arXiv subjects

Jeffrey A. Fessler

Publications and source records attributed to Jeffrey A. Fessler.

At least 19 recordsLinked to original sources

arXiv2026

MCLR: Improving Conditional Modeling via Inter-Class Likelihood-Ratio Maximization and Unifying Classifier-Free Guidance with Alignment Objectives

Diffusion models achieve strong performance in generative modeling, but their success often relies heavily on classifier-free guidance (CFG), an inference-time heuristic that modifies the sampling trajectory. In theory, diffusion models trained with standard denoising score matching (DSM) should recover the target data distribution, raising two fundamental questions: (i) why is inference-time guidance necessary in practice, and (ii) can its underlying effect be internalized into a principled training objective? In this work, we argue that a key limitation of standard DSM is insufficient inter-class separation. To address this issue, we propose MCLR, an alignment objective that explicitly maximizes inter-class likelihood-ratios during training. Fine-tuning diffusion models with MCLR induces CFG-like improvements under standard sampling, substantially improving guidance-free conditional generation and narrowing the gap to inference-time CFG. Beyond these empirical benefits, we show theoretically that the CFG-guided score is exactly the optimal solution to a sample-adaptive weighted MCLR objective. This result connects CFG to alignment-based objectives, providing a mechanistic interpretation of CFG as an implicit inference-time contrastive alignment procedure.

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arXiv2026

ALPCAH: Subspace Learning for Sample-wise Heteroscedastic Data

Principal component analysis (PCA) is a key tool in the field of data dimensionality reduction. However, some applications involve heterogeneous data that vary in quality due to noise characteristics associated with each data sample. Heteroscedastic methods aim to deal with such mixed data quality. This paper develops a subspace learning method, named ALPCAH, that can estimate the sample-wise noise variances and use this information to improve the estimate of the subspace basis associated with the low-rank structure of the data. Our method makes no distributional assumptions of the low-rank component and does not assume that the noise variances are known. Further, this method uses a soft rank constraint that does not require subspace dimension to be known. Additionally, this paper develops a matrix factorized version of ALPCAH, named LR-ALPCAH, that is much faster and more memory efficient at the cost of requiring subspace dimension to be known or estimated. Simulations and real data experiments show the effectiveness of accounting for data heteroscedasticity compared to existing algorithms. Code available at https://github.com/javiersc1/ALPCAH.

stat.ML↗

arXiv2026

Comparing Implicit Neural Representations and B-Splines for Continuous Function Fitting from Sparse Samples

Continuous signal representations are naturally suited for inverse problems, such as magnetic resonance imaging (MRI) and computed tomography, because the measurements depend on an underlying physically continuous signal. While classical methods rely on predefined analytical bases like B-splines, implicit neural representations (INRs) have emerged as a powerful alternative that use coordinate-based networks to parameterize continuous functions with implicitly defined bases. Despite their empirical success, direct comparisons of their intrinsic representation capabilities with conventional models remain limited. This preliminary empirical study compares a positional-encoded INR with a cubic B-spline model for continuous function fitting from sparse random samples, isolating the representation capacity difference by only using coefficient-domain Tikhonov regularization. Results demonstrate that, under oracle hyperparameter selection, the INR achieves a lower normalized root-mean-squared error, yielding sharper edge transitions and fewer oscillatory artifacts than the oracle-tuned B-spline model. Additionally, we show that a practical bilevel optimization framework for INR hyperparameter selection based on measurement data split effectively approximates oracle performance. These findings empirically support the superior representation capacity of INRs for sparse data fitting.

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arXiv2026

Scan-Adaptive Dynamic MRI Undersampling Using a Dictionary of Efficiently Learned Patterns

Cardiac MRI is limited by long acquisition times, which can lead to patient discomfort and motion artifacts. We aim to accelerate Cartesian dynamic cardiac MRI by learning efficient, scan-adaptive undersampling patterns that preserve diagnostic image quality. We develop a learning-based framework for designing scan- or slice-adaptive Cartesian undersampling masks tailored to dynamic cardiac MRI. Undersampling patterns are optimized using fully sampled training dynamic time-series data. At inference time, a nearest-neighbor search in low-frequency $k$-space selects an optimized mask from a dictionary of learned patterns. Our learned sampling approach improves reconstruction quality across multiple acceleration factors on public and in-house cardiac MRI datasets, including PSNR gains of 2-3 dB, reduced NMSE, improved SSIM, and higher radiologist ratings. The proposed scan-adaptive sampling framework enables faster and higher-quality dynamic cardiac MRI by adapting $k$-space sampling to individual scans.

