arXiv subjects

Hector Zenil

Publications and source records attributed to Hector Zenil.

At least 55 records · Page 3Linked to original sources

arXiv2022

Simulation Intelligence: Towards a New Generation of Scientific Methods

The original "Seven Motifs" set forth a roadmap of essential methods for the field of scientific computing, where a motif is an algorithmic method that captures a pattern of computation and data movement. We present the "Nine Motifs of Simulation Intelligence", a roadmap for the development and integration of the essential algorithms necessary for a merger of scientific computing, scientific simulation, and artificial intelligence. We call this merger simulation intelligence (SI), for short. We argue the motifs of simulation intelligence are interconnected and interdependent, much like the components within the layers of an operating system. Using this metaphor, we explore the nature of each layer of the simulation intelligence operating system stack (SI-stack) and the motifs therein: (1) Multi-physics and multi-scale modeling; (2) Surrogate modeling and emulation; (3) Simulation-based inference; (4) Causal modeling and inference; (5) Agent-based modeling; (6) Probabilistic programming; (7) Differentiable programming; (8) Open-ended optimization; (9) Machine programming. We believe coordinated efforts between motifs offers immense opportunity to accelerate scientific discovery, from solving inverse problems in synthetic biology and climate science, to directing nuclear energy experiments and predicting emergent behavior in socioeconomic settings. We elaborate on each layer of the SI-stack, detailing the state-of-art methods, presenting examples to highlight challenges and opportunities, and advocating for specific ways to advance the motifs and the synergies from their combinations. Advancing and integrating these technologies can enable a robust and efficient hypothesis-simulation-analysis type of scientific method, which we introduce with several use-cases for human-machine teaming and automated science.

cs.AI↗

arXiv2022

A Review of Mathematical and Computational Methods in Cancer Dynamics

Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires the integration of information dynamics across multidimensional spatiotemporal scales, including genetic, transcriptional, metabolic, proteomic, epigenetic, and multi-cellular networks. However, the time-series analysis of these complex networks remains vastly absent in cancer research. With longitudinal screening and time-series analysis of cellular dynamics, universally observed causal patterns pertaining to dynamical systems, may self-organize in the signaling or gene expression state-space of cancer triggering processes. A class of these patterns, strange attractors, may be mathematical biomarkers of cancer progression. The emergence of intracellular chaos and chaotic cell population dynamics remains a new paradigm in systems oncology. As such, chaotic and complex dynamics are discussed as mathematical hallmarks of cancer cell fate dynamics herein. Given the assumption that time-resolved single-cell datasets are made available, a survey of interdisciplinary tools and algorithms from complexity theory, are hereby reviewed to investigate critical phenomena and chaotic dynamics in cancer ecosystems. To conclude, the perspective cultivates an intuition for computational systems oncology in terms of nonlinear dynamics, information theory, inverse problems and complexity. We highlight the limitations we see in the area of statistical machine learning but the opportunity at combining it with the symbolic computational power offered by the mathematical tools explored.

q-bio.OT↗

arXiv2022

Algorithmic Information Dynamics of Cellular Automata

We illustrate an application of Algorithmic Information Dynamics to Cellular Automata (CA) demonstrating how this digital calculus is able to quantify change in discrete dynamical systems. We demonstrate the sensitivity of the Block Decomposition Method on 1D and 2D CA, including Conway's Game of Life, against measures of statistical nature such as compression (LZW) and Shannon Entropy in two different contexts (1) perturbation analysis and (2) dynamic-state colliding CA. The approach is interesting because it analyses a quintessential object native to software space (CA) in software space itself by using algorithmic information dynamics through a model-driven universal search instead of a traditional statistical approach e.g. LZW compression or Shannon entropy. The colliding example of two state-independent (if not three as one is regulating the collision itself) discrete dynamical systems offers a potential proof of concept for the development of a multivariate version of the AID calculus.

cs.IT↗

arXiv2021

Computable Model Discovery and High-Level-Programming Approximations to Algorithmic Complexity

