arXiv subjects

Jianqiang Li

Publications and source records attributed to Jianqiang Li.

At least 55 records · Page 3Linked to original sources

arXiv2024

Dockformer: A transformer-based molecular docking paradigm for large-scale virtual screening

Molecular docking is a crucial step in drug development, which enables the virtual screening of compound libraries to identify potential ligands that target proteins of interest. However, the computational complexity of traditional docking models increases as the size of the compound library increases. Recently, deep learning algorithms can provide data-driven research and development models to increase the speed of the docking process. Unfortunately, few models can achieve superior screening performance compared to that of traditional models. Therefore, a novel deep learning-based docking approach named Dockformer is introduced in this study. Dockformer leverages multimodal information to capture the geometric topology and structural knowledge of molecules and can directly generate binding conformations with the corresponding confidence measures in an end-to-end manner. The experimental results show that Dockformer achieves success rates of 90.53% and 82.71% on the PDBbind core set and PoseBusters benchmarks, respectively, and more than a 100-fold increase in the inference process speed, outperforming almost all state-of-the-art docking methods. In addition, the ability of Dockformer to identify the main protease inhibitors of coronaviruses is demonstrated in a real-world virtual screening scenario. Considering its high docking accuracy and screening efficiency, Dockformer can be regarded as a powerful and robust tool in the field of drug design.

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arXiv2024

Topology and Intersection-Union Constrained Loss Function for Multi-Region Anatomical Segmentation in Ocular Images

Ocular Myasthenia Gravis (OMG) is a rare and challenging disease to detect in its early stages, but symptoms often first appear in the eye muscles, such as drooping eyelids and double vision. Ocular images can be used for early diagnosis by segmenting different regions, such as the sclera, iris, and pupil, which allows for the calculation of area ratios to support accurate medical assessments. However, no publicly available dataset and tools currently exist for this purpose. To address this, we propose a new topology and intersection-union constrained loss function (TIU loss) that improves performance using small training datasets. We conducted experiments on a public dataset consisting of 55 subjects and 2,197 images. Our proposed method outperformed two widely used loss functions across three deep learning networks, achieving a mean Dice score of 83.12% [82.47%, 83.81%] with a 95% bootstrap confidence interval. In a low-percentage training scenario (10% of the training data), our approach showed an 8.32% improvement in Dice score compared to the baseline. Additionally, we evaluated the method in a clinical setting with 47 subjects and 501 images, achieving a Dice score of 64.44% [63.22%, 65.62%]. We did observe some bias when applying the model in clinical settings. These results demonstrate that the proposed method is accurate, and our code along with the trained model is publicly available.

cs.CV↗

arXiv2024

MentalGLM Series: Explainable Large Language Models for Mental Health Analysis on Chinese Social Media

As the prevalence of mental health challenges, social media has emerged as a key platform for individuals to express their emotions.Deep learning tends to be a promising solution for analyzing mental health on social media. However, black box models are often inflexible when switching between tasks, and their results typically lack explanations. With the rise of large language models (LLMs), their flexibility has introduced new approaches to the field. Also due to the generative nature, they can be prompted to explain decision-making processes. However, their performance on complex psychological analysis still lags behind deep learning. In this paper, we introduce the first multi-task Chinese Social Media Interpretable Mental Health Instructions (C-IMHI) dataset, consisting of 9K samples, which has been quality-controlled and manually validated. We also propose MentalGLM series models, the first open-source LLMs designed for explainable mental health analysis targeting Chinese social media, trained on a corpus of 50K instructions. The proposed models were evaluated on three downstream tasks and achieved better or comparable performance compared to deep learning models, generalized LLMs, and task fine-tuned LLMs. We validated a portion of the generated decision explanations with experts, showing promising results. We also evaluated the proposed models on a clinical dataset, where they outperformed other LLMs, indicating their potential applicability in the clinical field. Our models show strong performance, validated across tasks and perspectives. The decision explanations enhance usability and facilitate better understanding and practical application of the models. Both the constructed dataset and the models are publicly available via: https://github.com/zwzzzQAQ/MentalGLM.