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arXiv2026

Spatiotemporal Maps for Dynamic MRI Reconstruction

The partially separable functions (PSF) model is commonly adopted in dynamic MRI reconstruction, as is the underlying signal model in many reconstruction methods including the ones relying on low-rank assumptions. Even though the PSF model offers a parsimonious representation of the dynamic MRI signal in several applications, its representation capabilities tend to decrease in scenarios where voxels present different temporal/spectral characteristics at different spatial locations. In this work we account for this limitation by proposing a new model, called spatiotemporal maps (STMs), that leverages autoregressive properties of (k, t)-space. The STM model decomposes the spatiotemporal MRI signal into a sum of components, each one consisting of a product between a spatial function and a temporal function that depends on the spatial location. The proposed model can be interpreted as an extension of the PSF model whose temporal functions are independent of the spatial location. We show that spatiotemporal maps can be efficiently computed from autocalibration data by using advanced signal processing and randomized linear algebra techniques, enabling STMs to be used as part of many reconstruction frameworks for accelerated dynamic MRI. As proof-of-concept illustrations, we show that STMs can be used to reconstruct both 2D single-channel animal gastrointestinal MRI data and 3D multichannel human functional MRI data.

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arXiv2026

Scan-Adaptive MRI Undersampling Using Neighbor-based Optimization (SUNO)

Accelerated MRI involves collecting partial $k$-space measurements to reduce acquisition time, patient discomfort, and motion artifacts, and typically uses regular undersampling patterns or human-designed schemes. Recent works have studied population-adaptive sampling patterns learned from a group of patients (or scans). However, such patterns can be sub-optimal for individual scans, as they may fail to capture scan or slice-specific details, and their effectiveness can depend on the size and composition of the population. To overcome this issue, we propose a framework for jointly learning scan-adaptive Cartesian undersampling patterns and a corresponding reconstruction model from a training set. We use an alternating algorithm for learning the sampling patterns and the reconstruction model where we use an iterative coordinate descent (ICD) based offline optimization of scan-adaptive $k$-space sampling patterns for each example in the training set. A nearest neighbor search is then used to select the scan-adaptive sampling pattern at test time from initially acquired low-frequency $k$-space information. We applied the proposed framework (dubbed SUNO) to the fastMRI multi-coil knee and brain datasets, demonstrating improved performance over the currently used undersampling patterns at both $4\times$ and $8\times$ acceleration factors in terms of both visual quality and quantitative metrics. The code for the proposed framework is available at https://github.com/sidgautam95/adaptive-sampling-mri-suno. This paper has been accepted for publication in IEEE Transactions on Computational Imaging. The final published version is available at https://doi.org/10.1109/TCI.2026.3653330.

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arXiv2026

A Convergent Generalized Krylov Subspace Method for Compressed Sensing MRI Reconstruction with Gradient-Driven Denoisers

Model-based reconstruction plays a key role in compressed sensing (CS) MRI, as it incorporates effective image regularizers to improve the quality of reconstruction. The Plug-and-Play and Regularization-by-Denoising frameworks leverage advanced denoisers (e.g., convolutional neural network (CNN)-based denoisers) and have demonstrated strong empirical performance. However, their theoretical guarantees remain limited, as practical CNNs often violate key assumptions. In contrast, gradient-driven denoisers achieve competitive performance, and the required assumptions for theoretical analysis are easily satisfied. However, solving the associated optimization problem remains computationally demanding. To address this challenge, we propose a generalized Krylov subspace method (GKSM) to solve the optimization problem efficiently. Moreover, we also establish rigorous convergence guarantees for GKSM in nonconvex settings. Numerical experiments on CS MRI reconstruction with spiral and radial acquisitions validate both the computational efficiency of GKSM and the accuracy of the theoretical predictions. The proposed optimization method is applicable to any linear inverse problem.

