arXiv subjects

Jianxin Chen

Publications and source records attributed to Jianxin Chen.

At least 37 records · Page 2Linked to original sources

arXiv2025

Louvre: Relaxing Hardware Requirements of Quantum LDPC Codes by Routing with Expanded Quantum Instruction Set

Generalized bicycle codes (GB codes) represent a promising family of quantum low-density parity-check codes, characterized by high code rates and relatively local qubit connectivity. A subclass of the GB code called bivariate bicycle codes (BB codes) has garnered significant interest due to their compatibility with two-layer connectivity architectures on superconducting quantum processors. However, one key limitation of BB codes is their high qubit connectivity degree requirements (degree 6), which exacerbates the noise susceptibility of the system. Building on the recent progress in implementing multiple two-qubit gates on a single chip, this work introduces Louvre -- a routing-based framework designed to reduce qubit connectivity requirements in GB codes. Specifically, Louvre-7 achieves degree reduction while preserving the depth of the syndrome extraction circuit, whereas Louvre-8 further minimizes the connectivity by slightly increasing the circuit depth. When applied to BB codes, these two schemes could reduce the average degree to 4.5 and 4, respectively. Crucially, Louvre eliminates some of the long-range, error-prone connections, which is a distinct advantage over prior approaches. Numerical simulations demonstrate that Louvre-7 has an indistinguishable logical error rate as the standard syndrome extraction circuits of GB codes, while Louvre-8 only incurs a slight error rate penalty. Furthermore, by reordering some of the gates in the circuit, we can reduce the coupler length without degrading the performance. Though most of our analysis focuses on GB codes defined on periodic boundary conditions, we further discuss the adaptability of Louvre to open-boundary lattices and defect-containing grids, underscoring its broader applicability in practical quantum error correction architectures.

quant-ph↗

arXiv2025

Compiling Arbitrary Single-Qubit Gates Via the Phase-Shifts of Microwave Pulses

We give an arbitrary single-qubit gate compilation scheme on superconducting processors that takes advantage of tuning the phase shift of microwave pulses to obtain a continuous gate set. This scheme is compatible with any two-qubit gate, and we only need to calibrate the $X_π$ and $X_{π/2}$ pulses. We implement this on fluxonium and obtain state-of-the-art fidelities. We give two other schemes: the first requires one $X_π$ pulse and one pulse with a variable rotation angle, and the second requires four $X_{π/2}$ pulses. We also find that if we can do virtual $Z$ gates, then we can also do virtual gates around any axis. Our results apply to any physical platform that natively supports virtual $Z$.

quant-ph↗

arXiv2025

PHOENIX: Pauli-Based High-Level Optimization Engine for Instruction Execution on NISQ Devices

Variational quantum algorithms (VQA) based on Hamiltonian simulation represent a specialized class of quantum programs well-suited for near-term quantum computing applications due to its modest resource requirements in terms of qubits and circuit depth. Unlike the conventional single-qubit (1Q) and two-qubit (2Q) gate sequence representation, Hamiltonian simulation programs are essentially composed of disciplined subroutines known as Pauli exponentiations (Pauli strings with coefficients) that are variably arranged. To capitalize on these distinct program features, this study introduces PHOENIX, a highly effective compilation framework that primarily operates at the high-level Pauli-based intermediate representation (IR) for generic Hamiltonian simulation programs. PHOENIX exploits global program optimization opportunities to the greatest extent, compared to existing SOTA methods despite some of them also utilizing similar IRs. Experimental results demonstrate that PHOENIX outperforms SOTA VQA compilers across diverse program categories, backend ISAs, and hardware topologies.

