arXiv subjects

Ioannis Iossifidis

Publications and source records attributed to Ioannis Iossifidis.

17 recordsLinked to original sources

arXiv2026

Applicability of memorization indicators for early spotting of overfitting while recalibrating sEMG-decoders on low sample sizes

Deep learning models for surface electromyography (sEMG) can benefit substantially from subject-specific (re-)calibration, since no sufficiently large and diverse datasets are available to train fully generic decoders. However, for user acceptance, the number of repetitions that can realistically be collected during calibration is severely limited, which increases the risk of overfitting and, in extreme cases, can even degrade performance compared to the uncalibrated model. Classical overfitting indicators such as validation performance and regularization with early stopping are difficult to apply in this low-sample regime, as they require additional held-out data that is rarely available in practical calibration scenarios. In this work, we investigate a recently proposed class of memorization indicators based solely on the activation statistics of rectified linear units (ReLU) in deep neural networks, which can be computed directly from training data without any extra validation set. We conduct a transferlearning experiment on a benchmark sEMG dataset, where a convolutional neural network is first pre-trained on multiple subjects and subsequently fine-tuned on individual users using only a small number of repetitions. During calibration, we monitor both decoding performance and the activation behaviour of the last hidden layer. Our results provide first evidence that decreases in test accuracy during fine-tuning are ac companied by characteristic changes in activation rates, indicating that activation-based memorization indicators are a promising tool for early spotting of unsuccessful learning in low-sample sEMG calibration settings.

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arXiv2026

The Spatial and Temporal Resolution of Motor Intention in Multi-Target Prediction

Reaching for grasping, and manipulating objects are essential motor functions in everyday life. Decoding human motor intentions is a central challenge for rehabilitation and assistive technologies. This study focuses on predicting intentions by inferring movement direction and target location from multichannel electromyography (EMG) signals, and investigating how spatially and temporally accurate such information can be detected relative to movement onset. We present a computational pipeline that combines data-driven temporal segmentation with classical and deep learning classifiers in order to analyse EMG data recorded during the planning, early execution, and target contact phases of a delayed reaching task. Early intention prediction enables devices to anticipate user actions, improving responsiveness and supporting active motor recovery in adaptive rehabilitation systems. Random Forest achieves $80\%$ accuracy and Convolutional Neural Network $75\%$ accuracy across $25$ spatial targets, each separated by $14^\circ$ azimuth/altitude. Furthermore, a systematic evaluation of EMG channels, feature sets, and temporal windows demonstrates that motor intention can be efficiently decoded even with drastically reduced data. This work sheds light on the temporal and spatial evolution of motor intention, paving the way for anticipatory control in adaptive rehabilitation systems and driving advancements in computational approaches to motor neuroscience.

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arXiv2025

Error-related Potential driven Reinforcement Learning for adaptive Brain-Computer Interfaces

Brain-computer interfaces (BCIs) provide alternative communication methods for individuals with motor disabilities by allowing control and interaction with external devices. Non-invasive BCIs, especially those using electroencephalography (EEG), are practical and safe for various applications. However, their performance is often hindered by EEG non-stationarities, caused by changing mental states or device characteristics like electrode impedance. This challenge has spurred research into adaptive BCIs that can handle such variations. In recent years, interest has grown in using error-related potentials (ErrPs) to enhance BCI performance. ErrPs, neural responses to errors, can be detected non-invasively and have been integrated into different BCI paradigms to improve performance through error correction or adaptation. This research introduces a novel adaptive ErrP-based BCI approach using reinforcement learning (RL). We demonstrate the feasibility of an RL-driven adaptive framework incorporating ErrPs and motor imagery. Utilizing two RL agents, the framework adapts dynamically to EEG non-stationarities. Validation was conducted using a publicly available motor imagery dataset and a fast-paced game designed to boost user engagement. Results show the framework's promise, with RL agents learning control policies from user interactions and achieving robust performance across datasets. However, a critical insight from the game-based protocol revealed that motor imagery in a high-speed interaction paradigm was largely ineffective for participants, highlighting task design limitations in real-time BCI applications. These findings underscore the potential of RL for adaptive BCIs while pointing out practical constraints related to task complexity and user responsiveness.