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arXiv2025

Local Patches Meet Global Context: Scalable 3D Diffusion Priors for Computed Tomography Reconstruction

Diffusion models learn strong image priors that can be leveraged to solve inverse problems like medical image reconstruction. However, for real-world applications such as 3D Computed Tomography (CT) imaging, directly training diffusion models on 3D data presents significant challenges due to the high computational demands of extensive GPU resources and large-scale datasets. Existing works mostly reuse 2D diffusion priors to address 3D inverse problems, but fail to fully realize and leverage the generative capacity of diffusion models for high-dimensional data. In this study, we propose a novel 3D patch-based diffusion model that can learn a fully 3D diffusion prior from limited data, enabling scalable generation of high-resolution 3D images. Our core idea is to learn the prior of 3D patches to achieve scalable efficiency, while coupling local and global information to guarantee high-quality 3D image generation, by modeling the joint distribution of position-aware 3D local patches and downsampled 3D volume as global context. Our approach not only enables high-quality 3D generation, but also offers an unprecedentedly efficient and accurate solution to high-resolution 3D inverse problems. Experiments on 3D CT reconstruction across multiple datasets show that our method outperforms state-of-the-art methods in both performance and efficiency, notably achieving high-resolution 3D reconstruction of $512 \times 512 \times 256$ ($\sim$20 mins).

cs.CV↗

arXiv2025

Smooth optimization using global and local low-rank regularizers

Many inverse problems and signal processing problems involve low-rank regularizers based on the nuclear norm. Commonly, proximal gradient methods (PGM) are adopted to solve this type of non-smooth problems as they can offer fast and guaranteed convergence. However, PGM methods cannot be simply applied in settings where low-rank models are imposed locally on overlapping patches; therefore, heuristic approaches have been proposed that lack convergence guarantees. In this work we propose to replace the nuclear norm with a smooth approximation in which a Huber-type function is applied to each singular value. By providing a theoretical framework based on singular value function theory, we show that important properties can be established for the proposed regularizer, such as: convexity, differentiability, and Lipschitz continuity of the gradient. Moreover, we provide a closed-form expression for the regularizer gradient, enabling the use of standard iterative gradient-based optimization algorithms (e.g., nonlinear conjugate gradient) that can easily address the case of overlapping patches and have well-known convergence guarantees. In addition, we provide a novel step-size selection strategy based on a quadratic majorizer of the line-search function that leverages the Huber characteristics of the proposed regularizer. Finally, we assess the proposed optimization framework by providing empirical results in dynamic magnetic resonance imaging (MRI) reconstruction in the context of local low-rank models with overlapping patches.

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arXiv2025

Using Randomized Nyström Preconditioners to Accelerate Variational Image Reconstruction

Model-based iterative reconstruction plays a key role in solving inverse problems. However, the associated minimization problems are generally large-scale, nonsmooth, and sometimes even nonconvex, which present challenges in designing efficient iterative solvers. Preconditioning methods can significantly accelerate the convergence of iterative methods. In some applications, computing preconditioners on-the-fly is beneficial. Moreover, forward models in image reconstruction are typically represented as operators, and the corresponding explicit matrices are often unavailable, which brings additional challenges in designing preconditioners. Therefore, for practical use, computing and applying preconditioners should be computationally inexpensive. This paper adapts the randomized Nyström approximation to compute effective preconditioners that accelerate image reconstruction without requiring an explicit matrix for the forward model. We leverage modern GPU computational platforms to compute the preconditioner on-the-fly. Moreover, we propose efficient approaches for applying the preconditioners to problems with classical nonsmooth regularizers, i.e., wavelet, total variation, and Hessian Schatten-norm. Our numerical results on image deblurring, super-resolution with impulsive noise, and 2D computed tomography reconstruction illustrate the efficiency and effectiveness of the proposed preconditioner.

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arXiv2025

Convergent Complex Quasi-Newton Proximal Methods for Gradient-Driven Denoisers in Compressed Sensing MRI Reconstruction

In compressed sensing (CS) MRI, model-based methods are pivotal to achieving accurate reconstruction. One of the main challenges in model-based methods is finding an effective prior to describe the statistical distribution of the target image. Plug-and-Play (PnP) and REgularization by Denoising (RED) are two general frameworks that use denoisers as the prior. While PnP/RED methods with convolutional neural networks (CNNs) based denoisers outperform classical hand-crafted priors in CS MRI, their convergence theory relies on assumptions that do not hold for practical CNNs. The recently developed gradient-driven denoisers offer a framework that bridges the gap between practical performance and theoretical guarantees. However, the numerical solvers for the associated minimization problem remain slow for CS MRI reconstruction. This paper proposes a complex quasi-Newton proximal method that achieves faster convergence than existing approaches. To address the complex domain in CS MRI, we propose a modified Hessian estimation method that guarantees Hermitian positive definiteness. Furthermore, we provide a rigorous convergence analysis of the proposed method for nonconvex settings. Numerical experiments on both Cartesian and non-Cartesian sampling trajectories demonstrate the effectiveness and efficiency of our approach.

