arXiv subjects

Jianxin Lin

Publications and source records attributed to Jianxin Lin.

At least 19 recordsLinked to original sources

arXiv2026

The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomy

The growing ability of large language models and vision-language models to jointly interpret and reason over images and text is reshaping medical imaging AI, moving it from task-specific predictors toward autonomous agents that perceive, reason, plan, remember, and act in clinical environments. This survey departs from the capability-first perspective of existing literature and instead begins from clinical deployment, asking what tasks, contamination-resistant benchmarks, and interactive training environments are required before medical agents can be trusted in practice. Medical agents are formalized as sequential decision-making systems under partial observability, together with a three-level autonomy taxonomy spanning assisted, cooperative, and fully autonomous operation. The field is organized along a unified scaling spine consisting of framework scaling, capability scaling, and environment scaling. Within this framework, clinical environment scaling, the integration of tools, data, and clinical gyms, is identified as the most actionable yet underexplored direction for agents operating in PACS, EHR, and FHIR ecosystems. Clinical self-evolution, where agents improve through interaction with their environments rather than parameter scaling alone, is further positioned as a key research frontier, drawing insights from self-improving agents, agent gyms, and test-time compute scaling. Applications across radiology, pathology, ophthalmology, and hospital workflows are examined together with deployment challenges including hallucination, cascading failures, and fairness. By consolidating more than 300 references, with particular emphasis on advances from 2025 to 2026, this survey provides a roadmap toward trustworthy, self-improving medical imaging systems for real clinical practice.

cs.AI↗

arXiv2026

Subspace-Guided Semantic and Topological Invariant Registration for Annotation-Free Ultrasound Plane Quality Control

Reliable quality control (QC) of ultrasound images is essential for both real-time acquisition guidance and retrospective clinical audit, yet existing approaches rely heavily on per-plane annotations, or employ pseudo-labeling prone to systematic bias under spatial deformations inherent in clinical acquisition. We present STRIQ, a registration-driven framework that recasts annotation-free US plane quality control as a subspace-guided consistency measurement problem. Specifically, STRIQ introduces a Latent Registration Aligner (LRA) to establish hierarchical feature space correspondences between query images and variance-driven anchors, which are autonomously distilled from unlabeled data via a variance spectrum criterion to serve as structurally stable prototypes. To further disambiguate anatomical planes and mitigate negative knowledge transfer, we propose an Orthogonal Knowledge Subspace (OKS) module. The OKS decomposes plane-specific representations into mutually orthogonal subspaces, enabling fine-grained expert collaboration while preventing inter-plane interference, ensuring that the quality metric is grounded in principled subspace proximity. Extensive experiments on the in-house US4QA and public CAMUS datasets demonstrate that STRIQ achieves state-of-the-art correlation with clinical quality scores, establishing a new paradigm for annotation-free, real-time reliable ultrasound quality control. Our code is available at https://github.com/zhcz328/STRIQ.

cs.CV↗

arXiv2026

Anatomy-Anchored Self-Supervision: Distilling Vision Foundation Models for Invariant Ultrasound Representation

Self-supervised pre-training paradigm has gained increasing prominence for learning transferable representations in medical imaging, yet existing methods for ultrasound (US) images operate at the image or frame level, overlooking the anatomical context for clinical-aligned representation learning. In this work, we propose an anatomy-anchored ultrasound self-supervision framework ANAUS that shifts representation learning from generic visual regions to clinically meaningful anatomical structures. Utilizing a learnable latent prompt engine alongside a one-time domain adaptation on existing public image-mask pairs, we empower the LP-SAM module to achieve annotation-free anatomy delineation at scale. Building upon this anatomical grounding, we propose a dual-policy self-supervised learning paradigm consisting of inter-view semantics-aware anatomy-separating alignment and contextual core-region prediction to enhance representation learning. Specifically, the former enforces feature invariance within identical anatomical regions while promoting discriminability across distinct structures; the latter compels the model to reconstruct corrupted regions, thereby capturing fine-grained structural details. Extensive evaluations on six public datasets demonstrate that ANAUS consistently outstrips current state-of-the-art methods while maintaining the computational efficiency essential for clinical deployment. Code is available at https://github.com/zhcz328/ANAUS.