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arXiv2024

Deep Learning and Large Language Models for Audio and Text Analysis in Predicting Suicidal Acts in Chinese Psychological Support Hotlines

Suicide is a pressing global issue, demanding urgent and effective preventive interventions. Among the various strategies in place, psychological support hotlines had proved as a potent intervention method. Approximately two million people in China attempt suicide annually, with many individuals making multiple attempts. Prompt identification and intervention for high-risk individuals are crucial to preventing tragedies. With the rapid advancement of artificial intelligence (AI), especially the development of large-scale language models (LLMs), new technological tools have been introduced to the field of mental health. This study included 1284 subjects, and was designed to validate whether deep learning models and LLMs, using audio and transcribed text from support hotlines, can effectively predict suicide risk. We proposed a simple LLM-based pipeline that first summarizes transcribed text from approximately one hour of speech to extract key features, and then predict suicidial bahaviours in the future. We compared our LLM-based method with the traditional manual scale approach in a clinical setting and with five advanced deep learning models. Surprisingly, the proposed simple LLM pipeline achieved strong performance on a test set of 46 subjects, with an F1 score of 76\% when combined with manual scale rating. This is 7\% higher than the best speech-based deep learning models and represents a 27.82\% point improvement in F1 score compared to using the manual scale apporach alone. Our study explores new applications of LLMs and demonstrates their potential for future use in suicide prevention efforts.

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arXiv2024

An Exploratory Deep Learning Approach for Predicting Subsequent Suicidal Acts in Chinese Psychological Support Hotlines

Psychological support hotlines are an effective suicide prevention measure that typically relies on professionals using suicide risk assessment scales to predict individual risk scores. However, the accuracy of scale-based predictive methods for suicide risk assessment can vary widely depending on the expertise of the operator. This limitation underscores the need for more reliable methods, prompting this research's innovative exploration of the use of artificial intelligence to improve the accuracy and efficiency of suicide risk prediction within the context of psychological support hotlines. The study included data from 1,549 subjects from 2015-2017 in China who contacted a psychological support hotline. Each participant was followed for 12 months to identify instances of suicidal behavior. We proposed a novel multi-task learning method that uses the large-scale pre-trained model Whisper for feature extraction and fits psychological scales while predicting the risk of suicide. The proposed method yields a 2.4\% points improvement in F1-score compared to the traditional manual approach based on the psychological scales. Our model demonstrated superior performance compared to the other eight popular models. To our knowledge, this study is the first to apply deep learning to long-term speech data to predict suicide risk in China, indicating grate potential for clinical applications. The source code is publicly available at: \url{https://github.com/songchangwei/Suicide-Risk-Prediction}.

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arXiv2024

A Generic Review of Integrating Artificial Intelligence in Cognitive Behavioral Therapy

Cognitive Behavioral Therapy (CBT) is a well-established intervention for mitigating psychological issues by modifying maladaptive cognitive and behavioral patterns. However, delivery of CBT is often constrained by resource limitations and barriers to access. Advancements in artificial intelligence (AI) have provided technical support for the digital transformation of CBT. Particularly, the emergence of pre-training models (PTMs) and large language models (LLMs) holds immense potential to support, augment, optimize and automate CBT delivery. This paper reviews the literature on integrating AI into CBT interventions. We begin with an overview of CBT. Then, we introduce the integration of AI into CBT across various stages: pre-treatment, therapeutic process, and post-treatment. Next, we summarized the datasets relevant to some CBT-related tasks. Finally, we discuss the benefits and current limitations of applying AI to CBT. We suggest key areas for future research, highlighting the need for further exploration and validation of the long-term efficacy and clinical utility of AI-enhanced CBT. The transformative potential of AI in reshaping the practice of CBT heralds a new era of more accessible, efficient, and personalized mental health interventions.

