arXiv subjects

Jane Hillston

Publications and source records attributed to Jane Hillston.

26 records · Page 2Linked to original sources

arXiv2012

Hybrid performance modelling of opportunistic networks

We demonstrate the modelling of opportunistic networks using the process algebra stochastic HYPE. Network traffic is modelled as continuous flows, contact between nodes in the network is modelled stochastically, and instantaneous decisions are modelled as discrete events. Our model describes a network of stationary video sensors with a mobile ferry which collects data from the sensors and delivers it to the base station. We consider different mobility models and different buffer sizes for the ferries. This case study illustrates the flexibility and expressive power of stochastic HYPE. We also discuss the software that enables us to describe stochastic HYPE models and simulate them.

eess.SY↗

arXiv2011

A semi-quantitative equivalence for abstracting from fast reactions

Semantic equivalences are used in process algebra to capture the notion of similar behaviour, and this paper proposes a semi-quantitative equivalence for a stochastic process algebra developed for biological modelling. We consider abstracting away from fast reactions as suggested by the Quasi-Steady-State Assumption. We define a fast-slow bisimilarity based on this idea. We also show congruence under an appropriate condition for the cooperation operator of Bio-PEPA. The condition requires that there is no synchronisation over fast actions, and this distinguishes fast-slow bisimilarity from weak bisimilarity. We also show congruence for an operator which extends the reactions available for a species. We characterise models for which it is only necessary to consider the matching of slow transitions and we illustrate the equivalence on two models of competitive inhibition.

cs.CE↗

arXiv2011

HYPE with stochastic events

The process algebra HYPE was recently proposed as a fine-grained modelling approach for capturing the behaviour of hybrid systems. In the original proposal, each flow or influence affecting a variable is modelled separately and the overall behaviour of the system then emerges as the composition of these flows. The discrete behaviour of the system is captured by instantaneous actions which might be urgent, taking effect as soon as some activation condition is satisfied, or non-urgent meaning that they can tolerate some (unknown) delay before happening. In this paper we refine the notion of non-urgent actions, to make such actions governed by a probability distribution. As a consequence of this we now give HYPE a semantics in terms of Transition-Driven Stochastic Hybrid Automata, which are a subset of a general class of stochastic processes termed Piecewise Deterministic Markov Processes.

cs.LO↗

arXiv2010

Numerically Representing A Stochastic Process Algebra

The syntactic nature and compositionality characteristic of stochastic process algebras make models to be easily understood by human beings, but not convenient for machines as well as people to directly carry out mathematical analysis and stochastic simulation. This paper presents a numerical representation schema for the stochastic process algebra PEPA, which can provide a platform to directly and conveniently employ a variety of computational approaches to both qualitatively and quantitatively analyse the models. Moreover, these approaches developed on the basis of the schema are demonstrated and discussed. In particular, algorithms for automatically deriving the schema from a general PEPA model and simulating the model based on the derived schema to derive performance measures are presented.

cs.LO↗

arXiv2010

Modeling biological systems with delays in Bio-PEPA

Delays in biological systems may be used to model events for which the underlying dynamics cannot be precisely observed, or to provide abstraction of some behavior of the system resulting more compact models. In this paper we enrich the stochastic process algebra Bio-PEPA, with the possibility of assigning delays to actions, yielding a new non-Markovian process algebra: Bio-PEPAd. This is a conservative extension meaning that the original syntax of Bio-PEPA is retained and the delay specification which can now be associated with actions may be added to existing Bio-PEPA models. The semantics of the firing of the actions with delays is the delay-as-duration approach, earlier presented in papers on the stochastic simulation of biological systems with delays. These semantics of the algebra are given in the Starting-Terminating style, meaning that the state and the completion of an action are observed as two separate events, as required by delays. Furthermore we outline how to perform stochastic simulation of Bio-PEPAd systems and how to automatically translate a Bio-PEPAd system into a set of Delay Differential Equations, the deterministic framework for modeling of biological systems with delays. We end the paper with two example models of biological systems with delays to illustrate the approach.

cs.CE↗

arXiv2010

Fundamental Results on Fluid Approximations of Stochastic Process Algebra Models

In order to avoid the state space explosion problem encountered in the quantitative analysis of large scale PEPA models, a fluid approximation approach has recently been proposed, which results in a set of ordinary differential equations (ODEs) to approximate the underlying continuous time Markov chain (CTMC). This paper presents a mapping semantics from PEPA to ODEs based on a numerical representation scheme, which extends the class of PEPA models that can be subjected to fluid approximation. Furthermore, we have established the fundamental characteristics of the derived ODEs, such as the existence, uniqueness, boundedness and nonnegativeness of the solution. The convergence of the solution as time tends to infinity for several classes of PEPA models, has been proved under some mild conditions. For general PEPA models, the convergence is proved under a particular condition, which has been revealed to relate to some famous constants of Markov chains such as the spectral gap and the Log-Sobolev constant. This thesis has established the consistency between the fluid approximation and the underlying CTMCs for PEPA, i.e. the limit of the solution is consistent with the equilibrium probability distribution corresponding to a family of underlying density dependent CTMCs.

cs.LO↗

arXiv2010

Investigating modularity in the analysis of process algebra models of biochemical systems

Compositionality is a key feature of process algebras which is often cited as one of their advantages as a modelling technique. It is certainly true that in biochemical systems, as in many other systems, model construction is made easier in a formalism which allows the problem to be tackled compositionally. In this paper we consider the extent to which the compositional structure which is inherent in process algebra models of biochemical systems can be exploited during model solution. In essence this means using the compositional structure to guide decomposed solution and analysis. Unfortunately the dynamic behaviour of biochemical systems exhibits strong interdependencies between the components of the model making decomposed solution a difficult task. Nevertheless we believe that if such decomposition based on process algebras could be established it would demonstrate substantial benefits for systems biology modelling. In this paper we present our preliminary investigations based on a case study of the pheromone pathway in yeast, modelling in the stochastic process algebra Bio-PEPA.

cs.CE↗

arXiv2009

Quantifying the implicit process flow abstraction in SBGN-PD diagrams with Bio-PEPA

For a long time biologists have used visual representations of biochemical networks to gain a quick overview of important structural properties. Recently SBGN, the Systems Biology Graphical Notation, has been developed to standardise the way in which such graphical maps are drawn in order to facilitate the exchange of information. Its qualitative Process Diagrams (SBGN-PD) are based on an implicit Process Flow Abstraction (PFA) that can also be used to construct quantitative representations, which can be used for automated analyses of the system. Here we explicitly describe the PFA that underpins SBGN-PD and define attributes for SBGN-PD glyphs that make it possible to capture the quantitative details of a biochemical reaction network. We implemented SBGNtext2BioPEPA, a tool that demonstrates how such quantitative details can be used to automatically generate working Bio-PEPA code from a textual representation of SBGN-PD that we developed. Bio-PEPA is a process algebra that was designed for implementing quantitative models of concurrent biochemical reaction systems. We use this approach to compute the expected delay between input and output using deterministic and stochastic simulations of the MAPK signal transduction cascade. The scheme developed here is general and can be easily adapted to other output formalisms.

cs.PL↗