arXiv subjects

Igor Pshenichnov

Publications and source records attributed to Igor Pshenichnov.

16 recordsLinked to original sources

arXiv2024

Parameterization of dose profiles of therapeutic minibeams of protons, $^{4}$He, $^{12}$C, and $^{16}$O

Single minibeams of protons, $^{4}$He, $^{12}$C and $^{16}$O in water were modeled with Geant4, and their dose distributions were parameterized with double-Gauss-Rutherford (DGR) functions. Dose distributions from arrays of 16 parallel minibeams centered on a rectangular or hexagonal grid were constructed from the parameterized minibeam profiles to simulate the lateral convergence of the minibeams resulting in a homogeneous dose field in the target tumor volume. Peak-to-valley dose ratios (PVDR) and dose-volume histograms (DVH) were calculated for the parameterized dose distributions and compared with those obtained directly from Geant4 modeling of minibeam arrays. The similarity of the results obtained by these two methods suggests that the fast calculation of dose profiles of minibeam arrays based on the DGR parameterizations proposed in this work can replace the time-consuming MC modeling in future preclinical studies and also in the development of treatment planning systems for minibeam therapy.

physics.med-ph↗

arXiv2022

Peeling away neutron skin in ultracentral collisions of relativistic nuclei

In heavy nuclei the ratio between local densities of neutrons and protons increases towards the nuclear periphery. The excess of neutrons is known as the neutron skin (NS) with a subtle difference ($<0.5$~fm) between the r.m.s radii of the distributions of neutrons and protons. We show that the presence of NS in $^{208}$Pb leads to extra spectator neutrons in ultracentral $^{208}$Pb--$^{208}$Pb collisions at the CERN SPS and LHC. The yields of spectator neutrons and protons were calculated within a new version of Abrasion-Ablation Monte Carlo for Colliders model (AAMCC-MST) taking into account NS and pre-equilibrium clustering of spectator matter. While the average numbers of spectator neutrons and protons in ultracentral collisions vary insignificantly, the cross sections of emission of certain numbers of spectator neutrons in events with 0,1,...5 spectator protons are changed by 50--250\%, depending on the thickness of NS. These cross sections are less sensitive to other parameters in calculations, and their measurements in the ALICE experiment at the LHC will make it possible to restrict the existing variety of neutron density parameterizations in $^{208}$Pb.

nucl-th↗

arXiv2020

Nuclear resonance fluorescence of $^{208}$Pb in heavy-ion colliders

In ultraperipheral collisions (UPC) of nuclei the impact of Lorentz-contracted electromagnetic fields of collision partners leads to their excitations. In case of heavy nuclei the emission of neutrons is a main deexcitation channel and forward neutrons emitted in UPC were detected at the Relativistic Heavy-Ion Collider (RHIC) and at the Large Hadron Collider (LHC) by means of Zero Degree Calorimeters. However, the excitation of low-lying discrete nuclear states is also possible in UPC below the neutron separation energy. In this work by means of the Weizsacker-Williams method the data on nuclear resonance fluorescence (NRF) induced by real photons in 208 Pb are used to model the excitations of discrete levels in colliding nuclei. Due to Lorentz boosts one can expect that deexcitation photons with energies up to 40 GeV and 300 GeV are emitted in very forward direction, respectively, at the LHC and at the Future Circular Collider (FCC-hh). Energy, rapidity and angular distributions of such photons are calculated in the laboratory system, which can be used for monitoring of collider luminosity or triggering particle production in UPC.

