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Imran Razzak

Publications and source records attributed to Imran Razzak.

At least 37 records · Page 2Linked to original sources

TAVR-VLM: Risk-Conditioned Causal Grounding for Hallucination-Resistant Report Generation

Transcatheter Aortic Valve Replacement (TAVR) planning requires meticulous multimodal reasoning. However, adapting Multimodal Large Language Models (MLLMs) to this high-stakes domain is severely impeded by diagnostic hallucinations, where generated text lacks anatomical grounding. To address this, TAVR-VLM is introduced: a novel framework featuring Risk-Conditioned Causal Grounding Attention (R-CGA) that instantiates a model-internal ``Risk $\rightarrow$ Region $\rightarrow$ Word'' structural grounding pathway. R-CGA compresses multimodal inputs into a causal risk bottleneck, purifying dense visual features into a global risk mask. During autoregressive generation, a support-projected causal consistency objective constrains token-level grounding within the risk-defined support mask. Evaluated on $\text{M}^3\text{TAVR}$, a comprehensive 1,482-patient cohort, TAVR-VLM establishes a new state-of-the-art. It achieves an AUROC of 0.896, boosts CIDEr to 0.936, and drastically reduces the hallucination rate to 8.1\%, thereby improving interpretability for evidence-based surgical AI.

cs.AI↗

A Dual Edge Spatial Jacobian Image Graph for Interpretable Diabetic Retinopathy Grading

Automated diabetic retinopathy (DR) grading from colour fundus photographs can achieve strong predictive performance, but clinical interpretation requires more than an image-level label. It requires understanding how lesion evidence is distributed around retinal vessels and how this evidence relates to quantitative vascular biomarkers. We present a dual-edge spatial-Jacobian image graph for interpretable DR grading. Each fundus image is represented as a graph node with four aligned evidence streams: AutoMorph vessel information ($X_1$), DR-XAI-style lesion evidence maps ($X_2$), a 128-dimensional lesion-based contrastive image embedding ($X_3$), and AutoMorph morphometric biomarkers ($X_4$). The spatial edge branch ($X_{12}$) encodes vessel-lesion geometry, while the Jacobian branch ($X_{34}$) models embedding-biomarker sensitivity. Lightweight two-token attention fuses both edge families into a final image graph. On 2,910 matched non-augmented APTOS images, the full graph achieves 0.8076 accuracy, 0.8312 quadratic weighted kappa, 0.5915 macro-F1, and 0.9330 adjacent-grade accuracy; referable DR reaches 0.9055 accuracy and 0.9711 AUROC. The framework is positioned as an explainable representation-learning tool for lesion-biomarker hypothesis generation, rather than as a deployment-ready clinical classifier. The code is available at https://github.com/Inamullah-Colab/dual-edge-dr-graph-xai.

eess.IV↗

RetiSEM: Generalising Causal Models for Fragmented Biomedical Data

Learning causal models from fragmented biomedical data is challenging because clinical, molecular, and imaging variables are often incomplete or not jointly observed. We propose RetiSEM, a domain-constrained structural equation modelling (SEM) framework for causal graph recovery and mediation analysis under limited multimodal resources. This proposed work organises variables into biologically informed blocks, applies forbidden-edge constraints, and decomposes pathway-level effects into TE, NDE, and NIE components. We evaluate RetiSEM across ten synthetic benchmark scenarios that vary in dimensionality, nonlinearity, causal depth, and pathway structure, together with a fragmented real-world setting that combines NHANES clinical variables with externally derived retinal representations. This approach achieves lower structural error and higher causal accuracy than unconstrained baselines across the synthetic benchmarks. In the real-data analysis, retinal variables behave mainly as downstream biomarker-like indicators, with smaller but detectable indirect effects. These findings support our strategy as an interpretable framework for testing structured causal hypotheses in limited-resource biomedical AI. The code and resources for this work are publicly available at: https://github.com/Inamullah-Colab/ReitSEM.