cs.AI↗

arXiv2024

Chinese MentalBERT: Domain-Adaptive Pre-training on Social Media for Chinese Mental Health Text Analysis

In the current environment, psychological issues are prevalent and widespread, with social media serving as a key outlet for individuals to share their feelings. This results in the generation of vast quantities of data daily, where negative emotions have the potential to precipitate crisis situations. There is a recognized need for models capable of efficient analysis. While pre-trained language models have demonstrated their effectiveness broadly, there's a noticeable gap in pre-trained models tailored for specialized domains like psychology. To address this, we have collected a huge dataset from Chinese social media platforms and enriched it with publicly available datasets to create a comprehensive database encompassing 3.36 million text entries. To enhance the model's applicability to psychological text analysis, we integrated psychological lexicons into the pre-training masking mechanism. Building on an existing Chinese language model, we performed adaptive training to develop a model specialized for the psychological domain. We evaluated our model's performance across six public datasets, where it demonstrated improvements compared to eight other models. Additionally, in the qualitative comparison experiment, our model provided psychologically relevant predictions given the masked sentences. Due to concerns regarding data privacy, the dataset will not be made publicly available. However, we have made the pre-trained models and codes publicly accessible to the community via: https://github.com/zwzzzQAQ/Chinese-MentalBERT.

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arXiv2024

Supervised Learning and Large Language Model Benchmarks on Mental Health Datasets: Cognitive Distortions and Suicidal Risks in Chinese Social Media

On social media, users often express their personal feelings, which may exhibit cognitive distortions or even suicidal tendencies on certain specific topics. Early recognition of these signs is critical for effective psychological intervention. In this paper, we introduce two novel datasets from Chinese social media: SOS-HL-1K for suicidal risk classification and SocialCD-3K for cognitive distortions detection. The SOS-HL-1K dataset contained 1,249 posts and SocialCD-3K dataset was a multi-label classification dataset that containing 3,407 posts. We propose a comprehensive evaluation using two supervised learning methods and eight large language models (LLMs) on the proposed datasets. From the prompt engineering perspective, we experimented with two types of prompt strategies, including four zero-shot and five few-shot strategies. We also evaluated the performance of the LLMs after fine-tuning on the proposed tasks. The experimental results show that there is still a huge gap between LLMs relying only on prompt engineering and supervised learning. In the suicide classification task, this gap is 6.95% points in F1-score, while in the cognitive distortion task, the gap is even more pronounced, reaching 31.53% points in F1-score. However, after fine-tuning, this difference is significantly reduced. In the suicide and cognitive distortion classification tasks, the gap decreases to 4.31% and 3.14%, respectively. This research highlights the potential of LLMs in psychological contexts, but supervised learning remains necessary for more challenging tasks. All datasets and code are made available.

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arXiv2024

Self-degraded contrastive domain adaptation for industrial fault diagnosis with bi-imbalanced data

Modern industrial fault diagnosis tasks often face the combined challenge of distribution discrepancy and bi-imbalance. Existing domain adaptation approaches pay little attention to the prevailing bi-imbalance, leading to poor domain adaptation performance or even negative transfer. In this work, we propose a self-degraded contrastive domain adaptation (Sd-CDA) diagnosis framework to handle the domain discrepancy under the bi-imbalanced data. It first pre-trains the feature extractor via imbalance-aware contrastive learning based on model pruning to learn the feature representation efficiently in a self-supervised manner. Then it forces the samples away from the domain boundary based on supervised contrastive domain adversarial learning (SupCon-DA) and ensures the features generated by the feature extractor are discriminative enough. Furthermore, we propose the pruned contrastive domain adversarial learning (PSupCon-DA) to pay automatically re-weighted attention to the minorities to enhance the performance towards bi-imbalanced data. We show the superiority of the proposed method via two experiments.