Motivated by algorithmic information theory, the problem of program discovery can help find candidates of underlying generative mechanisms of natural and artificial phenomena. The uncomputability of such inverse problem, however, significantly restricts a wider application of exhaustive methods. Here we present a proof of concept of an approach based on IMP, a high-level imperative programming language. Its main advantage is that conceptually complex computational routines are more succinctly expressed, unlike lower-level models such as Turing machines or cellular automata. We investigate if a more expressive higher-level programming language can be more efficient at generating approximations to algorithmic complexity of recursive functions, often of particular mathematical interest.

cs.IT↗

arXiv2021

Emergence and algorithmic information dynamics of systems and observers

Previous work has shown that perturbation analysis in software space can produce candidate computable generative models and uncover possible causal properties from the finite description of an object or system quantifying the algorithmic contribution of each of its elements relative to the whole. One of the challenges for defining emergence is that one observer's prior knowledge may cause a phenomenon to present itself to such observer as emergent while for another as reducible. By formalising the act of observing as mutual perturbations between dynamical systems, we demonstrate that emergence of algorithmic information do depend on the observer's formal knowledge, while robust to other subjective factors, particularly: the choice of the programming language and the measurement method; errors or distortions during the information acquisition; and the informational cost of processing. This is called observer-dependent emergence (ODE). In addition, we demonstrate that the unbounded and fast increase of emergent algorithmic information implies asymptotically observer-independent emergence (AOIE). Unlike ODE, AOIE is a type of emergence for which emergent phenomena will remain considered to be emergent for every formal theory that any observer might devise. We demonstrate the existence of an evolutionary model that displays the diachronic variant of AOIE and a network model that displays the holistic variant of AOIE. Our results show that, restricted to the context of finite discrete deterministic dynamical systems, computable systems, and irreducible information content measures, AOIE is the strongest form of emergence that formal theories can attain.

cs.IT↗

arXiv2021

A Computable Piece of Uncomputable Art whose Expansion May Explain the Universe in Software Space

At the intersection of what I call uncomputable art and computational epistemology, a form of experimental philosophy, we find an exciting and promising area of science related to causation with an alternative, possibly best possible, solution to the challenge of the inverse problem. That is the problem of finding the possible causes, mechanistic origins, first principles, and generative models of a piece of data from a physical phenomenon. Here we explain how generating and exploring software space following the framework of Algorithmic Information Dynamics, it is possible to find small models and learn to navigate a sci-fi-looking space that can advance the field of scientific discovery with complementary tools to offer an opportunity to advance science itself.

cs.OH↗

arXiv2021

Compression is Comprehension, and the Unreasonable Effectiveness of Digital Computation in the Natural World

Chaitin's work, in its depth and breadth, encompasses many areas of scientific and philosophical interest. It helped establish the accepted mathematical concept of randomness, which in turn is the basis of tools that I have developed to justify and quantify what I think is clear evidence of the algorithmic nature of the world. To illustrate the concept I will establish novel upper bounds of algorithmic randomness for elementary cellular automata. I will discuss how the practice of science consists in conceiving a model that starts from certain initial values, running a computable instantiation, and awaiting a result in order to determine where the system may be in a future state--in a shorter time than the time taken by the actual unfolding of the phenomenon in question. If a model does not comply with all or some of these requirements it is traditionally considered useless or even unscientific, so the more precise and faster the better. A model is thus better if it can explain more with less, which is at the core of Chaitin's "compression is comprehension". I will pursue these questions related to the random versus possibly algorithmic nature of the world in two directions, drawing heavily on the work of Chaitin. I will also discuss how the algorithmic approach is related to the success of science at producing models of the world, allowing computer simulations to better understand it and make more accurate predictions and interventions.

cs.IT↗

arXiv2020

An Algorithmic Information Distortion in Multidimensional Networks

Network complexity, network information content analysis, and lossless compressibility of graph representations have been played an important role in network analysis and network modeling. As multidimensional networks, such as time-varying, multilayer, or dynamic multilayer networks, gain more relevancy in network science, it becomes crucial to investigate in which situations universal algorithmic methods based on algorithmic information theory applied to graphs cannot be straightforwardly imported into the multidimensional case. In this direction, as a worst-case scenario of lossless compressibility distortion that increases linearly with the number of distinct dimensions, this article presents a counter-intuitive phenomenon that occurs when dealing with networks within non-uniform and sufficiently large multidimensional spaces. In particular, we demonstrate that the algorithmic information necessary to encode multidimensional networks that are isomorphic to logarithmically compressible monoplex networks may display exponentially larger distortions in the general case.