cs.CV↗

Graph-of-Differences: Anatomy-Structured Difference Alignment for Medical Image Re-Identification

Medical image re-identification (MedReID) enables longitudinal patient linkage but remains vulnerable to shortcut learning and often produces decisions that clinicians cannot audit against named anatomy. We propose Graph-of-Differences (GoD), which grounds identity comparisons in explicit anatomical structure. Each image is represented as an anatomy graph whose nodes correspond to named anatomical regions; given an image pair, soft node correspondence is established, and differences are computed over matched anatomy. A graph-level difference alignment objective ties these anatomy-matched differences to the global backbone difference, ensuring the retrieval signal is anchored in homologous structures rather than arbitrary spatial tokens. Explanations are defined over named graph nodes and quantitatively audited via node insertion/deletion tests, replacing unstable pixel heatmaps with verifiable structure-level evidence. On internal benchmarks, GoD improves Rank-1 by +7.1 pp on fundus and +3.1 pp on CXR over a strong frozen-backbone baseline, with further gains on zero-shot external transfers confirming that anatomy grounding improves both accuracy and generalization. Code is available at https://github.com/GenMI-Lab/GoD.git.

cs.CV↗

EnTrust: Modeling Inter-Modal Conflict for Trustworthy Multimodal Medical Image Analysis

Multimodal medical imaging fuses complementary anatomical and functional information, yet modalities frequently disagree in pathologically heterogeneous regions. Current segmentation models handle this in one of two inadequate ways: deterministic fusion that averages away disagreement, or post-hoc uncertainty estimation decoupled from the fusion process that produces it. Both obscure the clinically critical question: why is this prediction unreliable? We present EnTrust, a framework that treats inter-modal conflict as the primary source of predictive uncertainty. Our EnFuse module decomposes multimodal features into three disentangled components: shared anatomical consensus (F_c), modality-specific cues (F_{u,m}), and spatially localized conflict signals (F_{cf}), with independence enforced via a cross-covariance objective. This structured decomposition conditions SegDiff, a diffusion-based generative segmentation model whose sampled hypotheses diverge specifically in regions of modal disagreement. TrustMap then translates this hypothesis divergence into calibrated, pixel-wise uncertainty using ensemble entropy, conflict-guided perturbation probing, and a learned calibration head, enabling clinicians to understand not only where predictions are uncertain, but why. Across four benchmarks spanning brain, cardiac, lesion, and oncology domains, EnTrust achieves state-of-the-art segmentation accuracy while reducing calibration error by 40% compared to the strongest baseline. Notably, it outperforms 5x deep ensembles using a single model at roughly half the memory footprint. Code and checkpoints are available at https://github.com/GenMI-Lab/EnTrust.git.

cs.CV↗

PROTON: Prototype-Based Test-Time Online OOD Detection for Medical VLMs

Medical vision-language models (VLMs) enable zero-shot clinical image classification, yet reliably detecting out-of-distribution (OOD) inputs at deployment remains an open problem. No static scoring method works across all shift types: Maximum Concept Matching (MCM) on FLAIR achieves 76.4% AUROC for far-OOD but only 42.4% for covariate shifts such as ultra-wide-field fundus images, effectively random. We trace this to a structural mismatch: covariate-shifted inputs are indistinguishable from in-distribution samples in softmax space, yet occupy distinct regions in the VLM embedding space. To exploit this untapped signal, we propose PROTON (PROtotype-based Test-time ONline OOD detection), a lightweight post-hoc module that maintains an online prototype bank from high-confidence test predictions and adaptively fuses prototype distance with MCM scoring via stream-level variance statistics, requiring no model modification, training data, or prompt engineering. On the ophthalmology benchmark FLAIR + FIVES, PROTON improves MCM by +23.9 AUROC on covariate shift, +8.8 on semantic shift, and +8.1 on far-OOD, making it the only zero-shot method to improve all three without hierarchical prompts or labeled data. Code is available at https://github.com/GenMI-Lab/PROTON, and the project page is available at https://genmi-lab.github.io/PROTON.

