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Jianning Li

Publications and source records attributed to Jianning Li.

32 records · Page 2Linked to original sources

Training β-VAE by Aggregating a Learned Gaussian Posterior with a Decoupled Decoder

The reconstruction loss and the Kullback-Leibler divergence (KLD) loss in a variational autoencoder (VAE) often play antagonistic roles, and tuning the weight of the KLD loss in $β$-VAE to achieve a balance between the two losses is a tricky and dataset-specific task. As a result, current practices in VAE training often result in a trade-off between the reconstruction fidelity and the continuity$/$disentanglement of the latent space, if the weight $β$ is not carefully tuned. In this paper, we present intuitions and a careful analysis of the antagonistic mechanism of the two losses, and propose, based on the insights, a simple yet effective two-stage method for training a VAE. Specifically, the method aggregates a learned Gaussian posterior $z \sim q_θ (z|x)$ with a decoder decoupled from the KLD loss, which is trained to learn a new conditional distribution $p_ϕ (x|z)$ of the input data $x$. Experimentally, we show that the aggregated VAE maximally satisfies the Gaussian assumption about the latent space, while still achieves a reconstruction error comparable to when the latent space is only loosely regularized by $\mathcal{N}(\mathbf{0},I)$. The proposed approach does not require hyperparameter (i.e., the KLD weight $β$) tuning given a specific dataset as required in common VAE training practices. We evaluate the method using a medical dataset intended for 3D skull reconstruction and shape completion, and the results indicate promising generative capabilities of the VAE trained using the proposed method. Besides, through guided manipulation of the latent variables, we establish a connection between existing autoencoder (AE)-based approaches and generative approaches, such as VAE, for the shape completion problem. Codes and pre-trained weights are available at https://github.com/Jianningli/skullVAE

cs.CV↗

The HoloLens in Medicine: A systematic Review and Taxonomy

The HoloLens (Microsoft Corp., Redmond, WA), a head-worn, optically see-through augmented reality display, is the main player in the recent boost in medical augmented reality research. In medical settings, the HoloLens enables the physician to obtain immediate insight into patient information, directly overlaid with their view of the clinical scenario, the medical student to gain a better understanding of complex anatomies or procedures, and even the patient to execute therapeutic tasks with improved, immersive guidance. In this systematic review, we provide a comprehensive overview of the usage of the first-generation HoloLens within the medical domain, from its release in March 2016, until the year of 2021, were attention is shifting towards it's successor, the HoloLens 2. We identified 171 relevant publications through a systematic search of the PubMed and Scopus databases. We analyze these publications in regard to their intended use case, technical methodology for registration and tracking, data sources, visualization as well as validation and evaluation. We find that, although the feasibility of using the HoloLens in various medical scenarios has been shown, increased efforts in the areas of precision, reliability, usability, workflow and perception are necessary to establish AR in clinical practice.

cs.HC↗

Medical Deep Learning -- A systematic Meta-Review

Deep learning (DL) has remarkably impacted several different scientific disciplines over the last few years. E.g., in image processing and analysis, DL algorithms were able to outperform other cutting-edge methods. Additionally, DL has delivered state-of-the-art results in tasks like autonomous driving, outclassing previous attempts. There are even instances where DL outperformed humans, for example with object recognition and gaming. DL is also showing vast potential in the medical domain. With the collection of large quantities of patient records and data, and a trend towards personalized treatments, there is a great need for automated and reliable processing and analysis of health information. Patient data is not only collected in clinical centers, like hospitals and private practices, but also by mobile healthcare apps or online websites. The abundance of collected patient data and the recent growth in the DL field has resulted in a large increase in research efforts. In Q2/2020, the search engine PubMed returned already over 11,000 results for the search term 'deep learning', and around 90% of these publications are from the last three years. However, even though PubMed represents the largest search engine in the medical field, it does not cover all medical-related publications. Hence, a complete overview of the field of 'medical deep learning' is almost impossible to obtain and acquiring a full overview of medical sub-fields is becoming increasingly more difficult. Nevertheless, several review and survey articles about medical DL have been published within the last few years. They focus, in general, on specific medical scenarios, like the analysis of medical images containing specific pathologies. With these surveys as a foundation, the aim of this article is to provide the first high-level, systematic meta-review of medical DL surveys.

