arXiv subjects

Jiaqi Lv

Publications and source records attributed to Jiaqi Lv.

At least 19 recordsLinked to original sources

arXiv2026

Computationally Efficient Pathology Segmentation using Knowledge Distillation from Foundation Models

Automatic tissue segmentation is essential for large-scale analysis of histopathology whole-slide images (WSIs), but accurate pixel-level segmentation remains challenging. Pixel-level annotations are expensive to obtain, models pre-trained on natural images may transfer poorly to histopathology, and pathology foundation models, despite their strong representations, are computationally expensive to deploy at scale. We address these challenges with a foundation-model knowledge distillation framework for efficient tissue segmentation. We first train Virchow2-based segmentation teachers, including a LoRA-adapted variant, achieving state-of-the-art or highly competitive performance across four datasets: PUMA, IGNITE, BEETLE, and a private blood vessel segmentation dataset. We then transfer response-level and feature-level knowledge from these teachers into compact student networks. Distillation consistently improves student performance over supervised training alone, producing state-of-the-art or near state-of-the-art results with substantially fewer parameters and up to ten-fold higher inference throughput than foundation-model-based segmentation networks. These results show that foundation-model knowledge can be effectively transferred to efficient segmentation models for scalable deployment without compromising performance. Models trained on the public datasets will be released through TIAToolbox.

eess.IV↗

arXiv2026

Beyond Next-Observation Prediction: Agent-Authored World Modeling for Sequential Decision Making

Recent studies on world modeling for Large Language Model (LLM) agents typically formulate the learning objective as next-observation prediction. However, this objective ties supervision to what a transition happens to reveal, which may omit the dynamics most relevant to the agent's current decision. To bridge this gap, we propose Agent-Authored World Modeling (AAWM), a training procedure that constructs supervision from the policy's own decision needs. Specifically, at each state, the agent identifies what it needs to understand about the environment before acting. These needs drive the retrieval of relevant transition evidence across trajectories, which is then synthesized into training targets that capture decision-oriented dynamics instead of reconstructing the next observation. This aligns the training objective with the dynamics the policy needs before acting, not with the contents of the next observation. Experimental results validate the effectiveness of AAWM across multiple environments and training settings. These results show that decision-aware world-model targets provide a more effective learning signal than next-observation prediction.

cs.CL↗

arXiv2026

Mitosis Detection in the Wild: Multi-Tumor and Context-Aware Generalization in the MIDOG 2025 Challenge

Automated mitosis detection is a well-established task in computational pathology. While previous benchmarks focused on scanner-induced domain shift, clinical "real-world" application requires models to be robust across the vast variance to be expected in the histological landscape. The MItosis DOmain Generalization (MIDOG) 2025 challenge was designed to evaluate algorithmic performance across unprecedented biological and contextual diversity. We curated a test dataset of 365 cases, encompassing 12 distinct human, canine and feline tumor types, digitized across multiple scanning platforms. Moving beyond hand-selected hotspots, the challenge required detection also in random tissue areas (representative of the whole slide detection situation) and challenging areas (areas rich in hard negatives). In the second track, we introduced the classification of atypical mitotic figures (AMFs). There were 18 teams submitting to the detection track, with F1 scores ranging up to 0.740. In the AMF detection track, we had 21 submissions with balanced accuracy values up to 0.908. Our analysis reveals that while most models perform reliably in traditional hotspots, significant performance degradation occurs in challenging ROIs, where false positive rates tripled. Furthermore, performance varied significantly across the 12 tumor types, highlighting "blind spots" in current state-of-the-art architectures when encountering rare or highly pleomorphic malignancies. Moreover, we evaluated the effectiveness of ensembling and found a mean increases of 1.5 and 1.3 percentage points in F1 score and balanced accuracy, respectively. In contrast, TTA showed no relevant improvement. MIDOG 2025 demonstrates that "in the wild" mitosis detection remains a significant hurdle. The transition from hotspot-only evaluation to a multi-contextual framework provides a more realistic proxy for clinical reliability.

cs.CV↗

arXiv2026

A deep learning framework for glomeruli segmentation with boundary attention

Accurate detection and segmentation of glomeruli in kidney tissue are essential for diagnostic applications. Traditional deep learning methods primarily rely on semantic segmentation, which often fails to precisely delineate adjacent glomeruli. To address this challenge, we propose a novel glomerulus detection and segmentation model that emphasises boundary separation. Leveraging pathology foundation models, the proposed U-Net-based architecture incorporates a specialised attention decoder designed to highlight critical regions and improve instancelevel segmentation. Experimental evaluations demonstrate that our approach surpasses state-of-the-art methods in both Dice score and Intersection over Union, indicating superior performance in glomerular delineation.

