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Humasak Tommy Argo Simanjuntak

Publications and source records attributed to Humasak Tommy Argo Simanjuntak.

2 recordsLinked to original sources

AI for Cultural Heritage Textiles: Fine-Tuned Latent Diffusion for Novel Ulos Motif Synthesis

Preserving and revitalising traditional textiles such as Ulos, a cultural heritage of the Batak ethnic group in North Sumatra, Indonesia, requires balancing fidelity to tradition with innovative approaches that meet contemporary design demands. Traditional Ulos weaving faces two key limitations: a narrow range of motifs and a time-intensive design process. This study presents a generative AI framework that fine-tunes two pretrained latent diffusion models: Protogen v3.4 and Stable Diffusion v1.4, on a curated, annotated dataset of high-resolution Ulos motifs to generate culturally consistent yet novel designs. Model performance is evaluated quantitatively using Frechet Inception Distance (FID), Inception Score (IS), and qualitatively through assessments by traditional weavers and members of the public. Protogen v3.4 consistently outperforms Stable Diffusion v1.4, achieving substantially lower FID (~10.5x) and higher IS (2.0x), indicating superior visual fidelity, diversity, and closer alignment with the real Ulos motif distribution. We further examine the effects of strength and guidance scale on generation quality across both models. Lower strength values consistently yield higher fidelity (lower FID), while higher strength values increase generative diversity at the cost of realism, revealing a clear fidelity-diversity tradeoff for both models. Across all tested configurations, a guidance scale of 5-9 provides the most effective balance between fidelity and diversity, stabilising FID, KID, and IS, and is recommended as the operating range for high-quality, diverse Ulos motif generation. These findings demonstrate that carefully fine-tuned generative AI can support the creative renewal of intangible cultural heritage while preserving its stylistic and symbolic integrity.

cs.CV↗

Reconstructing the Developmental Trajectory of Adipocytes in Human Adipose Tissue Using Single-Cell RNA Sequencing

Obesity is a global health crisis associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. This study employed single-cell RNA sequencing to reconstruct the developmental trajectory of human adipocytes from adipose tissue samples. Our analysis identified 15 transcriptionally distinct cell clusters, including 7 transitional states, revealing the dynamic process of adipocyte differentiation. We detected 16 functionally active signaling pathways mediating cellular communication between adipocytes and their progenitors. Among these, insulin-like growth factor (IGF) and fibroblast growth factor (FGF) pathways emerged as the most prominent networks, showing consistent activity across differentiation stages (p<0.05). The study revealed depot-specific differences, with visceral adipocytes undergoing additional extracellular matrix remodeling absent in subcutaneous differentiation. Spatial analysis further showed that IGF signaling was particularly active in perivascular niches, while FGF activity dominated in mature adipocyte zones. These results provide the first comprehensive map of human adipocyte development, highlighting IGF and FGF pathways as potential therapeutic targets. The identified signaling networks offer new insights for developing interventions to promote healthy adipose expansion or inhibit pathological fat accumulation. This work advances our fundamental understanding of adipose tissue biology while providing clinically relevant data for metabolic disorder treatments.

q-bio.GN↗