nucl-th↗

arXiv2018

On the performance of Zero Degree Calorimeters in detecting multinucleon events

The facilities designed to study collisions of relativistic nuclei, such as the MPD at NICA (JINR), STAR at RHIC (BNL), ALICE, ATLAS and CMS at the LHC (CERN), are equipped with pairs of hadronic Zero Degree Calorimeters (ZDC) to detect forward nucleons at the both sides of the interaction point and estimate the collision centrality. The energy deposited in a ZDC fluctuates from one event to another, but on average it is proportional to the number of absorbed nucleons. Forward nucleons are also emitted in electromagnetic dissociation (EMD) of nuclei in ultraperipheral collisions, and they are used to monitor the luminosity. As known, ZDC energy spectra are specific to each facility, because they are affected by the ZDC acceptance, and the ZDC energy resolution depends on the beam energy. In this work a simple combinatorial model leading to handy formulas has been proposed to connect the numbers of emitted and detected forward nucleons taking into account a limited ZDC acceptance. The ZDC energy spectra from the EMD with the emission of one, two, three and four forward neutrons and protons have been modeled for collision energies of NICA and the LHC. The case of a rather small ZDC acceptance has been investigated and a possibility to measure the inclusive nucleon emission cross section has been demonstrated.

physics.ins-det↗

arXiv2014

Synthesis of neutron-rich transuranic nuclei in fissile spallation targets

A possibility of synthesizing neutron-reach super-heavy elements in spallation targets of Accelerator Driven Systems (ADS) is considered. A dedicated software called Nuclide Composition Dynamics (NuCoD) was developed to model the evolution of isotope composition in the targets during a long-time irradiation by intense proton and deuteron beams. Simulation results show that transuranic elements up to Bk-249 can be produced in multiple neutron capture reactions in macroscopic quantities. However, the neutron flux achievable in a spallation target is still insufficient to overcome the so-called fermium gap. Further optimization of the target design, in particular, by including moderating material and covering it by a reflector will turn ADS into an alternative source of transuranic elements in addition to nuclear fission reactors.

physics.ins-det↗

arXiv2014

Monte Carlo modeling of spallation targets containing uranium and americium

Neutron production and transport in spallation targets made of uranium and americium are studied with a Geant4-based code MCADS (Monte Carlo model for Accelerator Driven Systems). A good agreement of MCADS results with experimental data on neutron- and proton-induced reactions on $^{241}$Am and $^{243}$Am nuclei allows to use this model for simulations with extended Am targets. It was demonstrated that MCADS model can be used for calculating the values of critical mass for $^{233,235}$U, $^{237}$Np, $^{239}$Pu and $^{241}$Am. Several geometry options and material compositions (U, U+Am, Am, Am$_2$O$_3$) are considered for spallation targets to be used in Accelerator Driven Systems. All considered options operate as deep subcritical targets having neutron multiplication factor of $k \sim 0.5$. It is found that more than 4 kg of Am can be burned in one spallation target during the first year of operation.

physics.ins-det↗

arXiv2014

Comparative study of RBE and cell survival fractions for $^{1}$H, $^{4}$He, $^{12}$C and $^{16}$O beams using Geant4 and Microdosimetric Kinetic model

Beams of $^{4}$He and $^{16}$O nuclei are considered for ion-beam cancer therapy as alternative options to protons and $^{12}$C nuclei. Spread-out Bragg peak (SOBP) distributions of physical dose and relative biological effectiveness for 10% survival are calculated by means of our Geant4-based Monte Carlo model for Heavy Ion Therapy (MCHIT) and the modified microdosimetric kinetic model. The depth distributions of cell survival fractions are calculated for $^{1}$H, $^{4}$He, $^{12}$C and $^{16}$O for tissues with normal (HSG cells), low and high radiosensitivity. In each case the cell survival fractions were compared separately for the target volume, behind and in front of it. In the case of normal radiosensitivity $^{4}$He and $^{12}$C better spare tissues in the entrance channel compared to protons and $^{16}$O. The cell survival fractions calculated, respectively, for the entrance channel and target volume are similar for $^{4}$He and $^{12}$C. When it is important to spare healthy tissues located after the distal edge of the SOBP plateau, $^{4}$He can be recommended due to reduced nuclear fragmentation of these projectiles. No definite advantages of $^{16}$O with respect to $^{12}$C were found, with the except of an enhanced impact of these heavier projectiles on radioresistant tumors.

physics.med-ph↗

arXiv2013

Microdosimetry spectra and RBE of H-1, He-4, Li-7 and C-12 nuclei in water studied with Geant4