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arXiv2024

Deep-learning-based identification of individual motion characteristics from upper-limb trajectories towards disorder stage evaluation

The identification of individual movement characteristics sets the foundation for the assessment of personal rehabilitation progress and can provide diagnostic information on levels and stages of movement disorders. This work presents a preliminary study for differentiating individual motion patterns using a dataset of 3D upper-limb transport trajectories measured in task-space. Identifying individuals by deep time series learning can be a key step to abstracting individual motion properties. In this study, a classification accuracy of about 95% is reached for a subset of nine, and about 78% for the full set of 31 individuals. This provides insights into the separability of patient attributes by exerting a simple standardized task to be transferred to portable systems.

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arXiv2024

GET: A Generative EEG Transformer for Continuous Context-Based Neural Signals

Generating continuous electroencephalography (EEG) signals through advanced artificial neural networks presents a novel opportunity to enhance brain-computer interface (BCI) technology. This capability has the potential to significantly enhance applications ranging from simulating dynamic brain activity and data augmentation to improving real-time epilepsy detection and BCI inference. By harnessing generative transformer neural networks, specifically designed for EEG signal generation, we can revolutionize the interpretation and interaction with neural data. Generative AI has demonstrated significant success across various domains, from natural language processing (NLP) and computer vision to content creation in visual arts and music. It distinguishes itself by using large-scale datasets to construct context windows during pre-training, a technique that has proven particularly effective in NLP, where models are fine-tuned for specific downstream tasks after extensive foundational training. However, the application of generative AI in the field of BCIs, particularly through the development of continuous, context-rich neural signal generators, has been limited. To address this, we introduce the Generative EEG Transformer (GET), a model leveraging transformer architecture tailored for EEG data. The GET model is pre-trained on diverse EEG datasets, including motor imagery and alpha wave datasets, enabling it to produce high-fidelity neural signals that maintain contextual integrity. Our empirical findings indicate that GET not only faithfully reproduces the frequency spectrum of the training data and input prompts but also robustly generates continuous neural signals. By adopting the successful training strategies of the NLP domain for BCIs, the GET sets a new standard for the development and application of neural signal generation technologies.

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arXiv2023

Ruhr Hand Motion Catalog of Human Center-Out Transport Trajectories in 3D Task-Space Captured by a Redundant Measurement System

Neurological conditions are a major source of movement disorders. Motion modelling and variability analysis have the potential to identify pathology but require profound data. We introduce a systematic dataset of 3D center-out task-space trajectories of human hand transport movements in a natural setting. The transport tasks of this study consist of grasping a cylindric object from a unified start position and transporting it to one of nine target locations in unconstrained operational space. The measurement procedure is automatized to record ten trials per target location. With that, the dataset consists of 90 movement trajectories for each hand of 31 participants without known movement disorders. The participants are aged between 21 and 78 years, covering a wide range. Data are recorded redundantly by both an optical tracking system and an IMU sensor. As opposed to the stationary capturing system, the IMU can be considered as a portable, low-cost and energy-efficient alternative to be implemented on embedded systems.

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arXiv2023

Advancements in Upper Body Exoskeleton: Implementing Active Gravity Compensation with a Feedforward Controller

In this study, we present a feedforward control system designed for active gravity compensation on an upper body exoskeleton. The system utilizes only positional data from internal motor sensors to calculate torque, employing analytical control equations based on Newton-Euler Inverse Dynamics. Compared to feedback control systems, the feedforward approach offers several advantages. It eliminates the need for external torque sensors, resulting in reduced hardware complexity and weight. Moreover, the feedforward control exhibits a more proactive response, leading to enhanced performance. The exoskeleton used in the experiments is lightweight and comprises 4 Degrees of Freedom, closely mimicking human upper body kinematics and three-dimensional range of motion. We conducted tests on both hardware and simulations of the exoskeleton, demonstrating stable performance. The system maintained its position over an extended period, exhibiting minimal friction and avoiding undesired slewing.

