arXiv subjects

Hugo Ladret

Publications and source records attributed to Hugo Ladret.

4 recordsLinked to original sources

arXiv2025

Neural mechanisms of predictive processing: a collaborative community experiment through the OpenScope program

This review synthesizes advances in predictive processing within the sensory cortex. Predictive processing theorizes that the brain continuously predicts sensory inputs, refining neuronal responses by highlighting prediction errors. We identify key computational primitives, such as stimulus adaptation, dendritic computation, excitatory/inhibitory balance and hierarchical processing, as central to this framework. Our review highlights convergences, such as top-down inputs and inhibitory interneurons shaping mismatch signals, and divergences, including species-specific hierarchies and modality-dependent layer roles. To address these conflicts, we propose experiments in mice and primates using in-vivo two-photon imaging and electrophysiological recordings to test whether temporal, motor, and omission mismatch stimuli engage shared or distinct mechanisms. The resulting dataset, collected and shared via the OpenScope program, will enable model validation and community analysis, fostering iterative refinement and refutability to decode the neural circuits of predictive processing.

q-bio.NC↗

arXiv2024

A Predictive Approach To Enhance Time-Series Forecasting

Accurate time-series forecasting is crucial in various scientific and industrial domains, yet deep learning models often struggle to capture long-term dependencies and adapt to data distribution shifts over time. We introduce Future-Guided Learning, an approach that enhances time-series event forecasting through a dynamic feedback mechanism inspired by predictive coding. Our method involves two models: a detection model that analyzes future data to identify critical events and a forecasting model that predicts these events based on current data. When discrepancies occur between the forecasting and detection models, a more significant update is applied to the forecasting model, effectively minimizing surprise, allowing the forecasting model to dynamically adjust its parameters. We validate our approach on a variety of tasks, demonstrating a 44.8% increase in AUC-ROC for seizure prediction using EEG data, and a 23.4% reduction in MSE for forecasting in nonlinear dynamical systems (outlier excluded).By incorporating a predictive feedback mechanism, Future-Guided Learning advances how deep learning is applied to time-series forecasting.

cs.LG↗

arXiv2023

Dynamic Imaging using any Ultrasound Localization Microscopy Dataset

Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 {\mu}m ~ {\lambda}/10 in the rodent brain. Static mean velocity maps can be extracted but are intrinsically biased by potential significant changes in the number of MBs detected during the cardiac cycle. Dynamic ULM (DULM) is a technique developed for non-invasive pulsatility measurements in the brain of rodents, leading to temporally resolved velocity and density cine-loops. It was previously based on external triggers such as the electrocardiogram (ECG), limiting its use to datasets acquired specifically for DULM applications while also increasing the required acquisition time. This study presents a new motion matching method using tissue Doppler that eliminates the need for ECG-gating in DULM experiments. DULM can now be performed on any ULM datasets, recovering pertinent temporal information, and improving the robustness of the mean velocity estimates.

physics.med-ph↗

arXiv2023

Quantitative pulsatility measurements using 3D Dynamic Ultrasound Localization Microscopy

A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wide pulsatility measurements, with high penetration depth and high spatiotemporal resolution. The development of Dynamic Ultrasound Localization Microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. However, 2D imaging accesses only one slice of the brain and measures biased velocities due to 2D projection. Herein, we present 3D DULM, which can extract quantitative pulsatility measurements in the cat brain with craniotomy and in the whole mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. We highlighted a decrease in pulsatility along the vascular tree in the cat brain, and performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the whole brain volume, which could be linked to early signs of neurodegenerative diseases.

physics.med-ph↗