arXiv subjects

Hongmei Zhang

Publications and source records attributed to Hongmei Zhang.

10 recordsLinked to original sources

arXiv2025

Testing-driven Variable Selection in Bayesian Modal Regression

We propose a Bayesian variable selection method in the framework of modal regression for heavy-tailed responses. An efficient expectation-maximization algorithm is employed to expedite parameter estimation. A test statistic is constructed to exploit the shape of the model error distribution to effectively separate informative covariates from unimportant ones. Through simulations, we demonstrate and evaluate the efficacy of the proposed method in identifying important covariates in the presence of non-Gaussian model errors. Finally, we apply the proposed method to analyze two datasets arising in genetic and epigenetic studies.

stat.ME↗

arXiv2024

A Deep Learning-Driven Pipeline for Differentiating Hypertrophic Cardiomyopathy from Cardiac Amyloidosis Using 2D Multi-View Echocardiography

Hypertrophic cardiomyopathy (HCM) and cardiac amyloidosis (CA) are both heart conditions that can progress to heart failure if untreated. They exhibit similar echocardiographic characteristics, often leading to diagnostic challenges. This paper introduces a novel multi-view deep learning approach that utilizes 2D echocardiography for differentiating between HCM and CA. The method begins by classifying 2D echocardiography data into five distinct echocardiographic views: apical 4-chamber, parasternal long axis of left ventricle, parasternal short axis at levels of the mitral valve, papillary muscle, and apex. It then extracts features of each view separately and combines five features for disease classification. A total of 212 patients diagnosed with HCM, and 30 patients diagnosed with CA, along with 200 individuals with normal cardiac function(Normal), were enrolled in this study from 2018 to 2022. This approach achieved a precision, recall of 0.905, and micro-F1 score of 0.904, demonstrating its effectiveness in accurately identifying HCM and CA using a multi-view analysis.

eess.IV↗

arXiv2023

A Localization Method of High Energy Transients for All-Sky Gamma-Ray Monitor

Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up observations. Localization based on the relative counts of different detectors has been widely used for all-sky gamma-ray monitors. There are two major methods for this counts distribution localization: $χ^{2}$ minimization method and the Bayesian method. Here we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the $χ^{2}$ method. With comprehensive simulations, we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than $χ^{2}$ method, especially for weak bursts. We further proposed a location-spectrum iteration approach based on the Bayesian inference, which could alleviate the problems caused by the spectral difference between the burst and location templates. Our method is very suitable for scenarios with limited computation resources or time-sensitive applications, such as in-flight localization software, and low-latency localization for rapid follow-up observations.

astro-ph.HE↗

arXiv2022

An Insight-HXMT view of the mHz quasi-regular modulation phenomenon in the black hole X-ray binary 4U 1630-47

Here we report the spectral-timing results of the black hole X-ray binary 4U 1630-47 during its 2021 outburst using observations from the Hard X-ray Modulation Telescope. Type-C quasi-periodic oscillations (QPOs) in 1.6--4.2 Hz and quasi-regular modulation (QRM) near 60 mHz are detected during the outburst. The mHz QRM has a fractional rms of 10%--16% in the 8--35 keV energy band with a Q factor (frequency/width) of 2--4. Benefiting from the broad energy band of hxmt, we study the energy dependence of the 60 mHz QRM in 1--100 keV for the first time. We find that the fractional rms of the mHz QRM increases with photon energy, while the time lags of the mHz QRM are soft and decrease with photon energy. Fast recurrence of the mHz QRM, in a timescale of less than one hour, has been observed during the outburst. During this period, the corresponding energy spectra moderately change when the source transitions from the QRM state to the non-QRM state. The QRM phenomena also shows a dependence with the accretion rate. We suggest that the QRM could be caused by an unknown accretion instability aroused from the corona.

astro-ph.HE↗

arXiv2022

Quasi-periodic oscillations of the X-ray burst from the magnetar SGR J1935+2154 and associated with the fast radio burst FRB 200428

The origin(s) and mechanism(s) of fast radio bursts (FRBs), which are short radio pulses from cosmological distances, have remained a major puzzle since their discovery. We report a strong Quasi-Periodic Oscillation(QPO) of 40 Hz in the X-ray burst from the magnetar SGR J1935+2154 and associated with FRB 200428, significantly detected with the Hard X-ray Modulation Telescope (Insight-HXMT) and also hinted by the Konus-Wind data. QPOs from magnetar bursts have only been rarely detected; our 3.4 sigma (p-value is 2.9e-4) detection of the QPO reported here reveals the strongest QPO signal observed from magnetars (except in some very rare giant flares), making this X-ray burst unique among magnetar bursts. The two X-ray spikes coinciding with the two FRB pulses are also among the peaks of the QPO. Our results suggest that at least some FRBs are related to strong oscillation processes of neutron stars. We also show that we may overestimate the significance of the QPO signal and underestimate the errors of QPO parameters if QPO exists only in a fraction of the time series of a X-ray burst which we use to calculate the Leahy-normalized periodogram.

