Structurally Constrained Brain Network Dynamics Reveal Reduced Functional Flexibility in Cocaine Use Disorder
Cocaine Use Disorder (CUD) is associated with widespread alterations in large-scale functional brain networks, yet the mechanisms contributing to these changes and their relationship to clinical and cognitive outcomes remain poorly understood. To address this gap, we introduce a framework to extract structurally informed dynamic functional connectivity patterns. We then leverage these connectivity patterns to characterize differences in functional brain network organization associated with CUD and to examine their relationship with clinical measures. Specifically, we applied Laplacian spectral smoothing to each participant's functional connectivity matrix using individualized structural priors derived from diffusion imaging. These structurally informed connectivity features were subsequently used to examine cross-network interactions and characterize dynamic community organization across functional brain states. Our findings indicate that individuals with cocaine use disorder exhibit increased integration and recruitment accompanied by reduced flexibility in the functional brain networks, with the most pronounced alterations in visual, attentional, and control systems. In addition, structurally informed functional connectivity features were predictive of weekly cocaine use within the CUD cohort. Overall, these results highlight the value of structurally informed dynamic connectivity measures for characterizing network-level alterations associated with cocaine addiction and for linking these alterations to clinically meaningful measures of cocaine use severity.