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Jianqing Fan

Publications and source records attributed to Jianqing Fan.

At least 199 records · Page 11Linked to original sources

Nonparametric estimation of genewise variance for microarray data

Estimation of genewise variance arises from two important applications in microarray data analysis: selecting significantly differentially expressed genes and validation tests for normalization of microarray data. We approach the problem by introducing a two-way nonparametric model, which is an extension of the famous Neyman--Scott model and is applicable beyond microarray data. The problem itself poses interesting challenges because the number of nuisance parameters is proportional to the sample size and it is not obvious how the variance function can be estimated when measurements are correlated. In such a high-dimensional nonparametric problem, we proposed two novel nonparametric estimators for genewise variance function and semiparametric estimators for measurement correlation, via solving a system of nonlinear equations. Their asymptotic normality is established. The finite sample property is demonstrated by simulation studies. The estimators also improve the power of the tests for detecting statistically differentially expressed genes. The methodology is illustrated by the data from microarray quality control (MAQC) project.

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Estimation in additive models with highly or nonhighly correlated covariates

Motivated by normalizing DNA microarray data and by predicting the interest rates, we explore nonparametric estimation of additive models with highly correlated covariates. We introduce two novel approaches for estimating the additive components, integration estimation and pooled backfitting estimation. The former is designed for highly correlated covariates, and the latter is useful for nonhighly correlated covariates. Asymptotic normalities of the proposed estimators are established. Simulations are conducted to demonstrate finite sample behaviors of the proposed estimators, and real data examples are given to illustrate the value of the methodology.

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Penalized Composite Quasi-Likelihood for Ultrahigh-Dimensional Variable Selection

In high-dimensional model selection problems, penalized simple least-square approaches have been extensively used. This paper addresses the question of both robustness and efficiency of penalized model selection methods, and proposes a data-driven weighted linear combination of convex loss functions, together with weighted $L_1$-penalty. It is completely data-adaptive and does not require prior knowledge of the error distribution. The weighted $L_1$-penalty is used both to ensure the convexity of the penalty term and to ameliorate the bias caused by the $L_1$-penalty. In the setting with dimensionality much larger than the sample size, we establish a strong oracle property of the proposed method that possesses both the model selection consistency and estimation efficiency for the true non-zero coefficients. As specific examples, we introduce a robust method of composite L1-L2, and optimal composite quantile method and evaluate their performance in both simulated and real data examples.

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Non-Gaussian Quasi Maximum Likelihood Estimation of GARCH Models

The non-Gaussian quasi maximum likelihood estimator is frequently used in GARCH models with intension to improve the efficiency of the GARCH parameters. However, unless the quasi-likelihood happens to be the true one, non-Gaussian QMLE methods suffers inconsistency even if shape parameters in the quasi-likelihood are estimated. To correct this bias, we identify an unknown scale parameter that is critical to the consistent estimation of non-Gaussian QMLE, and propose a two-step non-Gaussian QMLE (2SNG-QMLE) for estimation of the scale parameter and GARCH parameters. This novel approach is consistent and asymptotically normal. Moreover, it has higher efficiency than the Gaussian QMLE, particularly when the innovation error has heavy tails. Two extensions are proposed to further improve the efficiency of 2SNG-QMLE. The impact of relative heaviness of tails of the innovation and quasi-likelihood distributions on the asymptotic efficiency has been thoroughly investigated. Monte Carlo simulations and an empirical study confirm the advantages of the proposed approach.

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High-dimensional variable selection for Cox's proportional hazards model

Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate information such as microarray, proteomic and SNP data via bioimaging technology while observing survival information on patients in clinical studies. Thus, the same challenge applies to the survival analysis in order to understand the association between genomics information and clinical information about the survival time. In this work, we extend the sure screening procedure Fan and Lv (2008) to Cox's proportional hazards model with an iterative version available. Numerical simulation studies have shown encouraging performance of the proposed method in comparison with other techniques such as LASSO. This demonstrates the utility and versatility of the iterative sure independent screening scheme.

