arXiv subjects

Jay Harvey

Publications and source records attributed to Jay Harvey.

4 recordsLinked to original sources

arXiv2025

AI-Driven SEEG Channel Ranking for Epileptogenic Zone Localization

Stereo-electroencephalography (SEEG) is an invasive technique to implant depth electrodes and collect data for pre-surgery evaluation. Visual inspection of signals recorded from hundreds of channels is time consuming and inefficient. We propose a machine learning approach to rank the impactful channels by incorporating clinician's selection and computational finding. A classification model using XGBoost is trained to learn the discriminative features of each channel during ictal periods. Then, the SHapley Additive exPlanations (SHAP) scoring is utilized to rank SEEG channels based on their contribution to seizures. A channel extension strategy is also incorporated to expand the search space and identify suspicious epileptogenic zones beyond those selected by clinicians. For validation, SEEG data for five patients were analyzed showing promising results in terms of accuracy, consistency, and explainability.

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arXiv2024

An Unobtrusive and Lightweight Ear-worn System for Continuous Epileptic Seizure Detection

Epilepsy is one of the most common neurological diseases globally (around 50 million people worldwide). Fortunately, up to 70% of people with epilepsy could live seizure-free if properly diagnosed and treated, and a reliable technique to monitor the onset of seizures could improve the quality of life of patients who are constantly facing the fear of random seizure attacks. The scalp-based EEG test, despite being the gold standard for diagnosing epilepsy, is costly, necessitates hospitalization, demands skilled professionals for operation, and is discomforting for users. In this paper, we propose EarSD, a novel lightweight, unobtrusive, and socially acceptable ear-worn system to detect epileptic seizure onsets by measuring the physiological signals from behind the user's ears. EarSD includes an integrated custom-built sensing-computing-communication PCB to collect and amplify the signals of interest, remove the noises caused by motion artifacts and environmental impacts, and stream the data wirelessly to the computer/mobile phone nearby, where data are uploaded to the host computer for further processing. We conducted both in-lab and in-hospital experiments with epileptic seizure patients who were hospitalized for seizure studies.

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arXiv2023

Real-Time Diagnostic Integrity Meets Efficiency: A Novel Platform-Agnostic Architecture for Physiological Signal Compression

Head-based signals such as EEG, EMG, EOG, and ECG collected by wearable systems will play a pivotal role in clinical diagnosis, monitoring, and treatment of important brain disorder diseases. However, the real-time transmission of the significant corpus physiological signals over extended periods consumes substantial power and time, limiting the viability of battery-dependent physiological monitoring wearables. This paper presents a novel deep-learning framework employing a variational autoencoder (VAE) for physiological signal compression to reduce wearables' computational complexity and energy consumption. Our approach achieves an impressive compression ratio of 1:293 specifically for spectrogram data, surpassing state-of-the-art compression techniques such as JPEG2000, H.264, Direct Cosine Transform (DCT), and Huffman Encoding, which do not excel in handling physiological signals. We validate the efficacy of the compressed algorithms using collected physiological signals from real patients in the Hospital and deploy the solution on commonly used embedded AI chips (i.e., ARM Cortex V8 and Jetson Nano). The proposed framework achieves a 91% seizure detection accuracy using XGBoost, confirming the approach's reliability, practicality, and scalability.

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arXiv2021

Analog Seizure Detection for Implanted Responsive Neurostimulation

Epilepsy can be treated with medication, however, $30\%$ of epileptic patients are still drug resistive. Devices like responsive neurostimluation systems are implanted in select patients who may not be amenable to surgical resection. However, state-of-the-art devices suffer from low accuracy and high sensitivity. We propose a novel patient-specific seizure detection system based on naïve Bayesian inference using Müller C-elements. The system improves upon the current leading neurostimulation device, NeuroPace's RNS by implementing analog signal processing for feature extraction, minimizing the power consumption compared to the digital counterpart. Preliminary simulations were performed in MATLAB, demonstrating that through integrating multiple channels and features, up to $98\%$ detection accuracy for individual patients can be achieved. Similarly, power calculations were performed, demonstrating that the system uses $6.5 μW$ per channel, which when compared to the state-of-the-art NeuroPace system would increase battery life by up to $50 \%$.

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