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Hiroyasu Abe

Publications and source records attributed to Hiroyasu Abe.

2 recordsLinked to original sources

Generalized Poisson Matrix Factorization for Overdispersed Count Data

Non-negative matrix factorization (NMF) is widely used as a feature extraction technique for matrices with non-negative entries, such as image data, purchase histories, and other types of count data. In NMF, a non-negative matrix is decomposed into the product of two non-negative matrices, and the approximation accuracy is evaluated by a loss function. If the Kullback-Leibler divergence is chosen as the loss function, the estimation coincides with maximum likelihood under the assumption that the data entries are distributed according to a Poisson distribution. To address overdispersion, negative binomial matrix factorization has recently been proposed as an extension of the Poisson-based model. However, the negative binomial distribution often generates an excessive number of zeros, which limits its expressive capacity. In this study, we propose a non-negative matrix factorization based on the generalized Poisson distribution, which can flexibly accommodate overdispersion, and we introduce a maximum likelihood approach for parameter estimation. This methodology provides a more versatile framework than existing models, thereby extending the applicability of NMF to a broader class of count data.

stat.CO

A Semi-parametric Bayesian Approach to Population Finding with Time-to-Event and Toxicity Data in a Randomized Clinical Trial

A utility-based Bayesian population finding (BaPoFi) method was proposed by Morita and M\"uller (2017, Biometrics, 1355-1365) to analyze data from a randomized clinical trial with the aim of identifying good predictive baseline covariates for optimizing the target population for a future study. The approach casts the population finding process as a formal decision problem together with a flexible probability model using a random forest to define a regression mean function. BaPoFi is constructed to handle a single continuous or binary outcome variable. In this paper, we develop BaPoFi-TTE as an extension of the earlier approach for clinically important cases of time-to-event (TTE) data with censoring, and also accounting for a toxicity outcome. We model the association of TTE data with baseline covariates using a semi-parametric failure time model with a P\'olya tree prior for an unknown error term and a random forest for a flexible regression mean function. We define a utility function that addresses a trade-off between efficacy and toxicity as one of the important clinical considerations for population finding. We examine the operating characteristics of the proposed method in extensive simulation studies. For illustration, we apply the proposed method to data from a randomized oncology clinical trial. Concerns in a preliminary analysis of the same data based on a parametric model motivated the proposed more general approach.

stat.AP