eess.IV↗

Back to the Roots: Reconstructing Large and Complex Cranial Defects using an Image-based Statistical Shape Model

Designing implants for large and complex cranial defects is a challenging task, even for professional designers. Current efforts on automating the design process focused mainly on convolutional neural networks (CNN), which have produced state-of-the-art results on reconstructing synthetic defects. However, existing CNN-based methods have been difficult to translate to clinical practice in cranioplasty, as their performance on complex and irregular cranial defects remains unsatisfactory. In this paper, a statistical shape model (SSM) built directly on the segmentation masks of the skulls is presented. We evaluate the SSM on several cranial implant design tasks, and the results show that, while the SSM performs suboptimally on synthetic defects compared to CNN-based approaches, it is capable of reconstructing large and complex defects with only minor manual corrections. The quality of the resulting implants is examined and assured by experienced neurosurgeons. In contrast, CNN-based approaches, even with massive data augmentation, fail or produce less-than-satisfactory implants for these cases. Codes are publicly available at https://github.com/Jianningli/ssm

cs.CV↗

Automated cross-sectional view selection in CT angiography of aortic dissections with uncertainty awareness and retrospective clinical annotations

Objective: Surveillance imaging of chronic aortic diseases, such as dissections, relies on obtaining and comparing cross-sectional diameter measurements at predefined aortic landmarks, over time. Due to a lack of robust tools, the orientation of the cross-sectional planes is defined manually by highly trained operators. We show how manual annotations routinely collected in a clinic can be efficiently used to ease this task, despite the presence of a non-negligible interoperator variability in the measurements. Impact: Ill-posed but repetitive imaging tasks can be eased or automated by leveraging imperfect, retrospective clinical annotations. Methodology: In this work, we combine convolutional neural networks and uncertainty quantification methods to predict the orientation of such cross-sectional planes. We use clinical data randomly processed by 11 operators for training, and test on a smaller set processed by 3 independent operators to assess interoperator variability. Results: Our analysis shows that manual selection of cross-sectional planes is characterized by 95% limits of agreement (LOA) of $10.6^\circ$ and $21.4^\circ$ per angle. Our method showed to decrease static error by $3.57^\circ$ ($40.2$%) and $4.11^\circ$ ($32.8$%) against state of the art and LOA by $5.4^\circ$ ($49.0$%) and $16.0^\circ$ ($74.6$%) against manual processing. Conclusion: This suggests that pre-existing annotations can be an inexpensive resource in clinics to ease ill-posed and repetitive tasks like cross-section extraction for surveillance of aortic dissections.

eess.IV↗

Deep Learning -- A first Meta-Survey of selected Reviews across Scientific Disciplines, their Commonalities, Challenges and Research Impact

Deep learning belongs to the field of artificial intelligence, where machines perform tasks that typically require some kind of human intelligence. Similar to the basic structure of a brain, a deep learning algorithm consists of an artificial neural network, which resembles the biological brain structure. Mimicking the learning process of humans with their senses, deep learning networks are fed with (sensory) data, like texts, images, videos or sounds. These networks outperform the state-of-the-art methods in different tasks and, because of this, the whole field saw an exponential growth during the last years. This growth resulted in way over 10,000 publications per year in the last years. For example, the search engine PubMed alone, which covers only a sub-set of all publications in the medical field, provides already over 11,000 results in Q3 2020 for the search term 'deep learning', and around 90% of these results are from the last three years. Consequently, a complete overview over the field of deep learning is already impossible to obtain and, in the near future, it will potentially become difficult to obtain an overview over a subfield. However, there are several review articles about deep learning, which are focused on specific scientific fields or applications, for example deep learning advances in computer vision or in specific tasks like object detection. With these surveys as a foundation, the aim of this contribution is to provide a first high-level, categorized meta-survey of selected reviews on deep learning across different scientific disciplines. The categories (computer vision, language processing, medical informatics and additional works) have been chosen according to the underlying data sources (image, language, medical, mixed). In addition, we review the common architectures, methods, pros, cons, evaluations, challenges and future directions for every sub-category.

cs.DL↗

Learning to Rearrange Voxels in Binary Segmentation Masks for Smooth Manifold Triangulation

