arXiv subjects

Indranath Chaudhuri

Publications and source records attributed to Indranath Chaudhuri.

13 recordsLinked to original sources

arXiv2025

Universal features of epidemic and vaccine models

In this paper, we study a stochastic susceptible-infected-susceptible (SIS) epidemic model that includes an additional immigration process. In the presence of multiplicative noise, generated by environmental perturbations, the model exhibits noise-induced transitions. The bifurcation diagram has two distinct regions of unimodality and bimodality in which the steady-state probability distribution has one and two peaks, respectively. Apart from first-order transitions between the two regimes, a critical-point transition occurs at a cusp point with the transition belonging to the mean-field Ising universality class. The epidemic model shares these features with the well-known Horsthemke-Lefever model of population genetics. The effect of vaccination on the spread/containment of the epidemic in a stochastic setting is also studied. We further propose a general vaccine-hesitancy model, along the lines of Kirman's ant model, with the steady-state distribution of the fraction of the vaccine-willing population given by the Beta distribution. The distribution is shown to give a good fit to the COVID-19 data on vaccine hesitancy and vaccination. We derive the steady-state probability distribution of the basic reproduction number, a key parameter in epidemiology, based on a beta-distributed fraction of the vaccinated population. Our study highlights the universal features that epidemic and vaccine models share with other dynamical models.

q-bio.PE↗

arXiv2024

Studying ECG signals using nonlinear oscillators and Genetic Algorithm

Cardiovascular diseases are the leading cause of death and disability in the world and thus their detection is extremely important as early as possible so that it can be prognosed and managed appropriately. Hence, electrophysiological models dealing with cardiac conduction are critically important in the field of interdisciplinary sciences. The primary aim of this paper is to reproduce a normal sinus rhythm ECG waveform which will act as the baseline for fitting and then fit any clinical ECG waveform that does not deviate much from normal sinus rhythm. To reproduce the ECG, we modeled the pacemaker complex using three coupled van der Pol (VDP) oscillators with appropriate delays to generate the action potentials. These action potentials are responsible for the excitation of the non-pacemaker cells of the atria and ventricles whose electrical activity gets recorded as the ECG signal. The ECG signal is composed of a periodic set of individual waves corresponding to atrial and ventricular contraction and relaxation. These waves are modeled with the help of four FitzHugh-Nagumo (FHN) equations with impulses corresponding to the action potentials generated by the pacemaker cells. After the successful reproduction of a normal sinus rhythm ECG, we have developed a framework where we have used genetic algorithm (GA) to fit a given clinical ECG data with parameters belonging to the above mentioned system of delay differential equations (DDEs). The GA framework has enabled us to fit ECG data representing different cardiac conditions reasonably well. We aim to use this work to get a better understanding of the cardiac conduction system and cardiovascular diseases which will help humanity in the future.

physics.med-ph↗

arXiv2023

Effect of air pollution on the growth of diabetic population

Diabetes mellitus is a disease which is currently a huge health hazard globally. The cases of diabetes had increased by a significant amount in past decades. Also it has been predicted that it will further increase in future. Diabetes depends on various factors like obesity, physical inactivity. Also diabetes can depend on various environmental issues. In this article, our main focus is to study the dependence of the diabetic cases on the air pollution. We have used the data for diabetic population and PM2.5 concentration in the air for five countries from 2010 to 2021. Here we have studied the correlation between the diabetic cases data and PM2.5 concentration data. Also, we have done the linear regression analysis to find whether this correlation is statistically significant.

physics.bio-ph↗

arXiv2023

Cellular automata in the light of COVID-19

Currently, the world has been facing the brunt of a pandemic due to a disease called COVID-19 for the last 2 years. To study the spread of such infectious diseases it is important to not only understand their temporal evolution but also the spatial evolution. In this work, the spread of this disease has been studied with a cellular automata (CA) model to find the temporal and the spatial behavior of it. Here, we have proposed a neighborhood criteria which will help us to measure the social confinement at the time of the disease spread. The two main parameters of our model are (i) disease transmission probability (q) which helps us to measure the infectivity of a disease and (ii) exponent (n) which helps us to measure the degree of the social confinement. Here, we have studied various spatial growths of the disease by simulating this CA model. Finally we have tried to fit our model with the COVID-19 data of India for various waves and have attempted to match our model predictions with regards to each wave to see how the different parameters vary with respect to infectivity and restrictions in social interaction.

physics.bio-ph↗

arXiv2023

Simulating the spread of COVID-19 with cellular automata: A new approach

Between the years 2020 to 2022, the world was hit by the pandemic of COVID-19 giving rise to an extremely grave situation. The global economy was badly hurt due to the consequences of various intervention strategies (like social distancing, lockdown) which were applied by different countries to control this pandemic. There are multiple speculations that humanity will again face such pandemics in the future. Thus it is very important to learn and gain knowledge about the spread of such infectious diseases and the various factors which are responsible for it. In this study, we have extended our previous work (Chowdhury et.al., 2022) on the probabilistic cellular automata (CA) model to reproduce the spread of COVID-19 in several countries by modifying its earlier used neighbourhood criteria. This modification gives us the liberty to adopt the effect of different restrictions like lockdown and social distancing in our model. We have done some theoretical analysis for initial infection and simulations to gain insights into our model. We have also studied the data from eight countries for COVID-19 in a window of 876 days and compared it with our model. We have developed a proper framework to fit our model on the data for confirmed cases of COVID-19 and have also re-checked the goodness of the fit with the data of the deceased cases for this pandemic. This model fits well with different peaks of COVID-19 data for all the eight countries and can be possibly generalized for a global prediction.

physics.soc-ph↗

arXiv2021

A robust prediction from a minimal model of COVID-19 -- Can we avoid the third wave?

