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Jie Kate Hu

Publications and source records attributed to Jie Kate Hu.

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SpaCE: The Spatial Confounding Environment

Spatial confounding poses a significant challenge in scientific studies involving spatial data, where unobserved spatial variables can influence both treatment and outcome, possibly leading to spurious associations. To address this problem, we introduce SpaCE: The Spatial Confounding Environment, the first toolkit to provide realistic benchmark datasets and tools for systematically evaluating causal inference methods designed to alleviate spatial confounding. Each dataset includes training data, true counterfactuals, a spatial graph with coordinates, and smoothness and confounding scores characterizing the effect of a missing spatial confounder. It also includes realistic semi-synthetic outcomes and counterfactuals, generated using state-of-the-art machine learning ensembles, following best practices for causal inference benchmarks. The datasets cover real treatment and covariates from diverse domains, including climate, health and social sciences. SpaCE facilitates an automated end-to-end pipeline, simplifying data loading, experimental setup, and evaluating machine learning and causal inference models. The SpaCE project provides several dozens of datasets of diverse sizes and spatial complexity. It is publicly available as a Python package, encouraging community feedback and contributions.

cs.LG

A Bayesian Nonparametric Method to Adjust for Unmeasured Confounding with Negative Controls

Unmeasured confounding bias threatens the validity of observational studies. While sensitivity analyses and study designs have been proposed to address this issue, they often overlook the growing availability of auxiliary data. Using negative controls from these data is a promising new approach to reduce unmeasured confounding bias. In this article, we develop a Bayesian nonparametric method to estimate a causal exposure-response function (CERF) leveraging information from negative controls to adjust for unmeasured confounding. We model the CERF as a mixture of linear models. This strategy captures the potential nonlinear shape of CERFs while maintaining computational efficiency, and it leverages closed-form results that hold under the linear model assumption. We assess the performance of our method through simulation studies. We found that the proposed method can recover the true shape of the CERF in the presence of unmeasured confounding under assumptions. To show the practical utility of our approach, we apply it to adjust for a possible unmeasured confounder when evaluating the relationship between long-term exposure to ambient $PM_{2.5}$ and cardiovascular hospitalization rates among the elderly in the continental US. We implement our estimation procedure in open-source software and have made the code publicly available to ensure reproducibility.

stat.ME

Small area estimation of forest biomass via a two-stage model for continuous zero-inflated data

The United States (US) Forest Inventory & Analysis Program (FIA) collects data on and monitors the trends of forests in the US. FIA is increasingly interested in monitoring forest attributes such as biomass at fine geographic and temporal scales, resulting in a need for assessment and development of small area estimation techniques in forest inventory. We implement a small area estimator and parametric bootstrap estimator that account for zero-inflation in biomass data via a two-stage model-based approach and compare its performance to a post-stratified estimator and to the unit- and area-level empirical best linear unbiased prediction (EBLUP) estimators. For estimator comparison, we conduct a simulation study with counties in the US state Nevada as domains based on sampled plot data and remote sensing data products. Results show the zero-inflated estimator has the lowest relative bias and the smallest empirical root mean square error. Moreover, the 95% confidence interval coverages of the zero-inflated estimator and the unit-level EBLUP are more accurate than the other two estimators. To further illustrate the practical utility, we employ a data application across the 2019 measurement year in Nevada. We introduce the R package, saeczi, which efficiently implements the zero-inflated estimator and its mean squared error estimator.

stat.AP

Z-estimation system: a modular approach to asymptotic analysis

Asymptotic analysis for related inference problems often involves similar steps and proofs. These intermediate results could be shared across problems if each of them is made self-contained and easily identified. However, asymptotic analysis using Taylor expansions is limited for result borrowing because it is a step-to-step procedural approach. This article introduces EEsy, a modular system for estimating finite and infinitely dimensional parameters in related inference problems. It is based on the infinite-dimensional Z-estimation theorem, Donsker and Glivenko-Cantelli preservation theorems, and weight calibration techniques. This article identifies the systematic nature of these tools and consolidates them into one system containing several modules, which can be built, shared, and extended in a modular manner. This change to the structure of method development allows related methods to be developed in parallel and complex problems to be solved collaboratively, expediting the development of new analytical methods. This article considers four related inference problems -- estimating parameters with random sampling, two-phase sampling, auxiliary information incorporation, and model misspecification. We illustrate this modular approach by systematically developing 9 parameter estimators and 18 variance estimators for the four related inference problems regarding semi-parametric additive hazards models. Simulation studies show the obtained asymptotic results for these 27 estimators are valid. In the end, I describe how this system can simplify the use of empirical process theory, a powerful but challenging tool to be adopted by the broad community of methods developers. I discuss challenges and the extension of this system to other inference problems.

math.ST