arXiv subjects

Jelena Bradic

Publications and source records attributed to Jelena Bradic.

42 records · Page 3Linked to original sources

arXiv2016

Robust Confidence Intervals in High-Dimensional Left-Censored Regression

This paper develops robust confidence intervals in high-dimensional and left-censored regression. Type-I censored regression models are extremely common in practice, where a competing event makes the variable of interest unobservable. However, techniques developed for entirely observed data do not directly apply to the censored observations. In this paper, we develop smoothed estimating equations that augment the de-biasing method, such that the resulting estimator is adaptive to censoring and is more robust to the misspecification of the error distribution. We propose a unified class of robust estimators, including Mallow's, Schweppe's and Hill-Ryan's one-step estimator. In the ultra-high-dimensional setting, where the dimensionality can grow exponentially with the sample size, we show that as long as the preliminary estimator converges faster than $n^{-1/4}$, the one-step estimator inherits asymptotic distribution of fully iterated version. Moreover, we show that the size of the residuals of the Bahadur representation matches those of the simple linear models, $s^{3/4 } (\log (p \vee n))^{3/4} / n^{1/4}$ -- that is, the effects of censoring asymptotically disappear. Simulation studies demonstrate that our method is adaptive to the censoring level and asymmetry in the error distribution, and does not lose efficiency when the errors are from symmetric distributions. Finally, we apply the developed method to a real data set from the MAQC-II repository that is related to the HIV-1 study.

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arXiv2015

Boosting in the presence of outliers: adaptive classification with non-convex loss functions

This paper examines the role and efficiency of the non-convex loss functions for binary classification problems. In particular, we investigate how to design a simple and effective boosting algorithm that is robust to the outliers in the data. The analysis of the role of a particular non-convex loss for prediction accuracy varies depending on the diminishing tail properties of the gradient of the loss -- the ability of the loss to efficiently adapt to the outlying data, the local convex properties of the loss and the proportion of the contaminated data. In order to use these properties efficiently, we propose a new family of non-convex losses named $γ$-robust losses. Moreover, we present a new boosting framework, {\it Arch Boost}, designed for augmenting the existing work such that its corresponding classification algorithm is significantly more adaptable to the unknown data contamination. Along with the Arch Boosting framework, the non-convex losses lead to the new class of boosting algorithms, named adaptive, robust, boosting (ARB). Furthermore, we present theoretical examples that demonstrate the robustness properties of the proposed algorithms. In particular, we develop a new breakdown point analysis and a new influence function analysis that demonstrate gains in robustness. Moreover, we present new theoretical results, based only on local curvatures, which may be used to establish statistical and optimization properties of the proposed Arch boosting algorithms with highly non-convex loss functions. Extensive numerical calculations are used to illustrate these theoretical properties and reveal advantages over the existing boosting methods when data exhibits a number of outliers.

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arXiv2015

Randomized maximum-contrast selection: subagging for large-scale regression

We introduce a very general method for sparse and large-scale variable selection. The large-scale regression settings is such that both the number of parameters and the number of samples are extremely large. The proposed method is based on careful combination of penalized estimators, each applied to a random projection of the sample space into a low-dimensional space. In one special case that we study in detail, the random projections are divided into non-overlapping blocks; each consisting of only a small portion of the original data. Within each block we select the projection yielding the smallest out-of-sample error. Our random ensemble estimator then aggregates the results according to new maximal-contrast voting scheme to determine the final selected set. Our theoretical results illuminate the effect on performance of increasing the number of non-overlapping blocks. Moreover, we demonstrate that statistical optimality is retained along with the computational speedup. The proposed method achieves minimax rates for approximate recovery over all estimators using the full set of samples. Furthermore, our theoretical results allow the number of subsamples to grow with the subsample size and do not require irrepresentable condition. The estimator is also compared empirically with several other popular high-dimensional estimators via an extensive simulation study, which reveals its excellent finite-sample performance.

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arXiv2014

Structured Estimation in Nonparameteric Cox Model

To better understand the interplay of censoring and sparsity we develop finite sample properties of nonparametric Cox proportional hazard's model. Due to high impact of sequencing data, carrying genetic information of each individual, we work with over-parametrized problem and propose general class of group penalties suitable for sparse structured variable selection and estimation. Novel non-asymptotic sandwich bounds for the partial likelihood are developed. We establish how they extend notion of local asymptotic normality (LAN) of Le Cam's. Such non-asymptotic LAN principles are further extended to high dimensional spaces where $p \gg n$. Finite sample prediction properties of penalized estimator in non-parametric Cox proportional hazards model, under suitable censoring conditions, agree with those of penalized estimator in linear models.

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arXiv2012

Regularization for Cox's proportional hazards model with NP-dimensionality

High throughput genetic sequencing arrays with thousands of measurements per sample and a great amount of related censored clinical data have increased demanding need for better measurement specific model selection. In this paper we establish strong oracle properties of nonconcave penalized methods for nonpolynomial (NP) dimensional data with censoring in the framework of Cox's proportional hazards model. A class of folded-concave penalties are employed and both LASSO and SCAD are discussed specifically. We unveil the question under which dimensionality and correlation restrictions can an oracle estimator be constructed and grasped. It is demonstrated that nonconcave penalties lead to significant reduction of the "irrepresentable condition" needed for LASSO model selection consistency. The large deviation result for martingales, bearing interests of its own, is developed for characterizing the strong oracle property. Moreover, the nonconcave regularized estimator, is shown to achieve asymptotically the information bound of the oracle estimator. A coordinate-wise algorithm is developed for finding the grid of solution paths for penalized hazard regression problems, and its performance is evaluated on simulated and gene association study examples.

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arXiv2010

Penalized Composite Quasi-Likelihood for Ultrahigh-Dimensional Variable Selection

In high-dimensional model selection problems, penalized simple least-square approaches have been extensively used. This paper addresses the question of both robustness and efficiency of penalized model selection methods, and proposes a data-driven weighted linear combination of convex loss functions, together with weighted $L_1$-penalty. It is completely data-adaptive and does not require prior knowledge of the error distribution. The weighted $L_1$-penalty is used both to ensure the convexity of the penalty term and to ameliorate the bias caused by the $L_1$-penalty. In the setting with dimensionality much larger than the sample size, we establish a strong oracle property of the proposed method that possesses both the model selection consistency and estimation efficiency for the true non-zero coefficients. As specific examples, we introduce a robust method of composite L1-L2, and optimal composite quantile method and evaluate their performance in both simulated and real data examples.

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