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arXiv2023

Understanding Activation Patterns in Artificial Neural Networks by Exploring Stochastic Processes

To gain a deeper understanding of the behavior and learning dynamics of (deep) artificial neural networks, it is valuable to employ mathematical abstractions and models. These tools provide a simplified perspective on network performance and facilitate systematic investigations through simulations. In this paper, we propose utilizing the framework of stochastic processes, which has been underutilized thus far. Our approach models activation patterns of thresholded nodes in (deep) artificial neural networks as stochastic processes. We focus solely on activation frequency, leveraging neuroscience techniques used for real neuron spike trains. During a classification task, we extract spiking activity and use an arrival process following the Poisson distribution. We examine observed data from various artificial neural networks in image recognition tasks, fitting the proposed model's assumptions. Through this, we derive parameters describing activation patterns in each network. Our analysis covers randomly initialized, generalizing, and memorizing networks, revealing consistent differences across architectures and training sets. Calculating Mean Firing Rate, Mean Fano Factor, and Variances, we find stable indicators of memorization during learning, providing valuable insights into network behavior. The proposed model shows promise in describing activation patterns and could serve as a general framework for future investigations. It has potential applications in theoretical simulations, pruning, and transfer learning.

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arXiv2023

Adaptive SpikeDeep-Classifier: Self-organizing and self-supervised machine learning algorithm for online spike sorting

Objective. Research on brain-computer interfaces (BCIs) is advancing towards rehabilitating severely disabled patients in the real world. Two key factors for successful decoding of user intentions are the size of implanted microelectrode arrays and a good online spike sorting algorithm. A small but dense microelectrode array with 3072 channels was recently developed for decoding user intentions. The process of spike sorting determines the spike activity (SA) of different sources (neurons) from recorded neural data. Unfortunately, current spike sorting algorithms are unable to handle the massively increasing amount of data from dense microelectrode arrays, making spike sorting a fragile component of the online BCI decoding framework. Approach. We proposed an adaptive and self-organized algorithm for online spike sorting, named Adaptive SpikeDeep-Classifier (Ada-SpikeDeepClassifier), which uses SpikeDeeptector for channel selection, an adaptive background activity rejector (Ada-BAR) for discarding background events, and an adaptive spike classifier (Ada-Spike classifier) for classifying the SA of different neural units. Results. Our algorithm outperformed our previously published SpikeDeep-Classifier and eight other spike sorting algorithms, as evaluated on a human dataset and a publicly available simulated dataset. Significance. The proposed algorithm is the first spike sorting algorithm that automatically learns the abrupt changes in the distribution of noise and SA. It is an artificial neural network-based algorithm that is well-suited for hardware implementation on neuromorphic chips that can be used for wearable invasive BCIs.

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arXiv2022

Invariance to Quantile Selection in Distributional Continuous Control

In recent years distributional reinforcement learning has produced many state of the art results. Increasingly sample efficient Distributional algorithms for the discrete action domain have been developed over time that vary primarily in the way they parameterize their approximations of value distributions, and how they quantify the differences between those distributions. In this work we transfer three of the most well-known and successful of those algorithms (QR-DQN, IQN and FQF) to the continuous action domain by extending two powerful actor-critic algorithms (TD3 and SAC) with distributional critics. We investigate whether the relative performance of the methods for the discrete action space translates to the continuous case. To that end we compare them empirically on the pybullet implementations of a set of continuous control tasks. Our results indicate qualitative invariance regarding the number and placement of distributional atoms in the deterministic, continuous action setting.

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arXiv2022

ConTraNet: A single end-to-end hybrid network for EEG-based and EMG-based human machine interfaces

Objective: Electroencephalography (EEG) and electromyography (EMG) are two non-invasive bio-signals, which are widely used in human machine interface (HMI) technologies (EEG-HMI and EMG-HMI paradigm) for the rehabilitation of physically disabled people. Successful decoding of EEG and EMG signals into respective control command is a pivotal step in the rehabilitation process. Recently, several Convolutional neural networks (CNNs) based architectures are proposed that directly map the raw time-series signal into decision space and the process of meaningful features extraction and classification are performed simultaneously. However, these networks are tailored to the learn the expected characteristics of the given bio-signal and are limited to single paradigm. In this work, we addressed the question that can we build a single architecture which is able to learn distinct features from different HMI paradigms and still successfully classify them. Approach: In this work, we introduce a single hybrid model called ConTraNet, which is based on CNN and Transformer architectures that is equally useful for EEG-HMI and EMG-HMI paradigms. ConTraNet uses CNN block to introduce inductive bias in the model and learn local dependencies, whereas the Transformer block uses the self-attention mechanism to learn the long-range dependencies in the signal, which are crucial for the classification of EEG and EMG signals. Main results: We evaluated and compared the ConTraNet with state-of-the-art methods on three publicly available datasets which belong to EEG-HMI and EMG-HMI paradigms. ConTraNet outperformed its counterparts in all the different category tasks (2-class, 3-class, 4-class, and 10-class decoding tasks). Significance: The results suggest that ConTraNet is robust to learn distinct features from different HMI paradigms and generalizes well as compared to the current state of the art algorithms.

