arXiv subjects

Jiahua Zhang

Publications and source records attributed to Jiahua Zhang.

8 recordsLinked to original sources

arXiv2026

All-optical intracellular thermal profiling using nanodiamond-based "thermal radar"

The local thermal conductivity (\k{appa}) is a pivotal biophysical parameter, governing intracellular heat flux and underlying functional processes like metabolic regulation and stress response. However, label-free mapping with sub-micron resolution in living cells remains challenge. Here, we present frequency-domain fluorescence thermometry (FD-FTM), an all-optical method based on a hybrid nanodiamond-on-gold-membrane platform, which enables quantitative mapping of \k{appa} in biological systems. Fluorescence nanodiamonds (FNDs) are deposited on substrates coated with a 50 nm gold membrane, where FNDs function as nanoscale thermometers, and the gold membrane serves as a photothermal heat source. We validate FD-FTM across reference materials and biological media, with fitting uncertainties of ~10%. By varying the modulation frequency, we tune the thermal penetration depths, enabling controlled heat propagation from the substrate to the cell nucleus. The method delivers sensitivity sufficient to resolve changes in biofluid thermal conductivity on the order of 16% relative to water. Using these capabilities, we demonstrate non-invasive thermal profiling across scales: at the cellular level, nuclear chromatin packing yields \k{appa} higher by ~10% relative to the cytoplasm; at the organelle level, we resolve \k{appa} variations associated with protein aggregates formed during liquid-liquid phase separation in an amyotrophic lateral sclerosis disease model. Temporal measurements in living cells over 30 minutes further reveal spatially resolved intracellular responses to osmotic stress, linking nanoscale thermal dynamics to biomolecular condensates. These results establish FD-FTM as a label-free, robust, and quantitative platform for thermally decoding intracellular processes, opening avenues for studying metabolic heterogeneity, disease mechanisms, and therapeutic responses.

physics.bio-ph↗

arXiv2024

Towards ubiquitous radio access using nanodiamond based quantum receivers

The development of sixth-generation (6G) wireless communication systems demands innovative solutions to address challenges in the deployment of a large number of base stations and the detection of multi-band signals. Quantum technology, specifically nitrogen vacancy (NV) centers in diamonds, offers promising potential for the development of compact, robust receivers capable of supporting multiple users. For the first time, we propose a multiple access scheme using fluorescent nanodiamonds (FNDs) containing NV centers as nano-antennas. The unique response of each FND to applied microwaves allows for distinguishable patterns of fluorescence intensities, enabling multi-user signal demodulation. We demonstrate the effectiveness of our FNDs-implemented receiver by simultaneously transmitting two uncoded digitally modulated information bit streams from two separate transmitters, achieving a low bit error ratio. Moreover, our design supports tunable frequency band communication and reference-free signal decoupling, reducing communication overhead. Furthermore, we implement a miniaturized device comprising all essential components, highlighting its practicality as a receiver serving multiple users simultaneously. This approach paves the way for the integration of quantum sensing technologies in future 6G wireless communication networks.

eess.SP↗

arXiv2024

ResVG: Enhancing Relation and Semantic Understanding in Multiple Instances for Visual Grounding

Visual grounding aims to localize the object referred to in an image based on a natural language query. Although progress has been made recently, accurately localizing target objects within multiple-instance distractions (multiple objects of the same category as the target) remains a significant challenge. Existing methods demonstrate a significant performance drop when there are multiple distractions in an image, indicating an insufficient understanding of the fine-grained semantics and spatial relationships between objects. In this paper, we propose a novel approach, the Relation and Semantic-sensitive Visual Grounding (ResVG) model, to address this issue. Firstly, we enhance the model's understanding of fine-grained semantics by injecting semantic prior information derived from text queries into the model. This is achieved by leveraging text-to-image generation models to produce images representing the semantic attributes of target objects described in queries. Secondly, we tackle the lack of training samples with multiple distractions by introducing a relation-sensitive data augmentation method. This method generates additional training data by synthesizing images containing multiple objects of the same category and pseudo queries based on their spatial relationships. The proposed ReSVG model significantly improves the model's ability to comprehend both object semantics and spatial relations, leading to enhanced performance in visual grounding tasks, particularly in scenarios with multiple-instance distractions. We conduct extensive experiments to validate the effectiveness of our methods on five datasets. Code is available at https://github.com/minghangz/ResVG.

cs.CV↗

arXiv2024

A diamond heater-thermometer microsensor for measuring localized thermal conductivity: a case study in gelatin hydrogel