astro-ph.HE↗

arXiv2022

Deep Q-learning of global optimizer of multiply model parameters for viscoelastic imaging

Objective: Estimation of the global optima of multiple model parameters is valuable in imaging to form a reliable diagnostic image. Given non convexity of the objective function, it is challenging to avoid from different local minima. Methods: We first formulate the global searching of multiply parameters to be a k-D move in the parametric space, and convert parameters updating to be state-action decision-making problem. We proposed a novel Deep Q-learning of Model Parameters (DQMP) method for global optimization of model parameters by updating the parameter configurations through actions that maximize a Q-value, which employs a Deep Reward Network designed to learn global reward values from both visible curve fitting errors and hidden parameter errors. Results: The DQMP method was evaluated by viscoelastic imaging on soft matter by Kelvin-Voigt fractional derivative (KVFD) modeling. In comparison to other methods, imaging of parameters by DQMP yielded the smallest errors (< 2%) to the ground truth images. DQMP was applied to viscoelastic imaging on biological tissues, which indicated a great potential of imaging on physical parameters in diagnostic applications. Conclusions: DQMP method is able to achieve global optima, yielding accurate model parameter estimates in viscoelastic imaging. Assessment of DQMP by simulation imaging and ultrasound breast imaging demonstrated the consistency, reliability of the imaged parameters, and powerful global searching ability of DQMP. Significance: DQMP method is promising for imaging of multiple parameters, and can be generalized to global optimization for many other complex nonconvex functions and imaging of physical parameters.

cs.LG↗

arXiv2020

Corrected score methods for estimating Bayesian networks with error-prone nodes

Motivated by inferring cellular signaling networks using noisy flow cytometry data, we develop procedures to draw inference for Bayesian networks based on error-prone data. Two methods for inferring causal relationships between nodes in a network are proposed based on penalized estimation methods that account for measurement error and encourage sparsity. We discuss consistency of the proposed network estimators and develop an approach for selecting the tuning parameter in the penalized estimation methods. Empirical studies are carried out to compare the proposed methods and a naive method that ignores measurement error with applications to synthetic data and to single cell flow cytometry data.

stat.ME↗

arXiv2019

Semi-parametric Bayesian variable selection for gene-environment interactions

Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Study of gene-environment (G$\times$E) interactions is important for elucidating the disease etiology. Existing Bayesian methods for G$\times$E interaction studies are challenged by the high-dimensional nature of the study and the complexity of environmental influences. Many studies have shown the advantages of penalization methods in detecting G$\times$E interactions in "large p, small n" settings. However, Bayesian variable selection, which can provide fresh insight into G$\times$E study, has not been widely examined. We propose a novel and powerful semi-parametric Bayesian variable selection model that can investigate linear and nonlinear G$\times$E interactions simultaneously. Furthermore, the proposed method can conduct structural identification by distinguishing nonlinear interactions from main-effects-only case within the Bayesian framework. Spike and slab priors are incorporated on both individual and group levels to identify the sparse main and interaction effects. The proposed method conducts Bayesian variable selection more efficiently than existing methods. Simulation shows that the proposed model outperforms competing alternatives in terms of both identification and prediction. The proposed Bayesian method leads to the identification of main and interaction effects with important implications in a high-throughput profiling study with high-dimensional SNP data.

stat.ME↗

arXiv2019

Insight-HXMT observations of Swift J0243.6+6124 during its 2017-2018 outburst

The recently discovered neutron star transient Swift J0243.6+6124 has been monitored by {\it the Hard X-ray Modulation Telescope} ({\it Insight-\rm HXMT). Based on the obtained data, we investigate the broadband spectrum of the source throughout the outburst. We estimate the broadband flux of the source and search for possible cyclotron line in the broadband spectrum. No evidence of line-like features is, however, found up to $\rm 150~keV$. In the absence of any cyclotron line in its energy spectrum, we estimate the magnetic field of the source based on the observed spin evolution of the neutron star by applying two accretion torque models. In both cases, we get consistent results with $B\rm \sim 10^{13}~G$, $D\rm \sim 6~kpc$ and peak luminosity of $\rm >10^{39}~erg~s^{-1}$ which makes the source the first Galactic ultraluminous X-ray source hosting a neutron star.

astro-ph.HE↗

arXiv2016

Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression

This paper explores the transgenerational DNA methylation pattern (DNA methylation transmitted from one generation to the next) via a clustering approach. Beta regression is employed to model the transmission pattern from parents to their offsprings at the population level. To facilitate this goal, an expectation maximization algorithm for parameter estimation along with a BIC criterion to determine the number of clusters is proposed. Applying our method to the DNA methylation data composed of 4063 CpG sites of 41 mother-father-infant triads, we identified a set of CpG sites in which DNA methylation transmission is dominated by fathers, while at a large number of CpG sites, DNA methylation is mainly maternally transmitted to the offspring.

stat.AP↗