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Vast Volatility Matrix Estimation using High Frequency Data for Portfolio Selection

Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of selected portfolios among a vast pool of assets, as demonstrated in Fan et al (2008). The required high-dimensional volatility matrix can be estimated by using high frequency financial data. This enables us to better adapt to the local volatilities and local correlations among vast number of assets and to increase significantly the sample size for estimating the volatility matrix. This paper studies the volatility matrix estimation using high-dimensional high-frequency data from the perspective of portfolio selection. Specifically, we propose the use of "pairwise-refresh time" and "all-refresh time" methods proposed by Barndorff-Nielsen et al (2008) for estimation of vast covariance matrix and compare their merits in the portfolio selection. We also establish the concentration inequalities of the estimates, which guarantee desirable properties of the estimated volatility matrix in vast asset allocation with gross exposure constraints. Extensive numerical studies are made via carefully designed simulations. Comparing with the methods based on low frequency daily data, our methods can capture the most recent trend of the time varying volatility and correlation, hence provide more accurate guidance for the portfolio allocation in the next time period. The advantage of using high-frequency data is significant in our simulation and empirical studies, which consist of 50 simulated assets and 30 constituent stocks of Dow Jones Industrial Average index.

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Local quasi-likelihood with a parametric guide

Generalized linear models and the quasi-likelihood method extend the ordinary regression models to accommodate more general conditional distributions of the response. Nonparametric methods need no explicit parametric specification, and the resulting model is completely determined by the data themselves. However, nonparametric estimation schemes generally have a slower convergence rate such as the local polynomial smoothing estimation of nonparametric generalized linear models studied in Fan, Heckman and Wand [J. Amer. Statist. Assoc. 90 (1995) 141--150]. In this work, we propose a unified family of parametrically-guided nonparametric estimation schemes. This combines the merits of both parametric and nonparametric approaches and enables us to incorporate prior knowledge. Asymptotic results and numerical simulations demonstrate the improvement of our new estimation schemes over the original nonparametric counterpart.

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Sparsistency and rates of convergence in large covariance matrix estimation

This paper studies the sparsistency and rates of convergence for estimating sparse covariance and precision matrices based on penalized likelihood with nonconvex penalty functions. Here, sparsistency refers to the property that all parameters that are zero are actually estimated as zero with probability tending to one. Depending on the case of applications, sparsity priori may occur on the covariance matrix, its inverse or its Cholesky decomposition. We study these three sparsity exploration problems under a unified framework with a general penalty function. We show that the rates of convergence for these problems under the Frobenius norm are of order $(s_n\log p_n/n)^{1/2}$, where $s_n$ is the number of nonzero elements, $p_n$ is the size of the covariance matrix and $n$ is the sample size. This explicitly spells out the contribution of high-dimensionality is merely of a logarithmic factor. The conditions on the rate with which the tuning parameter $λ_n$ goes to 0 have been made explicit and compared under different penalties. As a result, for the $L_1$-penalty, to guarantee the sparsistency and optimal rate of convergence, the number of nonzero elements should be small: $s_n'=O(p_n)$ at most, among $O(p_n^2)$ parameters, for estimating sparse covariance or correlation matrix, sparse precision or inverse correlation matrix or sparse Cholesky factor, where $s_n'$ is the number of the nonzero elements on the off-diagonal entries. On the other hand, using the SCAD or hard-thresholding penalty functions, there is no such a restriction.

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Non-Concave Penalized Likelihood with NP-Dimensionality

Penalized likelihood methods are fundamental to ultra-high dimensional variable selection. How high dimensionality such methods can handle remains largely unknown. In this paper, we show that in the context of generalized linear models, such methods possess model selection consistency with oracle properties even for dimensionality of Non-Polynomial (NP) order of sample size, for a class of penalized likelihood approaches using folded-concave penalty functions, which were introduced to ameliorate the bias problems of convex penalty functions. This fills a long-standing gap in the literature where the dimensionality is allowed to grow slowly with the sample size. Our results are also applicable to penalized likelihood with the $L_1$-penalty, which is a convex function at the boundary of the class of folded-concave penalty functions under consideration. The coordinate optimization is implemented for finding the solution paths, whose performance is evaluated by a few simulation examples and the real data analysis.

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A Selective Overview of Variable Selection in High Dimensional Feature Space (Invited Review Article)

High dimensional statistical problems arise from diverse fields of scientific research and technological development. Variable selection plays a pivotal role in contemporary statistical learning and scientific discoveries. The traditional idea of best subset selection methods, which can be regarded as a specific form of penalized likelihood, is computationally too expensive for many modern statistical applications. Other forms of penalized likelihood methods have been successfully developed over the last decade to cope with high dimensionality. They have been widely applied for simultaneously selecting important variables and estimating their effects in high dimensional statistical inference. In this article, we present a brief account of the recent developments of theory, methods, and implementations for high dimensional variable selection. What limits of the dimensionality such methods can handle, what the role of penalty functions is, and what the statistical properties are rapidly drive the advances of the field. The properties of non-concave penalized likelihood and its roles in high dimensional statistical modeling are emphasized. We also review some recent advances in ultra-high dimensional variable selection, with emphasis on independence screening and two-scale methods.