quant-ph↗

arXiv2025

Efficient Implementation of Arbitrary Two-Qubit Gates via Unified Control

The native gate set is fundamental to the performance of quantum devices, as it governs the accuracy of basic quantum operations and dictates the complexity of implementing quantum algorithms. Traditional approaches to extending gate sets often require accessing multiple transitions within an extended Hilbert space, leading to increased control complexity while offering only a limited set of gates. Here, we experimentally demonstrate a unified and highly versatile gate scheme capable of natively generating arbitrary two-qubit gates using only exchange interaction and qubit driving on a superconducting quantum processor, achieving maximum expressivity. Using a state-of-the-art transmon-coupler-transmon architecture, we achieve high fidelities averaging $99.37 \pm 0.07\%$ across a wide range of commonly used two-qubit unitaries. This outstanding performance, combined with reduced complexity, enables precise multipartite entangled state preparation, as demonstrated. To further enhance its applicability, we also show the high-fidelity realization of the unique B gate, which efficiently synthesizes the entire family of two-qubit gates. Our results highlight that fully exploiting the capabilities of a single interaction can yield a comprehensive and highly accurate gate set. With maximum expressivity, gate-time optimality, demonstrated high fidelity, and easy adaptability to other quantum platforms, our unified control scheme paves the way for optimal performance in quantum devices, offering exciting prospects for advancing quantum hardware and algorithm development.

quant-ph↗

arXiv2024

NP-TCMtarget: a network pharmacology platform for exploring mechanisms of action of Traditional Chinese medicine

The biological targets of traditional Chinese medicine (TCM) are the core effectors mediating the interaction between TCM and the human body. Identification of TCM targets is essential to elucidate the chemical basis and mechanisms of TCM for treating diseases. Given the chemical complexity of TCM, both in silico high-throughput drug-target interaction predicting models and biological profile-based methods have been commonly applied for identifying TCM targets based on the structural information of TCM chemical components and biological information, respectively. However, the existing methods lack the integration of TCM chemical and biological information, resulting in difficulty in the systematic discovery of TCM action pathways. To solve this problem, we propose a novel target identification model NP-TCMtarget to explore the TCM target path by combining the overall chemical and biological profiles. First, NP-TCMtarget infers TCM effect targets by calculating associations between drug/disease inducible gene expression profiles and specific gene signatures for 8,233 targets. Then, NP-TCMtarget utilizes a constructed binary classification model to predict binding targets of herbal ingredients. Finally, we can distinguish TCM direct and indirect targets by comparing the effect targets and binding targets to establish the action pathways of herbal components-direct targets-indirect targets by mapping TCM targets in the biological molecular network. We apply NP-TCMtarget to the formula XiaoKeAn to demonstrate the power of revealing the action pathways of herbal formula. We expect that this novel model could provide a systematic framework for exploring the molecular mechanisms of TCM at the target level. NP-TCMtarget is available at http://www.bcxnfz.top/NP-TCMtarget.

q-bio.MN↗

arXiv2024

Leakage Benchmarking for Universal Gate Sets

Errors are common issues in quantum computing platforms, among which leakage is one of the most challenging to address. This is because leakage, i.e., the loss of information stored in the computational subspace to undesired subspaces in a larger Hilbert space, is more difficult to detect and correct than errors that preserve the computational subspace. As a result, leakage presents a significant obstacle to the development of fault-tolerant quantum computation. In this paper, we propose an efficient and accurate benchmarking framework called leakage randomized benchmarking (LRB) for measuring leakage rates on multi-qubit quantum systems. Our approach is more insensitive to state preparation and measurement (SPAM) noise than existing leakage benchmarking protocols, requires fewer assumptions about the gate set itself, and can be used to benchmark multi-qubit leakages, which was not done previously. We also extend the LRB protocol to an interleaved variant called interleaved LRB (iLRB), which can benchmark the average leakage rate of generic $n$-site quantum gates with reasonable noise assumptions. We demonstrate the iLRB protocol on benchmarking generic two-qubit gates realized using flux tuning, and analyze the behavior of iLRB under corresponding leakage models. Our numerical experiments show good agreement with theoretical estimations, indicating the feasibility of both the LRB and iLRB protocols. Keywords: quantum computing; randomized benchmarking; leakage error; quantum gates

quant-ph↗

arXiv2024

Drug-target interaction prediction by integrating heterogeneous information with mutual attention network

