arXiv subjects

Houda Filali

Publications and source records attributed to Houda Filali.

3 recordsLinked to original sources

arXiv2025

Holographic F(Q,T) Gravity with Lambert Solution

In this work, we study a model of holographic dark energy using FLRW cosmology in the context of modified gravity. An extension of the symmetric teleparallel gravity is obtained by considering the gravitational action L is given by an arbitrary function f of the nonmetricity Q, where the nonmetricity Q is responsible for the gravitational interaction, and the trace of the matter energy momentum tensor T, so that L=f(Q,T). We expand on the features of the derived cosmological model in view of the relation between cosmic time and redshift as t(z)=kt0/b*f(z) where f(z) = W[b/k*e((b-ln(1+z))/k)] and W denotes the Lambert function, and discuss the evolution of the trajectories of the equation of state parameters and deceleration parameter in the evolving universe using a special then generalized version of the model.

gr-qc↗

arXiv2025

Dynamics of Linear Scalar Perturbation in f(Q)+f(T) class of f(Q,T) gravity

In this work, we study the f(Q,T) model of symmetric teleparallel modified gravity in the framework of cosmological perturbation theory. Using a general approach, we extract the differential matter density equation then we simplify it as a second-order equation by considering the sub-Hubble approximation. Our analysis is then based on two different forms of f(Q,T) that we study in a classic approach and again using Holographic dark energy. Our initial results yield a significant divergence from the perturbed behavior of the LambdaCDM model, imposing stringent constraints on the feasibility of this class of theories but the HDE contribution triggers an interesting discussion.

gr-qc↗

arXiv2023

In silico Identification of tipifarnib-like compounds by structure-based pharmacophore, virtual screening and molecular docking against K-Ras post-translation in colorectal cancer

Colorectal cancer is a public health problem.Approximately 30 to 50 \% of colorectal tumors are caused by mutations in the KRAS gene.These mutations induce uncontrolled proliferation.To date,There is no approved effective treatment for the mutated KRAS oncogene.Farnesyltransferase (FTI) inhibitors are considered a therapeutic target against the mutated KRAS oncogene.Tipifarnib is a farnesyltransferase inhibitor that was analyzed in a Phase II trial.In the present study, the three-dimensional structure of farnesyltransferase complexed with tipifarnib [1SA4] was used as a basis to exploit the characteristics of tipifarnib.A pharmacophore model was generated based on the structure using the Asinex (Gold and Platinum Collections) database.A total of 299 molecules were obtained after screening.The 299 molecules were anchored to the tipifarnib binding site in the farnesyltransferase crystal structure for docking analysis.During the molecular docking process, the pharmacophore that was modeled, and was used as a constraint to eliminate the molecules that do not satisfy the pharmacophore.Finally, four Hits identified as farnesyltransferase inhibitors for biological tests. Keywords: colorectal cancer, structure-based pharmacophore, molecular docking, KRAS, farnesyltransferase inhibitors, Virtual Screening.

q-bio.BM↗