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Hyunjin Shim

Publications and source records attributed to Hyunjin Shim.

At least 37 records · Page 2Linked to original sources

The JCMT SCUBA-2 Survey of the James Webb Space Telescope North Ecliptic Pole Time-Domain Field

The James Webb Space Telescope Time-Domain Field (JWST-TDF) is an $\sim$14$'$ diameter field near the North Ecliptic Pole that will be targeted by one of the JWST Guaranteed Time Observations programs. Here, we describe our James Clerk Maxwell Telescope SCUBA-2 850 $μ$m imaging of the JWST-TDF and present the submillimeter source catalog and properties. We also present a catalog of radio sources from Karl J. Jansky Very Large Array 3 GHz observations of the field. These observations were obtained to aid JWST's study of the dust-obscured galaxies that contribute significantly to the cosmic star formation at high redshifts. Our deep 850 $μ$m map covers the JWST TDF at a noise level of $σ_{850}$ = 1.0 mJy beam$^{-1}$, detecting 83/31 sources in the main/supplementary signal-to-noise ratio (S/N $>$ 4 / S/N = 3.5 - 4) sample respectively. The 3 GHz observations cover a 24$'$ diameter field with a 1 $σ$ noise of 1$μ$Jy beam$^{-1}$ at a 0$.\!\!^{\prime\prime}$7 FWHM. We identified eighty-five 3 GHz counterparts to sixty-six 850 $μ$m sources and then matched these with multiwavelength data from the optical to the mid-infrared wave bands. We performed spectral energy distribution fitting for 61 submillimeter galaxies (SMGs) matched with optical/near-infrared data, and found that SMGs at S/N $>$ 4 have a median value of $z_{phot} = $2.22 $\pm$ 0.12, star formation rates of 300 $\pm$ 40 M$_{\odot}\,{\rm yr^{-1}}$ (Chabrier initial mass function), and typical cold dust masses of 5.9 $\pm$ 0.7 $ \times$ 10$^{8} $M$_{\odot}$, in line with bright SMGs from other surveys. The large cold dust masses indicate correspondingly large cool gas masses, which we suggest are a key factor necessary to drive the high star formation rates seen in this population

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Metallicity-PAH Relation of MIR-selected Star-forming Galaxies in AKARI North Ecliptic Pole-wide Survey

We investigate the variation in the mid-infrared spectral energy distributions of 373 low-redshift ($z<0.4$) star-forming galaxies, which reflects a variety of polycyclic aromatic hydrocarbon (PAH) emission features. The relative strength of PAH emission is parameterized as $q_\mathrm{PAH}$, which is defined as the mass fraction of PAH particles in the total dust mass. With the aid of continuous mid-infrared photometric data points covering 7-24$μ$m and far-infrared flux densities, $q_\mathrm{PAH}$ values are derived through spectral energy distribution fitting. The correlation between $q_\mathrm{PAH}$ and other physical properties of galaxies, i.e., gas-phase metallicity ($12+\mathrm{log(O/H)}$), stellar mass, and specific star-formation rate (sSFR) are explored. As in previous studies, $q_\mathrm{PAH}$ values of galaxies with high metallicity are found to be higher than those with low metallicity. The strength of PAH emission is also positively correlated with the stellar mass and negatively correlated with the sSFR. The correlation between $q_\mathrm{PAH}$ and each parameter still exists even after the other two parameters are fixed. In addition to the PAH strength, the application of metallicity-dependent gas-to-dust mass ratio appears to work well to estimate gas mass that matches the observed relationship between molecular gas and physical parameters. The result obtained will be used to calibrate the observed PAH luminosity-total infrared luminosity relation, based on the variation of MIR-FIR SED, which is used in the estimation of hidden star formation.

