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Jiajia Tang

Publications and source records attributed to Jiajia Tang.

2 recordsLinked to original sources

The Parts Are Greater Than the Sum: Automated Task Sequencing for Efficient Training of Multi-Policy LLMs

Parameter-Efficient Fine-Tuning (PEFT) commonly adapts large language models using a single shared Low-Rank Adapter (LoRA). This shared optimization space often suffers from interference when adapting heterogeneous task sequences, leading to poor transfer and catastrophic forgetting. Existing approaches mainly improve adapter expressiveness by increasing parameter capacity or composing multiple adapters, yet they still rely on a shared optimization path. In this paper, we propose an optimization-path organization framework for parameter-efficient fine-tuning of large language models, implemented as an automatic multi-policy PEFT architecture. Specifically, optimization-compatible adaptation paths are automatically organized through task grouping and task sequencing under a fixed parameter budget. The organized optimization paths are implemented as independent Quantized Low-Rank Adapters (QLoRA), enabling heterogeneous tasks to be optimized in decoupled adaptation spaces while preserving positive transfer among compatible tasks. Experiments on the TRACE benchmark demonstrate that performance consistently improves from conventional single-policy PEFT to multi-policy PEFT, with the proposed automatic multi-policy framework achieving the best performance of 44.78 under the same trainable capacity. This suggests that optimization-path organization is more effective than simply increasing adapter capacity for heterogeneous parameter-efficient fine-tuning.

cs.LG

Multimodal Radiomics Model for Predicting Gold Nanoparticles Accumulation in Mouse Tumors

Background: Nanoparticles can accumulate in solid tumors, serving as diagnostic or therapeutic agents for cancer. Clinical translation is challenging due to low accumulation in tumors and heterogeneity between tumor types and individuals. Tools to identify this heterogeneity and predict nanoparticle accumulation are needed. Advanced imaging techniques combined with radiomics and AI may offer a solution. Methods: 183 mice were used to create seven subcutaneous tumor models, with three sizes (15nm, 40nm, 70nm) of gold nanoparticles injected via the tail vein. Accumulation was measured using ICP-OES. Data were divided into training and test sets (7:3). Tumors were categorized into high and low uptake groups based on the median value of the training set. Before injection, multimodal imaging data (CT, B-mode ultrasound, SWE, CEUS) were acquired, and radiomics features extracted. LASSO and RFE algorithms built a radiomics signature. This, along with tumor type and mean values from CT and SWE, constructed the best model using SVM. For each tumor in the test set, the radiomics signature predicted gold nanoparticle uptake. Model performance was evaluated by AUC. Results: Significant variability in gold nanoparticle accumulation was observed among tumors (P < 0.001). The median accumulation in the training set was 3.37% ID/g. Nanoparticle size was not a main determinant of uptake (P > 0.05). The composite model based on radiomics signature outperformed the basic model in both training (AUC 0.93 vs. 0.68) and testing (0.78 vs. 0.61) datasets. Conclusion: The composite model identifies tumor heterogeneity and predicts high uptake of gold nanoparticles, improving patient stratification and supporting nanomedicine's clinical application.

q-bio.QM