arXiv subjects
Publications and source records attributed to Jakub Kmiecik.
This paper is concerned with a novel method allowing communication between FRET nanonetworks and nerve cells. It is focused on two system components: fluorophores and channelrhodopsins which serve as transmitters and receivers, respectively. Channelrhodopsins are used here also as a FRET signal-to-voltage converter. The trade-off between throughput and bit error rate is also investigated.
The paper is concerned with Forster Resonance Energy Transfer (FRET) considered as a mechanism for communication between nanodevices. Two solved issues are reported in the paper, namely: signal generation and signal storage in FRET-based nanonetworks. First, luciferase molecules as FRET transmitters which are able to generate FRET signals themselves, taking energy from chemical reactions without any external light exposure, are proposed. Second, channelrhodopsins as FRET receivers, as they can convert FRET signals into voltage, are suggested. Further, medical in-body systems where both molecule types might be successfully applied, are discussed. Luciferase-channelrhodopsin communication is modeled and its performance is numerically validated, reporting on its throughput, bit error rate, propagation delay and energy consumption.
A practical, biologically motivated case of protein complexes (immunoglobulin G and FcRII receptors) moving on the surface of mastcells, that are common parts of an immunological system, is investigated. Proteins are considered as nanomachines creating a nanonetwork. Accurate molecular models of the proteins and the fluorophores which act as their nanoantennas are used to simulate the communication between the nanomachines when they are close to each other. The theory of diffusion-based Brownian motion is applied to model movements of the proteins. It is assumed that fluorophore molecules send and receive signals using the Forster Resonance Energy Transfer. The probability of the efficient signal transfer and the respective bit error rate are calculated and discussed.