Identification of drug-target interactions is an indispensable part of drug discovery. While conventional shallow machine learning and recent deep learning methods based on chemogenomic properties of drugs and target proteins have pushed this prediction performance improvement to a new level, these methods are still difficult to adapt to novel structures. Alternatively, large-scale biological and pharmacological data provide new ways to accelerate drug-target interaction prediction. Here, we propose DrugMAN, a deep learning model for predicting drug-target interaction by integrating multiplex heterogeneous functional networks with a mutual attention network (MAN). DrugMAN uses a graph attention network-based integration algorithm to learn network-specific low-dimensional features for drugs and target proteins by integrating four drug networks and seven gene/protein networks, respectively. DrugMAN then captures interaction information between drug and target representations by a mutual attention network to improve drug-target prediction. DrugMAN achieves the best prediction performance under four different scenarios, especially in real-world scenarios. DrugMAN spotlights heterogeneous information to mine drug-target interactions and can be a powerful tool for drug discovery and drug repurposing.

q-bio.QM↗

arXiv2024

Superconducting processor design optimization for quantum error correction performance

In the quest for fault-tolerant quantum computation using superconducting processors, accurate performance assessment and continuous design optimization stands at the forefront. To facilitate both meticulous simulation and streamlined design optimization, we introduce a multi-level simulation framework that spans both Hamiltonian and quantum error correction levels, and is equipped with the capability to compute gradients efficiently. This toolset aids in design optimization, tailored to specific objectives like quantum memory performance. Within our framework, we investigate the often-neglected spatially correlated unitary errors, highlighting their significant impact on logical error rates. We exemplify our approach through the multi-path coupling scheme of fluxonium qubits.

quant-ph↗

arXiv2024

A genome-scale deep learning model to predict gene expression changes of genetic perturbations from multiplex biological networks

Systematic characterization of biological effects to genetic perturbation is essential to the application of molecular biology and biomedicine. However, the experimental exhaustion of genetic perturbations on the genome-wide scale is challenging. Here, we show that TranscriptionNet, a deep learning model that integrates multiple biological networks to systematically predict transcriptional profiles to three types of genetic perturbations based on transcriptional profiles induced by genetic perturbations in the L1000 project: RNA interference (RNAi), clustered regularly interspaced short palindromic repeat (CRISPR) and overexpression (OE). TranscriptionNet performs better than existing approaches in predicting inducible gene expression changes for all three types of genetic perturbations. TranscriptionNet can predict transcriptional profiles for all genes in existing biological networks and increases perturbational gene expression changes for each type of genetic perturbation from a few thousand to 26,945 genes. TranscriptionNet demonstrates strong generalization ability when comparing predicted and true gene expression changes on different external tasks. Overall, TranscriptionNet can systemically predict transcriptional consequences induced by perturbing genes on a genome-wide scale and thus holds promise to systemically detect gene function and enhance drug development and target discovery.

q-bio.GN↗

arXiv2023

A Classical Architecture For Digital Quantum Computers

Scaling bottlenecks the making of digital quantum computers, posing challenges from both the quantum and the classical components. We present a classical architecture to cope with a comprehensive list of the latter challenges {\em all at once}, and implement it fully in an end-to-end system by integrating a multi-core RISC-V CPU with our in-house control electronics. Our architecture enables scalable, high-precision control of large quantum processors and accommodates evolving requirements of quantum hardware. A central feature is a microarchitecture executing quantum operations in parallel on arbitrary predefined qubit groups. Another key feature is a reconfigurable quantum instruction set that supports easy qubit re-grouping and instructions extensions. As a demonstration, we implement the widely-studied surface code quantum computing workflow, which is instructive for being demanding on both the controllers and the integrated classical computation. Our design, for the first time, reduces instruction issuing and transmission costs to constants, which do not scale with the number of qubits, without adding any overheads in decoding or dispatching. Rather than relying on specialized hardware for syndrome decoding, our system uses a dedicated multi-core CPU for both qubit control and classical computation, including syndrome decoding. This simplifies the system design and facilitates load-balancing between the quantum and classical components. We implement recent proposals as decoding firmware on a RISC-V system-on-chip (SoC) that parallelizes general inner decoders. By using our in-house Union-Find and PyMatching 2 implementations, we can achieve unprecedented decoding capabilities of up to distances 47 and 67 with the currently available SoCs, under realistic and optimistic assumptions of physical error rate $p=0.001 and p=0.0001, respectively, all in just 1 \textmu s.