q-bio.TO↗

arXiv2026

A Unified Framework for Knowledge Transfer in Bidirectional Model Scaling

Transferring pre-trained knowledge from a source model to a target model of a different architectural size is a key challenge for flexible and efficient model scaling. However, current parameter-space methods treat Small-to-Large (S2L) and Large-to-Small (L2S) scaling as separate, incompatible problems, focusing on parameter synthesis and selection, respectively. This fragmented perspective has resulted in specialized tools, hindering a unified, bidirectional framework. In this paper, we propose BoT (Bidirectional knowledge Transfer), the first size-agnostic framework to unify S2L and L2S scaling. Our core insight is to treat model weights as continuous signals, where models of different sizes represent distinct discretizations of the transferable knowledge. This multi-resolution perspective directly casts S2L and L2S scaling as the signal processing operations of upsampling and downsampling, naturally leading to the adoption of the Discrete Wavelet Transform (DWT) and its Inverse (IDWT). BoT leverages the recursive nature of wavelets, using the decomposition level as a dynamic scaling factor to bridge disparate model sizes in a parameter-free and computationally efficient manner. Extensive experiments on DeiT, BERT, and GPT demonstrate significant pre-training FLOPs savings (up to 67.1% for S2L, 52.8% for L2S) and state-of-the-art performance on benchmarks like GLUE and SQuAD.

cs.LG↗

arXiv2026

Breaking the Scale Barrier: One-Shot Knowledge Transfer via Frequency Transform

Transferring knowledge by fine-tuning large-scale pre-trained networks has become a standard paradigm for downstream tasks, yet the knowledge of a pre-trained model is tightly coupled with monolithic architecture, which restricts flexible reuse across models of varying scales. In response to this challenge, recent approaches typically resort to either parameter selection, which fails to capture the interdependent structure of this knowledge, or parameter prediction using generative models that depend on impractical access to large network collections. In this paper, we identify the low-frequency components of model weights as the concrete carrier of foundational, task-agnostic knowledge, its ``learngene", and validate this by demonstrating its efficient inheritance by downstream models and tasks. Based on this insight, we propose FRONT (FRequency dOmain kNowledge Transfer), a novel framework that uses the Discrete Cosine Transform (DCT) to isolate the low-frequency ``learngene". This learngene can be seamlessly adapted to initialize models of arbitrary size via simple truncation or padding, a process that is entirely training-free. For enhanced performance, we propose an optional low-cost refinement process that introduces a spectral regularizer to further improve the learngene's transferability. Extensive experiments demonstrate that FRONT achieves the state-of-the-art performance, accelerates convergence by up to $15\times$ in vision tasks, and reduces training FLOPs by an average of 40.5% in language tasks. Code is available at https://github.com/LUcy0505/FRONT.

cs.LG↗

arXiv2026

Graph Negative Feedback Bias Correction Framework for Adaptive Heterophily Modeling

Graph Neural Networks (GNNs) have emerged as a powerful framework for processing graph-structured data. However, conventional GNNs and their variants are inherently limited by the homophily assumption, leading to degradation in performance on heterophilic graphs. Although substantial efforts have been made to mitigate this issue, they remain constrained by the message-passing paradigm, which is inherently rooted in homophily. In this paper, a detailed analysis of how the underlying label autocorrelation of the homophily assumption introduces bias into GNNs is presented. We innovatively leverage a negative feedback mechanism to correct the bias and propose Graph Negative Feedback Bias Correction (GNFBC), a simple yet effective framework that is independent of any specific aggregation strategy. Specifically, we introduce a negative feedback loss that penalizes the sensitivity of predictions to label autocorrelation. Furthermore, we incorporate the output of graph-agnostic models as a feedback term, leveraging independent node feature information to counteract correlation-induced bias guided by Dirichlet energy. GNFBC can be seamlessly integrated into existing GNN architectures, improving overall performance with comparable computational and memory overhead.

cs.LG↗

arXiv2026

iScript: A Domain-Adapted Large Language Model and Benchmark for Physical Design Tcl Script Generation

