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Hongbin Guo

Publications and source records attributed to Hongbin Guo.

6 recordsLinked to original sources

Provenance Before Prose: Claim-Locked Reporting

Large language models (LLMs) can fluently verbalize statistical evidence, yet statistical reports can still drift numerical values, invert effect directions, or restate thresholded contrasts as categorical effects. We frame these failures as a control problem: the evidence-bearing content of a scientific report should be fixed by structured statistical results rather than sampled during prose generation. We therefore use cross-run reproducibility to stress-test whether report-visible numbers and claims are bound before prose generation. Existing controls operate at the text or slot level; a deterministic hybrid template reproduces only 61.1% of report-visible numerical content across seeds because the LLM still selects which findings and numbers the template renders. We propose claim-locked reporting, a provenance-before-prose protocol that fixes the evidence source, numbers, direction, and allowed language strength of each reportable claim before the LLM writes only connective prose. Across fMRI functional-connectivity reporting and randomized controlled trial reporting on Evidence Inference 2.0, claim-locked reporting improves reproducibility over the hybrid template by 37.4 and 20.5 points, respectively. Blinded human audits support the observed direction-preservation and governance trends. In an fMRI cost analysis with DeepSeek, claim-locked reporting also yields the lowest observed token use and median generation latency.

cs.CL

Frequency-Decorrelated Temporal Ensembles for EEG--fNIRS Imagined-Handwriting Decoding

Imagined handwriting offers a temporally rich paradigm for non-invasive neural decoding, yet reliable recognition across unseen participants remains difficult because scalp EEG is noisy and internally generated stroke sequences vary across individuals. The Multimodal Brain-Computer Interface Grand Challenge provides synchronized EEG and fNIRS for four-class subject-independent handwriting-trajectory classification. We propose FRED, a task-adapted system that models imagined handwriting as a multi-second motor sequence and trains a compact multi-scale temporal network on three complementary EEG frequency views. With three seeds per view, cross-band members produce substantially less-correlated errors than same-band replicas, yielding a clean nine-member ensemble accuracy of 0.8076/0.7242/0.7492 on the public/private/overall test partitions without test-set adaptation or output constraints. The submitted pipeline further incorporates transductive pseudo-label training, three EEG-Conformer members, posterior aggregation, and a paradigm-aware decoder. Because every 12-trial randomization block contains three instances of each class, the final predictions are obtained by Hungarian assignment under the known block quota. On one fixed posterior pool, independent, session-constrained, and block-constrained decoding achieve 0.7600, 0.7758, and 0.7952 overall accuracy, respectively. The complete system reaches 0.8498/0.7718/0.7952, ranking fourth on the private split. A modality audit finds fNIRS-only decoding at chance (0.2511 overall), while adding fNIRS to EEG changes accuracy by only +0.0025. These results identify frequency-diverse temporal EEG modeling and protocol-matched structured inference as the principal sources of performance in this sparse-montage EEG--fNIRS setting. The source code is available at https://github.com/XiuFan719/EEG-fNIRS-fuse-method-for-MM-challenge.

cs.CV

Generating Synthetic Computed Tomography for Radiotherapy: SynthRAD2023 Challenge Report

Radiation therapy plays a crucial role in cancer treatment, necessitating precise delivery of radiation to tumors while sparing healthy tissues over multiple days. Computed tomography (CT) is integral for treatment planning, offering electron density data crucial for accurate dose calculations. However, accurately representing patient anatomy is challenging, especially in adaptive radiotherapy, where CT is not acquired daily. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast. Still, it lacks electron density information while cone beam CT (CBCT) lacks direct electron density calibration and is mainly used for patient positioning. Adopting MRI-only or CBCT-based adaptive radiotherapy eliminates the need for CT planning but presents challenges. Synthetic CT (sCT) generation techniques aim to address these challenges by using image synthesis to bridge the gap between MRI, CBCT, and CT. The SynthRAD2023 challenge was organized to compare synthetic CT generation methods using multi-center ground truth data from 1080 patients, divided into two tasks: 1) MRI-to-CT and 2) CBCT-to-CT. The evaluation included image similarity and dose-based metrics from proton and photon plans. The challenge attracted significant participation, with 617 registrations and 22/17 valid submissions for tasks 1/2. Top-performing teams achieved high structural similarity indices (>0.87/0.90) and gamma pass rates for photon (>98.1%/99.0%) and proton (>97.3%/97.0%) plans. However, no significant correlation was found between image similarity metrics and dose accuracy, emphasizing the need for dose evaluation when assessing the clinical applicability of sCT. SynthRAD2023 facilitated the investigation and benchmarking of sCT generation techniques, providing insights for developing MRI-only and CBCT-based adaptive radiotherapy.

physics.med-ph

Model Error Correction for Linear Methods of Reversible Radioligand Binding Measurements in PET Studies

Graphical analysis methods are widely used in positron emission tomography quantification because of their simplicity and model independence. But they may, particularly for reversible kinetics, lead to bias in the estimated parameters. The source of the bias is commonly attributed to noise in the data. Assuming a two-tissue compartmental model, we investigate the bias that originates from model error. This bias is an intrinsic property of the simplified linear models used for limited scan durations, and it is exaggerated by random noise and numerical quadrature error. Conditions are derived under which Logan's graphical method either over- or under-estimates the distribution volume in the noise-free case. The bias caused by model error is quantified analytically. The presented analysis shows that the bias of graphical methods is inversely proportional to the dissociation rate. Furthermore, visual examination of the linearity of the Logan plot is not sufficient for guaranteeing that equilibrium has been reached. A new model which retains the elegant properties of graphical analysis methods is presented, along with a numerical algorithm for its solution. We perform simulations with the fibrillar amyloid-beta radioligand [11C] benzothiazole-aniline using published data from the University of Pittsburgh and Rotterdam groups. The results show that the proposed method significantly reduces the bias due to model error. Moreover, the results for data acquired over a 70 minutes scan duration are at least as good as those obtained using existing methods for data acquired over a 90 minutes scan duration.

q-bio.QM

Reducing the noise effects in Logan graphic analysis for PET receptor measurements

Logan's graphical analysis (LGA) is a widely-used approach for quantification of biochemical and physiological processes from Positron emission tomography (PET) image data. A well-noted problem associated with the LGA method is the bias in the estimated parameters. We recently systematically evaluated the bias associated with the linear model approximation and developed an alternative to minimize the bias due to model error. In this study, we examined the noise structure in the equations defining linear quantification methods, including LGA. The noise structure conflicts with the conditions given by the Gauss-Markov theorem for the least squares (LS) solution to generate the best linear unbiased estimator. By carefully taking care of the data error structure, we propose to use structured total least squares (STLS) to obtain the solution using a one-dimensional optimization problem. Simulations of PET data for [11C] benzothiazole-aniline (Pittsburgh Compound-B [PIB]) show that the proposed method significantly reduces the bias. We conclude that the bias associated with noise is primarily due to the unusual structure of he correlated noise and it can be reduced with the proposed STLS method.

q-bio.QM

FDG-PET Parametric Imaging by Total Variation Minimization

Parametric imaging of the cerebral metabolic rate for glucose (CMRGlc) using [18F]-fluorodeoxyglucose positron emission tomography is considered. Traditional imaging is hindered due to low signal to noise ratios at individual voxels. We propose to minimize the total variation of the tracer uptake rates while requiring good fit of traditional Patlak equations. This minimization guarantees spatial homogeneity within brain regions and good distinction between brain regions. Brain phantom simulations demonstrate significant improvement in quality of images by the proposed method as compared to Patlak images with post-filtering using Gaussian or median filters.

q-bio.QM