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Holger Müller

Publications and source records attributed to Holger Müller.

At least 19 recordsLinked to original sources

Microscopy of Bioelectric Potentials using Electrochromism

Studying the electrical signals generated by living cells is key to understanding numerous biological phenomena. Electrochromic optical recording (ECORE) uses the electrochromism exhibited by certain materials to noninvasively measure these signals in real time. In this work, we report on the development of ECORE based on a high-NA microscope objective. We demonstrate the recording of extracellular action potentials from cardiomyocytes with single-cell resolution and a high sensitivity of 6.3 μV. Combining ECORE with microscopy simplifies the optical setup, allows for the simultaneous imaging of specimens, and makes ECORE accessible to a broader community of researchers, allowing for a better understanding of the biological processes that are integral to life.

physics.optics

A thermoelastic limit on the focal intensity in Fabry-Pérot cavities

Light in the mode of a Fabry-Pérot cavity heats the mirror surfaces via optical absorption, causing thermoelastic deformation of the mirror substrates, which in turn dictates the shape of the mode. We develop an analytical model which predicts that this effect limits the maximum focal intensity of the mode. Using two near-concentric Fabry-Pérot cavities -- one with 4.5-fold higher mirror absorption than the other -- we measure the thermoelastic properties of the cavity mirrors and demonstrate that it is possible to achieve at least 70% of this predicted limit (in the high-absorption cavity), and that the predicted limit is 2.9 TW/cm^2 (in the low-absorption cavity).

physics.optics

Crossed laser phase plates for transmission electron microscopy

For decades since the development of phase-contrast optical microscopy, an analogous approach has been sought for maximizing the image contrast of weakly-scattering objects in transmission electron microscopy (TEM). The recent development of the laser phase plate (LPP) has demonstrated that an amplified, focused laser standing wave provides stable, tunable phase shift to the high-energy electron beam, achieving phase-contrast TEM. Building on proof-of-concept experimental demonstrations, this paper explores design improvements tailored to biological imaging. In particular, we introduce the approach of crossed laser phase plates (XLPP): two laser standing waves intersecting in the diffraction plane of the TEM, rather than a single beam as in the current LPP. We provide a theoretical model for the XLPP inside the microscope and use simulations to quantify its effect on image formation. Using simulations, we find that the XLPP increases information transfer at low spatial frequencies while also suppressing the ghost images formed by Kapitza-Dirac diffraction of the electron beam by the laser beam. We also present a simple acquisition scheme, enabled by the XLPP, which dramatically suppresses unwanted diffraction effects. Finally, we discuss important practical considerations of XLPP design and show experimental results from a prototype. The results of this study chart the course for future developments of LPP hardware.

physics.optics

Space magnetometry with a differential atom interferometer

Atom interferometers deployed in space are excellent tools for high precision measurements, navigation, or Earth observation. In particular, differential interferometric setups feature common-mode noise suppression and enable reliable measurements in the presence of ambient platform noise. Here we report on orbital magnetometry campaigns performed with differential single- and double-loop interferometers in NASA's Cold Atom Lab aboard the International Space Station. By comparing measurements with atoms in magnetically sensitive and insensitive states, we have realized atomic magnetometers mapping magnetic field curvatures. Our results pave the way towards precision quantum sensing missions in space.

physics.atom-ph

Coherence limits in lattice atom interferometry at the one-minute scale

In quantum metrology and quantum simulation, a coherent non-classical state must be manipulated before unwanted interactions with the environment lead to decoherence. In atom interferometry, the non-classical state is a spatial superposition, where each atom coexists in multiple locations as a collection of phase-coherent partial wavepackets. These states enable precise measurements in fundamental physics and inertial sensing. However, atom interferometers usually use atomic fountains, where the available interrogation time is limited to around 3 seconds for a 10 m fountain. Here, we realise an atom interferometer with a spatial superposition state that is maintained for as long as 70 seconds. We analyse the theoretical and experimental limits to coherence arising from collective dephasing of the atomic ensemble. This reveals that the decoherence rate slows down markedly at hold times that exceed tens of seconds. These gains in coherence may enable gravimetry measurements, searches for fifth forces or fundamental probes into the non-classical nature of gravity.

physics.atom-ph

Interferometry of Atomic Matter Waves in the Cold Atom Lab onboard the International Space Station