cs.IT↗

arXiv2020

A Review of Methods for Estimating Algorithmic Complexity: Options, Challenges, and New Directions

Some established and also novel techniques in the field of applications of algorithmic (Kolmogorov) complexity currently co-exist for the first time and are here reviewed, ranging from dominant ones such as statistical lossless compression to newer approaches that advance, complement and also pose new challenges and may exhibit their own limitations. Evidence suggesting that these different methods complement each other for different regimes is presented and despite their many challenges, some of these methods can be better motivated by and better grounded in the principles of algorithmic information theory. It will be explained how different approaches to algorithmic complexity can explore the relaxation of different necessary and sufficient conditions in their pursuit of numerical applicability, with some of these approaches entailing greater risks than others in exchange for greater relevance. We conclude with a discussion of possible directions that may or should be taken into consideration to advance the field and encourage methodological innovation, but more importantly, to contribute to scientific discovery. This paper also serves as a rebuttal of claims made in a previously published minireview by another author, and offers an alternative account.

cs.IT↗

arXiv2020

Evolving Neural Networks through a Reverse Encoding Tree

NeuroEvolution is one of the most competitive evolutionary learning frameworks for designing novel neural networks for use in specific tasks, such as logic circuit design and digital gaming. However, the application of benchmark methods such as the NeuroEvolution of Augmenting Topologies (NEAT) remains a challenge, in terms of their computational cost and search time inefficiency. This paper advances a method which incorporates a type of topological edge coding, named Reverse Encoding Tree (RET), for evolving scalable neural networks efficiently. Using RET, two types of approaches -- NEAT with Binary search encoding (Bi-NEAT) and NEAT with Golden-Section search encoding (GS-NEAT) -- have been designed to solve problems in benchmark continuous learning environments such as logic gates, Cartpole, and Lunar Lander, and tested against classical NEAT and FS-NEAT as baselines. Additionally, we conduct a robustness test to evaluate the resilience of the proposed NEAT algorithms. The results show that the two proposed strategies deliver improved performance, characterized by (1) a higher accumulated reward within a finite number of time steps; (2) using fewer episodes to solve problems in targeted environments, and (3) maintaining adaptive robustness under noisy perturbations, which outperform the baselines in all tested cases. Our analysis also demonstrates that RET expends potential future research directions in dynamic environments. Code is available from https://github.com/HaolingZHANG/ReverseEncodingTree.

cs.NE↗

arXiv2019

Controllability, Multiplexing, and Transfer Learning in Networks using Evolutionary Learning

Networks are fundamental building blocks for representing data, and computations. Remarkable progress in learning in structurally defined (shallow or deep) networks has recently been achieved. Here we introduce evolutionary exploratory search and learning method of topologically flexible networks under the constraint of producing elementary computational steady-state input-output operations. Our results include; (1) the identification of networks, over four orders of magnitude, implementing computation of steady-state input-output functions, such as a band-pass filter, a threshold function, and an inverse band-pass function. Next, (2) the learned networks are technically controllable as only a small number of driver nodes are required to move the system to a new state. Furthermore, we find that the fraction of required driver nodes is constant during evolutionary learning, suggesting a stable system design. (3), our framework allows multiplexing of different computations using the same network. For example, using a binary representation of the inputs, the network can readily compute three different input-output functions. Finally, (4) the proposed evolutionary learning demonstrates transfer learning. If the system learns one function A, then learning B requires on average less number of steps as compared to learning B from tabula rasa. We conclude that the constrained evolutionary learning produces large robust controllable circuits, capable of multiplexing and transfer learning. Our study suggests that network-based computations of steady-state functions, representing either cellular modules of cell-to-cell communication networks or internal molecular circuits communicating within a cell, could be a powerful model for biologically inspired computing. This complements conceptualizations such as attractor based models, or reservoir computing.

cs.NE↗

arXiv2019

Algorithmic Probability-guided Supervised Machine Learning on Non-differentiable Spaces