cs.AI↗

arXiv2024

HemSeg-200: A Voxel-Annotated Dataset for Intracerebral Hemorrhages Segmentation in Brain CT Scans

Acute intracerebral hemorrhage is a life-threatening condition that demands immediate medical intervention. Intraparenchymal hemorrhage (IPH) and intraventricular hemorrhage (IVH) are critical subtypes of this condition. Clinically, when such hemorrhages are suspected, immediate CT scanning is essential to assess the extent of the bleeding and to facilitate the formulation of a targeted treatment plan. While current research in deep learning has largely focused on qualitative analyses, such as identifying subtypes of cerebral hemorrhages, there remains a significant gap in quantitative analysis crucial for enhancing clinical treatments. Addressing this gap, our paper introduces a dataset comprising 222 CT annotations, sourced from the RSNA 2019 Brain CT Hemorrhage Challenge and meticulously annotated at the voxel level for precise IPH and IVH segmentation. This dataset was utilized to train and evaluate seven advanced medical image segmentation algorithms, with the goal of refining the accuracy of segmentation for these hemorrhages. Our findings demonstrate that this dataset not only furthers the development of sophisticated segmentation algorithms but also substantially aids scientific research and clinical practice by improving the diagnosis and management of these severe hemorrhages. Our dataset and codes are available at \url{https://github.com/songchangwei/3DCT-SD-IVH-ICH}.

eess.IV↗

arXiv2024

Morphology-Enhanced CAM-Guided SAM for weakly supervised Breast Lesion Segmentation

Ultrasound imaging plays a critical role in the early detection of breast cancer. Accurate identification and segmentation of lesions are essential steps in clinical practice, requiring methods to assist physicians in lesion segmentation. However, ultrasound lesion segmentation models based on supervised learning require extensive manual labeling, which is both time-consuming and labor-intensive. In this study, we present a novel framework for weakly supervised lesion segmentation in early breast ultrasound images. Our method uses morphological enhancement and class activation map (CAM)-guided localization. Finally, we employ the Segment Anything Model (SAM), a computer vision foundation model, for detailed segmentation. This approach does not require pixel-level annotation, thereby reducing the cost of data annotation. The performance of our method is comparable to supervised learning methods that require manual annotations, achieving a Dice score of 74.39% and outperforming comparative supervised models in terms of Hausdorff distance in the BUSI dataset. These results demonstrate that our framework effectively integrates weakly supervised learning with SAM, providing a promising solution for breast cancer image analysis. The code for this study is available at: https://github.com/YueXin18/MorSeg-CAM-SAM.

cs.CV↗

arXiv2024

Fine-grained Speech Sentiment Analysis in Chinese Psychological Support Hotlines Based on Large-scale Pre-trained Model

Suicide and suicidal behaviors remain significant challenges for public policy and healthcare. In response, psychological support hotlines have been established worldwide to provide immediate help to individuals in mental crises. The effectiveness of these hotlines largely depends on accurately identifying callers' emotional states, particularly underlying negative emotions indicative of increased suicide risk. However, the high demand for psychological interventions often results in a shortage of professional operators, highlighting the need for an effective speech emotion recognition model. This model would automatically detect and analyze callers' emotions, facilitating integration into hotline services. Additionally, it would enable large-scale data analysis of psychological support hotline interactions to explore psychological phenomena and behaviors across populations. Our study utilizes data from the Beijing psychological support hotline, the largest suicide hotline in China. We analyzed speech data from 105 callers containing 20,630 segments and categorized them into 11 types of negative emotions. We developed a negative emotion recognition model and a fine-grained multi-label classification model using a large-scale pre-trained model. Our experiments indicate that the negative emotion recognition model achieves a maximum F1-score of 76.96%. However, it shows limited efficacy in the fine-grained multi-label classification task, with the best model achieving only a 41.74% weighted F1-score. We conducted an error analysis for this task, discussed potential future improvements, and considered the clinical application possibilities of our study. All the codes are public available.