Ultracold atomic gases hold unique promise for space science by capitalizing on quantum advantages and extended freefall, afforded in a microgravity environment, to enable next-generation precision sensors. Atom interferometers are a class of quantum sensors which can use freely falling gases of atoms cooled to sub-photon-recoil temperatures to provide unprecedented sensitivities to accelerations, rotations, and gravitational forces, and are currently being developed for space-based applications in gravitational, earth, and planetary sciences, as well as to search for subtle forces that could signify physics beyond General Relativity and the Standard Model. NASA's Cold Atom Lab (CAL) operates onboard the International Space Station as a multi-user facility for studies of ultracold atoms and to mature quantum technologies, including atom interferometry, in persistent microgravity. In this paper, we report on path-finding experiments utilizing ultracold $^{87}$Rb atoms in the CAL atom interferometer, which was enabled by an on-orbit upgrade of the CAL science module: A three-pulse Mach-Zehnder interferometer was studied to understand limitations from the influence of ISS vibrations. Additionally, Ramsey shear-wave interferometry was used to manifest interference patterns in a single run that were observable for over 150 ms free-expansion time. Finally, the CAL atom interferometer was used to remotely measure the photon recoil from the atom interferometer laser as a demonstration of the first quantum sensor using matter-wave interferometry in space.

physics.atom-ph

Compact Electrochromic Optical Recording of Bioelectric Potentials

Electrochromic optical recording (ECORE) is a label-free method that utilizes electrochromism to optically detect electrical signals in biological cells with a high signal-to-noise ratio and is suitable for long-term recording. However, ECORE usually requires a large and intricate optical setup, making it relatively difficult to transport and to study specimens on a large scale. Here, we present a compact ECORE apparatus that drastically reduces the spatial footprint and complexity of the ECORE setup whilst maintaining high sensitivity. An autobalancing differential photodetector automates common-mode noise rejection, removing the need for manually adjustable optics, and a compact laser module conserves space compared to a typical laser mount. The result is a simple, easy-to-use, and relatively low cost system that achieves a sensitivity of 16.7 μV (within a factor of 5 of the shot noise limit), and reliably detects action potentials from Human-induced pluripotent stem cell (HiPSC) derived cardiomyocytes. This setup can be further improved to within 1.5 dB of the shot noise limit by filtering out power-line interference.

physics.optics

Measuring gravity by holding atoms

Despite being the dominant force of nature on large scales, gravity remains relatively elusive to experimental measurement. Many questions remain, such as its behavior at small scales or its role in phenomena ascribed to dark matter and dark energy. Atom interferometers are powerful tools for probing Earth's gravity, the gravitational constant, dark energy theories and general relativity. However, they typically use atoms in free fall, which limits the measurement time to only a few seconds, and to even briefer intervals when measuring the interaction of the atoms with a stationary source mass. Recently, interferometers with atoms suspended for as long as 70 seconds in an optical lattice have been demonstrated. To keep the atoms from falling, however, the optical lattice must apply forces that are billion-fold as strong as the putative signals, so even tiny imperfections reduce sensitivity and generate complex systematic effects. As a result, lattice interferometers have yet to demonstrate precision and accuracy on par with their free fall counterparts and have yet to be used for precision measurement. Here, we optimize the sensitivity of a lattice interferometer and use a system of signal inversions and switches to suppress and quantify systematic effects. This enables us to measure the attraction of a miniature source mass, ruling out the existence of screened dark energy theories over their natural parameter space. More importantly, the combined accuracy of $6.2~\rm{nm/s}^2$ is four times as good as the best similar measurements with freely falling atoms, demonstrating the advantages of lattice interferometry in fundamental physics measurements. Further upgrades may enable measuring forces at sub-millimeter ranges, the gravitational Aharonov-Bohm effect and the gravitational constant, compact gravimetry, and testing whether the gravitational field itself has quantum properties.