A Geant4-based Monte Carlo model for Heavy-Ion Therapy (MCHIT) is used to study radiation fields of H-1, He-4, Li-7 and C-12 beams with similar ranges (~160-180 mm) in water. Microdosimetry spectra are simulated for wall-less and walled Tissue Equivalent Proportional Counters (TEPCs) placed outside or inside a phantom, as in experiments performed, respectively, at NIRS, Japan and GSI, Germany. The impact of fragmentation reactions on microdosimetry spectra is investigated for He-4, Li-7 and C-12, and contributions from nuclear fragments of different charge are evaluated for various TEPC positions in the phantom. The microdosimetry spectra measured on the beam axis are well described by MCHIT, in particular, in the vicinity of the Bragg peak. However, the simulated spectra for the walled TEPC far from the beam axis are underestimated. Relative Biological Effectiveness (RBE) of the considered beams is estimated using a modified microdosimetric-kinetic model. Calculations show a similar rise of the RBE up to 2.2-2.9 close to the Bragg peak for helium, lithium and carbon beams compared to the modest values of 1-1.2 at the plateau region. Our results suggest that helium and lithium beams are also promising options for cancer therapy.

physics.med-ph↗

arXiv2013

Microdosimetry of radiation field from therapeutic C-12 beam in water: a study with Geant4 toolkit

We model the responses of Tissue-Equivalent Proportional Counters (TEPC) to radiation fields of therapeutic C-12 beams in a water phantom and to quasi-monoenergetic neutrons in a PMMA phantom. Simulations are performed with the Monte Carlo model for Heavy Ion Therapy (MCHIT) based on the Geant4 toolkit. The shapes of the calculated lineal energy spectra agree well with measurements in both cases. The influence of fragmentation reactions on the TEPC response to a narrow pencil-like beam with its width smaller than the TEPC diameter is investigated by Monte Carlo modeling. It is found that total lineal energy spectra are not very sensitive to the choice of the nuclear fragmentation model used. The calculated frequency-mean lineal energy y_f differs from the data on the axis of a therapeutic beam by less than 10% and by 10-20% at other TEPC positions. The validation of MCHIT with neutron beams gives us confidence in estimating the contributions to lineal energy spectra due to secondary neutrons produced in water by C-12 nuclei. As found, the neutron contribution at 10 cm distance from the beam axis amounts to ~ 50% close the entrance to the phantom and decreases to ~ 25% at the depth of the Bragg peak and beyond it. The presented results can help in evaluating biological out-of-field doses in carbon-ion therapy.

physics.med-ph↗

arXiv2009

Nuclear fragmentation reactions in extended media studied with Geant4 toolkit

It is well known from numerous experiments that nuclear multifragmentation is a dominating mechanism for production of intermediate-mass fragments in nucleus-nucleus collisions at energies above 100 A MeV. In this paper we investigate the validity and performance of the Fermi break-up model and the statistical multifragmentation model implemented as parts of the Geant4 toolkit. We study the impact of violent nuclear disintegration reactions on the depth-dose profiles and yields of secondary fragments for beams of light and medium-weight nuclei propagating in extended media. Implications for ion-beam cancer therapy and shielding from cosmic radiation are discussed.

physics.med-ph↗

arXiv2008

Ion-beam therapy: from electron production in tissue like media to DNA damage estimations

Radiation damage induced by ion beams is traditionally treated at different levels of theoretical approaches, for the different scales and mechanisms involved.We present here details of a combined approach that, from a method at a nanoscopic scale, attempts to merge with higher scales existing results, by tuning the analytical method employed when extended to larger scale and so yielding a consistent picture of the entire process. Results will show the possibility to get a good agreement with macroscale methods and, on the other hand, to produce a reliable electron energy spectra to be used for DNA damage estimations.

physics.bio-ph↗

arXiv2007

PET monitoring of cancer therapy with He-3 and C-12 beams: a study with the GEANT4 toolkit

