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Issei Nakamura

Publications and source records attributed to Issei Nakamura.

7 recordsLinked to original sources

Phase diagrams of polymer-containing liquid mixtures with a theory-embedded neural network

We develop a deep neural network (DNN) that accounts for the phase behaviors of polymer-containing liquid mixtures. The key component in the DNN consists of a theory-embedded layer that captures the characteristic features of the phase behavior via coarse-grained mean-field theory and scaling laws and substantially enhances the accuracy of the DNN. Moreover, this layer enables us to reduce the size of the DNN for the phase diagrams of the mixtures. This study also presents the predictive power of the DNN for the phase behaviors of polymer solutions and salt-free and salt-doped diblock copolymer melts.

cond-mat.soft

Monte Carlo simulation of electrostatic interactions in inhomogeneous dielectric media: Correct sampling for the local lattice simulation algorithm

We present a lattice Monte Carlo algorithm based on the one originally proposed by Maggs and Rossetto for simulating electrostatic interactions in inhomogeneous dielectric media. The original algorithm is known to produce attractive interactions between particles of the same dielectric constant in the medium of different dielectric constant. We demonstrate that such interactions are spurious, caused by incorrectly biased statistical weight arising from particle motion during the Monte Carlo moves. We propose a simple parallel tempering algorithm that corrects this unphysical bias. The efficacy of our algorithm is tested on a simple binary mixture and on an uncharged polymer in a solvent, and applied to salt-doped polymer solutions.

cond-mat.soft

Dose and dose-rate dependence of mutation frequency under long-term exposure - A new look at DDREF from WAM model -

We investigate the dose and dose-rate dependence of the mutation frequency caused by artificial radiations with Whack-A-Mole (WAM) model which we have recently proposed. In particular, we pay special attention to the case of long-term and low dose-rate exposure. The results indicate that the dose-rate dependence is successfully described with WAM model and it may replace the so-called DDREF, the concept of which has long been adopted to take account of the difference between the high dose-rate data and the low dose-rate ones. Basic properties of WAM model are discussed emphasizing the dose-rate dependence to demonstrate how the explicit dose-rate dependence built in the model plays a key role. By adopting the parameters that are determined to fit the mega mouse experiments, biological effects of long-term exposure to extremely low dose-rate radiation are discussed. In WAM model, the effects of the long-term exposure show a saturation property, which makes a clear distinction from the LNT hypothesis which predicts a linear increase of the effects with time.

physics.bio-ph

Whack-A-Mole Model: Towards unified description of biological effect caused by radiation-exposure

We present a novel model to estimate biological effects caused by artificial radiation exposure, Whack-a-mole (WAM) model. It is important to take account of the recovery effects during the time course of the cellular reactions. The inclusion of the dose-rate dependence is essential in the risk estimation of low dose radiation, while nearly all the existing theoretical models relies on the total dose dependence only. By analyzing the experimental data of the relation between the radiation dose and the induced mutation frequency of 5 organisms, mouse, drosophila, chrysanthemum, maize and tradescantia, we found that all the data can be reproduced by WAM model. Most remarkably, a scaling function, which is derived from WAM model, consistently accounts for the observed mutation frequencies of 5 organisms. This is the first rationale to account for the dose rate dependence as well as to give a unified understanding of a general feature of organisms.

physics.bio-ph

Reaction Rate Theory of Radiation Exposure and Scaling Hypothesis in Mutation Frequency

We develop a kinetic reaction model for cells having irradiated DNA molecules due to ionizing radiation exposure. Our theory simultaneously accounts for the time-dependent reactions of the DNA damage, the DNA mutation, the DNA repair, and the proliferation and apoptosis of cells in a tissue with a minimal set of model parameters. In contrast to existing theories for radiation exposition, we do not assume the relationships between the total dose and the induced mutation frequency. Our theory provides a universal scaling function that reasonably explains the mega-mouse experiments in Ref.[W. L. Russell and E. M. Kelly, Proc. Natl. Acad. Sci. USA. {\bf 79} (1982) 542.] with different dose rates. Furthermore, we have estimated the effective dose rate, which is biologically equivalent to the ionizing effects other than those caused by artificial irradiation. This value is $ 1.11 \times 10^{-3} ~\rm{[Gy/hr]}$, which is significantly larger than the effect caused by natural background radiation.

physics.bio-ph

Dynamical symmetry breaking and the Nambu-Goldstone theorem in the Gaussian wave functional approximation

We analyze the group-theoretical ramifications of the Nambu-Goldstone [NG] theorem in the self-consistent relativistic variational Gaussian wave functional approximation to spinless field theories. In an illustrative example we show how the Nambu-Goldstone theorem would work in the O(N) symmetric $ϕ^4$ scalar field theory, if the residual symmetry of the vacuum were lesser than O(N-1), e.g. if the vacuum were O(N-2), or O(N-3),... symmetric. [This does not imply that any of the "lesser" vacua is actually the absolute energy minimum: stability analysis has not been done.] The requisite number of NG bosons would be (2N - 3), or (3N - 6), ... respectively, which may exceed N, the number of elementary fields in the Lagrangian. We show how the requisite new NG bosons would appear even in channels that do not carry the same quantum numbers as one of N "elementary particles" (scalar field quanta, or Castillejo-Dalitz-Dyson [CDD] poles) in the Lagrangian, i.e. in those "flavour" channels that have no CDD poles. The corresponding Nambu-Goldstone bosons are composites (bound states) of pairs of massive elementary (CDD) scalar fields excitations. As a nontrivial example of this method we apply it to the physically more interesting 't Hooft $σ$ model (an extended $N_{f} = 2$ bosonic linear $σ$ model with four scalar and four pseudoscalar fields), with spontaneously and explicitly broken chiral $O(4) \times O(2) \simeq SU_{\rm R} (2) \times SU_{\rm L}(2) \times U_{\rm A}(1)$ symmetry.

hep-th

Linear Sigma model in the Gaussian wave functional approximation II: Analyticity of the S-matrix and the effective potential/action

We show an explicit connection between the solution to the equations of motion in the Gaussian functional approximation and the minimum of the (Gaussian) effective potential/action of the linear $Σ$ model, as well as with the N/D method in dispersion theory. The resulting equations contain analytic functions with branch cuts in the complex mass squared plane. Therefore the minimum of the effective action may lie in the complex mass squared plane. Many solutions to these equations can be found on the second, third, etc. Riemann sheets of the equation, though their physical interpretation is not clear. Our results and the established properties of the S-matrix in general, and of the N/D solutions in particular, guide us to the correct choice of the Riemann sheet. We count the number of states and find only one in each spin-parity and isospin channel with quantum numbers corresponding to the fields in the Lagrangian, i.e. to Castillejo-Dalitz-Dyson (CDD) poles. We examine the numerical solutions in both the strong and weak coupling regimes and calculate the Kallen-Lehmann spectral densities and then use them for physical interpretation.

hep-th