cs.CV↗

Evaluating LLM Personalization via Semantic Constraint Verification

Current evaluation paradigms for Large Language Model (LLM) personalization rely heavily on brittle surface-matching metrics or computationally expensive LLM-as-a-judge protocols, both of which lack interpretability. To address these limitations, we introduce Natural Language Inference Constraint Verification (NLICV), a scalable, semantically invariant framework that maps sentence meanings to truth-condition sets to verify personalization constraints via a Natural Language Inference (NLI) model. Moving beyond binary scoring, NLICV categorizes LLM behaviors into four distinct modes: personalization, generalization, sycophancy, and failure. Extensive experiments demonstrate that NLICV aligns closely with human annotations while drastically reducing the latency and token costs associated with LLM judges (up to 2100 inference speedup). Finally, through an ablation-based procedure, NLICV pinpoints the exact sentences driving the constraint verification, yielding faithful, understandable evidence for its evaluations.

cs.CL↗

Knowledge Graph Enhanced Memory-Augmented Retrieval for Long Context Modeling

Long-context language modeling requires not only extending context windows but maintaining coherent understanding of entity states and relationships across thousands of tokens -- a challenge that semantic similarity alone cannot address. KGERMAR addresses this by constructing dynamic, context-specific knowledge graphs from input text during inference, enabling domain-adaptive retrieval that leverages both semantic similarity and explicit entity relationships. The framework performs real-time entity and relation extraction to build contextual knowledge graphs, then integrates graph-structural embeddings with textual semantics through a multi-component memory architecture. Three memory banks -- contextual, semantic, and structural -- are maintained with retrieval signals fused via learned weights to capture both surface-level semantics and deeper relational patterns. Evaluated on SlimPajama (84.7K training examples), WikiText-103 (4,358 examples), PG-19 (100 examples), and Proof-pile (46.3K examples), KGERMAR achieves up to 8.5\% lower perplexity and 2--2.5x better memory efficiency than memory-augmented baselines across context lengths from 1K to 32K tokens, with superior in-context learning performance across five NLU tasks. The dynamic knowledge graph construction approach advances memory-augmented language modeling by enabling domain-specific knowledge representation that adapts to input contexts rather than relying on fixed knowledge bases.

cs.IR↗

Mitosis Detection in the Wild: Multi-Tumor and Context-Aware Generalization in the MIDOG 2025 Challenge

Automated mitosis detection is a well-established task in computational pathology. While previous benchmarks focused on scanner-induced domain shift, clinical "real-world" application requires models to be robust across the vast variance to be expected in the histological landscape. The MItosis DOmain Generalization (MIDOG) 2025 challenge was designed to evaluate algorithmic performance across unprecedented biological and contextual diversity. We curated a test dataset of 365 cases, encompassing 12 distinct human, canine and feline tumor types, digitized across multiple scanning platforms. Moving beyond hand-selected hotspots, the challenge required detection also in random tissue areas (representative of the whole slide detection situation) and challenging areas (areas rich in hard negatives). In the second track, we introduced the classification of atypical mitotic figures (AMFs). There were 18 teams submitting to the detection track, with F1 scores ranging up to 0.740. In the AMF detection track, we had 21 submissions with balanced accuracy values up to 0.908. Our analysis reveals that while most models perform reliably in traditional hotspots, significant performance degradation occurs in challenging ROIs, where false positive rates tripled. Furthermore, performance varied significantly across the 12 tumor types, highlighting "blind spots" in current state-of-the-art architectures when encountering rare or highly pleomorphic malignancies. Moreover, we evaluated the effectiveness of ensembling and found a mean increases of 1.5 and 1.3 percentage points in F1 score and balanced accuracy, respectively. In contrast, TTA showed no relevant improvement. MIDOG 2025 demonstrates that "in the wild" mitosis detection remains a significant hurdle. The transition from hotspot-only evaluation to a multi-contextual framework provides a more realistic proxy for clinical reliability.