We show how complexity theory can be introduced in machine learning to help bring together apparently disparate areas of current research. We show that this new approach requires less training data and is more generalizable as it shows greater resilience to random attacks. We investigate the shape of the discrete algorithmic space when performing regression or classification using a loss function parametrized by algorithmic complexity, demonstrating that the property of differentiation is not necessary to achieve results similar to those obtained using differentiable programming approaches such as deep learning. In doing so we use examples which enable the two approaches to be compared (small, given the computational power required for estimations of algorithmic complexity). We find and report that (i) machine learning can successfully be performed on a non-smooth surface using algorithmic complexity; (ii) that parameter solutions can be found using an algorithmic-probability classifier, establishing a bridge between a fundamentally discrete theory of computability and a fundamentally continuous mathematical theory of optimization methods; (iii) a formulation of an algorithmically directed search technique in non-smooth manifolds can be defined and conducted; (iv) exploitation techniques and numerical methods for algorithmic search to navigate these discrete non-differentiable spaces can be performed; in application of the (a) identification of generative rules from data observations; (b) solutions to image classification problems more resilient against pixel attacks compared to neural networks; (c) identification of equation parameters from a small data-set in the presence of noise in continuous ODE system problem, (d) classification of Boolean NK networks by (1) network topology, (2) underlying Boolean function, and (3) number of incoming edges.

cs.LG↗

arXiv2019

The Thermodynamics of Network Coding, and an Algorithmic Refinement of the Principle of Maximum Entropy

The principle of maximum entropy (Maxent) is often used to obtain prior probability distributions as a method to obtain a Gibbs measure under some restriction giving the probability that a system will be in a certain state compared to the rest of the elements in the distribution. Because classical entropy-based Maxent collapses cases confounding all distinct degrees of randomness and pseudo-randomness, here we take into consideration the generative mechanism of the systems considered in the ensemble to separate objects that may comply with the principle under some restriction and whose entropy is maximal but may be generated recursively from those that are actually algorithmically random offering a refinement to classical Maxent. We take advantage of a causal algorithmic calculus to derive a thermodynamic-like result based on how difficult it is to reprogram a computer code. Using the distinction between computable and algorithmic randomness we quantify the cost in information loss associated with reprogramming. To illustrate this we apply the algorithmic refinement to Maxent on graphs and introduce a Maximal Algorithmic Randomness Preferential Attachment (MARPA) Algorithm, a generalisation over previous approaches. We discuss practical implications of evaluation of network randomness. Our analysis provides insight in that the reprogrammability asymmetry appears to originate from a non-monotonic relationship to algorithmic probability. Our analysis motivates further analysis of the origin and consequences of the aforementioned asymmetries, reprogrammability, and computation.

cs.IT↗

arXiv2018

Training-free Measures Based on Algorithmic Probability Identify High Nucleosome Occupancy in DNA Sequences

We introduce and study a set of training-free methods of information-theoretic and algorithmic complexity nature applied to DNA sequences to identify their potential capabilities to determine nucleosomal binding sites. We test our measures on well-studied genomic sequences of different sizes drawn from different sources. The measures reveal the known in vivo versus in vitro predictive discrepancies and uncover their potential to pinpoint (high) nucleosome occupancy. We explore different possible signals within and beyond the nucleosome length and find that complexity indices are informative of nucleosome occupancy. We compare against the gold standard (Kaplan model) and find similar and complementary results with the main difference that our sequence complexity approach. For example, for high occupancy, complexity-based scores outperform the Kaplan model for predicting binding representing a significant advancement in predicting the highest nucleosome occupancy following a training-free approach.

q-bio.QM↗

arXiv2018

Algorithmic Causal Deconvolution of Intertwined Programs and Networks by Generative Mechanism

Complex data usually results from the interaction of objects produced by different generating mechanisms. Here we introduce a universal, unsupervised and parameter-free model-oriented approach, based upon the seminal concept of algorithmic probability, that decomposes an observation into its most likely algorithmic generative sources. Our approach uses a causal calculus to infer model representations. We demonstrate its ability to deconvolve interacting mechanisms regardless of whether the resultant objects are strings, space-time evolution diagrams, images or networks. While this is mostly a conceptual contribution and a novel framework, we provide numerical evidence evaluating the ability of our methods to separate data from observations produced by discrete dynamical systems such as cellular automata and complex networks. We think that these separating techniques can contribute to tackling the challenge of causation, thus complementing other statistically oriented approaches.