cs.CV↗

arXiv2026

MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution

High-precision medical diagnosis relies not only on static imaging features but also on the implicit diagnostic memory experts instantly invoke during image interpretation. We pinpoint a fundamental cognitive misalignment in medical VLMs caused by discrete tokenization, leading to quantization loss, long-range information dissipation, and missing case-adaptive expertise. To bridge this gap, we propose ours, a framework for latent diagnostic memory evolution that simulates the experiential invocation of clinicians by dynamically synthesizing implicit diagnostic memories within the model's hidden stream. Specifically, it begins with a Meta Query for Prior Memorization mechanism, where learnable probes retrieve structured priors from an anatomical prior encoder to generate condensed implicit memories. To ensure clinical fidelity, we introduce Causal Counterfactual Refinement (CCR), which leverages reinforcement learning and counterfactual rewards derived from region-level feature masking to quantify the causal contribution of each memory, thereby pruning redundancies and aligning latent representations with diagnostic logic. This evolutionary process culminates in Intrinsic Memory Transition (IMT), a privileged-autonomous dual-branch paradigm that internalizes teacher-branch diagnostic patterns into the student-branch via full-vocabulary divergence alignment. Comprehensive empirical evaluations across multiple datasets demonstrate that ours, by transferring external expertise into endogenous parameters, significantly outperforms existing state-of-the-art methods, particularly chain-of-thought paradigms, in diagnostic accuracy. The code is available at https://github.com/zhcz328/MedSynapse-V.

cs.CV↗

arXiv2026

When Models Learn to Ask Why: Adaptive Causal Reasoning for Trustworthy Medical Vision-Language Models

Vision-Language Models (VLMs) have enabled interpretable medical diagnosis by integrating visual perception with linguistic reasoning. Yet, existing medical chain-of-thought (CoT) models lack explicit mechanisms to represent and enforce causal reasoning, leaving them vulnerable to spurious correlations and limiting their clinical reliability. We pinpoint three core challenges in medical CoT reasoning: how to adaptively trigger causal correction, construct high-quality causal-spurious contrastive samples, and maintain causal consistency across reasoning trajectories. To address these challenges, we propose MedCausalX, an end-to-end framework explicitly models causal reasoning chains in medical VLMs. We first introduce the CRMed dataset providing fine-grained anatomical annotations, structured causal reasoning chains, and counterfactual variants that guide the learning of causal relationships beyond superficial correlations. Building upon CRMed, MedCausalX employs a two-stage adaptive reflection architecture equipped with $\langle$causal$\rangle$ and $\langle$verify$\rangle$ tokens, enabling the model to autonomously determine when and how to perform causal analysis and verification. Finally, a trajectory-level causal correction objective optimized through error-attributed reinforcement learning refines the reasoning chain, allowing the model to distinguish genuine causal dependencies from shortcut associations. Extensive experiments on multiple benchmarks show that MedCausalX consistently outperforms state-of-the-art methods, improving diagnostic consistency by +5.4 points, reducing hallucination by over 10 points, and attaining top spatial grounding IoU, thereby setting a new standard for causally grounded medical reasoning. The code and dataset are available at https://github.com/zhcz328/MedCausalX.

cs.AI↗

arXiv2025

fMRI2GES: Co-speech Gesture Reconstruction from fMRI Signal with Dual Brain Decoding Alignment