COVID-19 pandemic is one of the major disasters that humanity has ever faced. In this paper, we try to model the effect of vaccination in controlling the pandemic, particularly in context to the third wave which is predicted to hit globally. Here we have modified the SEIRD model by introducing a vaccination term. One of our main assumptions is that the infection rate (\b{eta}(t)) is oscillatory. This oscillatory nature has been discussed earlier in literature with reference to the seasonality of epidemics. However, in our case we invoke this nature of the infection rate (\b{eta}(t)) to model the cyclical behavior of the COVID-19 pandemic within a short period. This study focuses on a minimalistic approach where we have logically deduced that the infection rate (\b{eta}(t)) and the vaccination rate (λ) are the most important parameters while the other parameters can be assumed to be constants throughout the simulation. Finally, we have studied the rich interplay between the infection rate (\b{eta}(t)) and the vaccination rate (λ) on the infectious cases of COVID-19 and made some robust conclusions regarding the global behavior of this pandemic in near future.

q-bio.PE↗

arXiv2021

Universality and herd immunity threshold : Revisiting the SIR model for COVID-19

COVID-19 pandemic has been raging all around the world for almost a year now, as of November 1, 2020. In this paper, we try to analyze the variation of the COVID-19 pandemic in different countries in the light of some modifications to the susceptible-infected-recovered (SIR) model. The SIR model was modified by taking time-dependent rate parameters. From this modified SIR model, the basic reproduction number, effective reproduction number, herd immunity, and herd immunity threshold are redefined. The re-outbreak of the COVID-19 is a real threat to various countries. We have used the above-mentioned quantities to find the reasons behind the re-outbreak of this disease. Also, the effectiveness of herd immunity to prevent an epidemic has been analyzed with respect to this model. We have also tried to show that there are certain universal aspects in the spread and containment of the disease in various countries for a short period of time. Finally, we have also analyzed the current pandemic situation in India and have attempted to discuss the possibilities in order to predict its future behaviour using our model.

q-bio.PE↗

arXiv2020

Mathematical Model of ingested glucose in Glucose-Insulin Regulation

Here, we develop a mathematical model for glucose-insulin regulatory system. The model includes a new parameter which is the amount of ingested glucose. Ingested glucose is an external glucose source coming from digested food. We assume that the external glucose or ingested glucose decays exponentially with time. We establish a system of three linear ordinary differential equations with this new parameter, derive stability analysis and the solution of this model.

q-bio.TO↗

arXiv2002

Bacterial Evolution and Bak-Sneppen Model

Recently, Lenski et al [Elena,Lenski,Travisano] have carried out several experiments on bacterial evolution. Their findings support the theory of punctuated equilibrium in biological evolution. They have further quantified the relative contributions of adaptation, chance and history to bacterial evolution. In this paper, we show that a modified $M$-trait Bak-Sneppen model can explain many of the experimental results in a qualitative manner.

cond-mat.stat-mech↗

arXiv2001

Bacterial evolution and the Bak-Sneppen model

Recently, Lenski et al \cite{Elena,Lenski,Travisano} have carried out several experiments on bacterial evolution. Their findings support the theory of punctuated equilibrium in biological evolution. They have further quantified the relative contributions of adaptation, chance and history to bacterial evolution. In this Brief Report, we show that a modified M-trait Bak-Sneppen model can explain many of the experimental results in a qualitative manner.

cond-mat.stat-mech↗

arXiv1999

Punctuated equilibrium in an evolving bacterial population

Recently, Lenski et al have carried out an experiment on bacterial evolution. Their findings support the theory of punctuated equilibrium in biological evolution. We show that the M=2 Bak-Sneppen model can explain some of the experimental results in a qualitative manner.

cond-mat.stat-mech↗

arXiv1998

Percolation-like phase transition in a non-equilibrium steady state

We study the Gierer-Meinhardt model of reaction-diffusion on a site-disordered square lattice. Let $p$ be the site occupation probability of the square lattice. For $p$ greater than a critical value $p_c$, the steady state consists of stripe-like patterns with long-range connectivity. For $p < p_c$, the connectivity is lost. The value of $p_c$ is found to be much greater than that of the site percolation threshold for the square lattice. In the vicinity of $p_c$, the cluster-related quantities exhibit power-law scaling behaviour. The method of finite-size scaling is used to determine the values of the fractal dimension $d_f$, the ratio, $\fracγν$, of the average cluster size exponent $γ$ and the correlation length exponent $ν$ and also $ν$ itself. The values appear to indicate that the disordered GM model belongs to the universality class of ordinary percolation.

cond-mat.stat-mech↗

arXiv1997

Effect of randomness and anisotropy on Turing patterns in reaction-diffusion systems

We study the effect of randomness and anisotropy on Turing patterns in reaction-diffusion systems. For this purpose, the Gierer-Meinhardt model of pattern formation is considered. The cases we study are: (i)randomness in the underlying lattice structure, (ii)the case in which there is a probablity p that at a lattice site both reaction and diffusion occur, otherwise there is only diffusion and lastly, the effect of (iii) anisotropic and (iv) random diffusion coefficients on the formation of Turing patterns. The general conclusion is that the Turing mechanism of pattern formation is fairly robust in the presence of randomness and anisotropy.

cond-mat.stat-mech↗