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Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity

Antimicrobial resistance is a silent pandemic that is being exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end as the emergence and spread of antimicrobial resistance against these antibacterial compounds is outpacing the discovery and development of new antibiotics. The current antibiotic market suffers from various shortcomings, including the absence of profitability and investment. However, the most important underlying issue of traditional antibiotics arises from the inherent properties of these small molecules being mostly broad-spectrum and non-programmable. As the scientific knowledge of microbes progresses, the scientific community is starting to explore entirely novel approaches to tackling antimicrobial resistance. One of the most prominent approaches is to develop next-generation antibiotics. In this review, we discuss three innovations of next-generation antibiotics compared to traditional antibiotics as specificity, evolvability, and non-immunogenicity. We present a number of potential antimicrobial agents, including bacteriophage-based therapy, CRISPR-Cas-based antimicrobials, and microbiome-derived antimicrobial compounds. These alternative antimicrobial agents possess innovative properties that may overcome the inherent shortcomings of traditional antibiotics, and some of these next-generation antibiotics are not merely far-fetched ideas but are currently in clinical development. We further discuss some related issues and challenges such as infection diagnostics and regulatory frameworks that still need to be addressed to bring these next-generation antibiotics to the antibiotic market as viable products to combat antimicrobial resistance using a diversified set of strategies.

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Investigating the genomic background of CRISPR-Cas genomes for CRISPR-based antimicrobials

CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction. Due to the programmability and specificity of these genetic templates, CRISPR-Cas systems are potential alternative antibiotics that can be engineered to self-target antimicrobial resistance genes on the chromosome or plasmid. However, several fundamental questions remain to repurpose these tools against drug-resistant bacteria. For endogenous CRISPR-Cas self-targeting, antimicrobial resistance genes and functional CRISPR-Cas systems have to co-occur in the target cell. Furthermore, these tools have to outplay DNA repair pathways that respond to the nuclease activities of Cas proteins, even for exogenous CRISPR-Cas delivery. Here, we conduct a comprehensive survey of CRISPR-Cas genomes. First, we address the co-occurrence of CRISPR-Cas systems and antimicrobial resistance genes in the CRISPR-Cas genomes. We show that the average number of these genes varies greatly by the CRISPR-Cas type, and some CRISPR-Cas types (IE and IIIA) have over 20 genes per genome. Next, we investigate the DNA repair pathways of these CRISPR-Cas genomes, revealing that the diversity and frequency of these pathways differ by the CRISPR-Cas type. The interplay between CRISPR-Cas systems and DNA repair pathways is essential for the acquisition of new spacers in CRISPR arrays. We conduct simulation studies to demonstrate that the efficiency of these DNA repair pathways may be inferred from the time-series patterns in the RNA structure of CRISPR repeats. This bioinformatic survey of CRISPR-Cas genomes elucidates the necessity to consider multifaceted interactions between different genes and systems to design effective CRISPR-based antimicrobials.

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The evolution of merger fraction of galaxies at z < 0.6 depending on the star formation mode in the AKARI NEP Wide field

We study the galaxy merger fraction and its dependence on star formation mode in the5.4 square degrees of the North Ecliptic Pole-Wide field. We select 6352 galaxies withAKARI 9μm detections, and identify mergers among them using the Gini coefficientand M20derived from the Subaru/HSC optical images. We obtain the total infraredluminosity and star formation rate of galaxies using the spectral energy distributiontemplates based on one band, AKARI 9μm. We classify galaxies into three differentstar formation modes (i.e. starbursts, main sequence, and quiescent galaxies) andcalculate the merger fractions for each. We find that the merger fractions of galaxiesincrease with redshift atz<0.6. The merger fractions of starbursts are higher thanthose of main sequence and quiescent galaxies in all redshift bins. We also examinethe merger fractions of far-infrared detected galaxies which have at least one detectionfromHerschel/SPIRE. We find thatHerscheldetected galaxies have higher mergerfraction compared to non-Herscheldetected galaxies, and bothHerscheldetected andnon-Herscheldetected galaxies show clearly different merger fractions depending onthe star formation modes.

