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Jürgen Brugger

Publications and source records attributed to Jürgen Brugger.

5 recordsLinked to original sources

Surface nanostructuring of NbTi superconducting thin-film resonators for enhanced cryogenic thermometry

The rising complexity of cutting-edge cryogenic systems is currently imposing challenging technical constraints to the monitoring of ultra-cold temperatures through standard commercially available sensors. Among different alternative technologies, superconducting microwave resonators have been recently investigated as ideal candidates for performing on-chip cryogenic thermometry, in reason of their intrinsically low power dissipation, typically large temperature sensitivities and excellent sub-mK resolution below 10 K. In such a framework, through this study we aim at demonstrating the possibility to enhance the temperature performance of superconducting microwave resonators by means of surface nanostructuring. More specifically, different arrays of nanogaps are strategically patterned on the inductive line of a 1.3 GHz planar resonator, by partially etching a Nb50Ti50 thin film, in order to tune the critical transition of the material and, therefore, increase the curvature of the fres(T) response. Although the presence of such weak-links introduces larger microwave losses, a 1.5 K decrease of TC is recorded, which directly translates into an enhancement of the temperature sensitivity by a factor 10, with respect to a reference non-nanostructured sensor. In particular, a maximum value of dfres/dT = 62 MHz/K, at 4.2 K, is achieved for the device showing the largest nanogap width of about 350 nm, demonstrating that the surface nanostructuring of superconducting thin-films can be effectively engineered to enhance the temperature response of microwave resonators for high-performance cryogenic thermometry. We believe that similar approaches might be investigated and, eventually, adopted for the near-future development of the next generation of low-temperature sensors.

physics.app-ph↗

Effects of the thin-film thickness on superconducting NbTi microwave resonators for on-chip cryogenic thermometry

Superconducting microwave resonators have recently gained a primary importance in the development of cryogenic applications, such as circuit quantum electrodynamics, electron spin resonance spectroscopy and particles detection for high-energy physics and astrophysics. In this work, we investigate the influence of the film thickness on the temperature response of microfabricated Nb50Ti50 superconducting resonators. S-shaped split ring resonators (S-SRRs), 20 nm to 150 nm thick, are designed to be electromagnetically coupled with standard Cu coplanar waveguides (CPWs) and their microwave properties are characterized at temperatures below 10 K. The combined contributions of the kinetic inductance LK(T) increase and the decreasing loaded quality factor QL, for thinner films, induce an optimum condition on the temperature sensitivity and resolution of the resonators. A noise equivalent temperature (NET) as low as 0.5 uK/Hz^(1/2), at 1 Hz, is reported for 100 nm thick resonators at 4.2 K. We also asses the possibility of implementing a multiplexed frequency readout, allowing for the simultaneous temperature tracking of several sensors along a single CPW. Such results demonstrate the possibility to perform a distributed cryogenic temperature monitoring, with a sub-mK resolution. Thus, the application of superconducting S-SRRs, eventually benefiting from an even higher LK(T), for a further miniaturization, as well as a back-end integration directly on-chip, can be envisioned for the accurate monitoring of localized temperature of devices operating in cryogenic conditions.

physics.app-ph↗

Optical Antenna-based Fluorescence Correlation Spectroscopy to Probe the Nanoscale Dynamics of Biological Membranes

The plasma membrane of living cells is compartmentalized at multiple spatial scales ranging from the nano- to the meso-scale. This non-random organization is crucial for a large number of cellular functions. At the nanoscale, cell membranes organize into dynamic nano-assemblies enriched by cholesterol, sphingolipids and certain types of proteins. Investigating these nano-assemblies known as lipid rafts is of paramount interest in fundamental cell biology. However, this goal requires simultaneous nanometer spatial precision and microsecond temporal resolution which is beyond the reach of common microscopes. Optical antennas based on metallic nanostructures efficiently enhance and confine light into nanometer dimensions, breaching the diffraction limit of light. In this Perspective, we discuss recent progress combining optical antennas with fluorescence correlation spectroscopy (FCS) to monitor microsecond dynamics at nanoscale spatial dimensions. These new developments offer numerous opportunities to investigate lipid and protein dynamics in both mimetic and native biological membranes.

physics.bio-ph↗

Transient Nanoscopic Phase Separation in Biological Lipid Membranes Resolved by Planar Plasmonic Antennas

Nanoscale membrane assemblies of sphingolipids, cholesterol, and certain proteins, also known as lipid rafts, play a crucial role in facilitating a broad range of important cell functions. Whereas on living cell membranes lipid rafts have been postulated to have nanoscopic dimensions and to be highly transient, the existence of a similar type of dynamic nanodomains in multicomponent lipid bilayers has been questioned. Here, we perform fluorescence correlation spectroscopy on planar plasmonic antenna arrays with different nanogap sizes to assess the dynamic nanoscale organization of mimetic biological membranes. Our approach takes advantage of the highly enhanced and confined excitation light provided by the nanoantennas together with their outstanding planarity to investigate membrane regions as small as 10 nm in size with microsecond time resolution. Our diffusion data are consistent with the coexistence of transient nanoscopic domains in both the liquid-ordered and the liquid-disordered microscopic phases of multicomponent lipid bilayers. These nanodomains have characteristic residence times between 30 and 150 μs and sizes around 10 nm, as inferred from the diffusion data. Thus, although microscale phase separation occurs on mimetic membranes, nanoscopic domains also coexist, suggesting that these transient assemblies might be similar to those occurring in living cells, which in the absence of raft-stabilizing proteins are poised to be short-lived. Importantly, our work underscores the high potential of photonic nanoantennas to interrogate the nanoscale heterogeneity of native biological membranes with ultrahigh spatiotemporal resolution.

physics.bio-ph↗

Planar Optical Nanoantennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells

Optical nanoantennas can efficiently confine light into nanoscopic hotspots, enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual biomolecules in living cell membranes and their partitioning into cholesterol-dependent lipid nanodomains. Here, we present optical nanoantenna arrays with accessible surface hotspots to study the characteristic diffusion dynamics of phosphoethanolamine (PE) and sphingomyelin (SM) in the plasma membrane of living cells at the nanoscale. Fluorescence burst analysis and fluorescence correlation spectroscopy performed on nanoantennas of different gap sizes show that, unlike PE, SM is transiently trapped in cholesterol-enriched nanodomains of 10 nm diameter with short characteristic times around 100 μs. The removal of cholesterol led to the free diffusion of SM, consistent with the dispersion of nanodomains. Our results are consistent with the existence of highly transient and fluctuating nanoscale assemblies enriched by cholesterol and sphingolipids in living cell membranes, also known as lipid rafts. Quantitative data on sphingolipids partitioning into lipid rafts is crucial to understand the spatiotemporal heterogeneous organization of transient molecular complexes on the membrane of living cells at the nanoscale. The proposed technique is fully biocompatible and thus provides various opportunities for biophysics and live cell research to reveal details that remain hidden in confocal diffraction-limited measurements.

physics.bio-ph↗