Understanding how the brain responds to external stimuli and decoding this process has been a significant challenge in neuroscience. While previous studies typically concentrated on brain-to-image and brain-to-language reconstruction, our work strives to reconstruct gestures associated with speech stimuli perceived by brain. Unfortunately, the lack of paired \{brain, speech, gesture\} data hinders the deployment of deep learning models for this purpose. In this paper, we introduce a novel approach, \textbf{fMRI2GES}, that allows training of fMRI-to-gesture reconstruction networks on unpaired data using \textbf{Dual Brain Decoding Alignment}. This method relies on two key components: (i) observed texts that elicit brain responses, and (ii) textual descriptions associated with the gestures. Then, instead of training models in a completely supervised manner to find a mapping relationship among the three modalities, we harness an fMRI-to-text model, a text-to-gesture model with paired data and an fMRI-to-gesture model with unpaired data, establishing dual fMRI-to-gesture reconstruction patterns. Afterward, we explicitly align two outputs and train our model in a self-supervision way. We show that our proposed method can reconstruct expressive gestures directly from fMRI recordings. We also investigate fMRI signals from different ROIs in the cortex and how they affect generation results. Overall, we provide new insights into decoding co-speech gestures, thereby advancing our understanding of neuroscience and cognitive science.

cs.AI↗

arXiv2025

MedEyes: Learning Dynamic Visual Focus for Medical Progressive Diagnosis

Accurate medical diagnosis often involves progressive visual focusing and iterative reasoning, characteristics commonly observed in clinical workflows. While recent vision-language models demonstrate promising chain-of-thought (CoT) reasoning capabilities via reinforcement learning with verifiable rewards (RLVR), their purely on-policy learning paradigm tends to reinforce superficially coherent but clinically inaccurate reasoning paths. We propose MedEyes, a novel reinforcement learning framework that dynamically models clinician-style diagnostic reasoning by progressively attending to and interpreting relevant medical image regions. By incorporating off-policy expert guidance, MedEyes converts expert visual search trajectories into structured external behavioral signals, guiding the model toward clinically aligned visual reasoning. We design the Gaze-guided Reasoning Navigator (GRN) to emulate the diagnostic process through a dual-mode exploration strategy, scanning for systematic abnormality localization and drilling for detailed regional analysis. To balance expert imitation and autonomous discovery, we introduce the Confidence Value Sampler (CVS), which employs nucleus sampling and adaptive termination to create diverse yet credible exploration paths. Finally, the dual-stream GRPO optimization framework decouples on-policy and off-policy learning signals, mitigating reward assimilation and entropy collapse. Experiments demonstrate that MedEyes achieves an average performance improvement of +8.5pp across multiple medical VQA benchmarks, validating MedEyes's potential in building trustworthy medical AI systems. Code is available at https://github.com/zhcz328/MedEyes.

cs.CV↗

arXiv2025

Pathology-Aware Prototype Evolution via LLM-Driven Semantic Disambiguation for Multicenter Diabetic Retinopathy Diagnosis

Diabetic retinopathy (DR) grading plays a critical role in early clinical intervention and vision preservation. Recent explorations predominantly focus on visual lesion feature extraction through data processing and domain decoupling strategies. However, they generally overlook domain-invariant pathological patterns and underutilize the rich contextual knowledge of foundation models, relying solely on visual information, which is insufficient for distinguishing subtle pathological variations. Therefore, we propose integrating fine-grained pathological descriptions to complement prototypes with additional context, thereby resolving ambiguities in borderline cases. Specifically, we propose a Hierarchical Anchor Prototype Modulation (HAPM) framework to facilitate DR grading. First, we introduce a variance spectrum-driven anchor prototype library that preserves domain-invariant pathological patterns. We further employ a hierarchical differential prompt gating mechanism, dynamically selecting discriminative semantic prompts from both LVLM and LLM sources to address semantic confusion between adjacent DR grades. Finally, we utilize a two-stage prototype modulation strategy that progressively integrates clinical knowledge into visual prototypes through a Pathological Semantic Injector (PSI) and a Discriminative Prototype Enhancer (DPE). Extensive experiments across eight public datasets demonstrate that our approach achieves pathology-guided prototype evolution while outperforming state-of-the-art methods. The code is available at https://github.com/zhcz328/HAPM.

cs.AI↗

arXiv2025

The 1st International Workshop on Disentangled Representation Learning for Controllable Generation (DRL4Real): Methods and Results

