arXiv subjects

Jianwen Feng

Publications and source records attributed to Jianwen Feng.

5 recordsLinked to original sources

arXiv2025

Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model

Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Designer, an LLM-based approach for swiftly designing novel antimicrobial peptides (AMPs) with desired properties. Within 11 days, AMP-Designer achieved the de novo design of 18 AMPs with broad-spectrum activity against Gram-negative bacteria. In vitro validation revealed a 94.4% success rate, with two candidates demonstrating exceptional antibacterial efficacy, minimal hemotoxicity, stability in human plasma, and low potential to induce resistance, as evidenced by significant bacterial load reduction in murine lung infection experiments. The entire process, from design to validation, concluded in 48 days. AMP-Designer excels in creating AMPs targeting specific strains despite limited data availability, with a top candidate displaying a minimum inhibitory concentration of 2.0 μg/ml against Propionibacterium acnes. Integrating advanced machine learning techniques, AMP-Designer demonstrates remarkable efficiency, paving the way for innovative solutions to antibiotic resistance.

q-bio.BM↗

arXiv2021

Stabilization of continuous-time Markov/semi-Markov jump linear systems via finite data-rate feedback

This paper investigates almost sure exponential stabilization of continuous-time Markov jump linear systems (MJLSs) under communication data-rate constraints by introducing sampling and quantization into the feedback control. Different from previous works, the sampling times and the jump times are independent of each other in this paper. The quantization is recursively adjusted on the sampling time, and its updating strategy does not depend on the switching in a sampling interval. In other words, the explicit value of the switching signal in a sampling interval is not necessary. The numerically testable condition is developed to ensure almost sure exponential stabilization of MJLSs under the proposed communication and control protocols. We also drop the assumption of stabilizability of all individual modes required in previous works about the switched systems. Moreover, we extend the result to the case of continuous-time semi-Markov jump linear systems (semi-MJLSs) via the semi-Markov kernel approach. Finally, some numerical examples are presented to illustrate the effectiveness of the proposed communication and control protocols.

math.DS↗

arXiv2019

Synchronization of Networked Harmonic Oscillators via Quantized Sampled Velocity Feedback

In this technical note, we propose a practicable quantized sampled velocity data coupling protocol for synchronization of a set of harmonic oscillators. The coupling protocol is designed in a quantized way via interconnecting the velocities encoded by a uniform quantizer with a zooming parameter in either a fixed or an adjustable form over a directed communication network. We establish sufficient conditions for the networked harmonic oscillators to converge to a bounded neighborhood of the synchronized orbits with a fixed zooming parameter. We ensure the oscillators to achieve synchronization by designing the quantized coupling protocol with an adjustable zooming parameter. Finally, we show two numerical examples to illustrate the effectiveness of the proposed coupling protocol.

math.OC↗

arXiv2018

Feedback pinning control of collective behaviors aroused by epidemic spread on complex networks

This paper investigates epidemic control behavioral synchronization for a class of complex networks resulting from spread of epidemic diseases via pinning feedback control strategy. Based on the quenched mean field theory, epidemic control synchronization models with inhibition of contact behavior is constructed, combining with the epidemic transmission system and the complex dynamical network carrying extra controllers. By the properties of convex functions and Gerschgorin theorem, the epidemic threshold of the model is obtained, and the global stability of disease-free equilibrium is analyzed. For individual's infected situation, when epidemic spreads, two types of feedback control strategies depended on the diseases' information are designed: the one only adds controllers to infected individuals, the other adds controllers both to infected and susceptible ones. And by using Lyapunov stability theory, under designed controllers, some criteria that guarantee epidemic control synchronization system achieving behavior synchronization are also derived. Several numerical simulations are performed to show the effectiveness of our theoretical results. As far as we know, this is the first work to address the controlling behavioral synchronization induced by epidemic spreading under the pinning feedback mechanism. It is hopeful that we may have more deeper insight into the essence between disease's spreading and collective behavior controlling in complex dynamical networks.

physics.soc-ph↗

arXiv2017

Phase Synchronization on Spacially Embeded Duplex Networks with Total Cost Constraint

Synchronization on multiplex networks have attracted increasing attention in the past few years. We investigate collective behaviors of Kuramoto oscillators on single layer and duplex spacial networks with total cost restriction, which was introduced by Li et. al [Li G., Reis S. D., Moreira A. A., Havlin S., Stanley H. E. and Jr A. J., {\it Phys. Rev. Lett.} 104, 018701 (2010)] and termed as the Li network afterwards. In the Li network model, with the increase of its spacial exponent, the network's structure will vary from the random type to the small-world one, and finally to the regular lattice.We first explore how the spacial exponent influences the synchronizability of Kuramoto oscillators on single layer Li networks and find that the closer the Li network is to a regular lattice, the more difficult for it to evolve into synchronization. Then we investigate synchronizability of duplex Li networks and find that the existence of inter-layer interaction can greatly enhance inter-layer and global synchronizability. When the inter-layer coupling strength is larger than a certain critical value, whatever the intra-layer coupling strength is, the inter-layer synchronization will always occur. Furthermore, on single layer Li networks, nodes with larger degrees more easily reach global synchronization, while on duplex Li networks, this phenomenon becomes much less obvious. Finally, we study the impact of inter-link density on global synchronization and obtain that sparse inter-links can lead to the emergence of global synchronization for duplex Li networks just as dense inter-links do. In a word, inter-layer interaction plays a vital role in determining synchronizability for duplex spacial networks with total cost constraint.

nlin.CD↗