Medical images, especially volumetric images, are of high resolution and often exceed the capacity of standard desktop GPUs. As a result, most deep learning-based medical image analysis tasks require the input images to be downsampled, often substantially, before these can be fed to a neural network. However, downsampling can lead to a loss of image quality, which is undesirable especially in reconstruction tasks, where the fine geometric details need to be preserved. In this paper, we propose that high-resolution images can be reconstructed in a coarse-to-fine fashion, where a deep learning algorithm is only responsible for generating a coarse representation of the image, which consumes moderate GPU memory. For producing the high-resolution outcome, we propose two novel methods: learned voxel rearrangement of the coarse output and hierarchical image synthesis. Compared to the coarse output, the high-resolution counterpart allows for smooth surface triangulation, which can be 3D-printed in the highest possible quality. Experiments of this paper are carried out on the dataset of AutoImplant 2021 (https://autoimplant2021.grand-challenge.org/), a MICCAI challenge on cranial implant design. The dataset contains high-resolution skulls that can be viewed as 2D manifolds embedded in a 3D space. Codes associated with this study can be accessed at https://github.com/Jianningli/voxel_rearrangement.

eess.IV↗

Detecting the effects of quantum gravity with exceptional points in optomechanical sensors

In this manuscript, working with a binary mechanical system, we examine the effect of quantum gravity on the exceptional points of the system. On the one side, we find that the exceedingly weak effect of quantum gravity can be sensed via pushing the system towards a second-order exceptional point, where the spectra of the non-Hermitian system exhibits non-analytic and even discontinuous behavior. On the other side, the gravity perturbation will affect the sensitivity of the system to deposition mass. In order to further enhance the sensitivity of the system to quantum gravity, we extend the system to the other one which has a higher-order (third-order) exceptional point. Our work provides a feasible way to use exceptional points as a new tool to explore the effect of quantum gravity.

quant-ph↗

Cramér-Rao bound and quantum parameter estimation with non-Hermitian systems

The quantum Fisher information constrains the achievable precision in parameter estimation via the quantum Cramér-Rao bound, which has attracted much attention in Hermitian systems since the 60s of the last century. However, less attention has been paid to non-Hermitian systems. In this Letter, working with different logarithmic operators, we derive two previously unknown expressions for quantum Fisher information, and two Cramér-Rao bounds lower than the well-known one are found for non-Hermitian systems. These lower bounds are due to the merit of non-Hermitian observable and it can be understood as a result of extended regimes of optimization. Two experimentally feasible examples are presented to illustrate the theory, saturation of these bounds and estimation precisions beyond the Heisenberg limit are predicted and discussed. A setup to measure non-Hermitian observable is also proposed.

quant-ph↗

A Baseline Approach for AutoImplant: the MICCAI 2020 Cranial Implant Design Challenge

In this study, we present a baseline approach for AutoImplant (https://autoimplant.grand-challenge.org/) - the cranial implant design challenge, which, as suggested by the organizers, can be formulated as a volumetric shape learning task. In this task, the defective skull, the complete skull and the cranial implant are represented as binary voxel grids. To accomplish this task, the implant can be either reconstructed directly from the defective skull or obtained by taking the difference between a defective skull and a complete skull. In the latter case, a complete skull has to be reconstructed given a defective skull, which defines a volumetric shape completion problem. Our baseline approach for this task is based on the former formulation, i.e., a deep neural network is trained to predict the implants directly from the defective skulls. The approach generates high-quality implants in two steps: First, an encoder-decoder network learns a coarse representation of the implant from down-sampled, defective skulls; The coarse implant is only used to generate the bounding box of the defected region in the original high-resolution skull. Second, another encoder-decoder network is trained to generate a fine implant from the bounded area. On the test set, the proposed approach achieves an average dice similarity score (DSC) of 0.8555 and Hausdorff distance (HD) of 5.1825 mm. The code is publicly available at https://github.com/Jianningli/autoimplant.

cs.CV↗

An Online Platform for Automatic Skull Defect Restoration and Cranial Implant Design

