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Jiangfeng Xiao

Publications and source records attributed to Jiangfeng Xiao.

2 recordsLinked to original sources

GRASPrune: Global Gating for Budgeted Structured Pruning of Large Language Models

Large language models (LLMs) are expensive to serve because model parameters, attention computation, and KV caches impose substantial memory and latency costs. We present GRASPrune, a structured pruning framework applied after pretraining that jointly prunes FFN channels and KV head groups under a single global budget. Instead of learning importance scores without constraints and applying the budget only after training, GRASPrune learns lightweight gate scores with a projected straight-through estimator that enforces a hard mask satisfying the budget at every step while keeping the backbone weights frozen. After the mask is fixed, we calibrate scaling factors on the retained units to mitigate scale mismatch caused by pruning, and fold these factors into the pruned weights to obtain a smaller dense checkpoint with no extra parameters at inference. On LLaMA-2-7B, GRASPrune removes 50% of parameters and achieves 12.18 perplexity on WikiText-2 while maintaining competitive average zero-shot accuracy on five benchmarks, using four epochs on 512 unlabeled calibration sequences on a single NVIDIA A100 80GB GPU without any full model fine-tuning.

cs.AI

Comprehensive Multimodal and Multiscale Analysis of Alzheimer Disease in 5xFAD Mice: Optical Spectroscopies, TEM, Neuropathological, and Behavioral Investigations

Alzheimer disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable biomarkers and developing effective therapies. In this paper, we report on a comprehensive multimodal study of AD pathology using the 5xFAD mouse model. We employed light-scattering techniques, Partial Wave Spectroscopy (PWS) and Inverse Participation Ratio (IPR), to detect nanoscale structural alterations in brain tissues, nuclear components, and mitochondria. To support the light-scattering experiments, behavior, and histopathological studies were conducted. These analyses revealed significant increases in structural heterogeneity and mass density fluctuations in the brains of 5xFAD mice compared with Non-transgenic controls. Behavioral assessment demonstrated memory impairment in 5xFAD mice, reflected by a reduced recognition index. Histopathological analysis further revealed increased amyloid beta plaques and microglia activation in the hippocampus and cortex of 5xFAD mice compared with Non-transgenic controls. An increase in structural disorder within brain tissues can be attributed to higher mass density fluctuations, likely arising from macromolecular rearrangement driven by amyloid beta aggregation and neuroinflammatory responses as the disease progresses. Our findings suggest that PWS and IPR-derived metrics provide sensitive biophysical indicators of early cellular and subcellular disruption, offering potential as quantitative biomarkers for the detection and progression of AD.

physics.med-ph