Constructing Large Orthogonal Minimally Aliased Response Surface Designs Through Enumeration and Combination of Weighing Designs
Advances in automation and high-throughput experimentation have enabled larger and more complex studies involving many factors and tests, creating a growing demand for computationally effective design construction methods. Efficient experimental design remains a key challenge in this context, creating a need for frameworks that can generate large experiments while preserving orthogonality and minimal aliasing. Unlike existing approaches which struggle with scalability, this work introduces an algorithmic framework for constructing large Orthogonal Minimally Aliased Response Surface (OMARS) designs by enumerating and combining weighing designs, three-level matrices with orthogonal columns and a fixed number of non-zero entries per column. Complete enumerations of weighing designs are achieved for designs with up to 24 tests, covering multiple numbers of factors and weights corresponding to two or three zeros per factor. In addition, a validated partial enumeration procedure and a combination method extend the catalog to substantially larger designs. The combination method enables the construction of OMARS designs for any test size that is a multiple of selected base sizes. This paper thus provides the methodology for generating large catalogs of high-quality OMARS designs, well-suited for high-dimensional screening and response-surface modelling in complex industrial and scientific experiments.