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J. Ewart H. Shaw

Publications and source records attributed to J. Ewart H. Shaw.

3 recordsLinked to original sources

On Dealing with Censored Largest Observations under Weighted Least Squares

When observations are subject to right censoring, weighted least squares with appropriate weights (to adjust for censoring) is sometimes used for parameter estimation. With Stute's weighted least squares method, when the largest observation is censored ($Y_{(n)}^+$), it is natural to apply the redistribution to the right algorithm of Efron (1967). However, Efron's redistribution algorithm can lead to bias and inefficiency in estimation. This study explains the issues clearly and proposes some alternative ways of treating $Y_{(n)}^+$. The first four proposed approaches are based on the well known Buckley--James (1979) method of imputation with the Efron's tail correction and the last approach is indirectly based on a general mean imputation technique in literature. All the new schemes use penalized weighted least squares optimized by quadratic programming implemented with the accelerated failure time models. Furthermore, two novel additional imputation approaches are proposed to impute the tail tied censored observations that are often found in survival analysis with heavy censoring. Several simulation studies and real data analysis demonstrated that the proposed approaches generally outperform Efron's redistribution approach and lead to considerably smaller mean squared error and bias estimates.

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Robust Bias Estimation for Kaplan-Meier Survival Estimator with Jackknifing

For studying or reducing the bias of functionals of the Kaplan-Meier survival estimator, the jackknifing approach of Stute and Wang (1994) is natural. We have studied the behavior of the jackknife estimate of bias under different configurations of the censoring level, sample size, and the censoring and survival time distributions. The empirical research reveals some new findings about robust calculation of the bias, particularly for higher censoring levels. We have extended their jackknifing approach to cover the case where the largest observation is censored, using the imputation methods for the largest observations proposed in Khan and Shaw (2013b). This modification to the existing formula reduces the number of conditions for creating jackknife bias estimates to one from the original two, and also avoids the problem that the Kaplan--Meier estimator can be badly underestimated by the existing jackknife formula.

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Variable Selection for Survival Data with A Class of Adaptive Elastic Net Techniques

The accelerated failure time (AFT) models have proved useful in many contexts, though heavy censoring (as for example in cancer survival) and high dimensionality (as for example in microarray data) cause difficulties for model fitting and model selection. We propose new approaches to variable selection for censored data, based on AFT models optimized using regularized weighted least squares. The regularized technique uses a mixture of L1 and L2 norm penalties under two proposed elastic net type approaches. One is the the adaptive elastic net and the other is weighted elastic net. The approaches extend the original approaches proposed by Ghosh (2007), and Hong and Zhang (2010) respectively. We also extend the two proposed approaches by adding censoring observations as constraints into their model optimization frameworks. The approaches are evaluated on microarray and by simulation. We compare the performance of these approaches with six other variable selection techniques--three are generally used for censored data and the other three are correlation-based greedy methods used for high-dimensional data.

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