cs.CL↗

arXiv2024

SOS-1K: A Fine-grained Suicide Risk Classification Dataset for Chinese Social Media Analysis

In the social media, users frequently express personal emotions, a subset of which may indicate potential suicidal tendencies. The implicit and varied forms of expression in internet language complicate accurate and rapid identification of suicidal intent on social media, thus creating challenges for timely intervention efforts. The development of deep learning models for suicide risk detection is a promising solution, but there is a notable lack of relevant datasets, especially in the Chinese context. To address this gap, this study presents a Chinese social media dataset designed for fine-grained suicide risk classification, focusing on indicators such as expressions of suicide intent, methods of suicide, and urgency of timing. Seven pre-trained models were evaluated in two tasks: high and low suicide risk, and fine-grained suicide risk classification on a level of 0 to 10. In our experiments, deep learning models show good performance in distinguishing between high and low suicide risk, with the best model achieving an F1 score of 88.39%. However, the results for fine-grained suicide risk classification were still unsatisfactory, with an weighted F1 score of 50.89%. To address the issues of data imbalance and limited dataset size, we investigated both traditional and advanced, large language model based data augmentation techniques, demonstrating that data augmentation can enhance model performance by up to 4.65% points in F1-score. Notably, the Chinese MentalBERT model, which was pre-trained on psychological domain data, shows superior performance in both tasks. This study provides valuable insights for automatic identification of suicidal individuals, facilitating timely psychological intervention on social media platforms. The source code and data are publicly available.

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arXiv2024

AI-Enhanced Cognitive Behavioral Therapy: Deep Learning and Large Language Models for Extracting Cognitive Pathways from Social Media Texts

Cognitive Behavioral Therapy (CBT) is an effective technique for addressing the irrational thoughts stemming from mental illnesses, but it necessitates precise identification of cognitive pathways to be successfully implemented in patient care. In current society, individuals frequently express negative emotions on social media on specific topics, often exhibiting cognitive distortions, including suicidal behaviors in extreme cases. Yet, there is a notable absence of methodologies for analyzing cognitive pathways that could aid psychotherapists in conducting effective interventions online. In this study, we gathered data from social media and established the task of extracting cognitive pathways, annotating the data based on a cognitive theoretical framework. We initially categorized the task of extracting cognitive pathways as a hierarchical text classification with four main categories and nineteen subcategories. Following this, we structured a text summarization task to help psychotherapists quickly grasp the essential information. Our experiments evaluate the performance of deep learning and large language models (LLMs) on these tasks. The results demonstrate that our deep learning method achieved a micro-F1 score of 62.34% in the hierarchical text classification task. Meanwhile, in the text summarization task, GPT-4 attained a Rouge-1 score of 54.92 and a Rouge-2 score of 30.86, surpassing the experimental deep learning model's performance. However, it may suffer from an issue of hallucination. We have made all models and codes publicly available to support further research in this field.

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arXiv2024

Comparative Analysis of ImageNet Pre-Trained Deep Learning Models and DINOv2 in Medical Imaging Classification

Medical image analysis frequently encounters data scarcity challenges. Transfer learning has been effective in addressing this issue while conserving computational resources. The recent advent of foundational models like the DINOv2, which uses the vision transformer architecture, has opened new opportunities in the field and gathered significant interest. However, DINOv2's performance on clinical data still needs to be verified. In this paper, we performed a glioma grading task using three clinical modalities of brain MRI data. We compared the performance of various pre-trained deep learning models, including those based on ImageNet and DINOv2, in a transfer learning context. Our focus was on understanding the impact of the freezing mechanism on performance. We also validated our findings on three other types of public datasets: chest radiography, fundus radiography, and dermoscopy. Our findings indicate that in our clinical dataset, DINOv2's performance was not as strong as ImageNet-based pre-trained models, whereas in public datasets, DINOv2 generally outperformed other models, especially when using the frozen mechanism. Similar performance was observed with various sizes of DINOv2 models across different tasks. In summary, DINOv2 is viable for medical image classification tasks, particularly with data resembling natural images. However, its effectiveness may vary with data that significantly differs from natural images such as MRI. In addition, employing smaller versions of the model can be adequate for medical task, offering resource-saving benefits. Our codes are available at https://github.com/GuanghuiFU/medical_DINOv2_eval.