quant-ph↗

arXiv2022

Randomized Benchmarking Beyond Groups

Randomized benchmarking (RB) is the gold standard for experimentally evaluating the quality of quantum operations. The current framework for RB is centered on groups and their representations, but this can be problematic. For example, Clifford circuits need up to $O(n^2)$ gates, and thus Clifford RB cannot scale to larger devices. Attempts to remedy this include new schemes such as linear cross-entropy benchmarking (XEB), cycle benchmarking, and non-uniform RB, but they do not fall within the group-based RB framework. In this work, we formulate the \emph{universal randomized benchmarking (URB) framework} which does away with the group structure and also replaces the recovery gate plus measurement component with a general ``post-processing'' POVM. Not only does this framework cover most of the existing benchmarking schemes, but it also gives the language for and helps inspire the formulation of new schemes. We specifically consider a class of URB schemes called \emph{twirling schemes}. For twirling schemes, the post-processing POVM approximately factorizes into an intermediate channel, inverting maps, and a final measurement. This leads us to study the twirling map corresponding to the gate ensemble specified by the scheme. We prove that if this twirling map is strictly within unit distance of the Haar twirling map in induced diamond norm, the probability of measurement as a function of gate length is a single exponential decay up to small error terms. The core technical tool we use is the matrix perturbation theory of linear operators on quantum channels.

quant-ph↗

arXiv2022

Scalable surface code decoders with parallelization in time

Fast classical processing is essential for most quantum fault-tolerance architectures. We introduce a sliding-window decoding scheme that provides fast classical processing for the surface code through parallelism. Our scheme divides the syndromes in spacetime into overlapping windows along the time direction, which can be decoded in parallel with any inner decoder. With this parallelism, our scheme can solve the decoding throughput problem as the code scales up, even if the inner decoder is slow. When using min-weight perfect matching and union-find as the inner decoders, we observe circuit-level thresholds of $0.68\%$ and $0.55\%$, respectively, which are almost identical to $0.70\%$ and $0.55\%$ for the batch decoding.

quant-ph↗

arXiv2022

Quantum Instruction Set Design for Performance

A quantum instruction set is where quantum hardware and software meet. We develop new characterization and compilation techniques for non-Clifford gates to accurately evaluate different quantum instruction set designs. We specifically apply them to our fluxonium processor that supports mainstream instruction $\mathrm{iSWAP}$ by calibrating and characterizing its square root $\mathrm{SQiSW}$. We measure a gate fidelity of up to $99.72\%$ with an average of $99.31\%$ and realize Haar random two-qubit gates using $\mathrm{SQiSW}$ with an average fidelity of $96.38\%$. This is an average error reduction of $41\%$ for the former and a $50\%$ reduction for the latter compared to using $\mathrm{iSWAP}$ on the same processor. This shows designing the quantum instruction set consisting of $\mathrm{SQiSW}$ and single-qubit gates on such platforms leads to a performance boost at almost no cost.

quant-ph↗

arXiv2022

Linear Cross Entropy Benchmarking with Clifford Circuits

With the advent of quantum processors exceeding $100$ qubits and the high engineering complexities involved, there is a need for holistically benchmarking the processor to have quality assurance. Linear cross-entropy benchmarking (XEB) has been used extensively for systems with $50$ or more qubits but is fundamentally limited in scale due to the exponentially large computational resources required for classical simulation. In this work we propose conducting linear XEB with Clifford circuits, a scheme we call Clifford XEB. Since Clifford circuits can be simulated in polynomial time, Clifford XEB can be scaled to much larger systems. To validate this claim, we run numerical simulations for particular classes of Clifford circuits with noise and observe exponential decays. When noise levels are low, the decay rates are well-correlated with the noise of each cycle assuming a digital error model. We perform simulations of systems up to 1,225 qubits, where the classical processing task can be easily dealt with by a workstation. Furthermore, using the theoretical guarantees in Chen et al. (arXiv:2203.12703), we prove that Clifford XEB with our proposed Clifford circuits must yield exponential decays under a general error model for sufficiently low errors. Our theoretical results explain some of the phenomena observed in the simulations and shed light on the behavior of general linear XEB experiments.

quant-ph↗

arXiv2021

Integrating Quantum Processor Device and Control Optimization in a Gradient-based Framework

