Calibration-Free Cuffless Blood Pressure Estimation Using Multimodal ECG-PPG Fusion on a Google Pixel Watch
Inadequate blood pressure (BP) monitoring and management outside of clinical settings can worsen major cardiovascular risk factors such as hypertension. While cuff-based devices are commonly used for at-home monitoring, these devices can be inconvenient for daily use due to their sensitivity to body positions, upper-arm constrictions, and limited portability. A promising alternative is emerging in the form of consumer-grade smartwatches, where physiological signals related to cardiac activity can be used to estimate BP non-invasively and continuously across daily living conditions. In this work, we use data collected from a Google Pixel Watch in 40 participants to develop and compare several algorithm approaches for BP estimation. We found that our proposed deep learning model achieved the strongest overall performance, and that fusing smartwatch signals with demographic information improved model generalizability to unseen individuals. However, we also identified that model accuracy was not consistent across participant subgroups, with obese individuals yielding higher estimation errors than others. This study highlights the feasibility of consumer-grade smartwatches as accessible platforms for deploying robust BP estimation algorithms, though clinical reliability will require larger, more diverse populations and additional sensing modalities.