This paper reviews the 1st International Workshop on Disentangled Representation Learning for Controllable Generation (DRL4Real), held in conjunction with ICCV 2025. The workshop aimed to bridge the gap between the theoretical promise of Disentangled Representation Learning (DRL) and its application in realistic scenarios, moving beyond synthetic benchmarks. DRL4Real focused on evaluating DRL methods in practical applications such as controllable generation, exploring advancements in model robustness, interpretability, and generalization. The workshop accepted 9 papers covering a broad range of topics, including the integration of novel inductive biases (e.g., language), the application of diffusion models to DRL, 3D-aware disentanglement, and the expansion of DRL into specialized domains like autonomous driving and EEG analysis. This summary details the workshop's objectives, the themes of the accepted papers, and provides an overview of the methodologies proposed by the authors.

cs.LG↗

arXiv2025

Restoring Real-World Images with an Internal Detail Enhancement Diffusion Model

Restoring real-world degraded images, such as old photographs or low-resolution images, presents a significant challenge due to the complex, mixed degradations they exhibit, such as scratches, color fading, and noise. Recent data-driven approaches have struggled with two main challenges: achieving high-fidelity restoration and providing object-level control over colorization. While diffusion models have shown promise in generating high-quality images with specific controls, they often fail to fully preserve image details during restoration. In this work, we propose an internal detail-preserving diffusion model for high-fidelity restoration of real-world degraded images. Our method utilizes a pre-trained Stable Diffusion model as a generative prior, eliminating the need to train a model from scratch. Central to our approach is the Internal Image Detail Enhancement (IIDE) technique, which directs the diffusion model to preserve essential structural and textural information while mitigating degradation effects. The process starts by mapping the input image into a latent space, where we inject the diffusion denoising process with degradation operations that simulate the effects of various degradation factors. Extensive experiments demonstrate that our method significantly outperforms state-of-the-art models in both qualitative assessments and perceptual quantitative evaluations. Additionally, our approach supports text-guided restoration, enabling object-level colorization control that mimics the expertise of professional photo editing.

cs.CV↗

arXiv2024

HR-Extreme: A High-Resolution Dataset for Extreme Weather Forecasting

The application of large deep learning models in weather forecasting has led to significant advancements in the field, including higher-resolution forecasting and extended prediction periods exemplified by models such as Pangu and Fuxi. Despite these successes, previous research has largely been characterized by the neglect of extreme weather events, and the availability of datasets specifically curated for such events remains limited. Given the critical importance of accurately forecasting extreme weather, this study introduces a comprehensive dataset that incorporates high-resolution extreme weather cases derived from the High-Resolution Rapid Refresh (HRRR) data, a 3-km real-time dataset provided by NOAA. We also evaluate the current state-of-the-art deep learning models and Numerical Weather Prediction (NWP) systems on HR-Extreme, and provide a improved baseline deep learning model called HR-Heim which has superior performance on both general loss and HR-Extreme compared to others. Our results reveal that the errors of extreme weather cases are significantly larger than overall forecast error, highlighting them as an crucial source of loss in weather prediction. These findings underscore the necessity for future research to focus on improving the accuracy of extreme weather forecasts to enhance their practical utility.

cs.LG↗

arXiv2024

MaskMol: Knowledge-guided Molecular Image Pre-Training Framework for Activity Cliffs

Activity cliffs, which refer to pairs of molecules that are structurally similar but show significant differences in their potency, can lead to model representation collapse and make the model challenging to distinguish them. Our research indicates that as molecular similarity increases, graph-based methods struggle to capture these nuances, whereas image-based approaches effectively retain the distinctions. Thus, we developed MaskMol, a knowledge-guided molecular image self-supervised learning framework. MaskMol accurately learns the representation of molecular images by considering multiple levels of molecular knowledge, such as atoms, bonds, and substructures. By utilizing pixel masking tasks, MaskMol extracts fine-grained information from molecular images, overcoming the limitations of existing deep learning models in identifying subtle structural changes. Experimental results demonstrate MaskMol's high accuracy and transferability in activity cliff estimation and compound potency prediction across 20 different macromolecular targets, outperforming 25 state-of-the-art deep learning and machine learning approaches. Visualization analyses reveal MaskMol's high biological interpretability in identifying activity cliff-relevant molecular substructures. Notably, through MaskMol, we identified candidate EP4 inhibitors that could be used to treat tumors. This study not only raises awareness about activity cliffs but also introduces a novel method for molecular image representation learning and virtual screening, advancing drug discovery and providing new insights into structure-activity relationships (SAR).

