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He Geng

Publications and source records attributed to He Geng.

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Dense Clinical Contrasts Enhance Medical Knowledge Updating in Large Language Models

Medical knowledge changes continually, making large language models vulnerable to relying on outdated yet clinically plausible information. We study whether the format of supervision affects medical knowledge updating under a matched training-budget setting. We introduce SEER-Bench, a temporally anchored oncology-staging benchmark curated from the latest versioned SEER Research Data release, and render identical medical update events from NCCN oncology guidelines into four supervision formats: EMQ, MSQ, FITB, and SAQ. Across SEER-Bench and HealthBench Professional, EMQ gives the most stable external transfer and retention among same-budget SFT variants. With EMQ supervision, the updated 4B model produces competitive results on temporally anchored oncology staging, reaching 64.8% answer accuracy and 59.6% rationale accuracy on SEER-Bench. Diagnostic analyses suggest that EMQ exposes denser clinical contrast signals while preserving discriminative representations with smaller movement from the base model. These results show that medical knowledge updating depends not only on the update algorithm, but also on how knowledge is structured as supervision.

cs.AI

A Blind Spot in Alignment: Quantifying Biosecurity Risks in Large Language Models

Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse. Current safety evaluations, however, operate in natural language and cannot determine whether a model-generated amino acid sequence is biological gibberish or a computational risk signal. To address this evaluation blind spot, we introduce SPIKE-Bench, coupling 631 curated toxin-design prompts across seven functional categories with the SPIKE funnel, a three-stage protocol that filters output through compliance, biological plausibility, and predicted toxicity, producing stage-level diagnostics and an aggregate function-aware metric: the Functional Harmfulness Rate (FHR). An audit of 32 LLMs reveals that most models freely comply with toxin-design requests; FHR is driven primarily by biological generation capability rather than safety alignment, reaching 50.7%; and Refusal Rate fails to predict functional risk. As a first step toward mitigation, we provide BioSafe-Guard, a domain-specialized classifier that substantially reduces predicted functional risk while preserving benign utility. We release SPIKE-Bench and BioSafe-Guard at https://github.com/PKU-Alignment/SPIKE-Bench to support more rigorous biosecurity evaluation of LLMs.

q-bio.QM

Fluid Antennas Assisted RIS-NOMA Communication Networks

This paper introduces a fluid antenna system (FAS) into reconfigurable intelligent surface (RIS) assisted non-orthogonal multiple access (NOMA) communication networks, where the non-orthogonal users are equipped with planar fluid antennas. Specifically, we formulate a sum rate maximization problem for FAS-RIS-NOMA networks, which jointly optimizes the fluid ports, the RIS deployment, and the phase shift matrix. To solve the resulting non-convex optimization problem involving highly coupled variables, an iterative algorithm based on alternating optimization is employed to decompose the original problem into three subproblems. Exhaustive search is employed for optimizing the fluid ports, particle swarm optimization is used for the RIS deployment, and semidefinite relaxation with successive convex approximation is adopted for optimizing the phase shift matrix. Finally, the simulation results show that: 1) compared with traditional antenna systems and orthogonal multiple access, the FAS-RIS-NOMA networks achieve higher system throughput under high signal-to-noise ratio conditions; and 2) by increasing the number of RIS elements and enlarging the FAS size, the sum rate of FAS-RIS-NOMA networks can be significantly enhanced.

cs.IT

ProMedical: Hierarchical Fine-Grained Criteria Modeling for Medical LLM Alignment via Explicit Injection

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical protocols. To bridge this gap, we introduce ProMedical, a unified alignment framework grounded in fine-grained clinical criteria. We first construct ProMedical-Preference-50k, a dataset generated via a human-in-the-loop pipeline that augments medical instructions with rigorous, physician-derived rubrics. Leveraging this corpus, we propose the Explicit Criteria Injection paradigm to train a multi-dimensional reward model. Unlike traditional scalar reward models, our approach explicitly disentangles safety constraints from general proficiency, enabling precise guidance during reinforcement learning. To rigorously validate this framework, we establish ProMedical-Bench, a held-out evaluation suite anchored by double-blind expert adjudication. Empirical evaluations demonstrate that optimizing the Qwen3-8B base model via ProMedical-RM-guided GRPO yields substantial gains, improving overall accuracy by 22.3% and safety compliance by 21.7%, effectively rivaling proprietary frontier models. Furthermore, the aligned policy generalizes robustly to external benchmarks, demonstrating performance comparable to state-of-the-art models on UltraMedical. We publicly release our datasets, reward models, and benchmarks to facilitate reproducible research in safety-aware medical alignment.

cs.AI

VLA-Mark: A cross modal watermark for large vision-language alignment model

Vision-language models demand watermarking solutions that protect intellectual property without compromising multimodal coherence. Existing text watermarking methods disrupt visual-textual alignment through biased token selection and static strategies, leaving semantic-critical concepts vulnerable. We propose VLA-Mark, a vision-aligned framework that embeds detectable watermarks while preserving semantic fidelity through cross-modal coordination. Our approach integrates multiscale visual-textual alignment metrics, combining localized patch affinity, global semantic coherence, and contextual attention patterns, to guide watermark injection without model retraining. An entropy-sensitive mechanism dynamically balances watermark strength and semantic preservation, prioritizing visual grounding during low-uncertainty generation phases. Experiments show 7.4% lower PPL and 26.6% higher BLEU than conventional methods, with near-perfect detection (98.8% AUC). The framework demonstrates 96.1\% attack resilience against attacks such as paraphrasing and synonym substitution, while maintaining text-visual consistency, establishing new standards for quality-preserving multimodal watermarking

cs.CV

A Survey on Proactive Defense Strategies Against Misinformation in Large Language Models

The widespread deployment of large language models (LLMs) across critical domains has amplified the societal risks posed by algorithmically generated misinformation. Unlike traditional false content, LLM-generated misinformation can be self-reinforcing, highly plausible, and capable of rapid propagation across multiple languages, which traditional detection methods fail to mitigate effectively. This paper introduces a proactive defense paradigm, shifting from passive post hoc detection to anticipatory mitigation strategies. We propose a Three Pillars framework: (1) Knowledge Credibility, fortifying the integrity of training and deployed data; (2) Inference Reliability, embedding self-corrective mechanisms during reasoning; and (3) Input Robustness, enhancing the resilience of model interfaces against adversarial attacks. Through a comprehensive survey of existing techniques and a comparative meta-analysis, we demonstrate that proactive defense strategies offer up to 63\% improvement over conventional methods in misinformation prevention, despite non-trivial computational overhead and generalization challenges. We argue that future research should focus on co-designing robust knowledge foundations, reasoning certification, and attack-resistant interfaces to ensure LLMs can effectively counter misinformation across varied domains.

cs.IR