arXiv subjects

Hong-Ming Yin

Publications and source records attributed to Hong-Ming Yin.

10 recordsLinked to original sources

arXiv2026

On a Mathematical Model Describing Chemotherapeutic Drug Treatment for Tumor Cells

In this paper, we study a semilinear parabolic PDE system which describes the interaction of normal cells, tumor cells, immune cells, with a chemotherapeutic drug. The model extends the previous model with incorporating strong Allee affects in the normal-tissue and tumor dynamics. Under mild assumptions, we establish global-in-time existence and uniqueness of nonnegative weak solutions and derive L-infinity bounds for all time. We then investigate spatiotemporal dynamics of the model and therapy scheduling using an implicit Crank Nicolson Backward Euler (CNBE) scheme. Simulations in a heterogeneous two-dimensional space-dimensional tissue region with three tumor peaks indicate rapid tumor invasion without treatment and significant tumor suppression under pulsed chemotherapeutic treatment. Moreover, in a fixed total dose delivered within the treatment cycle, while keeping each injection duration fixed, concentrated pulses produce stronger early knock-down of tumor density, while more frequent but gentler pulses achieve comparable control of the tumor invasive front while better preserving normal tissue over a four-week period.

math.AP↗

arXiv2025

On a cross-diffusion hybrid model: Cancer Invasion Tissue with Normal Cell Involved

In this paper, we study a well-posedness problem on a new mathematical model for cancer invasion within the plasminogen activation system, which explicitly incorporates cooperation with host normal cells. Key biological mechanisms--including chemotaxis, haptotaxis, recruitment, logistic growth, and natural degradation of normal cells--along with other primary components (cancer cells, vitronectin, uPA, uPAI-1 and plasmin) are modeled via a continuum framework of cancer cell invasion of the extracellular matrix. The resulting model constitutes a strongly coupled, cross-diffusion hybrid system of differential equations. The primary mathematical challenges arise from the strongly coupled cross-diffusion terms, the parabolic operators of divergence form, and the interaction between the cross-diffusion fluxes and the ODE components. We address these by deriving several a priori estimates for dimensions d less or equal to 3. Subsequently, we employ a decoupling strategy to split the system into proper sub-problems, establishing the existence (and uniqueness) for each subsystem. Finally, we demonstrate the global existence and uniqueness of the solution for dimensions d less or equal to 2 and the global existence of a solution for dimension d = 3.

math.AP↗

arXiv2025

On a Modified Mathematical Model Arising from a Trojan Y Chromosome Strategy

In this paper, we investigate a modified Trojan Y chromosome (TYC) strategy aimed at eradicating invasive species from natural habitats. The proposed mathematical model enhances the original TYC framework by ensuring the non-negativity of population densities and preventing potential solution blow-up. The new model is formulated as a strongly coupled reaction-diffusion system with distinct diffusion coefficients for each species. We first establish the global well-posedness of the system. Subsequently, a stability analysis is conducted. In particular, we demonstrate that the population densities converge to zero when the birth rate for each species falls below a critical threshold. Additionally, we prove the existence of a positive steady-state solution even as the artificially introduced YY-female population density tends to zero as $t$ tends to $\infty$. Furthermore, we identify a bifurcation in the system's solutions as the birth rate crosses the critical value.

math.AP↗

arXiv2024

Existence, Stability and Optimal Drug Dosage for a Reaction-Diffusion System Arising in a Cancer Treatment

In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug and the normal, tumor and immune cells. We first establish well-posedness for the nonlinear reaction-diffusion system, then investigate the long-time behavior of solutions. Particularly, it is shown that the cancer cells will be eliminated assuming that its reproduction rate is sufficiently small in a short time period in each treatment interval. The analysis is then essentially exploited to study an optimal drug injection rate problem during a chemotherapeutic drug treatment for tumor cells, which is formulated as an optimal boundary control problem with constraints. For this, we show that the existence of an optimal drug injection rate through the boundary, and derive the first-order optimality condition.

math.AP↗

arXiv2022

On a Mathematical Model Arising from an Optimal Chemotherapeutic Drug Treatment for Tumor Cells