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Environmental Effects on AGN activity via Extinction-free Mid-Infrared Census

How does the environment affect active galactic nucleus (AGN) activity? We investigated this question in an extinction-free way, by selecting 1120 infrared galaxies in the $AKARI$ North Ecliptic Pole Wide field at redshift $z$ $\leq$ 1.2. A unique feature of the $AKARI$ satellite is its continuous 9-band infrared (IR) filter coverage, providing us with an unprecedentedly large sample of IR spectral energy distributions (SEDs) of galaxies. By taking advantage of this, for the first time, we explored the AGN activity derived from SED modelling as a function of redshift, luminosity, and environment. We quantified AGN activity in two ways: AGN contribution fraction (ratio of AGN luminosity to the total IR luminosity), and AGN number fraction (ratio of number of AGNs to the total galaxy sample). We found that galaxy environment (normalised local density) does not greatly affect either definitions of AGN activity of our IRG/LIRG samples (log ${\rm L}_{\rm TIR}$ $\leq$ 12). However, we found a different behavior for ULIRGs (log ${\rm L}_{\rm TIR}$ $>$ 12). At our highest redshift bin (0.7 $\lesssim$ z $\lesssim$ 1.2), AGN activity increases with denser environments, but at the intermediate redshift bin (0.3 $\lesssim$ z $\lesssim$ 0.7), the opposite is observed. These results may hint at a different physical mechanism for ULIRGs. The trends are not statistically significant (p $\geq$ 0.060 at the intermediate redshift bin, and p $\geq$ 0.139 at the highest redshift bin). Possible different behavior of ULIRGs is a key direction to explore further with future space missions (e.g., $JWST$, $Euclid$, $SPHEREx$).

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Active galactic nuclei catalog from the AKARI NEP Wide field

Context. The North Ecliptic Pole (NEP) field provides a unique set of panchromatic data, well suited for active galactic nuclei (AGN) studies. Selection of AGN candidates is often based on mid-infrared (MIR) measurements. Such method, despite its effectiveness, strongly reduces a catalog volume due to the MIR detection condition. Modern machine learning techniques can solve this problem by finding similar selection criteria using only optical and near-infrared (NIR) data. Aims. Aims of this work were to create a reliable AGN candidates catalog from the NEP field using a combination of optical SUBARU/HSC and NIR AKARI/IRC data and, consequently, to develop an efficient alternative for the MIR-based AKARI/IRC selection technique. Methods. A set of supervised machine learning algorithms was tested in order to perform an efficient AGN selection. Best of the models were formed into a majority voting scheme, which used the most popular classification result to produce the final AGN catalog. Additional analysis of catalog properties was performed in form of the spectral energy distribution (SED) fitting via the CIGALE software. Results. The obtained catalog of 465 AGN candidates (out of 33 119 objects) is characterized by 73% purity and 64% completeness. This new classification shows consistency with the MIR-based selection. Moreover, 76% of the obtained catalog can be found only with the new method due to the lack of MIR detection for most of the new AGN candidates. Training data, codes and final catalog are available via the github repository. Final AGN candidates catalog will be also available via the CDS service after publication.

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Diverse ATPase proteins in mobilomes constitute a large potential sink for prokaryotic host ATP

Prokaryote mobilome genomes rely on host machineries for survival and replication. Given that mobile genetic elements (MGEs) derive their energy from host cells, we investigated the diversity of ATP-utilizing proteins in MGE genomes to determine whether they might be associated with proteins that could suppress related host proteins that consume host energy. A comprehensive search of 353 huge phage genomes revealed that up to 9% of the proteins have ATPase domains. For example, ATPase proteins constitute ~3% of the genomes of Lak phages with ~550 kbp genomes that occur in the microbiomes of humans and other animals. Statistical analysis shows the number of ATPase proteins increases linearly with genome length, consistent with a large sink for host ATP during replication of megaphages. Using metagenomic data from diverse environments, we found 505 mobilome proteins with ATPase domains fused to diverse functional domains. Among these composite ATPase proteins, 61.6% have known functional domains that could contribute to host energy diversion during the mobilome life cycle. As many have domains that are known to interact with nucleic acids and proteins, we infer that numerous ATPase proteins are used during replication and for protection from host immune systems. We found a set of uncharacterized ATPase proteins with nuclease and protease activities, displaying unique domain architectures that are energy intensive based on the presence of multiple ATPase domains. In many cases, these composite ATPase proteins genomically co-localize with small proteins in genomic contexts that are reminiscent of toxin-antitoxin systems. Small proteins that function as inhibitors may be a common strategy for control of cellular processes, thus could inspire the development of new nucleic acid and protein manipulation tools, with diverse biotechnological applications.