cs.AI↗

arXiv2018

On complexity of post-processing in analyzing GATE-driven X-ray spectrum

Computed Tomography (CT) imaging is one of the most influential diagnostic methods. In clinical reconstruction, an effective energy is used instead of total X-ray spectrum. This approximation causes an accuracy decline. To increase the contrast, single source or dual source dual energy CT can be used to reach optimal values of tissue differentiation. However, these infrastructures are still at the laboratory level, and their safeties for patients are still yet to mature. Therefore, computer modelling of DECT could be used. We propose a novel post-processing approach for converting a total X-ray spectrum into irregular intervals of quantized energy. We simulate a phantom in GATE/GEANT4 and irradiate it based on CT configuration. Inverse Radon transform is applied to the acquired sinogram to construct the Pixel-based Attenuation Matrix (PAM). To construct images represented by each interval, water attenuation coefficient of the interval is extracted from NIST and used in the Hounsfield unit (HU) scale in conjunction with PAM. The CT image is modified by using of an associated normalized photon flux and calculated HU corresponding to the interval. We demonstrate the proposed method efficiency via complexity analysis, using absolute and relative complexities, entropy measures, Kolmogorov complexity, morphological richness, and quantitative segmentation criteria associated with standard fuzzy C-means. The irregularity of the modified CT images decreases over the simulated ones.

cs.ET↗

arXiv2018

Algorithmically probable mutations reproduce aspects of evolution such as convergence rate, genetic memory, and modularity

Natural selection explains how life has evolved over millions of years from more primitive forms. The speed at which this happens, however, has sometimes defied formal explanations when based on random (uniformly distributed) mutations. Here we investigate the application of a simplicity bias based on a natural but algorithmic distribution of mutations (no recombination) in various examples, particularly binary matrices in order to compare evolutionary convergence rates. Results both on synthetic and on small biological examples indicate an accelerated rate when mutations are not statistical uniform but \textit{algorithmic uniform}. We show that algorithmic distributions can evolve modularity and genetic memory by preservation of structures when they first occur sometimes leading to an accelerated production of diversity but also population extinctions, possibly explaining naturally occurring phenomena such as diversity explosions (e.g. the Cambrian) and massive extinctions (e.g. the End Triassic) whose causes are currently a cause for debate. The natural approach introduced here appears to be a better approximation to biological evolution than models based exclusively upon random uniform mutations, and it also approaches a formal version of open-ended evolution based on previous formal results. These results validate some suggestions in the direction that computation may be an equally important driver of evolution. We also show that inducing the method on problems of optimization, such as genetic algorithms, has the potential to accelerate convergence of artificial evolutionary algorithms.

cs.NE↗

arXiv2018

A Decomposition Method for Global Evaluation of Shannon Entropy and Local Estimations of Algorithmic Complexity

We investigate the properties of a Block Decomposition Method (BDM), which extends the power of a Coding Theorem Method (CTM) that approximates local estimations of algorithmic complexity based upon Solomonoff-Levin's theory of algorithmic probability providing a closer connection to algorithmic complexity than previous attempts based on statistical regularities e.g. as spotted by some popular lossless compression schemes. The strategy behind BDM is to find small computer programs that produce the components of a larger, decomposed object. The set of short computer programs can then be artfully arranged in sequence so as to produce the original object and to estimate an upper bound on the length of the shortest computer program that produces said original object. We show that the method provides efficient estimations of algorithmic complexity but that it performs like Shannon entropy when it loses accuracy. We estimate errors and study the behaviour of BDM for different boundary conditions, all of which are compared and assessed in detail. The measure may be adapted for use with more multi-dimensional objects than strings, objects such as arrays and tensors. To test the measure we demonstrate the power of CTM on low algorithmic-randomness objects that are assigned maximal entropy (e.g. $π$) but whose numerical approximations are closer to the theoretical low algorithmic-randomness expectation. We also test the measure on larger objects including dual, isomorphic and cospectral graphs for which we know that algorithmic randomness is low. We also release implementations of the methods in most major programming languages---Wolfram Language (Mathematica), Matlab, R, Perl, Python, Pascal, C++, and Haskell---and a free online algorithmic complexity calculator.

cs.IT↗