We introduce a fully automatic system for cranial implant design, a common task in cranioplasty operations. The system is currently integrated in Studierfenster (http://studierfenster.tugraz.at/), an online, cloud-based medical image processing platform for medical imaging applications. Enhanced by deep learning algorithms, the system automatically restores the missing part of a skull (i.e., skull shape completion) and generates the desired implant by subtracting the defective skull from the completed skull. The generated implant can be downloaded in the STereoLithography (.stl) format directly via the browser interface of the system. The implant model can then be sent to a 3D printer for in loco implant manufacturing. Furthermore, thanks to the standard format, the user can thereafter load the model into another application for post-processing whenever necessary. Such an automatic cranial implant design system can be integrated into the clinical practice to improve the current routine for surgeries related to skull defect repair (e.g., cranioplasty). Our system, although currently intended for educational and research use only, can be seen as an application of additive manufacturing for fast, patient-specific implant design.

physics.med-ph↗

Detection of Premature Ventricular Contractions Using Densely Connected Deep Convolutional Neural Network with Spatial Pyramid Pooling Layer

Premature ventricular contraction(PVC) is a type of premature ectopic beat originating from the ventricles. Automatic method for accurate and robust detection of PVC is highly clinically desired.Currently, most of these methods are developed and tested using the same database divided into training and testing set and their generalization performance across databases has not been fully validated. In this paper, a method based on densely connected convolutional neural network and spatial pyramid pooling is proposed for PVC detection which can take arbitrarily-sized QRS complexes as input both in training and testing. With a much less complicated and more straightforward architecture,the proposed network achieves comparable results to current state-of-the-art deep learning based method with regard to accuracy,sensitivity and specificity by training and testing using the MIT-BIH arrhythmia database as benchmark.Besides the benchmark database,QRS complexes are extracted from four more open databases namely the St-Petersburg Institute of Cardiological Technics 12-lead Arrhythmia Database,The MIT-BIH Normal Sinus Rhythm Database,The MIT-BIH Long Term Database and European ST-T Database. The extracted QRS complexes are different in length and sampling rate among the five databases.Cross-database training and testing is also experimented.The performance of the network shows an improvement on the benchmark database according to the result demonstrating the advantage of using multiple databases for training over using only a single database.The network also achieves satisfactory scores on the other four databases showing good generalization capability.

cs.CV↗

Towards Personalized Management of Type B Aortic Dissection Using STENT: a STandard cta database with annotation of the ENtire aorta and True-false lumen

Type B Aortic Dissection(TBAD) is a rare aortic disease with a high 5-year mortality.Personalized and precise management of TBAD has been increasingly desired in clinic which requires the geometric parameters of TBAD specific to the patient be measured accurately.This remains to be a challenging task for vascular surgeons as manual measurement is highly subjective and imprecise. To solve this problem,we introduce STENT-a STandard cta database with annotation of the ENtire aorta and True-false lumen. The database contains 274 CT angiography (CTA) scans from 274 unique TBAD patients and is split into a training set(254 cases including 210 preoperative and 44 postoperative scans ) and a test set(20 cases).Based on STENT,we develop a series of methods including automated TBAD segmentation and automated measurement of TBAD parameters that facilitate personalized and precise management of the disease. In this work, the database and the proposed methods are thoroughly introduced and evaluated and the results of our study shows the feasibility and effectiveness of our approach to easing the decision-making process for vascular surgeons during personalized TBAD management.

physics.med-ph↗

Multi-Task Deep Convolutional Neural Network for the Segmentation of Type B Aortic Dissection

Segmentation of the entire aorta and true-false lumen is crucial to inform plan and follow-up for endovascular repair of the rare yet life threatening type B aortic dissection. Manual segmentation by slice is time-consuming and requires expertise, while current computer-aided methods focus on the segmentation of the entire aorta, are unable to concurrently segment true-false lumen, and some require human interaction. We here report a fully automated approach based on a 3-D multi-task deep convolutional neural network that segments the entire aorta and true-false lumen from CTA images in a unified framework. For training, we built a database containing 254 CTA images (210 preoperative and 44 postoperative) obtained using various systems from 254 unique patients with type B aortic dissection. Slice-wise manual segmentation of the entire aorta and the true-false lumen for each 3-D CTA image was provided. Upon evaluation of another 16 CTA images (11 preoperative and 5 postoperative) with ground truth segmentation provided by experienced vascular surgeons, our method achieves a mean dice similarity score(DSC) of 0.910,0.849 and 0.821 for the entire aorta,true lumen and false lumen respectively.

cs.CV↗