arXiv subjects

James D. Gunton

Publications and source records attributed to James D. Gunton.

7 recordsLinked to original sources

arXiv2011

Encapsulation by Janus spheroids

The micro/nano encapsulation technology has acquired considerable attention in the fields of drug delivery, biomaterial engineering, and materials science. Based on recent advances in chemical particle synthesis, we propose a primitive model of an encapsulation system produced by the self-assembly of Janus oblate spheroids, particles with oblate spheroidal bodies and two hemi-surfaces coded with dissimilar chemical properties. Using Monte Carlo simulation, we investigate the encapsulation system with spherical particles as encapsulated guests, for different densities. We study the anisotropic effect due to the encapsulating agent's geometric shape and chemical composition on the encapsulation morphology and efficiency. Given the relatively high encapsulation efficiency we find from the simulations, we believe that this method of encapsulation has potential practical value.

cond-mat.soft↗

arXiv2008

Diversity-induced resonance in a system of globally coupled linear oscillators

The purpose of this paper to analyze in some detail the arguably simplest case of diversity-induced reseonance: that of a system of globally-coupled linear oscillators subjected to a periodic forcing. Diversity appears as the parameters characterizing each oscillator, namely its mass, internal frequency and damping coefficient are drawn from a probability distribution. The main ingredients for the diversity-induced-resonance phenomenon are present in this system as the oscillators display a variability in the individual responses but are induced, by the coupling, to synchronize their responses. A steady state solution for this model is obtained. We also determine the conditions under which it is possible to find a resonance effect.

nlin.AO↗

arXiv2007

Role of network connectivity in intercellular calcium oscillations

It is important to understand the coordinated performance of cells in tissue. One possible mechanism in this coordination involves intracellular calcium signaling. The topology of intercellular connections in tissue should also play an important role in this process. It is most relevant for plane tissues, in which the interaction between cells is due to gap junctions (epithelium, blood vessels). We demonstrate the importance of the topology of intercellular connectivity by investigating the properties of a model of calcium signaling for a small number of connected cells.

physics.bio-ph↗

arXiv2006

Diversity-induced resonance

We present conclusive evidence showing that different sources of diversity, such as those represented by quenched disorder or noise, can induce a resonant collective behavior in an ensemble of coupled bistable or excitable systems. Our analytical and numerical results show that when such systems are subjected to an external subthreshold signal, their response is optimized for an intermediate value of the diversity. These findings show that intrinsic diversity might have a constructive role and suggest that natural systems might profit from their diversity in order to optimize the response to an external stimulus.

cond-mat.stat-mech↗

arXiv2005

Simple Model of Sickle Hemogloblin

A microscopic model is proposed for the interactions between sickle hemoglobin molecules based on information from the protein data bank. A Monte Carlo simulation of a simplified two patch model is carried out, with the goal of understanding fiber formation. A gradual transition from monomers to one dimensional chains is observed as one varies the density of molecules at fixed temperature, somewhat similar to the transition from monomers to polymer fibers in sickle hemoglobin molecules in solution. An observed competition between chain formation and crystallization for the model is also discussed. The results of the simulation of the equation of state are shown to be in excellent agreement with a theory for a model of globular proteins, for the case of two interacting sites.

cond-mat.soft↗

arXiv2003

Crystal nucleation for a model of globular proteins

A continuum model of globular proteins proposed by Talanquer and Oxtoby (J. Chem. Phys. vol. 109, p. 223 (1998)) is investigated numerically, with particular emphasis on the region near the metastable fluid-fluid coexistence curve. Classical nucleation theory is shown to be invalid not only in the vicinity of the metastable critical point but also close to the liquidus line. An approximate analytic solution is also presented for the shape and properties of the nucleating crystal droplet.

cond-mat.soft↗

arXiv2002

System size coherence resonance

We show the existence of a system size coherence resonance effect for an ensemble of globally coupled excitable systems. Namely, we demonstrate numerically that the regularity in the signal emitted by an ensemble of globally coupled Fitzhugh-Nagumo systems, under excitation by independent noise sources, is optimal for a particular value of the number of coupled systems. This resonance is shown through several different dynamical measures: the time correlation function, correlation time and jitter.

cond-mat↗