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Javier Costas

Publications and source records attributed to Javier Costas.

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Tests for categorical data beyond Pearson: A distance covariance and energy distance approach

Categorical variables are of uttermost importance in biomedical research. When two of them are considered, it is often the case that one wants to test whether or not they are statistically dependent. We show weaknesses of classical methods -- such as Pearson's and the G-test -- and we propose testing strategies based on distances that lack those drawbacks. We first develop this theory for classical two-dimensional contingency tables, within the context of distance covariance, an association measure that characterizes general statistical independence of two variables. We then apply the same fundamental ideas to one-dimensional tables, namely to the testing for goodness of fit to a discrete distribution, for which we resort to an analogous statistic called energy distance. We prove that our methodology has desirable theoretical properties, and we show that we can calibrate the null distribution of our test statistics without resampling. We illustrate all this in simulations, as well as with some real data examples, demonstrating the adequate performance of our approach for biostatistical practice.

stat.ME

Testing for genetic interactions in complex disease with distance correlation

Understanding epistasis (genetic interaction) may shed some light on the genomic basis of common diseases, including disorders of maximum interest due to their high socioeconomic burden, like schizophrenia. Distance correlation is an association measure that characterises general statistical independence between random variables, not only the linear one. Here, we propose distance correlation as a novel tool for the detection of epistasis from case-control data of single-nucleotide polymorphisms (SNPs). On the methodological side, we highlight the derivation of the explicit asymptotic distribution of the test statistic. We show that this is the only way to obtain enough computational speed for the method to be used in practice, in a scenario where the resampling techniques found in the literature are impractical. Our simulations show satisfactory calibration of significance, as well as comparable or better power than existing methodology. We conclude with the application of our technique to a schizophrenia genetics dataset, obtaining biologically sound insights.

math.ST