We study the spatial distributions of $β^+$-activity produced by therapeutic beams of $^3$He and $^{12}$C ions in various tissue-like materials. The calculations were performed within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit. The contributions from $^{10,11}$C, $^{13}$N, $^{14,15}$O, $^{17,18}$F and $^{30}$P positron-emitting nuclei were calculated and compared with experimental data obtained during and after irradiation. Positron emitting nuclei are created by $^{12}$C beam in fragmentation reactions of projectile and target nuclei. This leads to a $β^+$-activity profile characterised by a noticeable peak located close to the Bragg peak in the corresponding depth-dose distribution. On the contrary, as the most of positron-emitting nuclei are produced by $^3$He beam in target fragmentation reactions, the calculated total $β^+$-activity during or soon after the irradiation period is evenly distributed within the projectile range. However, we predict also the presence of $^{13}$N, $^{14}$O, $^{17,18}$F created in charge-transfer reactions by low-energy $^3$He ions close to the end of their range in several tissue-like media. The time evolution of $β^+$-activity profiles was investigated for both kinds of beams. Due to the production of $^{18}$F nuclide the $β^+$-activity profile measured 2 or 3 hours after irradiation with $^{3}$He ions will have a distinct peak correlated with the maximum of depth-dose distribution. We found certain advantages of low-energy $^{3}$He beams over low-energy proton beams for reliable PET monitoring during particle therapy of shallow located tumours. In this case the distal edge of $β^+$-activity distribution from $^{17}$F nuclei clearly marks the range of $^{3}$He in tissues.

physics.med-ph↗

arXiv2007

MCHIT - Monte Carlo model for proton and heavy-ion therapy

We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2). The model takes into account fragmentation of projectile nuclei and secondary interactions of produced nuclear fragments. Model predictions are validated with available experimental data obtained for water and PMMA phantoms irradiated by monoenergetic carbon-ion beams. The MCHIT model describes well (1) the depth-dose distributions in water and PMMA, (2) the doses measured for fragments of certain charge, (3) the distributions of positron emitting nuclear fragments produced by carbon-ion beams, and (4) the energy spectra of secondary neutrons measured at different angles to the beam direction. Radial dose profiles for primary nuclei and for different projectile fragments are calculated and discussed as possible input for evaluation of biological dose distributions. It is shown that at the periphery of the transverse dose profile close to the Bragg peak the dose from secondary nuclear fragments is comparable to the dose from primary nuclei.

physics.med-ph↗

arXiv2007

Comparative study of depth-dose distributions for beams of light and heavy nuclei in tissue-like media

We study the energy deposition by light and heavy nuclei in tissue-like media as used for cancer therapy. The depth-dose distributions for protons, $^{3}$He, $^{12}$C, $^{20}$Ne, and $^{58}$Ni nuclei are calculated within a Monte Carlo model based on the GEANT4 toolkit. These distributions are compared with each other and with available experimental data. It is demonstrated that nuclear fragmentation reactions essentially reduce the peak-to-plateau ratio of the dose profiles for deeply penetrating energetic ions heavier than $^{3}$He. On the other hand, all projectiles up to $^{20}$Ne were found equally suitable for therapeutic use at low penetration depths.

physics.med-ph↗

arXiv2006

Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4

Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C and $^{15}$O nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e$^+$ annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in surrounding medium. A finite spatial resolution of the Positron Emission Tomography (PET) is taken into account in a simplified way. Depth distributions of $β^+$-activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The calculated $β^+$-activity profiles are in good agreement with PET data for proton and $^{12}$C beams at energies suitable for particle therapy. The MCHIT capability to predict the $β^+$-activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.

physics.med-ph↗

arXiv2005

Neutrons from fragmentation of light nuclei in tissue-like media: a study with GEANT4 toolkit

We study energy deposition by light nuclei in tissue-like media taking into account nuclear fragmentation reactions, in particular, production of secondary neutrons. The calculations are carried out within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit. Experimental data on depth-dose distributions for 135A-400A MeV C-12 and O-18 beams are described very well without any adjustment of the model parameters. This gives confidence in successful use of the GEANT4 toolkit for MC simulations of cancer therapy with beams of light nuclei. The energy deposition due to secondary neutrons produced by C-12 and Ne-20 beams in a (40-50 cm)^3 water phantom is estimated to 1-2% of the total dose, that is only slightly above the neutron contribution (~1%) induced by a 200 MeV proton beam.

physics.med-ph↗