physics.atom-ph

Dynamics of a buffer-gas-loaded, deep optical trap for molecules

We describe an approach to optically trapping small, chemically stable molecules at cryogenic temperatures by buffer-gas loading a deep optical dipole trap. The ~10 K trap depth will be produced by a tightly-focused, 1064-nm cavity capable of reaching intensities of hundreds of GW/cm$^2$. Molecules will be directly buffer-gas loaded into the trap using a helium buffer gas at 1.5 K. The very far-off-resonant, quasielectrostatic trapping mechanism is insensitive to a molecule's internal state, energy level structure, and its electric and magnetic dipole moment. Here, we theoretically investigate the trapping and loading dynamics, as well as the heating and loss rates, and conclude that $10^4$-$10^6$ molecules are likely to be trapped. Our trap would open new possibilities in molecular spectroscopy, studies of cold chemical reactions, and precision measurement, amongst other fields of physics.

physics.atom-ph

Quantum Gas Mixtures and Dual-Species Atom Interferometry in Space

The capability to reach ultracold atomic temperatures in compact instruments has recently been extended into space. Ultracold temperatures amplify quantum effects, while free-fall allows further cooling and longer interactions time with gravity - the final force without a quantum description. On Earth, these devices have produced macroscopic quantum phenomena such as Bose-Einstein condensation (BECs), superfluidity, and strongly interacting quantum gases. Quantum sensors interfering the superposition of two ultracold atomic isotopes have tested the Universality of Free Fall (UFF), a core tenet of Einstein's classical gravitational theory, at the $10^{-12}$ level. In space, cooling the elements needed to explore the rich physics of strong interactions and preparing the multiple species required for quantum tests of the UFF has remained elusive. Here, utilizing upgraded capabilities of the multi-user Cold Atom Lab (CAL) instrument within the International Space Station (ISS), we report the first simultaneous production of a dual species Bose-Einstein condensate in space (formed from $^{87}$Rb and $^{41}$K), observation of interspecies interactions, as well as the production of $^{39}$K ultracold gases. We have further achieved the first space-borne demonstration of simultaneous atom interferometry with two atomic species ($^{87}$Rb and $^{41}$K). These results are an important step towards quantum tests of UFF in space, and will allow scientists to investigate aspects of few-body physics, quantum chemistry, and fundamental physics in novel regimes without the perturbing asymmetry of gravity.

cond-mat.quant-gas

Atomic gravimeter robust to environmental effects

Atomic accelerometers and gravimeters are usually based on freely-falling atoms in atomic fountains, which not only limits their size, but also their robustness to environmental factors such as tilts, magnetic fields or vibrations. Such limitations have precluded their broad adoption in the field, for geophysics, geology, and inertial navigation. More recently, atom interferometers based on holding atoms in an optical lattice have been developed. Such gravimeters also suppress the influence of vibrations in the frequency range of ~1 Hz and above by several orders of magnitude relative to conventional atomic gravimeters. Here, we show that such interferometers are robust to tilts of more than 8 mrad with respect to the vertical and can suppress the effect of even strong environmental magnetic fields and field gradients by using atoms in the F=3,4 hyperfine ground states as co-magnetometers, potentially eliminating the need for shielding. We demonstrate gravimeter sensitivity of $0.7~\rm{mGal}/\sqrt{\rm Hz}$ ($1~{\rm mGal}=10~μ\rm{m/s}^2$) in a compact geometry where atoms only travel over mm of space.

physics.atom-ph

Snowmass 2021 White Paper: Tabletop experiments for infrared quantum gravity

Progress in the quantum readout and control of mechanical devices from single atoms to large masses may enable a first generation of experiments probing the gravitational interaction in the quantum regime, conceivably within the next decade. In this Snowmass whitepaper, we briefly outline the possibilities and challenges facing the realization of these experiments. In particular, we emphasize the need for detailed theories of modifications to the usual effective QFT of gravitons in the infrared regime $E/L^3 \ll m_{\rm Pl}/\ell_{\rm Pl}^3$ in which these experiments operate, and relations to possible UV completions.

gr-qc

Using an atom interferometer to infer gravitational entanglement generation

If gravitational perturbations are quantized into gravitons in analogy with the electromagnetic field and photons, the resulting graviton interactions should lead to an entangling interaction between massive objects. We suggest a test of this prediction. To do this, we introduce the concept of interactive quantum information sensing. This novel sensing protocol is tailored to provable verification of weak dynamical entanglement generation between a pair of systems. We show that this protocol is highly robust to typical thermal noise sources. The sensitivity can moreover be increased both using an initial thermal state and/or an initial phase of entangling via a non-gravitational interaction. We outline a concrete implementation testing the ability of the gravitational field to generate entanglement between an atomic interferometer and mechanical oscillator. Preliminary numerical estimates suggest that near-term devices could feasibly be used to perform the experiment.