Understanding the microscopic thermal effects of the hydrogel is important for its application in diverse fields, including thermal-related studies in tissue engineering and thermal management for flexible electronic devices. In recent decades, localized thermal properties, such as thermal conductivity, have often been overlooked due to technical limitations. To tackle this, we propose a new hybrid diamond microsensor that is capable of simultaneous temperature control and readout in a decoupled manner. Specifically, the sensor consists of a silicon pillar (heater) at about 10 microns in length, topped by a micron-sized diamond particle that contains silicon-vacancy (SiV) centers (thermometer) with 1.29 K*Hz^(-1/2) temperature measurement sensitivity. Combining this innovative, scalable sensor with a newly established simulation model that can transform heating-laser-induced temperature change into thermal conductivity, we introduced an all-optical decoupled method with about 0.05 W/(m* K) precision, which can reduce laser crosstalk. For the first time, we track the thermal conductivity change of hydrogels during the gelation process and demonstrate the existence of variation. We introduce a rapid, undisturbed technique for measuring microscale thermal conductivity, potentially serving as a valuable tool for cellular thermometry and highlight the idea that decoupling can reduce crosstalk from different lasers, which is helpful for quantum sensing.

physics.optics↗

arXiv2023

YUAN 2.0: A Large Language Model with Localized Filtering-based Attention

In this work, we develop and release Yuan 2.0, a series of large language models with parameters ranging from 2.1 billion to 102.6 billion. The Localized Filtering-based Attention (LFA) is introduced to incorporate prior knowledge of local dependencies of natural language into Attention. A data filtering and generating system is presented to build pre-training and fine-tuning dataset in high quality. A distributed training method with non-uniform pipeline parallel, data parallel, and optimizer parallel is proposed, which greatly reduces the bandwidth requirements of intra-node communication, and achieves good performance in large-scale distributed training. Yuan 2.0 models display impressive ability in code generation, math problem-solving, and chatting compared with existing models. The latest version of YUAN 2.0, including model weights and source code, is accessible at Github.

cs.CL↗

arXiv2023

Cross-correlated quantum thermometry using diamond containing dual-defect centers

The contactless temperature measurement at micro/nanoscale is vital to a broad range of fields in modern science and technology. The nitrogen vacancy (NV) center, a kind of diamond defect with unique spin-dependent photoluminescence, has been recognized as one of the most promising nanothermometers. However, this quantum thermometry technique has been prone to a number of possible perturbations, which will unavoidably degrade its actual temperature sensitivity. Here, for the first time, we have developed a cross-validated optical thermometry method using a bulk diamond sample containing both NV centers and silicon vacancy (SiV) centers. Particularly, the latter allowing all-optical method has been intrinsically immune to those influencing perturbations for the NV-based quantum thermometry, hence serving as a real-time cross validation system. As a proof-of-concept demonstration, we have shown a trustworthy temperature measurement under the influence of varying magnetic fields. This multi-modality approach allows a synchronized cross-validation of the measured temperature, which is required for micro/nanoscale quantum thermometry in complicated environments such as a living cell.

quant-ph↗

arXiv2023

High-precision and low-latency widefield diamond quantum sensing with neuromorphic vision sensors

During the past decade, interest has grown significantly in developing ultrasensitive widefield diamond magnetometry for various applications. Despite attempts to improve the adoption of conventional frame-based sensors, achieving high temporal resolution and sensitivity simultaneously remains a key challenge. This is largely due to the transfer and processing of massive amounts of sensor data to capture the widefield fluorescence intensity changes of spin defects in diamonds. In this study, we adopt a neuromorphic vision sensor to address this issue. This sensor pre-processes the detected signals in optically detected magnetic resonance (ODMR) measurements for quantum sensing, employing a working principle that closely resembles the operation of the human vision system. By encoding the changes of light intensity into spikes, this approach results in a vast dynamic range, high temporal resolution, and exceptional signal-to-background ratio. After a thorough evaluation of theoretical feasibility, our experiment with an off-the-shelf event camera demonstrated a 13x improvement in temporal resolution with comparable precision of detecting ODMR resonance frequencies compared with the state-of-the-art highly specialized frame-based approach. A specialized camera system with the same mechanism has the potential to enhance these benefits further. This performance improvement is primarily attributable to orders of magnitude smaller data volumes and, thus, reduced latency. We further showcase the deployment of this technology in monitoring dynamically modulated laser heating of gold nanoparticles coated on a diamond surface, a recognizably difficult task using existing approaches. The current development provides new insights for high-precision and low-latency widefield quantum sensing, with possibilities for integration with emerging memory devices for more efficient event-based data processing.

physics.ins-det↗

arXiv2021

Morning commute in congested urban rail transit system: A macroscopic model for equilibrium distribution of passenger arrivals

This paper proposes a macroscopic model to describe the equilibrium distribution of passenger arrivals for the morning commute problem in a congested urban rail transit system. We use a macroscopic train operation sub-model developed by Seo et al (2017a,b) to express the interaction between the dynamics of passengers and trains in a simplified manner while maintaining their essential physical relations. The equilibrium conditions of the proposed model are derived and a solution method is provided. The characteristics of the equilibrium are then examined through analytical discussion and numerical examples. As an application of the proposed model, we analyze a simple time-dependent timetable optimization problem with equilibrium constraints and reveal that a "capacity increasing paradox" exists such that a higher dispatch frequency can increase the equilibrium cost. Furthermore, insights into the design of the timetable are obtained and the timetable influence on passengers' equilibrium travel costs are evaluated.

eess.SY↗