In this paper we consider an optimal control problem arising from a chemotherapeutic drug treatment for tumor cells in a living tissue. The mathematical model for the interaction of chemotherapeutic drug and the normal, tumor and immune cells are governed by a nonlinear reaction-diffusion system. We first establish the well-posedness for the nonlinear system. Then we study the long-time behavior of the solution for the model problem. Finally, we design an optimal drug dosage, which leads to an optimal control problem under certain constrains. A complicated factor for the optimal control problem is that a minimum level of normal cells in patients must be maintained during a treatment. It is shown that there is an optimal drug dosage for the chemotherapeutic treatment for patients.

math.AP↗

arXiv2022

Asymptotic Analysis for a Nonlinear Reaction-Diffusion System Modeling an Infectious Disease

In this paper we study a nonlinear reaction-diffusion system which models an infectious disease caused by bacteria such as those for cholera. One of the significant features in this model is that a certain portion of the recovered human hosts may lose a lifetime immunity and could be infected again. Another important feature in the model is that the mobility for each species is allowed to be dependent upon both the location and time. With the whole population assumed to be susceptible with the bacteria, the model is a strongly coupled nonlinear reaction-diffusion system. We prove that the nonlinear system has a unique solution globally in any space dimension under some natural conditions on the model parameters and the given data. Moreover, the long-time behavior and stability analysis for the solutions are carried out rigorously. In particular, we characterize the precise conditions on variable parameters about the stability or instability of all steady-state solutions. These new results provide the answers to several open questions raised in the literature.

math.AP↗

arXiv2021

Reaction-Diffusion-Advection Systems with Discontinuous Diffusion and Mass Control

In this paper, we study unique, globally defined uniformly bounded weak solutions for a class of semilinear reaction-diffusion-advection systems. The coefficients of the differential operators and the initial data are only required to be measurable and uniformly bounded. The nonlinearities are quasi-positive and satisfy a commonly called mass control or dissipation of mass property. Moreover, we assume the intermediate sum condition of a certain order. The key feature of this work is the surprising discovery that quasi-positive systems that satisfy an intermediate sum condition automatically give rise to a new class of $L^p$-energy type functionals that allow us to obtain requisite uniform a priori bounds. Our methods are sufficiently robust to extend to different boundary conditions, or to certain quasi-linear systems. We also show that in case of mass dissipation, the solution is bounded in sup-norm uniformly in time. We illustrate the applicability of results by showing global existence and large time behavior of models arising from a spatio-temporal spread of infectious disease.

math.AP↗

arXiv2020

On a Reaction-Diffusion System Modeling Infectious Diseases Without Life-time Immunity

In this paper we study a mathematical model for an infectious disease such as Cholera without life-time immunity. Due to the different mobility for susceptible, infected human and recovered human hosts, the diffusion coefficients are assumed to be different. The resulting system is governed by a strongly coupled reaction-diffusion system with different diffusion coefficients. Global existence and uniqueness are established under certain assumptions on known data. Moreover, global asymptotic behavior of the solution is obtained when some parameters satisfy certain conditions. These results extend the existing results in the literature. The main tool used in this paper comes from the delicate theory of elliptic and parabolic equations. Moreover, the energy method and Sobolev embedding are used in deriving {\em apriori} estimates. The analysis developed in this paper can be employed to study other epidemic models in biological and ecological systems.

math.AP↗

arXiv1998

On a singular limit problem for nonlinear Maxwell's equations

In this paper we study the following nonlinear Maxwell's equations \\ $\varepsilon \E_{t}+σ(x,|\E|)\E= \g \vh +\F,\, \vh_{t}+\g \E=0$, where $σ(x,s)$ is a monotone graph of $s$. It is shown that the system has a unique weak solution. Moreover, the limit of the solution as $\varepsilon\rightarrow 0$ converges to the solution of quasi-stationary Maxwell's equations.

math.AP↗

arXiv1998

On a $p$-Laplacian type of evolution system and applications to the Bean model in the type-II superconductivity theory

We study the Cauchy problem for an $p$-Laplacian type of evolution system ${\mathbf H}_{t}+\g [ | \g {\mathbf H}|^{p-2} \g {\mathbf H}|]={\mathbf F}$. This system governs the evolution of a magnetic field ${\bf H}$, where the current displacement is neglected and the electrical resistivity is assumed to be some power of the current density. The existence, uniqueness and regularity of solutions to the system are established. Furthermore, it is shown that the limit solution as the power $p\rightarrow \infty$ solves the problem of Bean's model in the type-II superconductivity theory. The result provides us information about how the superconductor material under the external force to become the normal conductor and vice visa. It also provides an effective method to find numerical solutions to Bean's model.

math-ph↗