Modern EDA flows rely heavily on Tcl scripting, yet general LLMs perform poorly in this domain due to extreme data scarcity, domain-specific semantics, and the high reliability required in physical design. We present iScript, a domain-adapted Qwen3-8B model for Innovus Tcl script generation, and iScript-Bench, a comprehensive benchmark covering five task categories and three difficulty levels. To overcome the lack of training data, we introduce a multi-stage data synthesis pipeline that integrates command extraction, static linting, requirement back-inference, and Chain-of-Thought generation, producing a 10K-tuple (requirement, CoT, script) dataset. iScript is trained through a two-stage strategy combining domain-adaptive pretraining and supervised fine-tuning. To evaluate script correctness efficiently, we further propose a two-step verification framework consisting of static syntax verification and LLM-based functional evaluation. On our benchmark, iScript shows higher pass@k scores than currently state-of-the-art LLMs on average. These results demonstrate the effectiveness of domain adaptation and data synthesis for EDA scripting tasks.

cs.SE↗

arXiv2026

Multi-Scale Adaptive Neighborhood Awareness Transformer For Graph Fraud Detection

Graph fraud detection (GFD) is crucial for identifying fraudulent behavior within graphs, benefiting various domains such as financial networks and social media. Existing methods based on graph neural networks (GNNs) have succeeded considerably due to their effective expressive capacity for graph-structured data. However, the inherent inductive bias of GNNs, including the homogeneity assumption and the limited global modeling ability, hinder the effectiveness of these models. To address these challenges, we propose Multi-scale Neighborhood Awareness Transformer (MANDATE), which alleviates the inherent inductive bias of GNNs. Specifically, we design a multi-scale positional encoding strategy to encode the positional information of various distances from the central node. By incorporating it with the self-attention mechanism, the global modeling ability can be enhanced significantly. Meanwhile, we design different embedding strategies for homophilic and heterophilic connections. This mitigates the homophily distribution differences between benign and fraudulent nodes. Moreover, an embedding fusion strategy is designed for multi-relation graphs, which alleviates the distribution bias caused by different relationships. Experiments on three fraud detection datasets demonstrate the superiority of MANDATE.

cs.LG↗

arXiv2025

ModalSurv: Investigating opportunities and limitations of multimodal deep survival learning in prostate and bladder cancer

Accurate survival prediction is essential for personalised cancer treatment. We propose ModalSurv, a multimodal deep survival framework integrating clinical, MRI, histopathology, and RNA-sequencing data via modality-specific projections and cross-attention fusion. On the CHIMERA Grand Challenge datasets, ModalSurv achieved a C-index of 0.7402 (1st) for prostate and 0.5740 (5th) for bladder cancer. Notably, clinical features alone outperformed multimodal models on external tests, highlighting challenges of limited multimodal alignment and potential overfitting. Local validation showed multimodal gains but limited generalisation. ModalSurv provides a systematic evaluation of multimodal survival modelling, underscoring both its promise and current limitations for scalable, generalisable cancer prognosis.

cs.LG↗

arXiv2025

KongNet: A Multi-headed Deep Learning Model for Detection and Classification of Nuclei in Histopathology Images

Accurate detection and classification of nuclei in histopathology images are critical for diagnostic and research applications. We present KongNet, a multi-headed deep learning architecture featuring a shared encoder and parallel, cell-type-specialised decoders. Through multi-task learning, each decoder jointly predicts nuclei centroids, segmentation masks, and contours, aided by Spatial and Channel Squeeze-and-Excitation (SCSE) attention modules and a composite loss function. We validate KongNet in three Grand Challenges. The proposed model achieved first place on track 1 and second place on track 2 during the MONKEY Challenge. Its lightweight variant (KongNet-Det) secured first place in the 2025 MIDOG Challenge. KongNet pre-trained on the MONKEY dataset and fine-tuned on the PUMA dataset ranked among the top three in the PUMA Challenge without further optimisation. Furthermore, KongNet established state-of-the-art performance on the publicly available PanNuke and CoNIC datasets. Our results demonstrate that the specialised multi-decoder design is highly effective for nuclei detection and classification across diverse tissue and stain types. The pre-trained model weights along with the inference code have been publicly released to support future research.

eess.IV↗

arXiv2025

TokenSwap: Backdoor Attack on the Compositional Understanding of Large Vision-Language Models

