arXiv subjects

Ingrid Van Keilegom

Publications and source records attributed to Ingrid Van Keilegom.

At least 55 records · Page 3Linked to original sources

arXiv2018

On an extension of the promotion time cure model

We consider the problem of estimating the distribution of time-to-event data that are subject to censoring and for which the event of interest might never occur, i.e., some subjects are cured. To model this kind of data in the presence of covariates, one of the leading semiparametric models is the promotion time cure model \citep{yakovlev1996}, which adapts the Cox model to the presence of cured subjects. Estimating the conditional distribution results in a complicated constrained optimization problem, and inference is difficult as no closed-formula for the variance is available. We propose a new model, inspired by the Cox model, that leads to a simple estimation procedure and that presents a closed formula for the variance. We derive some asymptotic properties of the estimators and we show the practical behaviour of our procedure by means of simulations. We also apply our model and estimation method to a breast cancer data set.

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arXiv2018

Non-parametric cure rate estimation under insufficient follow-up using extremes

An important research topic in survival analysis is related to the modeling and estimation of the cure rate, i.e. the proportion of subjects that will never experience the event of interest. However, most estimation methods proposed so far in the literature do not handle the case of insufficient follow-up, that is when the right end point of the support of the censoring time is strictly less than that of the survival time of the susceptible subjects, and consequently these estimators overestimate the cure rate in that case. We fill this gap by proposing a new estimator of the cure rate that makes use of extrapolation techniques from the area of extreme value theory. We establish the asymptotic normality of the proposed estimator, and show how the estimator works for small samples by means of a simulation study. We also illustrate its practical applicability through the analysis of data on the survival of breast cancer patients.

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arXiv2018

The nonparametric location-scale mixture cure model

We propose completely nonparametric methodology to investigate location-scale modelling of two-component mixture cure models, where the responses of interest are only indirectly observable due to the presence of censoring and the presence of so-called long-term survivors that are always censored. We use covariate-localized nonparametric estimators, which depend on a bandwidth sequence, to propose an estimator of the error distribution function that has not been considered before in the literature. When this bandwidth belongs to a certain range of undersmoothing bandwidths, the asymptotic distribution of the proposed estimator of the error distribution function does not depend on this bandwidth, and this estimator is shown to be root-n consistent. This suggests that a computationally costly bandwidth selection procedure is unnecessary to obtain an effective estimator of the error distribution, and that a simpler rule-of-thumb approach can be used instead. A simulation study investigates the finite sample properties of our approach, and the methodology is illustrated using data obtained to study the behavior of distant metastasis in lymph-node-negative breast cancer patients.

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arXiv2017

Bootstrap of residual processes in regression: to smooth or not to smooth ?

In this paper we consider a location model of the form $Y = m(X) + \varepsilon$, where $m(\cdot)$ is the unknown regression function, the error $\varepsilon$ is independent of the $p$-dimensional covariate $X$ and $E(\varepsilon)=0$. Given i.i.d. data $(X_1,Y_1),\ldots,(X_n,Y_n)$ and given an estimator $\hat m(\cdot)$ of the function $m(\cdot)$ (which can be parametric or nonparametric of nature), we estimate the distribution of the error term $\varepsilon$ by the empirical distribution of the residuals $Y_i-\hat m(X_i)$, $i=1,\ldots,n$. To approximate the distribution of this estimator, Koul and Lahiri (1994) and Neumeyer (2008, 2009) proposed bootstrap procedures, based on smoothing the residuals either before or after drawing bootstrap samples. So far it has been an open question whether a classical non-smooth residual bootstrap is asymptotically valid in this context. In this paper we solve this open problem, and show that the non-smooth residual bootstrap is consistent. We illustrate this theoretical result by means of simulations, that show the accuracy of this bootstrap procedure for various models, testing procedures and sample sizes.

