arXiv subjects

Himanshu Maurya

Publications and source records attributed to Himanshu Maurya.

2 recordsLinked to original sources

arXiv2026

SAGE: Agentic Framework for Interpretable and Clinically Translatable Computational Pathology Biomarker Discovery

Engineered image-based biomarkers offer a clinically interpretable alternative to black-box AI in computational pathology, yet their discovery remains largely intuition-driven, guided by fragmented literature rather than rigorous biological validation. We introduce SAGE (Structured Agentic system for hypothesis Generation and Evaluation), a multi-agent framework that grounds biomarker discovery in biological evidence through three mechanisms: (i) knowledge-graph-anchored hypothesis generation via multi-path ontological reasoning, (ii) a debate-based multi-agent novelty assessment that stress-tests candidate biomarkers against existing literature, and (iii) an end-to-end automated validation pipeline that translates hypotheses directly into executable analyses on multimodal pathology datasets. Together, these components shift biomarker discovery from an intuition-driven, literature-browsing exercise into a structured, traceable reasoning process that clinicians and researchers can inspect, trust, and build upon.

cs.LG↗

arXiv2024

A Human-in-the-Loop Approach to Improving Cross-Text Prosody Transfer

Text-To-Speech (TTS) prosody transfer models can generate varied prosodic renditions, for the same text, by conditioning on a reference utterance. These models are trained with a reference that is identical to the target utterance. But when the reference utterance differs from the target text, as in cross-text prosody transfer, these models struggle to separate prosody from text, resulting in reduced perceived naturalness. To address this, we propose a Human-in-the-Loop (HitL) approach. HitL users adjust salient correlates of prosody to make the prosody more appropriate for the target text, while maintaining the overall reference prosodic effect. Human adjusted renditions maintain the reference prosody while being rated as more appropriate for the target text $57.8\%$ of the time. Our analysis suggests that limited user effort suffices for these improvements, and that closeness in the latent reference space is not a reliable prosodic similarity metric for the cross-text condition.

cs.CL↗