cs.CV↗

arXiv2024

KGExplainer: Towards Exploring Connected Subgraph Explanations for Knowledge Graph Completion

Knowledge graph completion (KGC) aims to alleviate the inherent incompleteness of knowledge graphs (KGs), which is a critical task for various applications, such as recommendations on the web. Although knowledge graph embedding (KGE) models have demonstrated superior predictive performance on KGC tasks, these models infer missing links in a black-box manner that lacks transparency and accountability, preventing researchers from developing accountable models. Existing KGE-based explanation methods focus on exploring key paths or isolated edges as explanations, which is information-less to reason target prediction. Additionally, the missing ground truth leads to these explanation methods being ineffective in quantitatively evaluating explored explanations. To overcome these limitations, we propose KGExplainer, a model-agnostic method that identifies connected subgraph explanations and distills an evaluator to assess them quantitatively. KGExplainer employs a perturbation-based greedy search algorithm to find key connected subgraphs as explanations within the local structure of target predictions. To evaluate the quality of the explored explanations, KGExplainer distills an evaluator from the target KGE model. By forwarding the explanations to the evaluator, our method can examine the fidelity of them. Extensive experiments on benchmark datasets demonstrate that KGExplainer yields promising improvement and achieves an optimal ratio of 83.3% in human evaluation.

cs.AI↗

arXiv2024

Instruction Multi-Constraint Molecular Generation Using a Teacher-Student Large Language Model

While various models and computational tools have been proposed for structure and property analysis of molecules, generating molecules that conform to all desired structures and properties remains a challenge. Here, we introduce a multi-constraint molecular generation large language model, TSMMG, which, akin to a student, incorporates knowledge from various small models and tools, namely, the 'teachers'. To train TSMMG, we construct a large set of text-molecule pairs by extracting molecular knowledge from these 'teachers', enabling it to generate novel molecules that conform to the descriptions through various text prompts. We experimentally show that TSMMG remarkably performs in generating molecules meeting complex, natural language-described property requirements across two-, three-, and four-constraint tasks, with an average molecular validity of over 99% and success ratio of 82.58%, 68.03%, and 67.48%, respectively. The model also exhibits adaptability through zero-shot testing, creating molecules that satisfy combinations of properties that have not been encountered. It can comprehend text inputs with various language styles, extending beyond the confines of outlined prompts, as confirmed through empirical validation. Additionally, the knowledge distillation feature of TSMMG contributes to the continuous enhancement of small models, while the innovative approach to dataset construction effectively addresses the issues of data scarcity and quality, which positions TSMMG as a promising tool in the domains of drug discovery and materials science.

cs.CL↗

arXiv2023

Breathing Life into Faces: Speech-driven 3D Facial Animation with Natural Head Pose and Detailed Shape

The creation of lifelike speech-driven 3D facial animation requires a natural and precise synchronization between audio input and facial expressions. However, existing works still fail to render shapes with flexible head poses and natural facial details (e.g., wrinkles). This limitation is mainly due to two aspects: 1) Collecting training set with detailed 3D facial shapes is highly expensive. This scarcity of detailed shape annotations hinders the training of models with expressive facial animation. 2) Compared to mouth movement, the head pose is much less correlated to speech content. Consequently, concurrent modeling of both mouth movement and head pose yields the lack of facial movement controllability. To address these challenges, we introduce VividTalker, a new framework designed to facilitate speech-driven 3D facial animation characterized by flexible head pose and natural facial details. Specifically, we explicitly disentangle facial animation into head pose and mouth movement and encode them separately into discrete latent spaces. Then, these attributes are generated through an autoregressive process leveraging a window-based Transformer architecture. To augment the richness of 3D facial animation, we construct a new 3D dataset with detailed shapes and learn to synthesize facial details in line with speech content. Extensive quantitative and qualitative experiments demonstrate that VividTalker outperforms state-of-the-art methods, resulting in vivid and realistic speech-driven 3D facial animation.