eess.IV↗

arXiv2023

RePaint-NeRF: NeRF Editting via Semantic Masks and Diffusion Models

The emergence of Neural Radiance Fields (NeRF) has promoted the development of synthesized high-fidelity views of the intricate real world. However, it is still a very demanding task to repaint the content in NeRF. In this paper, we propose a novel framework that can take RGB images as input and alter the 3D content in neural scenes. Our work leverages existing diffusion models to guide changes in the designated 3D content. Specifically, we semantically select the target object and a pre-trained diffusion model will guide the NeRF model to generate new 3D objects, which can improve the editability, diversity, and application range of NeRF. Experiment results show that our algorithm is effective for editing 3D objects in NeRF under different text prompts, including editing appearance, shape, and more. We validate our method on both real-world datasets and synthetic-world datasets for these editing tasks. Please visit https://starstesla.github.io/repaintnerf for a better view of our results.

cs.CV↗

arXiv2023

Towards a Psychological Generalist AI: A Survey of Current Applications of Large Language Models and Future Prospects

The complexity of psychological principles underscore a significant societal challenge, given the vast social implications of psychological problems. Bridging the gap between understanding these principles and their actual clinical and real-world applications demands rigorous exploration and adept implementation. In recent times, the swift advancement of highly adaptive and reusable artificial intelligence (AI) models has emerged as a promising way to unlock unprecedented capabilities in the realm of psychology. This paper emphasizes the importance of performance validation for these large-scale AI models, emphasizing the need to offer a comprehensive assessment of their verification from diverse perspectives. Moreover, we review the cutting-edge advancements and practical implementations of these expansive models in psychology, highlighting pivotal work spanning areas such as social media analytics, clinical nursing insights, vigilant community monitoring, and the nuanced exploration of psychological theories. Based on our review, we project an acceleration in the progress of psychological fields, driven by these large-scale AI models. These future generalist AI models harbor the potential to substantially curtail labor costs and alleviate social stress. However, this forward momentum will not be without its set of challenges, especially when considering the paradigm changes and upgrades required for medical instrumentation and related applications.

cs.AI↗

arXiv2023

CMed-GPT: Prompt Tuning for Entity-Aware Chinese Medical Dialogue Generation

Medical dialogue generation relies on natural language generation techniques to enable online medical consultations. Recently, the widespread adoption of large-scale models in the field of natural language processing has facilitated rapid advancements in this technology. Existing medical dialogue models are mostly based on BERT and pre-trained on English corpora, but there is a lack of high-performing models on the task of Chinese medical dialogue generation. To solve the above problem, this paper proposes CMed-GPT, which is the GPT pre-training language model based on Chinese medical domain text. The model is available in two versions, namely, base and large, with corresponding perplexity values of 8.64 and 8.01. Additionally, we incorporate lexical and entity embeddings into the dialogue text in a uniform manner to meet the requirements of downstream dialogue generation tasks. By applying both fine-tuning and p-tuning to CMed-GPT, we lowered the PPL from 8.44 to 7.35. This study not only confirms the exceptional performance of the CMed-GPT model in generating Chinese biomedical text but also highlights the advantages of p-tuning over traditional fine-tuning with prefix prompts. Furthermore, we validate the significance of incorporating external information in medical dialogue generation, which enhances the quality of dialogue generation.

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