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Jieyuan Liu

Publications and source records attributed to Jieyuan Liu.

8 recordsLinked to original sources

Lost at the End: Primacy Bias in Multimodal Retrieval-Augmented Question Answering

Knowledge-based visual question answering (KB-VQA) lets vision-language systems answer questions that exceed their parametric knowledge by conditioning a reader on passages retrieved from a Wikipedia-derived knowledge base. In pure-text long-context LLMs, retrieved-context use follows the U-shaped lost-in-the-middle effect of Liu et al. (2024): information at the start and end of context is used, the middle is lost. Whether this transfers to deployed multimodal KB-VQA is open. To close this gap, we design the first controlled probe of reader-side position dependence in multimodal KB-VQA: a gold-position protocol in which only the gold passage's prompt slot varies within question. We run it on three open-source 7B/8B VLM readers and two KB-VQA benchmarks with up to 20 retrieved passages. The shape flips from U to primacy: gold-at-first beats gold-at-last by 16 to 26 points on all six combinations of reader and benchmark, an effect we call Lost at the End; the gap holds at every scale we test, 3B to 32B, attenuating at 32B. Three targeted ablations narrow the cause. A text-only control that removes the image and changes nothing else shows the primacy is already present in text mode and does not depend on the image. Image-position and distractor-shuffle ablations trace the effect to prompt slot 0 of the instruction-tuned reader, where a second answer-bearing passage placed later is largely wasted. On a frozen reader, three retrieval-side fixes (MMR, oracle reranking, rank-based reordering) all fail to improve on the deployment default. Our findings indicate that recall@k is the wrong metric for deployed KB-VQA and that the remaining headroom sits on the reader side; we release our protocol as a controlled instrument for evaluating reader-side interventions.

cs.CL↗

HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

Scientific agents contribute to hypothesis discovery by synthesizing evidence, assessing proposals, and developing new explanations. Recent systems combine scientific agents with evolutionary search through critique, comparison, and revision. However, how different forms of agent collaboration affect hypothesis quality remains an open question. Answering this question requires separating the effects of agents' scientific capabilities from those of their collaboration. A framework must therefore preserve agents' scientific roles and support rules for combining, revising, and retaining hypotheses. Building on this view, we introduce HypoEvolve, which makes collaboration explicit through successive updates to a hypothesis population. Specifically, we propose a generational genetic algorithm to coordinate specialized large language model (LLM) agents that integrate mechanistic arguments, reconsider assumptions, and assess evidence and testability. Each generation specifies how scientific judgments and new proposals reshape the population, making collaboration effects on hypothesis quality directly testable. Moreover, we design our evaluation around scientifically meaningful hypotheses that explain how a proposed intervention could work. Drug repurposing links these explanations to target-level biological claims assessed against external evidence. Specifically, we adapt DepMap and Open Targets into complementary external measures grounded in experimental, genetic, and clinical evidence. Across 34 cancer types, HypoEvolve achieves the highest scores against six baselines on both measures. DepMap selectivity reaches 0.171, versus 0.115 for the strongest baseline. Gains over single-pass generation also generalize to held-out cancer types. HypoEvolve advances a vision of autonomous science in which AI research teams achieve a capacity for discovery beyond that of individual models.

cs.CL↗

FIRE-Bench: Evaluating AI Agents on the Rediscovery of Scientific Insights

Autonomous agents powered by large language models (LLMs) promise to accelerate scientific discovery end-to-end, but rigorously evaluating their capacity for verifiable discovery remains a central challenge. Existing benchmarks face a trade-off: they either heavily rely on LLM-as-judge evaluations of automatically generated research outputs or optimize convenient yet isolated performance metrics that provide coarse proxies for scientific insight. To address this gap, we introduce FIRE-Bench (Full-cycle Insight Rediscovery Evaluation), a benchmark that evaluates agents through the rediscovery of established findings from recent, high-impact machine learning research. Agents are given only a high-level research question extracted from a published, verified study and must autonomously explore ideas, design experiments, implement code, execute their plans, and derive conclusions supported by empirical evidence. We evaluate a range of state-of-the-art agents with frontier LLMs backbones like gpt-5 on FIRE-Bench. Our results show that full-cycle scientific research remains challenging for current agent systems: even the strongest agents achieve limited rediscovery success (<50 F1), exhibit high variance across runs, and display recurring failure modes in experimental design, execution, and evidence-based reasoning. FIRE-Bench provides a rigorous and diagnostic framework for measuring progress toward reliable agent-driven scientific discovery.

cs.AI↗

scPilot: Large Language Model Reasoning Toward Automated Single-Cell Analysis and Discovery