cs.CV↗

arXiv2023

Towards Better Multi-modal Keyphrase Generation via Visual Entity Enhancement and Multi-granularity Image Noise Filtering

Multi-modal keyphrase generation aims to produce a set of keyphrases that represent the core points of the input text-image pair. In this regard, dominant methods mainly focus on multi-modal fusion for keyphrase generation. Nevertheless, there are still two main drawbacks: 1) only a limited number of sources, such as image captions, can be utilized to provide auxiliary information. However, they may not be sufficient for the subsequent keyphrase generation. 2) the input text and image are often not perfectly matched, and thus the image may introduce noise into the model. To address these limitations, in this paper, we propose a novel multi-modal keyphrase generation model, which not only enriches the model input with external knowledge, but also effectively filters image noise. First, we introduce external visual entities of the image as the supplementary input to the model, which benefits the cross-modal semantic alignment for keyphrase generation. Second, we simultaneously calculate an image-text matching score and image region-text correlation scores to perform multi-granularity image noise filtering. Particularly, we introduce the correlation scores between image regions and ground-truth keyphrases to refine the calculation of the previously-mentioned correlation scores. To demonstrate the effectiveness of our model, we conduct several groups of experiments on the benchmark dataset. Experimental results and in-depth analyses show that our model achieves the state-of-the-art performance. Our code is available on https://github.com/DeepLearnXMU/MM-MKP.

cs.CV↗

arXiv2023

DiffColor: Toward High Fidelity Text-Guided Image Colorization with Diffusion Models

Recent data-driven image colorization methods have enabled automatic or reference-based colorization, while still suffering from unsatisfactory and inaccurate object-level color control. To address these issues, we propose a new method called DiffColor that leverages the power of pre-trained diffusion models to recover vivid colors conditioned on a prompt text, without any additional inputs. DiffColor mainly contains two stages: colorization with generative color prior and in-context controllable colorization. Specifically, we first fine-tune a pre-trained text-to-image model to generate colorized images using a CLIP-based contrastive loss. Then we try to obtain an optimized text embedding aligning the colorized image and the text prompt, and a fine-tuned diffusion model enabling high-quality image reconstruction. Our method can produce vivid and diverse colors with a few iterations, and keep the structure and background intact while having colors well-aligned with the target language guidance. Moreover, our method allows for in-context colorization, i.e., producing different colorization results by modifying prompt texts without any fine-tuning, and can achieve object-level controllable colorization results. Extensive experiments and user studies demonstrate that DiffColor outperforms previous works in terms of visual quality, color fidelity, and diversity of colorization options.

cs.CV↗

arXiv2023

EMoG: Synthesizing Emotive Co-speech 3D Gesture with Diffusion Model

Although previous co-speech gesture generation methods are able to synthesize motions in line with speech content, it is still not enough to handle diverse and complicated motion distribution. The key challenges are: 1) the one-to-many nature between the speech content and gestures; 2) the correlation modeling between the body joints. In this paper, we present a novel framework (EMoG) to tackle the above challenges with denoising diffusion models: 1) To alleviate the one-to-many problem, we incorporate emotion clues to guide the generation process, making the generation much easier; 2) To model joint correlation, we propose to decompose the difficult gesture generation into two sub-problems: joint correlation modeling and temporal dynamics modeling. Then, the two sub-problems are explicitly tackled with our proposed Joint Correlation-aware transFormer (JCFormer). Through extensive evaluations, we demonstrate that our proposed method surpasses previous state-of-the-art approaches, offering substantial superiority in gesture synthesis.

cs.CV↗