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arXiv2025

Learning Image Priors through Patch-based Diffusion Models for Solving Inverse Problems

Diffusion models can learn strong image priors from underlying data distribution and use them to solve inverse problems, but the training process is computationally expensive and requires lots of data. Such bottlenecks prevent most existing works from being feasible for high-dimensional and high-resolution data such as 3D images. This paper proposes a method to learn an efficient data prior for the entire image by training diffusion models only on patches of images. Specifically, we propose a patch-based position-aware diffusion inverse solver, called PaDIS, where we obtain the score function of the whole image through scores of patches and their positional encoding and utilize this as the prior for solving inverse problems. First of all, we show that this diffusion model achieves an improved memory efficiency and data efficiency while still maintaining the capability to generate entire images via positional encoding. Additionally, the proposed PaDIS model is highly flexible and can be plugged in with different diffusion inverse solvers (DIS). We demonstrate that the proposed PaDIS approach enables solving various inverse problems in both natural and medical image domains, including CT reconstruction, deblurring, and superresolution, given only patch-based priors. Notably, PaDIS outperforms previous DIS methods trained on entire image priors in the case of limited training data, demonstrating the data efficiency of our proposed approach by learning patch-based prior.

cs.CV↗

arXiv2025

Streaming Heteroscedastic Probabilistic PCA with Missing Data

Streaming principal component analysis (PCA) is an integral tool in large-scale machine learning for rapidly estimating low-dimensional subspaces from very high-dimensional data arriving at a high rate. However, modern datasets increasingly combine data from a variety of sources, and thus may exhibit heterogeneous quality across samples. Standard streaming PCA algorithms do not account for non-uniform noise, so their subspace estimates can quickly degrade. While the recently proposed Heteroscedastic Probabilistic PCA Technique (HePPCAT) addresses this heterogeneity, it was not designed to handle streaming data, which may exhibit non-stationary behavior. Moreover, HePPCAT does not allow for missing entries in the data, which can be common in streaming data. This paper proposes the Streaming HeteroscedASTic Algorithm for PCA (SHASTA-PCA) to bridge this divide. SHASTA-PCA employs a stochastic alternating expectation maximization approach that jointly learns the low-rank latent factors and the unknown noise variances from streaming data that may have missing entries and heteroscedastic noise, all while maintaining a low memory and computational footprint. Numerical experiments demonstrate the superior subspace estimation of our method compared to state-of-the-art streaming PCA algorithms in the heteroscedastic setting. Finally, we illustrate SHASTA-PCA applied to highly heterogeneous real data from astronomy.

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arXiv2025

Bilevel Optimized Implicit Neural Representation for Scan-Specific Accelerated MRI Reconstruction

Deep Learning (DL) methods can reconstruct highly accelerated magnetic resonance imaging (MRI) scans, but they rely on application-specific large training datasets and often generalize poorly to out-of-distribution data. Self-supervised deep learning algorithms perform scan-specific reconstructions, but still require complicated hyperparameter tuning based on the acquisition and often offer limited acceleration. This work develops a bilevel-optimized implicit neural representation (INR) approach for scan-specific MRI reconstruction. The method automatically optimizes the hyperparameters for a given acquisition protocol, enabling a tailored reconstruction without training data. The proposed algorithm uses Gaussian process regression to optimize INR hyperparameters, accommodating various acquisitions. The INR includes a trainable positional encoder for high-dimensional feature embedding and a small multilayer perceptron for decoding. The bilevel optimization is computationally efficient, requiring only a few minutes per typical 2D Cartesian scan. On scanner hardware, the subsequent scan-specific reconstruction-using offline-optimized hyperparameters-is completed within seconds and achieves improved image quality compared to previous model-based and self-supervised learning methods.

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arXiv2024

Patch-Based Diffusion Models Beat Whole-Image Models for Mismatched Distribution Inverse Problems

Diffusion models have achieved excellent success in solving inverse problems due to their ability to learn strong image priors, but existing approaches require a large training dataset of images that should come from the same distribution as the test dataset. When the training and test distributions are mismatched, artifacts and hallucinations can occur in reconstructed images due to the incorrect priors. In this work, we systematically study out of distribution (OOD) problems where a known training distribution is first provided. We first study the setting where only a single measurement obtained from the unknown test distribution is available. Next we study the setting where a very small sample of data belonging to the test distribution is available, and our goal is still to reconstruct an image from a measurement that came from the test distribution. In both settings, we use a patch-based diffusion prior that learns the image distribution solely from patches. Furthermore, in the first setting, we include a self-supervised loss that helps the network output maintain consistency with the measurement. Extensive experiments show that in both settings, the patch-based method can obtain high quality image reconstructions that can outperform whole-image models and can compete with methods that have access to large in-distribution training datasets. Furthermore, we show how whole-image models are prone to memorization and overfitting, leading to artifacts in the reconstructions, while a patch-based model can resolve these issues.