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arXiv2022

From Motion to Muscle

Voluntary human motion is the product of muscle activity that results from upstream motion planning of the motor cortical areas. We show that muscle activity can be artificially generated based on motion features such as position, velocity, and acceleration. For this purpose, we specifically develop an approach based on a recurrent neural network trained in a supervised learning session; additional neural network architectures are considered and evaluated. The performance is evaluated by a new score called the zero-line score. The latter adaptively rescales the loss function of the generated signal for all channels by comparing the overall range of muscle activity and thus dynamically evaluates similarities between both signals. The model achieves a remarkable precision for previously trained motion while new motions that were not trained before still have high accuracy. Further, these models are trained on multiple subjects and thus are able to generalize across individuals. In addition, we distinguish between a general model that has been trained on several subjects, a subject-specific model, and a specific pre-trained model that uses the general model as a basis and is adapted to a specific subject afterward. The subject-specific generation of muscle activity can be further exploited to improve the rehabilitation of neuromuscular diseases with myoelectric prostheses and functional electric stimulation.

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arXiv2021

Deep Transfer-Learning for patient specific model re-calibration: Application to sEMG-Classification

Accurate decoding of surface electromyography (sEMG) is pivotal for muscle-to-machine-interfaces (MMI) and their application for e.g. rehabilitation therapy. sEMG signals have high inter-subject variability, due to various factors, including skin thickness, body fat percentage, and electrode placement. Therefore, obtaining high generalization quality of a trained sEMG decoder is quite challenging. Usually, machine learning based sEMG decoders are either trained on subject-specific data, or at least recalibrated for each user, individually. Even though, deep learning algorithms produced several state of the art results for sEMG decoding,however, due to the limited amount of availability of sEMG data, the deep learning models are prone to overfitting. Recently, transfer learning for domain adaptation improved generalization quality with reduced training time on various machine learning tasks. In this study, we investigate the effectiveness of transfer learning using weight initialization for recalibration of two different pretrained deep learning models on a new subjects data, and compare their performance to subject-specific models. To the best of our knowledge, this is the first study that thoroughly investigated weight-initialization based transfer learning for sEMG classification and compared transfer learning to subject-specific modeling. We tested our models on three publicly available databases under various settings. On average over all settings, our transfer learning approach improves 5~\%-points on the pretrained models without fine-tuning and 12~\%-points on the subject-specific models, while being trained on average 22~\% fewer epochs. Our results indicate that transfer learning enables faster training on fewer samples than user-specific models, and improves the performance of pretrained models as long as enough data is available.

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arXiv2021

Anchored-STFT and GNAA: An extension of STFT in conjunction with an adversarial data augmentation technique for the decoding of neural signals

Brain-computer interfaces (BCIs) enable communication between humans and machines by translating brain activity into control commands. Electroencephalography (EEG) signals are one of the most used brain signals in non-invasive BCI applications but are often contaminated with noise. Therefore, it is possible that meaningful patterns for classifying EEG signals are deeply hidden. State-of-the-art deep-learning algorithms are successful in learning hidden, meaningful patterns. However, the quality and the quantity of the presented inputs is pivotal. Here, we propose a novel feature extraction method called anchored Short Time Fourier Transform (anchored-STFT), which is an advanced version of STFT, as it minimizes the trade-off between temporal and spectral resolution presented by STFT. In addition, we propose a novel augmentation method, called gradient norm adversarial augmentation (GNAA). GNAA is not only an augmentation method but is also used to harness adversarial inputs in EEG data, which not only improves the classification accuracy but also enhances the robustness of the classifier. In addition, we also propose a new CNN architecture, namely Skip-Net, for the classification of EEG signals. The proposed pipeline outperforms all state-of-the-art methods and yields an average classification accuracy of 90.7 % and 89.54 % on BCI competition II dataset III and BCI competition IV dataset 2b, respectively.

