arXiv subjects

Iain D Campbell

Publications and source records attributed to Iain D Campbell.

2 recordsLinked to original sources

arXiv2006

Integrin activation - the importance of a positive feedback

Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with known experimental parameters, is used to show that the binding of a stabilizing factor, such as talin, is alone insufficient to enable ligand-dependent integrin activation for all observed conditions; an additional positive feedback is required.

q-bio.MN↗

arXiv2005

Differential gene expression in Bacillus subtilis

Sporulation in Bacillus subtilis serves as a paradigm for the development of two different cell types (mother cell and prespore) from a single cell. The mechanism by which the two different developmental programs are initiated has been much studied but is not well understood. With the help of existing and new experimental results, a mathematical model has been developed that reproduces all published in vitro experiments and makes new predictions about the properties of the system in vivo.

q-bio.MN↗