cs.CV↗

MS-DKC: A Dataset Knowledge Card Framework for Designing and Adapting Medical Image Segmentation Models

Medical image segmentation is often framed as a search for stronger architectures, but this can obscure a more fundamental question: what does the dataset require from the model? In medical imaging, this requirement is shaped by foreground occupancy, morphology, boundary ambiguity, topology sensitivity, annotation quality, acquisition variation, and operating point. This paper introduces the Medical Segmentation Dataset Knowledge Card (MS-DKC), a framework for making these factors explicit. MS-DKC records dataset evidence through image/acquisition, morphology, supervision, context-dependence, and deployment-risk descriptors. These descriptors are mapped to failure modes, design priors, and risk-aligned criteria, making segmentation design more traceable than architecture-first comparison. We evaluate MS-DKC on DRIVE, ISIC2018, and ACDC, representing distinct regimes. DRIVE contains sparse, thin, branching vessels, favoring detail-preserving models, sensitivity-aware optimization, threshold analysis, and topology-aware metrics. DKC-TNet-v2 achieved Dice 0.8044 and IoU 0.6730 with 35103 parameters, while SA-UNetv2-DKC-AmbRef reached Dice 0.8141, IoU 0.6865, sensitivity 0.8265, specificity 0.9804, and AUC 0.9853. ISIC2018 involves compact but appearance-variable lesions; validation-constrained score-function selection on Att-Next-Topo/ATTNext produced MS-DKC-AttNextTopo-VCSF-NoAug with Dice 0.8872, IoU 0.8214, precision 0.9173, Boundary F1 0.4878, and ASSD 4.13, while plausible additions failed to improve the risk-aligned profile. ACDC provides a multi-class cardiac case, where MS-DKC recommends four-class softmax segmentation, class-balanced Dice/CE supervision, and class-wise surface evaluation. Overall, the results support dataset-conditioned design: different datasets require different priors, operating points, and evidence before a model can be judged appropriate.

cs.CV↗

DocAtlas: Multilingual Document Understanding Across 80+ Languages

Multilingual document understanding remains limited for low-resource languages due to scarce training data and model-based annotation pipelines that perpetuate existing biases. We introduce DocAtlas, a framework that constructs high-fidelity OCR datasets and benchmarks covering 82 languages and 9 evaluation tasks. Our dual pipelines, differential rendering of native DOCX documents and synthetic LaTeX-based generation for right-to-left scripts produce precise structural annotations in a unified DocTag format encoding layout, text, and component types, without learned models for core annotation. Evaluating 16 state-of-the-art models reveals persistent gaps in low-resource scripts. We show that Direct Preference Optimization (DPO) using rendering-derived ground truth as positive signal achieves stable multilingual adaptation, improving both in-domain (+1.9%) and out-of-domain (+1.8%) accuracy without measurable base-language degradation, where supervised fine-tuning degrades out-of-domain performance by up to 21%. Our best variant, DocAtlas-DeepSeek, improves +1.7% over the strongest baseline. Code is available at https://github.com/ahmedheakl/DocAtlas .

cs.CL↗

SMILE-UHURA Challenge -- Small Vessel Segmentation at Mesoscopic Scale from Ultra-High Resolution 7T Magnetic Resonance Angiograms

