arXiv subjects

I. Zymak

Publications and source records attributed to I. Zymak.

3 recordsLinked to original sources

arXiv2026

Controlled kHz laser-driven electron irradiations for pre-clinical applications

We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to characterize and deliver on-demand (i.e. pre-agreed date and time) the target electron beam energy, dose and dose uniformity. We present a tolerance analysis on the laser electron parameters, highlighting the importance of beam stability for precise irradiations of in vivo zebrafish embryos and in vitro U251 glioblastoma cell line. The observed improvement in the survival rate of the zebrafish embryos, combined with unchanged cytotoxicity in the cell cultures, indicates promising results for normal tissue sparing while maintaining anticancer efficacy. The pre-clinical results of this work represent an important milestone towards the clinical translation of laser-plasma accelerators.

physics.med-ph↗

arXiv2025

Towards High-Resolution Orbitrap Mass Spectrometry for Next- Generation In-Situ Space Dust Analysis

Cosmic and planetary dust hold vital clues to the chemical evolution of the solar system, yet in situ analysis of their molecular and elemental composition remains technically challenging. Here we present laboratory results from HANKA (High-resolution mass Analyzer for Nano-scale Kinetic Astro materials), a compact Orbitrap-based mass spectrometer developed towards the goal of a universal dust detector for space applications. Using infrared laser ablation and plasma formation under vacuum, we analyzed solid-state samples representative of Lunar, Martian, and Meteoritic material. The resulting mass spectra - recorded at resolving powers of R=60000 - reveal complex, but characteristic element mixtures. These results demonstrate the single event sensitivity of HANKA, and its mass resolution with the ability to resolve complex mass spectra and possibly differentiate geochemical signatures across planetary bodies. The dynamic range of 3-4 orders of magnitude enables even the detection of trace compounds. The minimalistic impact sampling approach enables fast, high-precision compositional mass analysis without complex sample preparation, making the instrument well-suited for orbital, surface, or flyby missions with expected dust impacts. Our system consists of an IR-laser system that simulates impacts of nano to micron sized solid-state dust and ice particles from space. It therefore allows to perform so called analogue experiments in the laboratory. We conclude that IR- laser pulses on a solid-state material are not only well suited for ice particle impact analogues but also a good analogue experiment for solid state particle impacts on a dust detector electrode in space. Moreover, the IR laser is employed only for an optimal analogue experiment simulating the impact event - it is not necessary in space on a spacecraft detecting space dust.

astro-ph.EP↗

arXiv2024

Ultrarelativistic electron beams accelerated by terawatt scalable kHz laser

We show the laser-driven acceleration of unprecedented, collimated ($ 2 \ \mathrm{mrad} $ divergence), and quasi-monoenergetic ($ 25 \ \% $ energy spread) electron beams with energy up to $ 50 \ \mathrm{MeV} $ at $ 1 \ \mathrm{kHz} $ repetition rate. The laser driver is a multi-cycle ($ 15 \ \mathrm{fs} $) $ 1 \ \mathrm{kHz} $ optical parametric chirped pulse amplification (OPCPA) system, operating at $ 26 \ \mathrm{mJ} $ ($ 1.7 \ \mathrm{TW} $). The scalability of the driver laser technology and the electron beams reported in this work pave the way towards developing high-brilliance x-ray sources for medical imaging, innovative devices for brain cancer treatment, and represent a step towards the realization of a kHz GeV electron beamline.

physics.plasm-ph↗