quant-ph

Raman transitions driven by phase-modulated light in a cavity atom interferometer

Atom interferometers in optical cavities benefit from strong laser intensities and high-quality wavefronts. The laser frequency pairs that are needed for driving Raman transitions (often generated by phase modulating a monochromatic beam) form multiple standing waves in the cavity, resulting in a periodic spatial variation of the properties of the atom-light interaction along the cavity axis. Here, we model this spatial dependence and calculate two-photon Rabi frequencies and ac Stark shifts. We compare the model to measurements performed with varying cavity and pulse parameters such as cavity offset from the carrier frequency and the longitudinal position of the atom cloud. We show how setting cavity parameters to optimal values can increase the Raman transition efficiency at all positions in the cavity and nearly double the contrast in a Mach-Zehnder cavity atom interferometer in comparison to the unoptimized case.

physics.atom-ph

Guided matter wave inertial sensing in a miniature physics package

We describe an ultra-compact ($\sim 10$ cm$^3$ physics package) inertial sensor based on atomic matter waves that are guided within an optical lattice during almost the entire interferometer cycle. We demonstrate large momentum transfer (LMT) of up to 8$\hbar k$ photon momentum with a combination of Bragg pulses and Bloch oscillations with scalability to larger numbers of photons. Between momentum transfer steps, we maintain the atoms in a co-moving optical lattice waveguide so that the atoms are in free space only during the Bragg pulses. Our guided matter wave approach paves the way for atomic inertial sensing in dynamic environments in which untrapped atoms would otherwise quickly collide with the walls of a miniature chamber.

physics.atom-ph

The Bose-Einstein Condensate and Cold Atom Laboratory

Microgravity eases several constraints limiting experiments with ultracold and condensed atoms on ground. It enables extended times of flight without suspension and eliminates the gravitational sag for trapped atoms. These advantages motivated numerous initiatives to adapt and operate experimental setups on microgravity platforms. We describe the design of the payload, motivations for design choices, and capabilities of the Bose-Einstein Condensate and Cold Atom Laboratory (BECCAL), a NASA-DLR collaboration. BECCAL builds on the heritage of previous devices operated in microgravity, features rubidium and potassium, multiple options for magnetic and optical trapping, different methods for coherent manipulation, and will offer new perspectives for experiments on quantum optics, atom optics, and atom interferometry in the unique microgravity environment on board the International Space Station.

physics.atom-ph

Gravity surveys using a mobile atom interferometer

Mobile gravimetry is important in metrology, navigation, geodesy, and geophysics. Atomic gravimeters could be among the most accurate mobile gravimeters, but are currently constrained by being complex and fragile. Here, we demonstrate a mobile atomic gravimeter, measuring tidal gravity variations in the laboratory as well as surveying gravity in the field. The tidal gravity measurements achieve a sensitivity of 37 $μ$Gal/$\sqrt{\rm Hz}$ and a long-term stability of better than 2 $μ$Gal, revealing ocean tidal loading effects and recording several distant earthquakes. We survey gravity in the Berkeley Hills with an accuracy of around 0.04 mGal and determine the density of the subsurface rocks from the vertical gravity gradient. With simplicity and sensitivity, our instrument paves the way for bringing atomic gravimeters to field applications.

physics.atom-ph

Probing gravity by holding atoms for 20 seconds

Atom interferometers are powerful tools for both measurements in fundamental physics and inertial sensing applications. Their performance, however, has been limited by the available interrogation time of freely falling atoms in a gravitational field. We realize an unprecedented interrogation time of 20 seconds by suspending the spatially-separated atomic wavepackets in a lattice formed by the mode of an optical cavity. Unlike traditional atom interferometers, this approach allows potentials to be measured by holding, rather than dropping, atoms. After seconds of hold time, gravitational potential energy differences from as little as microns of vertical separation generate megaradians of interferometer phase. This trapped geometry suppresses the phase sensitivity to vibrations by 3-4 orders of magnitude, overcoming the dominant noise source in atom-interferometric gravimeters. Finally, we study the wavefunction dynamics driven by gravitational potential gradients across neighboring lattice sites.

physics.atom-ph