The human brain receives nutrients and oxygen through an intricate network of blood vessels. Pathology affecting small vessels, at the mesoscopic scale, represents a critical vulnerability within the cerebral blood supply and can lead to severe conditions, such as Cerebral Small Vessel Diseases. The advent of 7 Tesla MRI systems has enabled the acquisition of higher spatial resolution images, making it possible to visualise such vessels in the brain. However, the lack of publicly available annotated datasets has impeded the development of robust, machine learning-driven segmentation algorithms. To address this, the SMILE-UHURA challenge was organised. This challenge, held in conjunction with the ISBI 2023, in Cartagena de Indias, Colombia, aimed to provide a platform for researchers working on related topics. The SMILE-UHURA challenge addresses the gap in publicly available annotated datasets by providing an annotated dataset of Time-of-Flight angiography acquired with 7T MRI. This dataset was created through a combination of automated pre-segmentation and extensive manual refinement. In this manuscript, sixteen submitted methods and two baseline methods are compared both quantitatively and qualitatively on two different datasets: held-out test MRAs from the same dataset as the training data (with labels kept secret) and a separate 7T ToF MRA dataset where both input volumes and labels are kept secret. The results demonstrate that most of the submitted deep learning methods, trained on the provided training dataset, achieved reliable segmentation performance. Dice scores reached up to 0.838 $\pm$ 0.066 and 0.716 $\pm$ 0.125 on the respective datasets, with an average performance of up to 0.804 $\pm$ 0.15.

eess.IV↗

Long Context Modeling with Ranked Memory-Augmented Retrieval

Effective long-term memory management is crucial for language models handling extended contexts. We introduce the Enhanced Ranked Memory Augmented Retrieval (ERMAR) framework, which dynamically ranks memory entries based on relevance. Unlike prior models, ERMAR employs a novel relevance scoring mechanism and a pointwise re-ranking model for key-value embeddings, inspired by learning-to-rank techniques in information retrieval. By integrating historical usage patterns and adaptive retrieval, ERMAR achieves state-of-the-art results on standard benchmarks, demonstrating superior scalability and performance in long-context tasks.

cs.IR↗

TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CT

Automated segmentation of liver lesions on non-contrast computed tomography (NCCT) is clinically important but fundamentally challenging, particularly in low-resource settings across Africa and Asia where contrast agents are frequently unavailable. Progress has been limited by the absence of annotated NCCT benchmarks. Here we describe the TriALS challenge for automated liver lesion segmentation under contrast-limited conditions, supported by a multi-centre dataset of 150 cases with four-phase CT acquisitions (600 volumes) from Egyptian and Chinese institutions. Algorithms were evaluated on 70 cases from three institutions, including an independent external cohort. The top-performing method achieved a mean venous-phase Dice of 0.754, consistent with human-level performance, yet dropped to 0.57 on NCCT. On external validation, the leading method outperformed off-the-shelf models by up to 28% in Dice on NCCT. Algorithm performance was most strongly predicted by training data scale and pre-training strategy. A cross-year comparison exposed a persistent perceptual barrier on NCCT that scaling pre-training alone cannot overcome. Data, annotations, and code are available at https://github.com/xmed-lab/TriALS.

cs.CV↗

Focal Modulation and Bidirectional Feature Fusion Network for Medical Image Segmentation

Medical image segmentation is essential for clinical applications such as disease diagnosis, treatment planning, and disease development monitoring because it provides precise morphological and spatial information on anatomical structures that directly influence treatment decisions. Convolutional neural networks significantly impact image segmentation; however, since convolution operations are local, capturing global contextual information and long-range dependencies is still challenging. Their capacity to precisely segment structures with complicated borders and a variety of sizes is impacted by this restriction. Since transformers use self-attention methods to capture global context and long-range dependencies efficiently, integrating transformer-based architecture with CNNs is a feasible approach to overcoming these challenges. To address these challenges, we propose the Focal Modulation and Bidirectional Feature Fusion Network for Medical Image Segmentation, referred to as FM-BFF-Net in the remainder of this paper. The network combines convolutional and transformer components, employs a focal modulation attention mechanism to refine context awareness, and introduces a bidirectional feature fusion module that enables efficient interaction between encoder and decoder representations across scales. Through this design, FM-BFF-Net enhances boundary precision and robustness to variations in lesion size, shape, and contrast. Extensive experiments on eight publicly available datasets, including polyp detection, skin lesion segmentation, and ultrasound imaging, show that FM-BFF-Net consistently surpasses recent state-of-the-art methods in Jaccard index and Dice coefficient, confirming its effectiveness and adaptability for diverse medical imaging scenarios.