In a quantum processor, the device design and external controls together contribute to the quality of the target quantum operations. As we continuously seek better alternative qubit platforms, we explore the increasingly large device and control design space. Thus, optimization becomes more and more challenging. In this work, we demonstrate that the figure of merit reflecting a design goal can be made differentiable with respect to the device and control parameters. In addition, we can compute the gradient of the design objective efficiently in a similar manner to the back-propagation algorithm and then utilize the gradient to optimize the device and the control parameters jointly and efficiently. This extends the scope of the quantum optimal control to superconducting device design. We also demonstrate the viability of gradient-based joint optimization over the device and control parameters through a few examples.

quant-ph↗

arXiv2021

Fluxonium: an alternative qubit platform for high-fidelity operations

Superconducting qubits provide a promising path toward building large-scale quantum computers. The simple and robust transmon qubit has been the leading platform, achieving multiple milestones. However, fault-tolerant quantum computing calls for qubit operations at error rates significantly lower than those exhibited in the state of the art. Consequently, alternative superconducting qubits with better error protection have attracted increasing interest. Among them, fluxonium is a particularly promising candidate, featuring large anharmonicity and long coherence times. Here, we engineer a fluxonium-based quantum processor that integrates high qubit-coherence, fast frequency-tunability, and individual-qubit addressability for reset, readout, and gates. With simple and fast gate schemes, we achieve an average single-qubit gate fidelity of 99.97% and a two-qubit gate fidelity of up to 99.72%. This performance is comparable to the highest values reported in the literature of superconducting circuits. Thus our work, for the first time within the realm of superconducting qubits, reveals an approach toward fault-tolerant quantum computing that is alternative and competitive to the transmon system.

quant-ph↗

arXiv2021

Background-Click Supervision for Temporal Action Localization

Weakly supervised temporal action localization aims at learning the instance-level action pattern from the video-level labels, where a significant challenge is action-context confusion. To overcome this challenge, one recent work builds an action-click supervision framework. It requires similar annotation costs but can steadily improve the localization performance when compared to the conventional weakly supervised methods. In this paper, by revealing that the performance bottleneck of the existing approaches mainly comes from the background errors, we find that a stronger action localizer can be trained with labels on the background video frames rather than those on the action frames. To this end, we convert the action-click supervision to the background-click supervision and develop a novel method, called BackTAL. Specifically, BackTAL implements two-fold modeling on the background video frames, i.e. the position modeling and the feature modeling. In position modeling, we not only conduct supervised learning on the annotated video frames but also design a score separation module to enlarge the score differences between the potential action frames and backgrounds. In feature modeling, we propose an affinity module to measure frame-specific similarities among neighboring frames and dynamically attend to informative neighbors when calculating temporal convolution. Extensive experiments on three benchmarks are conducted, which demonstrate the high performance of the established BackTAL and the rationality of the proposed background-click supervision. Code is available at https://github.com/VividLe/BackTAL.

cs.CV↗

arXiv2021

Rechargeable self-assembled droplet microswimmers driven by surface phase transitions

The design of artificial microswimmers is often inspired by the strategies of natural microorganisms. Many of these creatures exploit the fact that elasticity breaks the time-reversal symmetry of motion at low Reynolds numbers, but this principle has been notably absent from model systems of active, self-propelled microswimmers. Here we introduce a class of microswimmer that spontaneously self-assembles and swims without using external forces, driven instead by surface phase transitions induced by temperature variations. The swimmers are made from alkane droplets dispersed in aqueous surfactant solution, which start to self-propel upon cooling, pushed by rapidly growing thin elastic tails. When heated, the same droplets recharge by retracting their tails, swimming for up to tens of minutes in each cycle. Thermal oscillations of approximately 5 degrees Celsius induce the swimmers to harness heat from the environment and recharge multiple times. We develop a detailed elastohydrodynamic model of these processes and highlight the molecular mechanisms involved. The system offers a convenient platform for examining symmetry breaking in the motion of swimmers exploiting flagellar elasticity. The mild conditions and biocompatible media render these microswimmers potential probes for studying biological propulsion and interactions between artificial and biological swimmers.

cond-mat.soft↗