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Revisiting the Color-Color Selection: Submillimeter and AGN Properties of NUV-r-J Selected Quiescent Galaxies

We examine the robustness of the color-color selection of quiescent galaxies (QGs) against contamination of dusty star-forming galaxies using the latest submillimeter data. We selected 18,304 QG candidates out to $z\sim$ 3 using the commonly adopted $NUV-r-J$ selection based on the high-quality multi-wavelength COSMOS2015 catalog. Using extremely deep 450 and 850 $μ$m catalogs from the latest JCMT SCUBA-2 Large Programs, S2COSMOS, and STUDIES, as well as ALMA submillimeter, VLA 3 GHz, and $Spitzer$ MIPS 24 $μ$m catalogs, we identified luminous dusty star-forming galaxies among the QG candidates. We also conducted stacking analyses in the SCUBA-2 450 and 850 $μ$m images to look for less-luminous dusty galaxies among the QG candidates. By cross-matching to the 24 $μ$m and 3 GHz data, we were able to identify a sub-group of "IR-radio-bright" QGs who possess a strong 450 and 850 $μ$m stacking signal. The potential contamination of these luminous and less-luminous dusty galaxies accounts for approximately 10% of the color-selected QG candidates. In addition, there exists a spatial correlation between the luminous star-forming galaxies and the QGs at a $\lesssim60$ kpc scale. Finally, we found a high QG fraction among radio AGNs at $z<$ 1.5. Our data show a strong correlation between QGs and radio AGNs, which may suggest a connection between the quenching process and the radio-mode AGN feedback.

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An Active Galactic Nucleus Recognition Model based on Deep Neural Network

To understand the cosmic accretion history of supermassive black holes, separating the radiation from active galactic nuclei (AGNs) and star-forming galaxies (SFGs) is critical. However, a reliable solution on photometrically recognising AGNs still remains unsolved. In this work, we present a novel AGN recognition method based on Deep Neural Network (Neural Net; NN). The main goals of this work are (i) to test if the AGN recognition problem in the North Ecliptic Pole Wide (NEPW) field could be solved by NN; (ii) to shows that NN exhibits an improvement in the performance compared with the traditional, standard spectral energy distribution (SED) fitting method in our testing samples; and (iii) to publicly release a reliable AGN/SFG catalogue to the astronomical community using the best available NEPW data, and propose a better method that helps future researchers plan an advanced NEPW database. Finally, according to our experimental result, the NN recognition accuracy is around 80.29% - 85.15%, with AGN completeness around 85.42% - 88.53% and SFG completeness around 81.17% - 85.09%.

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Photometric Redshifts in the North Ecliptic Pole Wide Field based on a Deep Optical Survey with Hyper Suprime-Cam

The $AKARI$ space infrared telescope has performed near- to mid-infrared (MIR) observations on the North Ecliptic Pole Wide (NEPW) field (5.4 deg$^2$) for about one year. $AKARI$ took advantage of its continuous nine photometric bands, compared with NASA's $Spitzer$ and WISE space telescopes, which had only four filters with a wide gap in the MIR. The $AKARI$ NEPW field lacked deep and homogeneous optical data, limiting the use of nearly half of the IR sources for extra-galactic studies owing to the absence of photometric redshifts (photo-zs). To remedy this, we have recently obtained deep optical imaging over the NEPW field with 5 bands ($g$, $r$, $i$, $z$, and $Y$) of the Hyper Suprime-Camera (HSC) on the Subaru 8m telescope. We optically identify AKARI-IR sources along with supplementary $Spitzer$ and WISE data as well as pre-existing optical data. In this work, we derive new photo-zs using a $χ^2$ template-fitting method code ($Le$ $Phare$) and reliable photometry from 26 selected filters including HSC, $AKARI$, CFHT, Maidanak, KPNO, $Spitzer$ and WISE data. We take 2026 spectroscopic redshifts (spec-z) from all available spectroscopic surveys over the NEPW to calibrate and assess the accuracy of the photo-zs. At z < 1.5, we achieve a weighted photo-z dispersion of $σ_{Δ{z/(1+z)}}$ = 0.053 with $η$ = 11.3% catastrophic errors.