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A semiparametric model for cluster data

In the analysis of cluster data, the regression coefficients are frequently assumed to be the same across all clusters. This hampers the ability to study the varying impacts of factors on each cluster. In this paper, a semiparametric model is introduced to account for varying impacts of factors over clusters by using cluster-level covariates. It achieves the parsimony of parametrization and allows the explorations of nonlinear interactions. The random effect in the semiparametric model also accounts for within-cluster correlation. Local, linear-based estimation procedure is proposed for estimating functional coefficients, residual variance and within-cluster correlation matrix. The asymptotic properties of the proposed estimators are established, and the method for constructing simultaneous confidence bands are proposed and studied. In addition, relevant hypothesis testing problems are addressed. Simulation studies are carried out to demonstrate the methodological power of the proposed methods in the finite sample. The proposed model and methods are used to analyse the second birth interval in Bangladesh, leading to some interesting findings.

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Network exploration via the adaptive LASSO and SCAD penalties

Graphical models are frequently used to explore networks, such as genetic networks, among a set of variables. This is usually carried out via exploring the sparsity of the precision matrix of the variables under consideration. Penalized likelihood methods are often used in such explorations. Yet, positive-definiteness constraints of precision matrices make the optimization problem challenging. We introduce nonconcave penalties and the adaptive LASSO penalty to attenuate the bias problem in the network estimation. Through the local linear approximation to the nonconcave penalty functions, the problem of precision matrix estimation is recast as a sequence of penalized likelihood problems with a weighted $L_1$ penalty and solved using the efficient algorithm of Friedman et al. [Biostatistics 9 (2008) 432--441]. Our estimation schemes are applied to two real datasets. Simulation experiments and asymptotic theory are used to justify our proposed methods.

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High-dimensional classification using features annealed independence rules

Classification using high-dimensional features arises frequently in many contemporary statistical studies such as tumor classification using microarray or other high-throughput data. The impact of dimensionality on classifications is poorly understood. In a seminal paper, Bickel and Levina [Bernoulli 10 (2004) 989--1010] show that the Fisher discriminant performs poorly due to diverging spectra and they propose to use the independence rule to overcome the problem. We first demonstrate that even for the independence classification rule, classification using all the features can be as poor as the random guessing due to noise accumulation in estimating population centroids in high-dimensional feature space. In fact, we demonstrate further that almost all linear discriminants can perform as poorly as the random guessing. Thus, it is important to select a subset of important features for high-dimensional classification, resulting in Features Annealed Independence Rules (FAIR). The conditions under which all the important features can be selected by the two-sample $t$-statistic are established. The choice of the optimal number of features, or equivalently, the threshold value of the test statistics are proposed based on an upper bound of the classification error. Simulation studies and real data analysis support our theoretical results and demonstrate convincingly the advantage of our new classification procedure.

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Ultrahigh dimensional variable selection: beyond the linear model

Variable selection in high-dimensional space characterizes many contemporary problems in scientific discovery and decision making. Many frequently-used techniques are based on independence screening; examples include correlation ranking (Fan and Lv, 2008) or feature selection using a two-sample t-test in high-dimensional classification (Tibshirani et al., 2003). Within the context of the linear model, Fan and Lv (2008)showed that this simple correlation ranking possesses a sure independence screening property under certain conditions and that its revision, called iteratively sure independent screening (ISIS), is needed when the features are marginally unrelated but jointly related to the response variable. In this paper, we extend ISIS, without explicit definition of residuals, to a general pseudo-likelihood framework, which includes generalized linear models as a special case. Even in the least-squares setting, the new method improves ISIS by allowing variable deletion in the iterative process. Our technique allows us to select important features in high-dimensional classification where the popularly used two-sample t-method fails. A new technique is introduced to reduce the false discovery rate in the feature screening stage. Several simulated and two real data examples are presented to illustrate the methodology.

