arXiv subjects

Isshaan Singh

Publications and source records attributed to Isshaan Singh.

3 recordsLinked to original sources

arXiv2026

Enhancing Personalized Bladder Cancer Treatment Through Reinforcement Learning: A Recurrent Patient State Transition Decision Support Framework

Bladder cancer treatment requires personalized and adaptive decision-making, particularly for recurrent disease, where treatment effectiveness changes across successive clinical episodes. Conventional clinical decision support systems typically rely on static treatment guidelines or single-step predictive models, limiting their ability to capture disease progression over time. This paper presents a recurrent patient state-transition simulation framework for bladder cancer treatment planning that integrates predictive state-transition modeling with a Markov Decision Process (MDP) and a Deep Q-Network (DQN) reinforcement learning environment. The predictive module estimates changes in tumor characteristics following treatment, while the reinforcement learning agent sequentially optimizes treatment decisions by interacting with simulated patient trajectories. This framework enables dynamic, patient-specific treatment planning by continuously adapting recommendations to evolving clinical states. It also generates interpretable treatment trajectories and detailed simulation logs to improve transparency and support clinical decision-making. The proposed framework was evaluated against existing reinforcement learning-based treatment planning approaches. It achieved a cumulative reward of 63,918.87, an average training loss per episode of 0.0056, and a policy improvement score of 6.62%, demonstrating effective sequential learning and robust treatment optimization in a simulated recurrent treatment environment. These findings highlight the potential of recurrent patient state-transition simulation with reinforcement learning as a flexible decision-support framework for personalized bladder cancer treatment planning and AI-assisted precision oncology.

cs.LG↗

arXiv2026

Quantum Circuit Simulation of Compartmental Drug Dynamics: Leveraging Variational Algorithms for Nonlinear Mixed-Effects Population Pharmacokinetics

Population pharmacokinetic/pharmacodynamic (PK/PD) modeling traditionally relies on classical ordinary differential equations to simulate drug dynamics. In this work, we reformulate a compartmental PK/PD model as an open quantum system and implement it using quantum circuits developed in PennyLane. Four pharmacological compartments (central, peripheral, effect-site, and response) are encoded using twelve qubits, with inter-compartmental transitions represented through controlled quantum operations that emulate stochastic dynamics. The framework is evaluated on Phase 1 clinical data using a quantum-enhanced stochastic approximation expectation-maximization (SAEM) approach. Compared with the classical implementation, the quantum model achieves substantially improved log-likelihood values, indicating stronger statistical fit while preserving identical parameter estimates, thereby validating numerical consistency and model interpretability. The quantum-based optimization converges faster in terms of iterations, although total runtime is increased due to current simulation overhead. The study demonstrates stable large-scale simulation performance and establishes a hybrid quantum-classical approach that maintains biological fidelity while improving statistical modeling capacity. The dataset and problem statement originate from the Quantum Innovation Challenge 2025, and additional details are provided via the associated link.

cs.LG↗

arXiv2025

Interpretable Hybrid Deep Q-Learning Framework for IoT-Based Food Spoilage Prediction with Synthetic Data Generation and Hardware Validation

The need for an intelligent, real-time spoilage prediction system has become critical in modern IoT-driven food supply chains, where perishable goods are highly susceptible to environmental conditions. Existing methods often lack adaptability to dynamic conditions and fail to optimize decision making in real time. To address these challenges, we propose a hybrid reinforcement learning framework integrating Long Short-Term Memory (LSTM) and Recurrent Neural Networks (RNN) for enhanced spoilage prediction. This hybrid architecture captures temporal dependencies within sensor data, enabling robust and adaptive decision making. In alignment with interpretable artificial intelligence principles, a rule-based classifier environment is employed to provide transparent ground truth labeling of spoilage levels based on domain-specific thresholds. This structured design allows the agent to operate within clearly defined semantic boundaries, supporting traceable and interpretable decisions. Model behavior is monitored using interpretability-driven metrics, including spoilage accuracy, reward-to-step ratio, loss reduction rate, and exploration decay. These metrics provide both quantitative performance evaluation and insights into learning dynamics. A class-wise spoilage distribution visualization is used to analyze the agents decision profile and policy behavior. Extensive evaluations on simulated and real-time hardware data demonstrate that the LSTM and RNN based agent outperforms alternative reinforcement learning approaches in prediction accuracy and decision efficiency while maintaining interpretability. The results highlight the potential of hybrid deep reinforcement learning with integrated interpretability for scalable IoT-based food monitoring systems.

cs.LG↗