary mask to encode nuclei contour information. The proposed sharpness loss enhances the contrast of nuclei contour pixels. The proposed method is evaluated using four image quality metrics and segmentation results on two public datasets. Both quantitative and qualitative results demonstrate that the proposed approach can generate realistic histopathology images with clear nuclei contours.

eess.IV↗

arXiv2021

Bend-Net: Bending Loss Regularized Multitask Learning Network for Nuclei Segmentation in Histopathology Images

Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on nuclei segmentation; however, their performance on separating overlapped nuclei is quite limited. To address the issue, we propose a novel multitask learning network with a bending loss regularizer to separate overlapped nuclei accurately. The newly proposed multitask learning architecture enhances the generalization by learning shared representation from three tasks: instance segmentation, nuclei distance map prediction, and overlapped nuclei distance map prediction. The proposed bending loss defines high penalties to concave contour points with large curvatures, and applies small penalties to convex contour points with small curvatures. Minimizing the bending loss avoids generating contours that encompass multiple nuclei. In addition, two new quantitative metrics, Aggregated Jaccard Index of overlapped nuclei (AJIO) and Accuracy of overlapped nuclei (ACCO), are designed for the evaluation of overlapped nuclei segmentation. We validate the proposed approach on the CoNSeP and MoNuSegv1 datasets using seven quantitative metrics: Aggregate Jaccard Index, Dice, Segmentation Quality, Recognition Quality, Panoptic Quality, AJIO, and ACCO. Extensive experiments demonstrate that the proposed Bend-Net outperforms eight state-of-the-art approaches.

eess.IV↗

arXiv2021

Multi-Slice Low-Rank Tensor Decomposition Based Multi-Atlas Segmentation: Application to Automatic Pathological Liver CT Segmentation

Liver segmentation from abdominal CT images is an essential step for liver cancer computer-aided diagnosis and surgical planning. However, both the accuracy and robustness of existing liver segmentation methods cannot meet the requirements of clinical applications. In particular, for the common clinical cases where the liver tissue contains major pathology, current segmentation methods show poor performance. In this paper, we propose a novel low-rank tensor decomposition (LRTD) based multi-atlas segmentation (MAS) framework that achieves accurate and robust pathological liver segmentation of CT images. Firstly, we propose a multi-slice LRTD scheme to recover the underlying low-rank structure embedded in 3D medical images. It performs the LRTD on small image segments consisting of multiple consecutive image slices. Then, we present an LRTD-based atlas construction method to generate tumor-free liver atlases that mitigates the performance degradation of liver segmentation due to the presence of tumors. Finally, we introduce an LRTD-based MAS algorithm to derive patient-specific liver atlases for each test image, and to achieve accurate pairwise image registration and label propagation. Extensive experiments on three public databases of pathological liver cases validate the effectiveness of the proposed method. Both qualitative and quantitative results demonstrate that, in the presence of major pathology, the proposed method is more accurate and robust than state-of-the-art methods.

eess.IV↗

arXiv2021

Heterogeneous Interventions Reduce the Spread of COVID-19 in Simulations on Real Mobility Data

Major interventions have been introduced worldwide to slow down the spread of the SARS-CoV-2 virus. Large-scale lockdowns of human movements are effective in reducing the spread, but they come at a cost of significantly limited societal functions. We show that natural human movements are statistically diverse, and the spread of the disease is significantly influenced by a small group of active individuals and gathering venues. We find that interventions focused on these most mobile individuals and popular venues reduce both the peak infection rate and the total infected population while retaining high social activity levels. These trends are seen consistently in simulations with real human mobility data of different scales, resolutions, and modalities from multiple cities across the world. The observation implies that compared to broad sweeping interventions, more heterogeneous strategies that are targeted based on the network effects in human mobility provide a better balance between pandemic control and regular social activities.

cs.SI↗

arXiv2020

Approximation Algorithms for Multi-Robot Patrol-Scheduling with Min-Max Latency

We consider the problem of finding patrol schedules for $k$ robots to visit a given set of $n$ sites in a metric space. Each robot has the same maximum speed and the goal is to minimize the weighted maximum latency of any site, where the latency of a site is defined as the maximum time duration between consecutive visits of that site. The problem is NP-hard, as it has the traveling salesman problem as a special case (when $k=1$ and all sites have the same weight). We present a polynomial-time algorithm with an approximation factor of $O(k^2 \log \frac{w_{\max}}{w_{\min}})$ to the optimal solution, where $w_{\max}$ and $w_{\min}$ are the maximum and minimum weight of the sites respectively. Further, we consider the special case where the sites are in 1D. When all sites have the same weight, we present a polynomial-time algorithm to solve the problem exactly. If the sites may have different weights, we present a $12$-approximate solution, which runs in polynomial time when the number of robots, $k$, is a constant.

cs.DS↗

arXiv2020

Bending Loss Regularized Network for Nuclei Segmentation in Histopathology Images

Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on public datasets; however, their performance in segmenting overlapped nuclei are limited. To address the issue, we propose the bending loss regularized network for nuclei segmentation. The proposed bending loss defines high penalties to contour points with large curvatures, and applies small penalties to contour points with small curvature. Minimizing the bending loss can avoid generating contours that encompass multiple nuclei. The proposed approach is validated on the MoNuSeg dataset using five quantitative metrics. It outperforms six state-of-the-art approaches on the following metrics: Aggregate Jaccard Index, Dice, Recognition Quality, and Pan-optic Quality.

eess.IV↗

arXiv2019

An electrochemical thermal transistor

The ability to actively regulate heat flow at the nanoscale could be a game changer for applications in thermal management and energy harvesting. Such a breakthrough could also enable the control of heat flow using thermal circuits, in a manner analogous to electronic circuits. Here we demonstrate switchable thermal transistors with an order of magnitude thermal on/off ratio, based on reversible electrochemical lithium intercalation in MoS2 thin films. We use spatially-resolved time-domain thermoreflectance to map the lithium ion distribution during device operation, and atomic force microscopy to show that the lithiated state correlates with increased thickness and surface roughness. First principles calculations reveal that the thermal conductance modulation is due to phonon scattering by lithium rattler modes, c-axis strain, and stacking disorder. This study lays the foundation for electrochemically-driven nanoscale thermal regulators, and establishes thermal metrology as a useful probe of spatio-temporal intercalant dynamics in nanomaterials.

physics.app-ph↗