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Jürgen Geisler

Publications and source records attributed to Jürgen Geisler.

2 recordsLinked to original sources

A Green Solution for Breast Region Segmentation Using Deep Active Learning

Purpose: Annotation of medical breast images is an essential step toward better diagnostic but a time consuming task. This research aims to focus on different selecting sample strategies within deep active learning on Breast Region Segmentation (BRS) to lessen computational cost of training and effective use of resources. Methods: The Stavanger breast MRI dataset containing 59 patients was used in this study, with FCN-ResNet50 adopted as a sustainable deep learning (DL) model. A novel sample selection approach based on Breast Anatomy Geometry (BAG) analysis was introduced to group data with similar informative features for DL. Patient positioning and Breast Size were considered the key selection criteria in this process. Four selection strategies including Random Selection, Nearest Point, Breast Size, and a hybrid of all three strategies were evaluated using an active learning framework. Four training data proportions of 10%, 20%, 30%, and 40% were used for model training, with the remaining data reserved for testing. Model performance was assessed using Dice score, Intersection over Union, precision, and recall, along with 5-fold cross-validation to enhance generalizability. Results: Increasing the training data proportion from 10% to 40% improved segmentation performance for nearly all strategies, except for Random Selection. The Nearest Point strategy consistently achieved the lowest carbon footprint at 30% and 40% data proportions. Overall, combining the Nearest Point strategy with 30% of the training data provided the best balance between segmentation performance, efficiency, and environmental sustainability. Keywords: Deep Active Learning, Breast Region Segmentation, Human-center analysis

physics.med-ph↗

Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent

Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production. Here, we propose a mathematical model based on a system of ordinary differential equations to investigate the effect of high-fat diet on tumor growth. We inform the model with data from mouse experiments, where the animals are fed with high-fat or control (normal) diet. By incorporating AI treatment with drug resistance into the model and by solving optimal control problems we found differential responses for control and high-fat diet. To the best of our knowledge, this is the first attempt to model optimal anti-hormonal treatment for breast cancer in the presence of drug resistance. Our results underline the importance of considering high-fat diet and obesity as factors influencing clinical outcomes during anti-hormonal therapies in breast cancer patients.

math.OC↗