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arXiv2017

Expansion for moments of regression quantiles with application to nonparametric testing

We discuss nonparametric tests for parametric specifications of regression quantiles. The test is based on the comparison of parametric and nonparametric fits of these quantiles. The nonparametric fit is a Nadaraya-Watson quantile smoothing estimator. An asymptotic treatment of the test statistic requires the development of new mathematical arguments. An approach that makes only use of plugging in a Bahadur expansion of the nonparametric estimator is not satisfactory. It requires too strong conditions on the dimension and the choice of the bandwidth. Our alternative mathematical approach requires the calculation of moments of Nadaraya-Watson quantile regression estimators. This calculation is done by application of higher order Edgeworth expansions.

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arXiv2017

An Adapted Loss Function for Censored Quantile Regression

In this paper, we study a novel approach for the estimation of quantiles when facing potential right censoring of the responses. Contrary to the existing literature on the subject, the adopted strategy of this paper is to tackle censoring at the very level of the loss function usually employed for the computation of quantiles, the so-called "check" function. For interpretation purposes, a simple comparison with the latter reveals how censoring is accounted for in the newly proposed loss function. Subsequently, when considering the inclusion of covariates for conditional quantile estimation, by defining a new general loss function, the proposed methodology opens the gate to numerous parametric, semiparametric and nonparametric modelling techniques. In order to illustrate this statement, we consider the well-studied linear regression under the usual assumption of conditional independence between the true response and the censoring variable. For practical minimization of the studied loss function, we also provide a simple algorithmic procedure shown to yield satisfactory results for the proposed estimator with respect to the existing literature in an extensive simulation study. From a more theoretical prospect, consistency of the estimator for linear regression is obtained using very recent results on non-smooth semiparametric estimation equations with an infinite-dimensional nuisance parameter, while numerical examples illustrate the adequateness of a simple bootstrap procedure for inferential purposes. Lastly, an application to a real dataset is used to further illustrate the validity and finite sample performance of the proposed estimator.

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arXiv2017

A General Approach for Cure Models in Survival Analysis

In survival analysis it often happens that some subjects under study do not experience the event of interest; they are considered to be `cured'. The population is thus a mixture of two subpopulations: the one of cured subjects, and the one of `susceptible' subjects. When covariates are present, a so-called mixture cure model can be used to model the conditional survival function of the population. It depends on two components: the probability of being cured and the conditional survival function of the susceptible subjects. In this paper we propose a novel approach to estimate a mixture cure model when the data are subject to random right censoring. We work with a parametric model for the cure proportion (like e.g. a logistic model), while the conditional survival function of the uncured subjects is unspecified. The approach is based on an inversion which allows to write the survival function as a function of the distribution of the observable random variables. This leads to a very general class of models, which allows a flexible and rich modeling of the conditional survival function. We show the identifiability of the proposed model, as well as the weak consistency and the asymptotic normality of the model parameters. We also consider in more detail the case where kernel estimators are used for the nonparametric part of the model. The new estimators are compared with the estimators from a Cox mixture cure model via finite sample simulations. Finally, we apply the new model and estimation procedure on two medical data sets.

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arXiv2016

Semiparametric Copula Quantile Regression for Complete or Censored Data

When facing multivariate covariates, general semiparametric regression techniques come at hand to propose flexible models that are unexposed to the curse of dimensionality. In this work a semiparametric copula-based estimator for conditional quantiles is investigated for complete or right-censored data. In spirit, the methodology is extending the recent work of Noh et al. (2013) and Noh et al. (2015), as the main idea consists in appropriately defining the quantile regression in terms of a multivariate copula and marginal distributions. Prior estimation of the latter and simple plug-in lead to an easily implementable estimator expressed, for both contexts with or without censoring, as a weighted quantile of the observed response variable. In addition, and contrary to the initial suggestion in the literature, a semiparametric estimation scheme for the multivariate copula density is studied, motivated by the possible shortcomings of a purely parametric approach and driven by the regression context. The resulting quantile regression estimator has the valuable property of being automatically monotonic across quantile levels, and asymptotic normality for both complete and censored data is obtained under classical regularity conditions. Finally, numerical examples as well as a real data application are used to illustrate the validity and finite sample performance of the proposed procedure.