cs.CV↗

StreamAgent: Towards Anticipatory Agents for Streaming Video Understanding

Real-time streaming video understanding in domains such as autonomous driving and intelligent surveillance poses challenges beyond conventional offline video processing, requiring continuous perception, proactive decision making, and responsive interaction based on dynamically evolving visual content. However, existing methods rely on alternating perception-reaction or asynchronous triggers, lacking task-driven planning and future anticipation, which limits their real-time responsiveness and proactive decision making in evolving video streams. To this end, we propose a StreamAgent that anticipates the temporal intervals and spatial regions expected to contain future task-relevant information to enable proactive and goal-driven responses. Specifically, we integrate question semantics and historical observations through prompting the anticipatory agent to anticipate the temporal progression of key events, align current observations with the expected future evidence, and subsequently adjust the perception action (e.g., attending to task-relevant regions or continuously tracking in subsequent frames). To enable efficient inference, we design a streaming KV-cache memory mechanism that constructs a hierarchical memory structure for selective recall of relevant tokens, enabling efficient semantic retrieval while reducing the overhead of storing all tokens in the traditional KV-cache. Extensive experiments on streaming and long video understanding tasks demonstrate that our method outperforms existing methods in response accuracy and real-time efficiency, highlighting its practical value for real-world streaming scenarios.

cs.CV↗

RELOOP: Recursive Retrieval with Multi-Hop Reasoner and Planners for Heterogeneous QA

Retrieval-augmented generation (RAG) remains brittle on multi-step questions and heterogeneous evidence sources, trading accuracy against latency and token/tool budgets. This paper introduces RELOOP, a structure aware framework using Hierarchical Sequence (HSEQ) that (i) linearize documents, tables, and knowledge graphs into a reversible hierarchical sequence with lightweight structural tags, and (ii) perform structure-aware iteration to collect just-enough evidence before answer synthesis. A Head Agent provides guidance that leads retrieval, while an Iteration Agent selects and expands HSeq via structure-respecting actions (e.g., parent/child hops, table row/column neighbors, KG relations); Finally the head agent composes canonicalized evidence to genearte the final answer, with an optional refinement loop to resolve detected contradictions. Experiments on HotpotQA (text), HybridQA/TAT-QA (table+text), and MetaQA (KG) show consistent EM/F1 gains over strong single-pass, multi-hop, and agentic RAG baselines with high efficiency. Besides, RELOOP exhibits three key advantages: (1) a format-agnostic unification that enables a single policy to operate across text, tables, and KGs without per-dataset specialization; (2) \textbf{guided, budget-aware iteration} that reduces unnecessary hops, tool calls, and tokens while preserving accuracy; and (3) evidence canonicalization for reliable QA, improving answers consistency and auditability.

cs.CL↗

AIM 2025 Rip Current Segmentation (RipSeg) Challenge Report

This report presents an overview of the AIM 2025 RipSeg Challenge, a competition designed to advance techniques for automatic rip current segmentation in still images. Rip currents are dangerous, fast-moving flows that pose a major risk to beach safety worldwide, making accurate visual detection an important and underexplored research task. The challenge builds on RipVIS, the largest available rip current dataset, and focuses on single-class instance segmentation, where precise delineation is critical to fully capture the extent of rip currents. The dataset spans diverse locations, rip current types, and camera orientations, providing a realistic and challenging benchmark. In total, $75$ participants registered for this first edition, resulting in $5$ valid test submissions. Teams were evaluated on a composite score combining $F_1$, $F_2$, $AP_{50}$, and $AP_{[50:95]}$, ensuring robust and application-relevant rankings. The top-performing methods leveraged deep learning architectures, domain adaptation techniques, pretrained models, and domain generalization strategies to improve performance under diverse conditions. This report outlines the dataset details, competition framework, evaluation metrics, and final results, providing insights into the current state of rip current segmentation. We conclude with a discussion of key challenges, lessons learned from the submissions, and future directions for expanding RipSeg.

cs.CV↗