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Identification of AKARI infrared sources by Deep HSC Optical Survey: Construction of New Band-Merged Catalogue in the NEP-Wide field

The north ecliptic pole (NEP) field is a natural deep field location for many satellite observations. It has been targeted manytimes since it was surveyed by the AKARI space telescope with its unique wavelength coverage from the near- to mid-infrared(mid-IR). Many follow-up observations have been carried out and made this field one of the most frequently observed areas witha variety of facilities, accumulating abundant panchromatic data from X-ray to radio wavelength range. Recently, a deep opticalsurvey with the Hyper Suprime-Cam (HSC) at the Subaru telescope covered the NEP-Wide (NEPW) field, which enabled us toidentify faint sources in the near- and mid-IR bands, and to improve the photometric redshift (photo-z) estimation. In this work,we present newly identified AKARI sources by the HSC survey, along with multi-band photometry for 91,861 AKARI sourcesobserved over the NEPW field. We release a new band-merged catalogue combining various photometric data from GALEXUV to the submillimetre (sub-mm) bands (e.g., Herschel/SPIRE, JCMT/SCUBA-2). About 20,000 AKARI sources are newlymatched to the HSC data, most of which seem to be faint galaxies in the near- to mid-infrared AKARI bands. This cataloguemotivates a variety of current research, and will be increasingly useful as recently launched (eROSITA/ART-XC) and futurespace missions (such as JWST, Euclid, and SPHEREx) plan to take deep observations in the NEP field.

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Extinction-free Census of AGNs in the $AKARI$/IRC North Ecliptic Pole Field from 23-band Infrared Photometry from Space Telescopes

In order to understand the interaction between the central black hole and the whole galaxy or their co-evolution history along with cosmic time, a complete census of active galactic nuclei (AGN) is crucial. However, AGNs are often missed in optical, UV and soft X-ray observations since they could be obscured by gas and dust. A mid-infrared (mid-IR) survey supported by multiwavelength data is one of the best ways to find obscured AGN activities because it suffers less from extinction. Previous large IR photometric surveys, e.g., $WISE$ and $Spitzer$, have gaps between the mid-IR filters. Therefore, star forming galaxy (SFG)-AGN diagnostics in the mid-IR were limited. The $AKARI$ satellite has a unique continuous 9-band filter coverage in the near to mid-IR wavelengths. In this work, we take advantage of the state-of-the-art spectral energy distribution (SED) modelling software, CIGALE, to find AGNs in mid-IR. We found 126 AGNs in the NEP-Wide field with this method. We also investigate the energy released from the AGN as a fraction of the total IR luminosity of a galaxy. We found that the AGN contribution is larger at higher redshifts for a given IR luminosity. With the upcoming deep IR surveys, e.g., $JWST$, we expect to find more AGNs with our method.

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Search for Optically Dark Infrared Galaxies without Counterparts of Subaru Hyper Suprime-Cam in the AKARI North Ecliptic Pole Wide Survey Field