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arXiv2014

Heteroscedastic semiparametric transformation models: estimation and testing for validity

In this paper we consider a heteroscedastic transformation model, where the transformation belongs to a parametric family of monotone transformations, the regression and variance function are modelled nonparametrically and the error is independent of the multidimensional covariates. In this model, we first consider the estimation of the unknown components of the model, namely the transformation parameter, regression and variance function and the distribution of the error. We show the asymptotic normality of the proposed estimators. Second, we propose tests for the validity of the model, and establish the limiting distribution of the test statistics under the null hypothesis. A bootstrap procedure is proposed to approximate the critical values of the tests. Finally, we carry out a simulation study to verify the small sample behavior of the proposed estimators and tests.

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arXiv2013

Single index regression models in the presence of censoring depending on the covariates

Consider a random vector (X',Y)', where X is d-dimensional and Y is one-dimensional. We assume that Y is subject to random right censoring. The aim of this paper is twofold. First, we propose a new estimator of the joint distribution of (X',Y)'. This estimator overcomes the common curse-of-dimensionality problem, by using a new dimension reduction technique. Second, we assume that the relation between X and Y is given by a mean regression single index model, and propose a new estimator of the parameters in this model. The asymptotic properties of all proposed estimators are obtained.

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arXiv2013

On the identifiability of copulas in bivariate competing risks models

In competing risks models, the joint distribution of the event times is not identifiable even when the margins are fully known, which has been referred to as the "identifiability crisis in competing risks analysis" (Crowder, 1991). We model the dependence between the event times by an unknown copula and show that identification is actually possible within many frequently used families of copulas. The result is then extended to the case where one margin is unknown.

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arXiv2012

Uniform in bandwidth exact rates for a class of kernel estimators

Given an i.i.d sample $(Y_i,Z_i)$, taking values in $\RRR^{d'}\times \RRR^d$, we consider a collection Nadarya-Watson kernel estimators of the conditional expectations $\EEE( +d_g(z)\mid Z=z)$, where $z$ belongs to a compact set $H\subset \RRR^d$, $g$ a Borel function on $\RRR^{d'}$ and $c_g(\cdot),d_g(\cdot)$ are continuous functions on $\RRR^d$. Given two bandwidth sequences $h_n<\wth_n$ fulfilling mild conditions, we obtain an exact and explicit almost sure limit bounds for the deviations of these estimators around their expectations, uniformly in $g\in\GG,\;z\in H$ and $h_n\le h\le \wth_n$ under mild conditions on the density $f_Z$, the class $\GG$, the kernel $K$ and the functions $c_g(\cdot),d_g(\cdot)$. We apply this result to prove that smoothed empirical likelihood can be used to build confidence intervals for conditional probabilities $\PPP(Y\in C\mid Z=z)$, that hold uniformly in $z\in H,\; C\in \CC,\; h\in [h_n,\wth_n]$. Here $\CC$ is a Vapnik-Chervonenkis class of sets.

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arXiv2011

Estimation of the Error Density in a Semiparametric Transformation Model

Consider the semiparametric transformation model $Λ_{θ_o}(Y)=m(X)+ε$, where $θ_o$ is an unknown finite dimensional parameter, the functions $Λ_{θ_o}$ and $m$ are smooth, $ε$ is independent of $X$, and $\esp(ε)=0$. We propose a kernel-type estimator of the density of the error $ε$, and prove its asymptotic normality. The estimated errors, which lie at the basis of this estimator, are obtained from a profile likelihood estimator of $θ_o$ and a nonparametric kernel estimator of $m$. The practical performance of the proposed density estimator is evaluated in a simulation study.

