arXiv subjects

Igor Mishustin

Publications and source records attributed to Igor Mishustin.

41 records · Page 3Linked to original sources

arXiv2007

MCHIT - Monte Carlo model for proton and heavy-ion therapy

We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2). The model takes into account fragmentation of projectile nuclei and secondary interactions of produced nuclear fragments. Model predictions are validated with available experimental data obtained for water and PMMA phantoms irradiated by monoenergetic carbon-ion beams. The MCHIT model describes well (1) the depth-dose distributions in water and PMMA, (2) the doses measured for fragments of certain charge, (3) the distributions of positron emitting nuclear fragments produced by carbon-ion beams, and (4) the energy spectra of secondary neutrons measured at different angles to the beam direction. Radial dose profiles for primary nuclei and for different projectile fragments are calculated and discussed as possible input for evaluation of biological dose distributions. It is shown that at the periphery of the transverse dose profile close to the Bragg peak the dose from secondary nuclear fragments is comparable to the dose from primary nuclei.

physics.med-ph↗

arXiv2007

Comparative study of depth-dose distributions for beams of light and heavy nuclei in tissue-like media

We study the energy deposition by light and heavy nuclei in tissue-like media as used for cancer therapy. The depth-dose distributions for protons, $^{3}$He, $^{12}$C, $^{20}$Ne, and $^{58}$Ni nuclei are calculated within a Monte Carlo model based on the GEANT4 toolkit. These distributions are compared with each other and with available experimental data. It is demonstrated that nuclear fragmentation reactions essentially reduce the peak-to-plateau ratio of the dose profiles for deeply penetrating energetic ions heavier than $^{3}$He. On the other hand, all projectiles up to $^{20}$Ne were found equally suitable for therapeutic use at low penetration depths.

physics.med-ph↗

arXiv2006

Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4

Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C and $^{15}$O nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e$^+$ annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in surrounding medium. A finite spatial resolution of the Positron Emission Tomography (PET) is taken into account in a simplified way. Depth distributions of $β^+$-activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The calculated $β^+$-activity profiles are in good agreement with PET data for proton and $^{12}$C beams at energies suitable for particle therapy. The MCHIT capability to predict the $β^+$-activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.

physics.med-ph↗

arXiv2005

Neutrons from fragmentation of light nuclei in tissue-like media: a study with GEANT4 toolkit

We study energy deposition by light nuclei in tissue-like media taking into account nuclear fragmentation reactions, in particular, production of secondary neutrons. The calculations are carried out within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit. Experimental data on depth-dose distributions for 135A-400A MeV C-12 and O-18 beams are described very well without any adjustment of the model parameters. This gives confidence in successful use of the GEANT4 toolkit for MC simulations of cancer therapy with beams of light nuclei. The energy deposition due to secondary neutrons produced by C-12 and Ne-20 beams in a (40-50 cm)^3 water phantom is estimated to 1-2% of the total dose, that is only slightly above the neutron contribution (~1%) induced by a 200 MeV proton beam.

physics.med-ph↗

arXiv1999

Reconstruction of the Proton Source in Relativistic Heavy Ion Collisions

We describe a direct method to reconstruct the transverse proton source formed in a relativistic heavy ion collision, making use of experimentally measured proton and deuteron spectra and assuming that deuterons are formed via two-nucleon coalescence. We show that an ambiguity with respect to the source temperature still persists and we indicate a possible solution to the problem.

nucl-th↗