We present the physical properties of AKARI sources without optical counterparts in optical images from the Hyper Suprime-Cam (HSC) on the Subaru telescope. Using the AKARI infrared (IR) source catalog and HSC optical catalog, we select 583 objects that do not have HSC counterparts in the AKARI North Ecliptic Pole (NEP) wide survey field ($\sim 5$ deg$^{2}$). Because the HSC limiting magnitude is deep ($g_{\rm AB}$ $\sim 28.6$), these are good candidates for extremely red star-forming galaxies (SFGs) and/or active galactic nuclei (AGNs), possibly at high redshifts. We compile multi-wavelength data out to 500 $μ$m and use it for Spectral Energy Distribution (SED) fitting with CIGALE to investigate the physical properties of AKARI galaxies without optical counterparts. We also compare their physical quantities with AKARI mid-IR selected galaxies with HSC counterparts. The estimated redshifts of AKARI objects without HSC counterparts range up to $z\sim 4$, significantly higher than that of AKARI objects with HSC counterparts. We find that: (i) 3.6 $-$ 4.5 $μ$m color, (ii) AGN luminosity, (iii) stellar mass, (iv) star formation rate, and (v) $V$-band dust attenuation in the interstellar medium of AKARI objects without HSC counterparts are systematically larger than those of AKARI objects with counterparts. These results suggest that our sample includes luminous, heavily dust-obscured SFGs/AGNs at $z\sim 1-4$ that are missed by previous optical surveys, providing very interesting targets for the coming James Webb Space Telescope era.

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SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES) IV: Spatial clustering and halo masses of 450-$μ$m-selected sub-millimeter galaxies

We analyze an extremely deep 450-$μ$m image ($1σ=0.56$\,mJy\,beam$^{-1}$) of a $\simeq 300$\,arcmin$^{2}$ area in the CANDELS/COSMOS field as part of the SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). We select a robust (signal-to-noise ratio $\geqslant 4$) and flux-limited ($\geqslant 4$\,mJy) sample of 164 sub-millimeter galaxies (SMGs) at 450-$μ$m that have $K$-band counterparts in the COSMOS2015 catalog identified from radio or mid-infrared imaging. Utilizing this SMG sample and the 4705 $K$-band-selected non-SMGs that reside within the noise level $\leqslant 1$\,mJy\,beam$^{-1}$ region of the 450-$μ$m image as a training set, we develop a machine-learning classifier using $K$-band magnitude and color-color pairs based on the thirteen-band photometry available in this field. We apply the trained machine-learning classifier to the wider COSMOS field (1.6\,deg$^{2}$) using the same COSMOS2015 catalog and identify a sample of 6182 450-$μ$m SMG candidates with similar colors. The number density, radio and/or mid-infrared detection rates, redshift and stellar mass distributions, and the stacked 450-$μ$m fluxes of these SMG candidates, from the S2COSMOS observations of the wide field, agree with the measurements made in the much smaller CANDELS field, supporting the effectiveness of the classifier. Using this 450-$μ$m SMG candidate sample, we measure the two-point autocorrelation functions from $z=3$ down to $z=0.5$. We find that the 450-$μ$m SMG candidates reside in halos with masses of $\simeq (2.0\pm0.5) \times10^{13}\,h^{-1}\,\rm M_{\odot}$ across this redshift range. We do not find evidence of downsizing that has been suggested by other recent observational studies.

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SCUBA-2 Ultra Deep Imaging Eao Survey (Studies) III: Multi-wavelength properties, luminosity functions and preliminary source catalog of 450-$μ$m-selected galaxies