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arXiv2011

Nonparametric regression with filtered data

We present a general principle for estimating a regression function nonparametrically, allowing for a wide variety of data filtering, for example, repeated left truncation and right censoring. Both the mean and the median regression cases are considered. The method works by first estimating the conditional hazard function or conditional survivor function and then integrating. We also investigate improved methods that take account of model structure such as independent errors and show that such methods can improve performance when the model structure is true. We establish the pointwise asymptotic normality of our estimators.

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arXiv2010

A goodness-of-fit test for parametric and semi-parametric models in multiresponse regression

We propose an empirical likelihood test that is able to test the goodness of fit of a class of parametric and semi-parametric multiresponse regression models. The class includes as special cases fully parametric models; semi-parametric models, like the multiindex and the partially linear models; and models with shape constraints. Another feature of the test is that it allows both the response variable and the covariate be multivariate, which means that multiple regression curves can be tested simultaneously. The test also allows the presence of infinite-dimensional nuisance functions in the model to be tested. It is shown that the empirical likelihood test statistic is asymptotically normally distributed under certain mild conditions and permits a wild bootstrap calibration. Despite the large size of the class of models to be considered, the empirical likelihood test enjoys good power properties against departures from a hypothesized model within the class.

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arXiv2009

Nonparametric "regression" when errors are positioned at end-points

Increasing practical interest has been shown in regression problems where the errors, or disturbances, are centred in a way that reflects particular characteristics of the mechanism that generated the data. In economics this occurs in problems involving data on markets, productivity and auctions, where it can be natural to centre at an end-point of the error distribution rather than at the distribution's mean. Often these cases have an extreme-value character, and in that broader context, examples involving meteorological, record-value and production-frontier data have been discussed in the literature. We shall discuss nonparametric methods for estimating regression curves in these settings, showing that they have features that contrast so starkly with those in better understood problems that they lead to apparent contradictions. For example, merely by centring errors at their end-points rather than their means the problem can change from one with a familiar nonparametric character, where the optimal convergence rate is slower than $n^{-1/2}$, to one in the super-efficient class, where the optimal rate is faster than $n^{-1/2}$. Moreover, when the errors are centred in a non-standard way there is greater intrinsic interest in estimating characteristics of the error distribution, as well as of the regression mean itself. The paper will also address this aspect of the problem.

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arXiv2009

Extending the scope of empirical likelihood

This article extends the scope of empirical likelihood methodology in three directions: to allow for plug-in estimates of nuisance parameters in estimating equations, slower than $\sqrt{n}$-rates of convergence, and settings in which there are a relatively large number of estimating equations compared to the sample size. Calibrating empirical likelihood confidence regions with plug-in is sometimes intractable due to the complexity of the asymptotics, so we introduce a bootstrap approximation that can be used in such situations. We provide a range of examples from survival analysis and nonparametric statistics to illustrate the main results.

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arXiv2008

Empirical likelihood based testing for regression

Consider a random vector $(X,Y)$ and let $m(x)=E(Y|X=x)$. We are interested in testing $H_0:m\in {\cal M}_{Θ,{\cal G}}=\{γ(\cdot,θ,g):θ\in Θ,g\in {\cal G}\}$ for some known function $γ$, some compact set $Θ\subset $IR$^p$ and some function set ${\cal G}$ of real valued functions. Specific examples of this general hypothesis include testing for a parametric regression model, a generalized linear model, a partial linear model, a single index model, but also the selection of explanatory variables can be considered as a special case of this hypothesis. To test this null hypothesis, we make use of the so-called marked empirical process introduced by \citeD and studied by \citeSt for the particular case of parametric regression, in combination with the modern technique of empirical likelihood theory in order to obtain a powerful testing procedure. The asymptotic validity of the proposed test is established, and its finite sample performance is compared with other existing tests by means of a simulation study.

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