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arXiv2021

Biologically Inspired Model for Timed Motion in Robotic Systems

The goal of this work is the development of a motion model for sequentially timed movement actions in robotic systems under specific consideration of temporal stabilization, that is maintaining an approximately constant overall movement time (isochronous behavior). This is demonstrated both in simulation and on a physical robotic system for the task of intercepting a moving target in three-dimensional space. Motivated from humanoid motion, timing plays a vital role to generate a naturalistic behavior in interaction with the dynamic environment as well as adaptively planning and executing action sequences on-line. In biological systems, many of the physiological and anatomical functions follow a particular level of periodicity and stabilization, which exhibit a certain extent of resilience against external disturbances. A main aspect thereof is stabilizing movement timing against limited perturbations. Especially human arm movement, namely when it is tasked to reach a certain goal point, pose or configuration, shows a stabilizing behavior. This work incorporates the utilization of an extended Kalman filter (EKF) which was implemented to predict the target position while coping with non-linear system dynamics. The periodicity and temporal stabilization in biological systems was artificially generated by a Hopf oscillator, yielding a sinusoidal velocity profile for smooth and repeatable motion.

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arXiv2019

SpikeDeep-Classifier: A deep-learning based fully automatic offline spike sorting algorithm

Objective. Recent advancements in electrode designs and micro-fabrication technology has allowed existence of microelectrode arrays with hundreds of channels for single-cell recordings. In such electrophysiological recordings, each implanted micro-electrode can record the activities of more than one neuron in its vicinity. Recording the activities of multiple neurons may also be referred to as multiple unit activity. However, for any further analysis, the main goal is to isolate the activity of each recorded neuron and thus called single-unit activity. This process may also be referred to as spike sorting or spike classification. Recent approaches to extract SUA are time consuming, mainly due to the requirement of human intervention at various stages of spike sorting pipeline. Lack of standardization is another drawback of the current available approaches. Therefore, in this study we proposed a standard spike sorter: SpikeDeep-Classifier, a fully automatic spike sorting algorithm. Approach. We proposed a novel spike sorting pipeline, based on a set of supervised and unsupervised learning algorithms. We used supervised, deep learning-based algorithms for extracting meaningful channels and removing background activities (noise) from the extracted channels. We also showed that the process of clustering becomes straight-forward, once the noise/artifact is completely removed from the data. Therefore, in the next stage, we applied a simple clustering algorithm (K-mean) with predefined maximum number of clusters. Lastly, we used a similarity-based criterion to keep distinct clusters and merge similar-looking clusters. Main results. We evaluated our algorithm on a dataset collected from two different species (humans and non-human primates (NHPs)) without any retraining. We also validated our algorithm on two publicly available labeled datasets.

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arXiv2018

Universal Spike Classifier

In electrophysiology, microelectrodes are the primary source for recording neural data of single neurons (single unit activity). These microelectrodes can be implanted individually, or in the form of microelectrodes arrays, consisting of hundreds of electrodes. During recordings, some channels capture the activity of neurons, which is usually contaminated with external artifacts and noise. Another considerable fraction of channels does not record any neural data, but external artifacts and noise. Therefore, an automatic identification and tracking of channels containing neural data is of great significance and can accelerate the process of analysis, e.g. automatic selection of meaningful channels during offline and online spike sorting. Another important aspect is the selection of meaningful channels during online decoding in brain-computer interface applications, where threshold crossing events are usually for feature extraction, even though they do not necessarily correspond to neural events. Here, we propose a novel algorithm based on the newly introduced way of feature vector extraction and a supervised deep learning method: a universal spike classifier (USC). The USC enables us to address both above-raised issues. The USC uses the standard architecture of convolutional neural networks (Conv net). It takes the batch of the waveforms, instead of a single waveform as an input, propagates it through the multilayered structure, and finally classifies it as a channel containing neural spike data or artifacts. We have trained the model of USC on data recorded from single tetraplegic patient with Utah arrays implanted in different brain areas. This trained model was then evaluated without retraining on the data collected from six epileptic patients implanted with depth electrodes and two tetraplegic patients implanted with two Utah arrays, individually.

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