We construct a SCUBA-2 450-$μ$m map in the COSMOS field that covers an area of 300 arcmin$^{2}$ and reaches a 1$σ$ noise level of 0.65 mJy in the deepest region. We extract 256 sources detected at 450 $μ$m with signal-to-noise ratio $>$ 4.0 and analyze the physical properties of their multi-wavelength counterparts. We find that most of the sources are at $z\lesssim3$, with a median of $z = 1.79^{+0.03}_{-0.15}$. About $35^{+32}_{-25}$% of our sources are classified as starburst galaxies based on their total star-formation rates (SFRs) and stellar masses ($M_{\ast}$). By fitting the far-infrared spectral energy distributions, we find that our 450-$μ$m-selected sample has a wide range of dust temperatures (20 K $ \lesssim T_{\rm d} \lesssim$ 60 K), with a median of ${T}_{\rm d} = 38.3^{+0.4}_{-0.9}$ K. We do not find a redshift evolution in dust temperature for sources with $L_{\rm IR}$ > $10^{12}$ $\rm L_\odot$ at $z<3$. However, we find a moderate correlation where dust temperature increases with the deviation from the SFR-$M_{\ast}$ relation. The increase in dust temperature also correlates with optical morphology, which is consistent with merger-triggered starbursts in sub-millimeter galaxies. Our galaxies do not show the tight IRX-$β_{\rm UV}$ correlation that has been observed in the local Universe. We construct the infrared luminosity functions of our 450-$μ$m sources and measure their comoving SFR densities. The contribution of the $L_{\rm IR}$ > $10^{12}$ $\rm L_\odot$ population to the SFR density rises dramatically from $z$ = 0 to 2 ($\propto$ ($1+z$)$^{3.9\pm1.1}$) and dominates the total SFR density at $z \gtrsim 2$.

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Futuristic methods in virus genome evolution using the Third-Generation DNA sequencing and artificial neural networks

The Third-Generation in DNA sequencing has emerged in the last few years using new technologies that allow the production of long-read sequences. Applications of the Third-Generation sequencing enable real-time and on-site data production, changing the research paradigms in environmental and medical sampling in virology. To take full advantage of large-scale data generated from long-read sequencing, an innovation in the downstream data analysis is necessary. Here, we discuss futuristic methods using machine learning approaches to analyze big genetic data. Machine learning combines pattern recognition and computational learning to perform predictive and exploratory data analysis. In particular, deep learning is a field of machine learning that is used to solve complex problems through artificial neural networks. Unlike other methods, features can be learned using neural networks entirely from data without manual specifications. We discuss the future of 21st-century virology by presenting futuristic approaches for virus studies using real-time data production and on-site data analysis with the Third-Generation Sequencing and machine learning methods. We first introduce the basic concepts in conventional statistical models and methods in virology, building gradually into the necessity of innovating the downstream data analysis to meet the advances in sequencing technologies. We argue that artificial neural networks can innovate the downstream data analysis, as they can learn from big datasets without model assumptions or feature specifications, as opposed to the current data analysis in bioinformatics. Furthermore, we discuss how futuristic methods using artificial neural networks combined with long-read sequences can revolutionize virus studies, using specific examples in supervised and unsupervised settings.

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Characteristics of mid-infrared PAH emission from star-forming galaxies selected at 250 μm in the North Ecliptic Pole (NEP) field

Evolutionary properties of infrared (IR) luminous galaxies are important keys to understand dust-obscured star formation history and galaxy evolution. Based on the near- to mid-IR imaging with 9 continuous filters of AKARI space telescope, we present the characteristics of dusty star-forming (SF) galalxies showing polycyclic aromatic hydrocarbon (PAH) features observed by the North Ecliptic Pole (NEP) wide field survey of AKARI and Herschel. All the sample galaxies from the AKARI/NEP-Wide data are selected based both on the Herschel/SPIRE 250 μm detection and optical spectroscopic redshift data. The physical modelling of spectral energy distribution (SED) using all available data points from u to sub-mm 500 μm band, including WISE and PACS data where available, takes unique advantages of the continuous near to mid-IR coverage, reliable constraint on far-IR peak, spectroscopically determined accurate redshifts, as well as energy balance principle by MAGPHYS. This enables us to derive physically meaningful and accurate total infrared luminosity and 8 μm (or PAH) luminosity consistently. Our sample galaxies are in the redshift range z <1, and majority of them appear to be normal SF/spiral populations showing PAH features near the 8 μm. These SF galaxies showing PAHs in the mid-IR include various types from quiescent to starbursts. Some of our sample show shortage of 8 μm luminosity compared to the total IR luminosity and this PAH deficit gets severe in more luminous IR galaxies, suggesting PAH molecules in these galaxies destroyed by strong radiation field from SF region or a large amount of cold dust in ISM. The specific SFR of our sample shows mass dependent time evolution which is consistent with downsizing evolutionary pattern.

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