Large vision-language models (LVLMs) have achieved impressive performance across a wide range of vision-language tasks, while they remain vulnerable to backdoor attacks. Existing backdoor attacks on LVLMs aim to force the victim model to generate a predefined target pattern, which is either inserted into or replaces the original content. We find that these fixed-pattern attacks are relatively easy to detect, because the attacked LVLM tends to memorize such frequent patterns in the training dataset, thereby exhibiting overconfidence on these targets given poisoned inputs. To address these limitations, we introduce TokenSwap, a more evasive and stealthy backdoor attack that focuses on the compositional understanding capabilities of LVLMs. Instead of enforcing a fixed targeted content, TokenSwap subtly disrupts the understanding of object relationships in text. Specifically, it causes the backdoored model to generate outputs that mention the correct objects in the image but misrepresent their relationships (i.e., bags-of-words behavior). During training, TokenSwap injects a visual trigger into selected samples and simultaneously swaps the grammatical roles of key tokens in the corresponding textual answers. However, the poisoned samples exhibit only subtle differences from the original ones, making it challenging for the model to learn the backdoor behavior. To address this, TokenSwap employs an adaptive token-weighted loss that explicitly emphasizes the learning of swapped tokens, such that the visual triggers and bags-of-words behavior are associated. Extensive experiments demonstrate that TokenSwap achieves high attack success rates while maintaining superior evasiveness and stealthiness across multiple benchmarks and various LVLM architectures.

cs.CV↗

arXiv2025

MitoDetect++: A Domain-Robust Pipeline for Mitosis Detection and Atypical Subtyping

Automated detection and classification of mitotic figures especially distinguishing atypical from normal remain critical challenges in computational pathology. We present MitoDetect++, a unified deep learning pipeline designed for the MIDOG 2025 challenge, addressing both mitosis detection and atypical mitosis classification. For detection (Track 1), we employ a U-Net-based encoder-decoder architecture with EfficientNetV2-L as the backbone, enhanced with attention modules, and trained via combined segmentation losses. For classification (Track 2), we leverage the Virchow2 vision transformer, fine-tuned efficiently using Low-Rank Adaptation (LoRA) to minimize resource consumption. To improve generalization and mitigate domain shifts, we integrate strong augmentations, focal loss, and group-aware stratified 5-fold cross-validation. At inference, we deploy test-time augmentation (TTA) to boost robustness. Our method achieves a balanced accuracy of 0.892 across validation domains, highlighting its clinical applicability and scalability across tasks.

eess.IV↗

arXiv2025

Leveraging Pathology Foundation Models for Panoptic Segmentation of Melanoma in H&E Images

Melanoma is an aggressive form of skin cancer with rapid progression and high metastatic potential. Accurate characterisation of tissue morphology in melanoma is crucial for prognosis and treatment planning. However, manual segmentation of tissue regions from haematoxylin and eosin (H&E) stained whole-slide images (WSIs) is labour-intensive and prone to inter-observer variability, this motivates the need for reliable automated tissue segmentation methods. In this study, we propose a novel deep learning network for the segmentation of five tissue classes in melanoma H&E images. Our approach leverages Virchow2, a pathology foundation model trained on 3.1 million histopathology images as a feature extractor. These features are fused with the original RGB images and subsequently processed by an encoder-decoder segmentation network (Efficient-UNet) to produce accurate segmentation maps. The proposed model achieved first place in the tissue segmentation task of the PUMA Grand Challenge, demonstrating robust performance and generalizability. Our results show the potential and efficacy of incorporating pathology foundation models into segmentation networks to accelerate computational pathology workflows.

eess.IV↗

arXiv2025

HPCTransCompile: An AI Compiler Generated Dataset for High-Performance CUDA Transpilation and LLM Preliminary Exploration

The rapid growth of deep learning has driven exponential increases in model parameters and computational demands. NVIDIA GPUs and their CUDA-based software ecosystem provide robust support for parallel computing, significantly alleviating computational bottlenecks. Meanwhile, due to the cultivation of user programming habits and the high performance of GPUs, the CUDA ecosystem has established a dominant position in the field of parallel software. This dominance requires other hardware platforms to support CUDA-based software with performance portability. However, translating CUDA code to other platforms poses significant challenges due to differences in parallel programming paradigms and hardware architectures. Existing approaches rely on language extensions, domain-specific languages (DSLs), or compilers but face limitations in workload coverage and generalizability. Moreover, these methods often incur substantial development costs. Recently, LLMs have demonstrated extraordinary potential in various vertical domains, especially in code-related tasks. However, the performance of existing LLMs in CUDA transpilation, particularly for high-performance code, remains suboptimal. To address these challenges, we propose a novel framework for generating high-performance CUDA and corresponding platform code pairs, leveraging AI compiler and automatic optimization technology. We further enhance the framework with a graph-based data augmentation method and introduce HPCTransEval, a benchmark for evaluating LLM performance on CUDA transpilation. We conduct experiments using CUDA-to-CPU transpilation as a case study on leading LLMs. The speedup ratio of the CPU operators has an average improvemnet of 43.8\%, highlighting the potential of LLMs to address compatibility challenges within the CUDA ecosystem. Our code is available at https://github.com/PJLAB-CHIP/HPCTransCompile.