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Asset Allocation and Risk Assessment with Gross Exposure Constraints for Vast Portfolios

Markowitz (1952, 1959) laid down the ground-breaking work on the mean-variance analysis. Under his framework, the theoretical optimal allocation vector can be very different from the estimated one for large portfolios due to the intrinsic difficulty of estimating a vast covariance matrix and return vector. This can result in adverse performance in portfolio selected based on empirical data due to the accumulation of estimation errors. We address this problem by introducing the gross-exposure constrained mean-variance portfolio selection. We show that with gross-exposure constraint the theoretical optimal portfolios have similar performance to the empirically selected ones based on estimated covariance matrices and there is no error accumulation effect from estimation of vast covariance matrices. This gives theoretical justification to the empirical results in Jagannathan and Ma (2003). We also show that the no-short-sale portfolio is not diversified enough and can be improved by allowing some short positions. As the constraint on short sales relaxes, the number of selected assets varies from a small number to the total number of stocks, when tracking portfolios or selecting assets. This achieves the optimal sparse portfolio selection, which has close performance to the theoretical optimal one. Among 1000 stocks, for example, we are able to identify all optimal subsets of portfolios of different sizes, their associated allocation vectors, and their estimated risks. The utility of our new approach is illustrated by simulation and empirical studies on the 100 Fama-French industrial portfolios and the 400 stocks randomly selected from Russell 3000.

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Sure Independence Screening for Ultra-High Dimensional Feature Space

Variable selection plays an important role in high dimensional statistical modeling which nowadays appears in many areas and is key to various scientific discoveries. For problems of large scale or dimensionality $p$, estimation accuracy and computational cost are two top concerns. In a recent paper, Candes and Tao (2007) propose the Dantzig selector using $L_1$ regularization and show that it achieves the ideal risk up to a logarithmic factor $\log p$. Their innovative procedure and remarkable result are challenged when the dimensionality is ultra high as the factor $\log p$ can be large and their uniform uncertainty principle can fail. Motivated by these concerns, we introduce the concept of sure screening and propose a sure screening method based on a correlation learning, called the Sure Independence Screening (SIS), to reduce dimensionality from high to a moderate scale that is below sample size. In a fairly general asymptotic framework, the correlation learning is shown to have the sure screening property for even exponentially growing dimensionality. As a methodological extension, an iterative SIS (ISIS) is also proposed to enhance its finite sample performance. With dimension reduced accurately from high to below sample size, variable selection can be improved on both speed and accuracy, and can then be accomplished by a well-developed method such as the SCAD, Dantzig selector, Lasso, or adaptive Lasso. The connections of these penalized least-squares methods are also elucidated.

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Hazard models with varying coefficients for multivariate failure time data

Statistical estimation and inference for marginal hazard models with varying coefficients for multivariate failure time data are important subjects in survival analysis. A local pseudo-partial likelihood procedure is proposed for estimating the unknown coefficient functions. A weighted average estimator is also proposed in an attempt to improve the efficiency of the estimator. The consistency and asymptotic normality of the proposed estimators are established and standard error formulas for the estimated coefficients are derived and empirically tested. To reduce the computational burden of the maximum local pseudo-partial likelihood estimator, a simple and useful one-step estimator is proposed. Statistical properties of the one-step estimator are established and simulation studies are conducted to compare the performance of the one-step estimator to that of the maximum local pseudo-partial likelihood estimator. The results show that the one-step estimator can save computational cost without compromising performance both asymptotically and empirically and that an optimal weighted average estimator is more efficient than the maximum local pseudo-partial likelihood estimator. A data set from the Busselton Population Health Surveys is analyzed to illustrate our proposed methodology.

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High Dimensional Covariance Matrix Estimation Using a Factor Model

High dimensionality comparable to sample size is common in many statistical problems. We examine covariance matrix estimation in the asymptotic framework that the dimensionality $p$ tends to $\infty$ as the sample size $n$ increases. Motivated by the Arbitrage Pricing Theory in finance, a multi-factor model is employed to reduce dimensionality and to estimate the covariance matrix. The factors are observable and the number of factors $K$ is allowed to grow with $p$. We investigate impact of $p$ and $K$ on the performance of the model-based covariance matrix estimator. Under mild assumptions, we have established convergence rates and asymptotic normality of the model-based estimator. Its performance is compared with that of the sample covariance matrix. We identify situations under which the factor approach increases performance substantially or marginally. The impacts of covariance matrix estimation on portfolio allocation and risk management are studied. The asymptotic results are supported by a thorough simulation study.

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