arXiv subjects

Henry Pinkard

Publications and source records attributed to Henry Pinkard.

7 recordsLinked to original sources

arXiv2025

Computationally Efficient Information-Driven Optical Design with Interchanging Optimization

Recent work has demonstrated that imaging systems can be evaluated through the information content of their measurements alone, enabling application-agnostic optical design that avoids computational decoding challenges. Information-Driven Encoder Analysis Learning (IDEAL) was proposed to automate this process through gradient-based optimization. In this work, we study IDEAL across diverse imaging systems and find that it suffers from high memory usage, long runtimes, and a potentially mismatched objective function due to end-to-end differentiability requirements. We introduce IDEAL with Interchanging Optimization (IDEAL-IO), a method that decouples density estimation from optical parameter optimization by alternating between fitting models to current measurements and updating optical parameters using fixed models for information estimation. This approach reduces runtime and memory usage by up to 6x while enabling more expressive density models that guide optimization toward superior designs. We validate our method on diffractive optics, lensless imaging, and snapshot 3D microscopy applications, establishing information-theoretic optimization as a practical, scalable strategy for real-world imaging system design.

eess.IV↗

arXiv2025

Designing lensless imaging systems to maximize information capture

Mask-based lensless imaging uses an optical encoder (e.g. a phase or amplitude mask) to capture measurements, then a computational decoding algorithm to reconstruct images. In this work, we evaluate and design lensless encoders based on the information content of their measurements using mutual information estimation. Our approach formalizes the object-dependent nature of lensless imaging and quantifies the interdependence between object sparsity, encoder multiplexing, and noise. Our analysis reveals that optimal encoder designs should tailor encoder multiplexing to object sparsity for maximum information capture, and that all optimally-encoded measurements share the same level of sparsity. Using mutual information-based optimization, we design information-optimal encoders for compressive imaging of fixed object distributions. Our designs demonstrate improved downstream reconstruction performance for objects in the distribution, without requiring joint optimization with a specific reconstruction algorithm. We validate our approach experimentally by evaluating lensless imaging systems directly from captured measurements, without the need for image formation models, reconstruction algorithms, or ground truth data. Our comprehensive analysis establishes design and engineering principles for lensless imaging systems, and offers a model for the study of general multiplexing systems, especially those with object-dependent performance.

physics.optics↗

arXiv2025

ARC-AGI-2: A New Challenge for Frontier AI Reasoning Systems

The Abstraction and Reasoning Corpus for Artificial General Intelligence (ARC-AGI), introduced in 2019, established a challenging benchmark for evaluating the general fluid intelligence of artificial systems via a set of unique, novel tasks only requiring minimal prior knowledge. While ARC-AGI has spurred significant research activity over the past five years, recent AI progress calls for benchmarks capable of finer-grained evaluation at higher levels of cognitive complexity. We introduce ARC-AGI-2, an upgraded version of the benchmark. ARC-AGI-2 preserves the input-output pair task format of its predecessor, ensuring continuity for researchers. It incorporates a newly curated and expanded set of tasks specifically designed to provide a more granular signal to assess abstract reasoning and problem-solving abilities at higher levels of fluid intelligence. To contextualize the difficulty and characteristics of ARC-AGI-2, we present extensive results from human testing, providing a robust baseline that highlights the benchmark's accessibility to human intelligence, yet difficulty for current AI systems. ARC-AGI-2 aims to serve as a next-generation tool for rigorously measuring progress towards more general and human-like AI capabilities.

cs.AI↗

arXiv2024

Information-driven design of imaging systems

Imaging systems have traditionally been designed to mimic the human eye and produce visually interpretable measurements. Modern imaging systems, however, process raw measurements computationally before or instead of human viewing. As a result, the information content of raw measurements matters more than their visual interpretability. Despite the importance of measurement information content, current approaches for evaluating imaging system performance do not quantify it: they instead either use alternative metrics that assess specific aspects of measurement quality or assess measurements indirectly with performance on secondary tasks. We developed the theoretical foundations and a practical method to directly quantify mutual information between noisy measurements and unknown objects. By fitting probabilistic models to measurements and their noise characteristics, our method estimates information by upper bounding its true value. By applying gradient-based optimization to these estimates, we also developed a technique for designing imaging systems called Information-Driven Encoder Analysis Learning (IDEAL). Our information estimates accurately captured system performance differences across four imaging domains (color photography, radio astronomy, lensless imaging, and microscopy). Systems designed with IDEAL matched the performance of those designed with end-to-end optimization, the prevailing approach that jointly optimizes hardware and image processing algorithms. These results establish mutual information as a universal performance metric for imaging systems that enables both computationally efficient design optimization and evaluation in real-world conditions. A video summarizing this work can be found at: https://waller-lab.github.io/EncodingInformationWebsite/

physics.optics↗

arXiv2024

The Berkeley Single Cell Computational Microscopy (BSCCM) Dataset

Computational microscopy, in which hardware and algorithms of an imaging system are jointly designed, shows promise for making imaging systems that cost less, perform more robustly, and collect new types of information. Often, the performance of computational imaging systems, especially those that incorporate machine learning, is sample-dependent. Thus, standardized datasets are an essential tool for comparing the performance of different approaches. Here, we introduce the Berkeley Single Cell Computational Microscopy (BSCCM) dataset, which contains over ~12,000,000 images of 400,000 of individual white blood cells. The dataset contains images captured with multiple illumination patterns on an LED array microscope and fluorescent measurements of the abundance of surface proteins that mark different cell types. We hope this dataset will provide a valuable resource for the development and testing of new algorithms in computational microscopy and computer vision with practical biomedical applications.

cs.CV↗

arXiv2022

A visual introduction to information theory

Information theory, though originally developed for communications engineering, provides mathematical tools with broad applications across science. These tools characterize the fundamental limits of data compression and transmission in the presence of noise. Here, we present a visual, intuition-driven guide to key concepts in information theory. We show how entropy, mutual information, and channel capacity follow from basic probability, and how they determine the shortest possible encoding of a data source and the maximum rate of reliable communication through a noisy channel. Our presentation assumes only a familiarity with basic probability theory.

cs.IT↗

arXiv2020

Pycro-manager: open-source software for integrated microscopy hardware control and image processing

{\mu}Manager, an open-source microscopy acquisition software, has been an essential tool for many microscopy experiments over the past 15 years, but is not easy to use for experiments in which image acquisition and analysis are closely coupled. This is because {\mu}Manager libraries are written in C++ and Java, whereas image processing is increasingly carried out with data science and machine learning tools most easily accessible through the Python programming language. We present Pycro-Manager, a tool that enables rapid development of such experiments, while also providing access to the wealth of existing tools within {\mu}Manager through Python.

q-bio.QM↗