cs.DC↗

arXiv2025

ChatHLS: Towards Systematic Design Automation and Optimization for High-Level Synthesis

High-Level Synthesis (HLS) improves IC development productivity by enabling hardware design from C-like languages. However, strict coding constraints and design-specific optimizations limit its widespread adoption. While recent efforts employ large language models (LLMs) to assist HLS design, they often struggle with synthesizability rules and directive semantics. To this end, we introduce ChatHLS, a multi-agent HLS design framework that leverages specialized LLMs for automated debugging and directive tuning. ChatHLS incorporates an adaptive error case expansion mechanism, combined with a reasoning-to-instruction analysis method to accurately diagnose HLS errors. To optimize hardware performance, it enables QoR-aware reasoning to learn the impact of HLS directives on the quality of results (QoR). Experimental results demonstrate that ChatHLS outperforms Gemini-3-pro with a 32.6% relative improvement in debugging, while achieving significant speedups across various HLS kernels and neural network accelerators. These results underscore the potential of ChatHLS for agile hardware development.

cs.AR↗

arXiv2025

Harmonizing Generalization and Personalization in Ring-topology Decentralized Federated Learning

We introduce Ring-topology Decentralized Federated Learning (RDFL) for distributed model training, aiming to avoid the inherent risks of centralized failure in server-based FL. However, RDFL faces the challenge of low information-sharing efficiency due to the point-to-point communication manner when handling inherent data heterogeneity. Existing studies to mitigate data heterogeneity focus on personalized optimization of models, ignoring that the lack of shared information constraints can lead to large differences among models, weakening the benefits of collaborative learning. To tackle these challenges, we propose a Divide-and-conquer RDFL framework (DRDFL) that uses a feature generation model to extract personalized information and invariant shared knowledge from the underlying data distribution, ensuring both effective personalization and strong generalization. Specifically, we design a \textit{PersonaNet} module that encourages class-specific feature representations to follow a Gaussian mixture distribution, facilitating the learning of discriminative latent representations tailored to local data distributions. Meanwhile, the \textit{Learngene} module is introduced to encapsulate shared knowledge through an adversarial classifier to align latent representations and extract globally invariant information. Extensive experiments demonstrate that DRDFL outperforms state-of-the-art methods in various data heterogeneity settings.

cs.LG↗

arXiv2025

GENE-FL: Gene-Driven Parameter-Efficient Dynamic Federated Learning

Real-world \underline{F}ederated \underline{L}earning systems often encounter \underline{D}ynamic clients with \underline{A}gnostic and highly heterogeneous data distributions (DAFL), which pose challenges for efficient communication and model initialization. To address these challenges, we draw inspiration from the recently proposed Learngene paradigm, which compresses the large-scale model into lightweight, cross-task meta-information fragments. Learngene effectively encapsulates and communicates core knowledge, making it particularly well-suited for DAFL, where dynamic client participation requires communication efficiency and rapid adaptation to new data distributions. Based on this insight, we propose a Gene-driven parameter-efficient dynamic Federated Learning (GENE-FL) framework. First, local models perform quadratic constraints based on parameters with high Fisher values in the global model, as these parameters are considered to encapsulate generalizable knowledge. Second, we apply the strategy of parameter sensitivity analysis in local model parameters to condense the \textit{learnGene} for interaction. Finally, the server aggregates these small-scale trained \textit{learnGene}s into a robust \textit{learnGene} with cross-task generalization capability, facilitating the rapid initialization of dynamic agnostic client models. Extensive experimental results demonstrate that GENE-FL reduces \textbf{4 $\times$} communication costs compared to FEDAVG and effectively initializes agnostic client models with only about \textbf{9.04} MB.

cs.DC↗