We present scPilot, the first systematic framework to practice omics-native reasoning: a large language model (LLM) converses in natural language while directly inspecting single-cell RNA-seq data and on-demand bioinformatics tools. scPilot converts core single-cell analyses, i.e., cell-type annotation, developmental-trajectory reconstruction, and transcription-factor targeting, into step-by-step reasoning problems that the model must solve, justify, and, when needed, revise with new evidence. To measure progress, we release scBench, a suite of 9 expertly curated datasets and graders that faithfully evaluate the omics-native reasoning capability of scPilot w.r.t various LLMs. Experiments with o1 show that iterative omics-native reasoning lifts average accuracy by 11% for cell-type annotation and Gemini-2.5-Pro cuts trajectory graph-edit distance by 30% versus one-shot prompting, while generating transparent reasoning traces explain marker gene ambiguity and regulatory logic. By grounding LLMs in raw omics data, scPilot enables auditable, interpretable, and diagnostically informative single-cell analyses. Code, data, and package are available at https://github.com/maitrix-org/scPilot

cs.AI↗

CellMaster: Collaborative Cell Type Annotation in Single-Cell Analysis

Single-cell RNA-seq (scRNA-seq) enables atlas-scale profiling of complex tissues, revealing rare lineages and transient states. Yet, assigning biologically valid cell identities remains a bottleneck because markers are tissue- and state-dependent, and novel states lack references. We present CellMaster, an AI agent that mimics expert practice for zero-shot cell-type annotation. Unlike existing automated tools, CellMaster leverages LLM-encoded knowledge (e.g., GPT-4o) to perform on-the-fly annotation with interpretable rationales, without pre-training or fixed marker databases. Across 9 datasets spanning 8 tissues, CellMaster improved accuracy by 7.1% over best-performing baselines (including CellTypist and scTab) in automatic mode. With human-in-the-loop refinement, this advantage increased to 18.6%, with a 22.1% gain on subtype populations. The system demonstrates particular strength in rare and novel cell states where baselines often fail. Source code and the web application are available at \href{https://github.com/AnonymousGym/CellMaster}{https://github.com/AnonymousGym/CellMaster}.

q-bio.GN↗

DTP: A Simple yet Effective Distracting Token Pruning Framework for Vision-Language Action Models

Vision-Language Action (VLA) models have shown remarkable progress in robotic manipulation by leveraging the powerful perception abilities of Vision-Language Models (VLMs) to understand environments and directly output actions. However, by default, VLA models may overly attend to image tokens in the task-irrelevant region, which we describe as 'distracting tokens'. This behavior can disturb the model from the generation of the desired action tokens in each step, affecting the success rate of tasks. In this paper, we introduce a simple yet effective plug-and-play Distracting Token Pruning (DTP) framework, which dynamically detects and prunes these distracting image tokens. By correcting the model's visual attention patterns, we aim to improve the task success rate, as well as exploring the performance upper boundaries of the model without altering its original architecture or adding additional inputs. Experiments on the SIMPLER Benchmark (Li et al., 2024) show that our method consistently achieving relative improvements in task success rates across different types of novel VLA models, demonstrating generalizability to transformer-based VLAs. Further analysis reveals a negative correlation between the task success rate and the amount of attentions in the task-irrelevant region for all models tested, highlighting a common phenomenon of VLA models that could guide future research. We also publish our code at: https://anonymous.4open.science/r/CBD3.

cs.CV↗

Decentralized Arena: Towards Democratic and Scalable Automatic Evaluation of Language Models

The recent explosion of large language models (LLMs), each with its own general or specialized strengths, makes scalable, reliable benchmarking more urgent than ever. Standard practices nowadays face fundamental trade-offs: closed-ended question-based benchmarks (eg MMLU) struggle with saturation as newer models emerge, while crowd-sourced leaderboards (eg Chatbot Arena) rely on costly and slow human judges. Recently, automated methods (eg LLM-as-a-judge) shed light on the scalability, but risk bias by relying on one or a few "authority" models. To tackle these issues, we propose Decentralized Arena (dearena), a fully automated framework leveraging collective intelligence from all LLMs to evaluate each other. It mitigates single-model judge bias by democratic, pairwise evaluation, and remains efficient at scale through two key components: (1) a coarse-to-fine ranking algorithm for fast incremental insertion of new models with sub-quadratic complexity, and (2) an automatic question selection strategy for the construction of new evaluation dimensions. Across extensive experiments across 66 LLMs, dearena attains up to 97% correlation with human judgements, while significantly reducing the cost. Our code and data will be publicly released on https://github.com/maitrix-org/de-arena.

cs.CL↗

Phase-only signal reconstruction by MagnitudeCut

In this paper, we present a new algorithm, called MagnitudeCut, for recovering a signal from the phase of its Fourier transform. We casted our recovering problem into a new convex optimization problem, and then solved it by the block coordinate descent algorithm and the interior point algorithm, in which the iteration process consists of matrix vector product and inner product. We used the new method for reconstruction of a set of signal/image. The simulation results reveal that the proposed MagnitudeCut method can reconstruct the original signal with fewer sampling number of the phase information than that of the Greedy algorithm and iterative method under the same reconstruction error. Moreover, our algorithm can also reconstruct the symmetric image from its Fourier phase.

math.NA↗