cs.CV↗

arXiv2024

Provable Preconditioned Plug-and-Play Approach for Compressed Sensing MRI Reconstruction

Model-based methods play a key role in the reconstruction of compressed sensing (CS) MRI. Finding an effective prior to describe the statistical distribution of the image family of interest is crucial for model-based methods. Plug-and-play (PnP) is a general framework that uses denoising algorithms as the prior or regularizer. Recent work showed that PnP methods with denoisers based on pretrained convolutional neural networks outperform other classical regularizers in CS MRI reconstruction. However, the numerical solvers for PnP can be slow for CS MRI reconstruction. This paper proposes a preconditioned PnP (P^2nP) method to accelerate the convergence speed. Moreover, we provide proofs of the fixed-point convergence of the P^2nP iterates. Numerical experiments on CS MRI reconstruction with non-Cartesian sampling trajectories illustrate the effectiveness and efficiency of the P^2nP approach.

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arXiv2024

Swap-Net: A Memory-Efficient 2.5D Network for Sparse-View 3D Cone Beam CT Reconstruction

Reconstructing 3D cone beam computed tomography (CBCT) images from a limited set of projections is an important inverse problem in many imaging applications from medicine to inertial confinement fusion (ICF). The performance of traditional methods such as filtered back projection (FBP) and model-based regularization is sub-optimal when the number of available projections is limited. In the past decade, deep learning (DL) has gained great popularity for solving CT inverse problems. A typical DL-based method for CBCT image reconstruction is to learn an end-to-end mapping by training a 2D or 3D network. However, 2D networks fail to fully use global information. While 3D networks are desirable, they become impractical as image sizes increase because of the high memory cost. This paper proposes Swap-Net, a memory-efficient 2.5D network for sparse-view 3D CBCT image reconstruction. Swap-Net uses a sequence of novel axes-swapping operations to produce 3D volume reconstruction in an end-to-end fashion without using full 3D convolutions. Simulation results show that Swap-Net consistently outperforms baseline methods both quantitatively and qualitatively in terms of reducing artifacts and preserving details of complex hydrodynamic simulations of relevance to the ICF community.

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arXiv2024

Shorter SPECT Scans Using Self-supervised Coordinate Learning to Synthesize Skipped Projection Views

Purpose: This study addresses the challenge of extended SPECT imaging duration under low-count conditions, as encountered in Lu-177 SPECT imaging, by developing a self-supervised learning approach to synthesize skipped SPECT projection views, thus shortening scan times in clinical settings. Methods: We employed a self-supervised coordinate-based learning technique, adapting the neural radiance field (NeRF) concept in computer vision to synthesize under-sampled SPECT projection views. For each single scan, we used self-supervised coordinate learning to estimate skipped SPECT projection views. The method was tested with various down-sampling factors (DFs=2, 4, 8) on both Lu-177 phantom SPECT/CT measurements and clinical SPECT/CT datasets, from 11 patients undergoing Lu-177 DOTATATE and 6 patients undergoing Lu-177 PSMA-617 radiopharmaceutical therapy. Results: For SPECT reconstructions, our method outperformed the use of linearly interpolated projections and partial projection views in relative contrast-to-noise-ratios (RCNR) averaged across different downsampling factors: 1) DOTATATE: 83% vs. 65% vs. 67% for lesions and 86% vs. 70% vs. 67% for kidney, 2) PSMA: 76% vs. 69% vs. 68% for lesions and 75% vs. 55% vs. 66% for organs, including kidneys, lacrimal glands, parotid glands, and submandibular glands. Conclusion: The proposed method enables reduction in acquisition time (by factors of 2, 4, or 8) while maintaining quantitative accuracy in clinical SPECT protocols by allowing for the collection of fewer projections. Importantly, the self-supervised nature of this NeRF-based approach eliminates the need for extensive training data, instead learning from each patient's projection data alone. The reduction in acquisition time is particularly relevant for imaging under low-count conditions and for protocols that require multiple-bed positions such as whole-body imaging.

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